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All Journal Indonesian Journal of Cancer Chemoprevention Journal of Agromedicine and Medical Sciences Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Motiva: Jurnal Psikologi JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ilmu Kesehatan Jurnal Kebidanan Mutiara Mahakam Pediatric Sciences Journal Jurnal Medika: Karya Ilmiah Kesehatan Jurnal Sains dan Kesehatan
Eva Rachmi
Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Age-Associated with Worsening of Neurological Deficits in Ischemic Stroke Patients in Abdoel Wahab Sjahranie Regional Hospital, Samarinda Indria, Muhamad Dino; Rachmi, Eva; Hutahaean, Yetty Octavia
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 1 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I12024.34-40

Abstract

Highlights: The worsening of neurological deficits in ischemic stroke patients is associated with the patient's age, with those over 45 years old having a higher risk. The worsening of neurological deficits in ischemic stroke patients does not correlate with hemoglobin level, hematocrit value, gender, smoking history, blood pressure, or hyperglycemic state.   Abstract Introduction: Treatment of impairment is an important step to prevent advanced neurological deficits in ischemic stroke medicine. Ischemic stroke patients with likely worsening neurological deficits should receive appropriate interventions. Therefore, this study aimed to examine predictors that can identify worsening neurological deficits. Methods: This study used a cross-sectional design on 74 hospitalized ischemic stroke patients at Abdoel Wahab Sjahranie Regional Hospital, Samarinda, in 2019. The worsening of neurological deficits was based on the progression of the National Institutes of Health Stroke Scale (NIHSS) scores at hospital admission and discharge. Age, hemoglobin level, hematocrit value, gender, smoking history, blood pressure, and hyperglycemic state were based on patient data at the beginning of hospital admission. The Chi-Square and Fisher's exact tests were used in bivariate analysis. Results: The results showed that age had a significant association with the worsening of neurological deficits in ischemic stroke patients (p = 0.024). Hemoglobin level, hematocrit value, gender, smoking history, blood pressure, and hyperglycemic state showed no relationship with worsening neurological deficits in ischemic stroke patients (p > 0.05). Conclusion: Age can serve as a predictor of worsening neurological deficits in ischemic stroke patients, with those aged over 45 years old having a higher risk. Meanwhile, the other factors were not associated with a worsening neurological deficit in ischemic stroke patients.
Hubungan Status Gizi, Umur, Jenis Kelamin dengan Derajat Infeksi Dengue pada Anak di RSUD Abdul Wahab Sjahranie Samarinda: Relationship between Nutritional Status, Age, Gender and Degree of Dengue Infection in Children at Abdul Wahab Sjahranie Hospital Samarinda Putri Lintang Kharisma; Annisa Muhyi; Eva Rachmi
Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i3.288

Abstract

Dengue virus infection can manifest from mild to severe, which are undifferentiated fever, dengue hemorrhagic fever (DD), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS), respectively. Mild and severe dengue infection is difficult to distinguish early in the course of the disease, and the clinical course is also difficult to "predict". Therefore, indicators were needed to predict the degree of dengue virus infection, thus appropriate treatment can be given. The study was aimed to determine the association of nutritional status, age, and sex with the degree of dengue infection in children. This study was an analytic observational study with a cross-sectional design. The samples were pediatric patients (0-18 years), who have been diagnosed with dengue virus infection and were hospitalized at the Abdul Wahab Sjahranie Hospital Samarinda in 2019. Purposive sampling technique was used to appointed 88 patients. The data obtained from the medical records. The bivariate association was statistically analyzed with chi-square test. The result showed a significant association between sex (p = 0.041) with the degree of dengue infection in children. Meanwhile nutritional status (p = 0.127) and age (p = 0.077) had no significant association with the degree of dengue infection in children. In conclusion, sex might serve as a predictor of the degree of dengue infection in children, in which male is more susceptible to worse manifestations.
Gambaran Pasien Kanker Ovarium Tipe Epitel di RSUD Abdoel Wahab Sjahranie: Stadium, Usia, Status Menopause, dan Subtipe Histopatologis: Overview of Epithelial Ovarian Cancer Patients at Abdoel Wahab Sjahranie Regional Hospital: Stage, Age, Menopausal Status, and Histopathological Subtype Della Ayu Lestari; Eva Rachmi; Andika Adi Saputra Achmad
Jurnal Medika : Karya Ilmiah Kesehatan Vol 10 No 1 (2025): Jurnal Medika : Karya Ilmiah Kesehatan
Publisher : ITKES Wiyata Husada Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35728/jmkik.v10i1.1259

