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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JFIOnline Jurnal Masyarakat Madani Indonesia Widya Teknik Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Lannie Hadisoewignyo
Faculty Of Pharmacy, Widya Mandala Catholic University Surabaya, Jalan Raya Kalisari Selatan No. 1, Pakuwon City, Surabaya, Indonesia, 60112
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Studi on the in vitro release of ibuprofen from xanthan gum matrix combined with a crosslinking agent Hadisoewignyo, Lannie; Fudholi, Achmad
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.107 KB) | DOI: 10.14499/indonesianjpharm0iss0pp133-140

Abstract

Ibuprofen is non-steroidal anti-inflammatory drugs that is often used so frequently in a day that is can cause the patient to forget to take it. Besides it may cause gastro intestinal disturbances, which increase with the frequent of use. Many studies have been undertaken to obtain ibuprofen controlled release systems. Based on this, this study is done to find out the in vitro release kinetic of ibuprofen from xanthan gum matrix combined with a crosslinking agent, that is locust bean gum or calcium sulphate.In this research there were six formulas sustained release ibuprofen tablet that was made by the same compression pressure. Formula I, II and III used matrix combination of xanthan gum and locust bean gum (1:½, 1:1, 1:1½), while formula IV, V and VI used matrix combination of xanthan gum and calcium sulphate (1:½, 1:1, 1:1½). Afterward, the physical and release characteristics of the tablet were examined.The results showed that the compactibility of matrix combination of xanthan gum and locust bean gum was different from the matrix combination of xanthan gum and calcium sulphate. Combination of xanthan gum and locust bean gum and also calcium sulphate as crosslinking agent can influence the physical properties and the release profile of tablet.Key words: ibuprofen, xanthan gum, locust bean gum, calcium sulphate, dissolution, sustained release tablet.
Hepatoprotective effects of Curcumin-Mesoporous Silica Nanoparticles on CCl 4 -induced Hepatotoxicity Wistar rats Hadisoewignyo, Lannie; Soeliono, Ivonne; Hartono, Sandy Budi; Hestianah, Eka Pramhyrta; Mahanani, Sri Rahayu
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (995.217 KB) | DOI: 10.14499/indonesianjpharm30iss2pp114-121

Abstract

It has been reported that curcumin has a hepatoprotective effect, but its low solubility limited its utilization. Recently there was so many emerging research of advanced curcumin formulation, such as nanoparticles curcumin. In our previous study, curcumin has been loaded into mesoporous silica nanoparticles (C-MSN). This study was performed both to evaluate of C-MSN hepatoprotective effect in CCl4-induced rats. Sixteen rats were divided into four groups, namely normal and CCl4 control, curcumin, C-MSN group. Treatment was given according to its group for fourteen days consecutively. At day 14, three hours after the last administration, CCl4 (1,25 ml/kgBB) were administered orally. Twelve hours later the rats were sacrificed, and blood samples were drawn from their hearts. Blood serum examination result revealed that C-MSN caused a significantly lower ALT and AST than CCl4 control group (851±271 U/L vs 1734±275 U/L; 295±155 U/L vs 1348±235 U/L; p<0.05). Its effect on hepatic serum level resembled curcumin group. However, the result was not supported by histology examination which showed a higher number of necrotic hepatic cells in C-MSN group than in the curcumin group (147±9 vs 80±16; p<0.05). From this study, it can be concluded that C-MSN revealed an excellent hepatoprotective property, but it was suspected that MSN itself has the toxic effect on the liver. A further study of MSN toxicity was needed to support its safety use. 
Optimization of formula sustained releaase captopril tablet using factorial design method Pratiwi, Melinda; Hadisoewignyo, Lannie
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (556.845 KB) | DOI: 10.14499/indonesianjpharm0iss0pp272-282

Abstract

Captopril is one of the most frequently used  medicine  in the treatment of hypertension  with  repeatedly  used  frequency  in  a  day.  Therefore  captopril should  be  formulated  in  the  form  of  sustained  release  and  find  the  optimum formula.  The  purpose  of  this  study  was  to  determine  the  influence  of  both factors  and  their  interactions,  which  are  the  ratio  of  polymer  HPMC  K4M  -xanthan gum  factor at the level of 1:1 and 4:1 and the concentration of tartaric acid  at  levels  of  0%  and  5%  on  physical  properties  of  tablets,  drug  release, floating  lag  time.  Furthermore,  find  the  optimum  formula  that  meets  the requirements  and  produce  tablets  with  drug  release  pattern  according  to  zero order  kinetics.  Based  on  Design  Expert  optimization  program  was  obtained  the optimum  formula  using  a  combination  of  polymer  HPMC  K4M  –  xanthan  gum ratio  3.75:1  and  concentration  of  of  tartaric  acid  4.5%  would  be  result  the hardness  respons  12.02  Kp  the  friability  0.47%,  the  floating  lag  time  0.32 minutes,  and  the  rate  of  dissolution  0.05  mg/min.  The  results  show  that combination of factors polymer HPMC K4M -  xanthan gum ratio can increase the tablet  hardness,  lower  tablet  friability,  accelerate  the  floating  lag  time,  and increase the rate  of dissolution.  Tartaric acid can  decrease  the  tablet  hardness, increase  the  friability,  accelerate  the  floating  lag  time,  and  increase   the  rate  of dissolution.  Interaction  of  both  can  reduce  the  tablet  hardness,  increase  the tablet friability, slow floating lag time, and increase the rate of dissolution.Key words: captopril, HPMC K4M, xanthan gum, tartaric acid, factorial design
Ibuprofen salt production and its application in tablet dosage form Hadisoewignyo, Lannie; Fudholi, Achmad; Muchalal, M.
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.59 KB) | DOI: 10.14499/indonesianjpharm0iss0pp141-150

