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All Journal Medicina journal of internal medicine E-Jurnal Medika Udayana Berkala Kedokteran Journal of Medicine and Health Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Indonesian Journal of Rheumatology ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) PREPOTIF : Jurnal Kesehatan Masyarakat Neurologico Spinale Medico Chirurgico Jurnal Kesehatan Saintika Meditory Jurnal Ilmu Kesehatan Indonesia (JIKSI) GANESHA MEDICINA MEDICINUS Jurnal Kedokteran Meditek Journal of Medicine and Health Technology Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) Journal of Medicine and Health Cermin Dunia Kedokteran
Wira Gotera
Department Of Endocrinology And Metabolism, Medical Faculty, Udayana University/ Sanglah General Hospital, Denpasar, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Karsinoma Endometrium pada Seorang Pasien dengan Diabetes Mellitus Tipe 2: Laporan Kasus: Laporan Kasus Teron, Thomas Aquinas Ehe; Nugraha, Ida Bagus Aditya; Gotera, Wira; Daniella, Dian; Riandika, Gede Vendi Cahyad
Cermin Dunia Kedokteran Vol 53 No 05 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i05.1007

Abstract

Introduction: Endometrial cancer is often associated with obesity, type 2 diabetes mellitus (T2DM), insulin resistance, and hyperinsulinemia. Case: A 71-year-old woman with a history of T2DM, hypertension, and obesity (body mass index/BMI 32.08 kg/m²) presented with intermittent abdominal pain and vaginal bleeding. She had undergone a curettage procedure two weeks earlier. Ultrasound examination revealed a hyperechoic mass in the uterine corpus, and histopathological examination following staging laparotomy confirmed type 2 endometrial carcinoma (high-grade serous carcinoma) with omental metastasis. The diagnosis was stage IVB endometrial carcinoma. During hospitalization, the patient received intravenous ceftriaxone, insulin glargine, and oral antihypertensive medications (ramipril and nifedipine). She was scheduled to receive systemic chemotherapy with carboplatin and paclitaxel, the standard regimen for advanced-stage, aggressive non-endometrioid endometrial cancer. Discussion: Diabetes mellitus, particularly when accompanied by chronic hyperglycemia, insulin resistance, and hyperinsulinemia, is associated with an increased risk of various cancers, including endometrial cancer, as well as a poorer prognosis. Factors such as obesity, age, estrogen exposure, and insulin therapy may exacerbate this risk, while biomarkers such as IGF-2 and IGFBP-3 have the potential to be used for early detection and risk assessment of endometrial cancer. Conclusion: This case highlights the strong link between T2DM, obesity, and aggressive endometrial cancer, emphasizing the importance of early detection and comprehensive management in patients with metabolic risk factors.
Co-Authors A Santoso AAG Budhiarta Anak Agung Gede Budhiarta Anak Agung Wiradewi Lestari Anwar Santoso Budhiarta, Anak Agung Gde Daniella, Dian Dewa Gde Agung Budiyasa Dewi, Ni Made Ratih Purnama Dian Daniella Dwijo Anargha Sindhughosa Elizabet Haryant Gede Kambayana Gunadi, Hendra H Taniguchi I Ketut Mariadi I Ketut Suastika I Made Pande Dwipayana I Made Siswadi Semadi I Nyoman Wande I. K. Suastika Ida Bagus A Nugraha Ida Bagus Aditya Nugraha Ida Bagus Putu Putrawan IGN Gunadi IMR Saraswati Irianto, Petrus K Badjra Nadha K Rina Komang Agus Wira Nugraha LP Dea Sasmita P Luh Gede Sri Yenny Made Nian Anggara MADE RATNA SARASWATI . Mia Felina Prasetya Muhammad Ridwan N Kajiwara Ni Kadek Mulyantari Ni Made A Yudhawati Ni Made D Adnyani Novia, Juvita Nugraha, Ida Bagus Pande Ketut Kurniari Parastan, Rovie Hikari Prabawa, I Putu Yuda R. A.T. Kuswardhani Riandika, Gede Vendi Cahyad RIONALDO ANTHONIUS S., Hantono Saraswati, Kadek Sinta Dwi Saraswati, Putu Ayu Indah Sianny Herawati Siorcani, Putu Tasha Sudana, I Nyoman Gde Sutanegara - Teron, Thomas Aquinas Ehe W Wita Wan Muhamad Syafiq Wardana, Rr. Cattleya Allayka Wayan Evie Frida Yustin Widya Utama, I Putu Sista Yenny Kandarini