Abstract

Ovarian cancer is the third most common gynecological cancer in women worldwide and has increased by 31.5% in 2020 compared to 2012, with the majority of cases being the epithelial type (90%). Ovarian cancer is one of the deadliest gynecological cancers because it tends to be asymptomatic or often has no clear symptoms so it can only be diagnosed at an advanced stage. This study describes the stage, age, menopausal status, and histopathological subtype in patients with epithelial ovarian cancer at Abdoel Wahab Sjahranie Hospital, Samarinda, which was conducted from August to December 2023. The design of this study was descriptive observational with a cross-sectional approach. The sampling technique was purposive sampling and based on secondary data in the form of medical records, totaling 30 patients. The highest proportion was found in stage III (50%). The age distribution was dominated by 41 – 60 year (56.67%), menopausal status was dominated by the postmenopausal group (73.33%), and the most common histopathological subtype was serous (63.33%).
Hubungan Hipertensi dan Obesitas dengan Hipertensi Okular: Relationship between Hypertension and Obesity with Ocular Hypertension Chair, Naila Permata; Fatmawati, Nur Khoma; Rachmi, Eva
Jurnal Sains dan Kesehatan Vol. 7 No. 4 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i4.2438

Abstract

Intraocular pressure is the pressure inside the eye, which normally ranges from 10-21 mmHg, with an average of 16 ± 25 mmHg. Maintaining intraocular pressure within the normal range is crucial because elevated intraocular pressure (ocular hypertension) can lead to decreased perfusion in the eye which eventually increasing the risk of primary open-angle glaucoma (POAG) and retinal vein occlusion. High blood pressure and a high Body Mass Index (BMI) can influence an increase in intraocular pressure by disrupting the aqueous humor outflow mechanisms. The purpose of this study is to analyze the correlation between hypertension and obesity in ocular hypertension. The study employed an analytical observational design using a cross-sectional approach. Sample selection was performed using the purposive sampling method and involved 48 patients who met the study criteria. Researched data was obtained from both secondary and primary data through examination of blood pressure, body weight, height, and intraocular pressure. Bivariate data analysis was conducted using the Chi-Square test and Fisher's exact test. The results showed that the majority of the hypertensive patient group has normal intraocular pressure (41.6%), and the majority of obese patients also have normal intraocular pressure (43.7%). Based on bivariate analysis showed the correlation between hypertension and ocular hypertension yielded p-value = 0.458 and the correlation between obesity and ocular hypertension yielded p-value = 0.330. The analysis suggests that hypertension and obesity does not have a significant correlation with ocular hypertension. Keywords:          Ocular Hypertension, Hypertension, Obesity, Intraocular Pressure   Abstrak Tekanan intraokular merupakan tekanan di dalam bota mata, yang normalnya berkisar dari 10 – 21 mmHg, dengan rata-rata 16 ± 2,5 mmHg. Tekanan intraokular perlu dipertahankan dalam kisaran normal karena tekanan intraokular yang tinggi (hipertensi okular) memicu penurunan perfusi pada mata sehingga meningkatkan risiko terjadinya glaukoma sudut terbuka dan oklusi vena retina. Hipertensi dan indeks massa tubuh (IMT) tinggi dapat memengaruhi peningkatan tekanan intraokular melalui terganggunya mekanisme aliran humor aquos. Penelitian ini bertujuan untuk menganalisis hubungan antara hipertensi dan obesitas dengan hipertensi okular. Desain penelitian ini adalah observasional analitik dengan pendekatan cross-sectional. Pengambilan sampel dilakukan dengan metode purposive sampling dan melibatkan 48 pasien yang memenuhi kriteria penelitian. Data penelitian diperoleh dari data sekunder dan data primer melalui pemeriksaan tekanan darah, berat badan, tinggi badan, dan tekanan intraokular. Uji bivariat data dianalisis dengan uji Chi-Square dan Fisher’s Exact. Hasil penelitian menunjukkan mayoritas kelompok pasien hipertensi lebih banyak memiliki tekanan intraokular normal (41,6%) dan mayoritas pasien obesitas memiliki tekanan intraokular normal (43,7%). Berdasarkan analisis bivariat antara hubungan hipertensi dan hipertensi okular didapatkan p value = 0,616 dan hubungan obesitas dengan hipertensi okular didapatkan p value = 0,330. Dapat disimpulkan bahwa hipertensi dan obesitas tidak memiliki hubungan dengan hipertensi okular. Kata Kunci:         Hipertensi Okular, Hipertensi, Obesitas, Tekanan Intraokular
Hubungan Kadar Serum Cancer Antigen-125 dengan Stadium Kanker Ovarium Tipe Epitel: Correlation between Serum Levels of Cancer Antigen-125 and Stages of Epithelial Type Ovarian Cancer Lestari, Della Ayu; Rachmi, Eva; Achmad, Andika Adi Saputra
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.2237