Abstract

Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.
Influence of filler-binders on ibuprofen iablets with direct compression method Hadisoewignyo, Lannie; Teny, Gracesya Florensya; Handayani, Elok Tri; Yunita, Beby
Indonesian Journal of Pharmacy Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.932 KB) | DOI: 10.14499/indonesianjpharm0iss0pp279-285

Abstract

Ibuprofen  is  a  active  ingredient  that  have  low  melting  point,  but  it  has poor  flowability,  and  poor  compactibility,  this  causes  ibuprofen  tablets  are  not suitable  to  be  made  by   direct  compression  method.   The  use  of  appropiate filler-binders  can  improved  the  flow  properties  and  compactibility  powder  that can be made  by  direct compression. Filler binders  commonly use  are  Avicel PH 102, Emcompress, SDl, and Starch 1500. Formula tablet ibruprofen using Avicel PH 102 as filler-binder will produce tablet with good hardness, low friability, fast disintegrating,  and  high  dissolution.  This  is  because  the  hydrophilic  properties and plastic deformation which is owned by Avicel PH 102.Key words:Ibuprofen, Avicel PH 102, direct compression
Liquisolid ibuprofen tablets Lannie Hadisoewignyo; Evania hadi; Nehru Wibowo
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.538 KB) | DOI: 10.14499/indonesianjpharm0iss0pp197-203

Abstract

Ibuprofen  is  an  antiinflamatory  drugs  with  poor  solubility  in  water  but good  permeability  in  the  gastrointestinal  tract.  Liquisolid  tablet  is  the  one method of increasing solubility and dissolution rate of ibuprofen. The aims of this study  was  to  determine  the  effect  of  glycerine  and  propylene  glicol  as  non volatile  solvent  and  PVP  K-30   as  hydrophilic  polymer  on the  dissolution  rate of liquisolid  ibuprofen  tablets.  In  this  research,  there  are  7  formulas  of  liquisolid ibuprofen  tablets  were  made.  The  ratio of  ibuprofenin  glycerine  is 1  : 3  and of propilene glicol is 5:1 with various concentration of PVP K-30 (5, 10, and 15%). Formula I was made as a control so there was no addition of non volatile solvent and hydrophilic polymer. Based on the results, liquisolid ibuprofen tablets using glycerine  or  propylene  glycol  as  a  non  volatile  solvent  and  PVP  K-30  as  a hydrophilic  polymer  can  increase  the  dissolution  rate  constant  of  liquisolidibuprofen  tablets  comparedthat  of  ibuprofen  conventional  tablets  (non liquisolid).  The  addition  of  PVP  K-30  as  a  hydrophilic  polymer  can  increase  the dissolution  rate  constants  liquisolid  ibuprofen  tablets  until  a   concentration  of more  than  10%  because  the  polymer  will  swell  and  form  a  viscous  layer  that inhibits the disintegration so that the percent release decrease.Key words:Ibuprofen, liquisolid, non volatile solvent, hydrophilic polymer.
Ibuprofen salt production and its application in tablet dosage form Lannie Hadisoewignyo
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.59 KB) | DOI: 10.14499/indonesianjpharm0iss0pp141-150

Abstract

Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.
Co-Authors . Antaresti Achmad Fudholi Elim, Siska Emi Sukarti, Emi Evania hadi Farida Lanawati Darsono Fudholi, Achmad Handayani, Elok Tri Hartono, Sandy Budi Henny Dwi Arini Hestianah, Eka Pramhyrta Idajani Hadinoto Idajani Hadinoto Ivonne Soeliono Ivony Helen Ivony Helen Lisa Soegianto Lisa Soegianto Lucia Hendriati Mahanani, Sri Rahayu Martha Ervina Muchalal, M. Nehru Wibowo Nurak, Elisabeth Prasetyo, Jefri Pratiwi, Melinda Sandy Budi Hartono Sinansari, Restry Sumargo, Fredy Teguh Widodo Teny, Gracesya Florensya Wahyu Dewi Tamayanti, Wahyu Dewi Wuryanto Hadinugroho Yunita, Beby