Abstract

Ovarian cancer has the worst prognosis of all gynecologic malignancies in women. The five-year survival rate for ovarian cancer is only 30%–50% in Indonesia. The most common histological type in ovarian cancer incidence is epithelial ovarian cancer (90%). Ovarian cancer is still one of the deadliest gynecological cancers because there is no effective technique for predicting the stage of ovarian cancer. The accuracy of CA-125 as a tumor marker in determining the stage of ovarian cancer is still being argued. This study analyzes the relationship between serum CA-125 levels and the stage of epithelial type ovarian cancer at Abdoel Wahab Sjahranie Hospital Samarinda, which was conducted from August to December 2023. This research is an analytical observational with a cross-sectional approach. The sampling technique was purposive sampling, with secondary data in the form of medical records, sample totaled 30 patient. Bivariate analysis was carried out using the one way ANOVA test. The relationship between serum CA-125 levels and the stage of epithelial ovarian cancer was not significant overall (p = 0.052). Further tests revealed a significant difference between serum CA-125 levels and the stage of epithelial type ovarian cancer, especially at stage I and stage III (p = 0.027). Keywords:          Serum CA-125 Levels, Epithelial Type of Ovarian Cancer, Stage   Abstrak Kanker ovarium memiliki prognosis terburuk dari seluruh keganasan ginekologi pada wanita. Kesintasan lima tahun kanker ovarium hanya 30%–50% di Indonesia. Tipe histologis paling umum pada insidensi kanker ovarium adalah kanker ovarium tipe epitel (90%). Kanker ovarium masih menjadi salah satu kanker ginekologi paling mematikan karena belum ada teknik yang efektif untuk memprediksi stadium kanker ovarium. Akurasi CA-125 sebagai salah satu penanda tumor dalam menentukan stadium kanker ovarium masih menjadi perdebatan. Penelitian ini menganalisis hubungan antara kadar serum CA-125 dengan stadium kanker ovarium tipe epitel di RSUD Abdoel Wahab Sjahranie Samarinda, yang dilakukan pada bulan Agustus hingga Desember 2023. Penelitian ini berupa observasional analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel melalui purposive sampling, dengan data sekunder berupa rekam medis. Sampel berjumlah 30 pasien. Analisis bivariat dilakukan dengan uji one way ANOVA. Hubungan antara kadar serum CA-125 dengan stadium kanker ovarium tipe epitel secara keseluruhan adalah tidak bermakna (p = 0,052). Uji lanjut didapatkan perbedaan yang bermakna antara kadar serum CA-125 dengan stadium kanker ovarium tipe epitel, khususnya pada stadium I dan stadium III (p = 0,027). Kata Kunci:         Kadar Serum CA-125, Kanker Ovarium Tipe Epitel, Stadium
Ethanol Extract of Artocarpus odoratissimus (Tarap) Bark Inhibit Migration of MDA-MB-231 Triple Negative Breast Cancer Cells Rachmi, Eva; Hasanah, Nurul; Irawiraman, Hadi; Nuratifah, Annisa Puteri; Nahusuly, Fritz
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp83-93

Abstract

Breast cancer is the most diagnosed cancer in the world, with triple negative breast cancer (TNBC) being one of its subtypes that exhibits an aggressive clinical course, a tendency for early metastasis, and a poor prognosis. Tarap (Artocarpus odoratissimus Blanco) is an endemic plant of East Kalimantan, which possesses anticancer potential. This study aimed to explore the ability of ethanol extract of Tarap bark (EETB) in reducing cell viability, inducing apoptosis and inhibiting migration of MDA-MB-231 cells. Cell viability was observed by 3-(4.5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. EETB -induced apoptosis was analyzed by double staining allophycocyanin (APC) Annexin V with PI kit through flow cytometry. Cell migration was determined through scratch assay. EETB was found to decrease cell viability with an IC50 value of 1607.302 μg/ml (R=0.369). EETB’s ability to induce total apoptosis did not show significant differences across various concentrations. EETB was able to inhibit cell migration, especially at concentrations of 800 mg/ml, both at 24-h and 48-h observations. This finding demonstrates that EETB has a weak effect on reducing the viability and inducing the apoptosis of MDA-MB-231 cells. EETB induced morphological cells type change in to globular type and significantly inhibits two-dimensional migration of MDA-MB-231 cells.Keywords: Tarap, Artocarpus odoratissimus, triple negative breast cancer.
Co-Authors Abdillah, Muhammad Razaq Achmad, Andika Adi Saputra Ainurfaiz Fiqridiyanto Andi Erika Safitri Andi Erika Safitri Andika Adi Saputra Achmad Annisa Muhyi Arie Ibrahim Bidadari, Titis Mukti Chair, Naila Permata Christopher Kevin Susanto Danial Danial Della Ayu Lestari Hary Nugroho Hutahaean, Yetty Octavia Indria, Muhamad Dino Irawiraman, Hadi Jessica Manaek Manika Meiliati Aminyoto Moriko Pratiningrum Muhammad Rizqan Khalidi Murti, Sinta Nahusuly, Fritz Nur Khoma Fatmawati Nuratifah, Annisa Puteri Nurul Hasanah Prisilia, Cindy Putri Lintang Kharisma Ramadhanny, Candra Rio Mandala Putra Ruslan Sulistiawari . Sulistiawati sulistiawati