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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JFIOnline Jurnal Masyarakat Madani Indonesia Widya Teknik Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Lannie Hadisoewignyo
Faculty Of Pharmacy, Widya Mandala Catholic University Surabaya, Jalan Raya Kalisari Selatan No. 1, Pakuwon City, Surabaya, Indonesia, 60112
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Liquisolid ibuprofen tablets Lannie Hadisoewignyo; Evania hadi; Nehru Wibowo
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.538 KB) | DOI: 10.14499/indonesianjpharm0iss0pp197-203

Abstract

Ibuprofen  is  an  antiinflamatory  drugs  with  poor  solubility  in  water  but good  permeability  in  the  gastrointestinal  tract.  Liquisolid  tablet  is  the  one method of increasing solubility and dissolution rate of ibuprofen. The aims of this study  was  to  determine  the  effect  of  glycerine  and  propylene  glicol  as  non volatile  solvent  and  PVP  K-30   as  hydrophilic  polymer  on the  dissolution  rate of liquisolid  ibuprofen  tablets.  In  this  research,  there  are  7  formulas  of  liquisolid ibuprofen  tablets  were  made.  The  ratio of  ibuprofenin  glycerine  is 1  : 3  and of propilene glicol is 5:1 with various concentration of PVP K-30 (5, 10, and 15%). Formula I was made as a control so there was no addition of non volatile solvent and hydrophilic polymer. Based on the results, liquisolid ibuprofen tablets using glycerine  or  propylene  glycol  as  a  non  volatile  solvent  and  PVP  K-30  as  a hydrophilic  polymer  can  increase  the  dissolution  rate  constant  of  liquisolidibuprofen  tablets  comparedthat  of  ibuprofen  conventional  tablets  (non liquisolid).  The  addition  of  PVP  K-30  as  a  hydrophilic  polymer  can  increase  the dissolution  rate  constants  liquisolid  ibuprofen  tablets  until  a   concentration  of more  than  10%  because  the  polymer  will  swell  and  form  a  viscous  layer  that inhibits the disintegration so that the percent release decrease.Key words:Ibuprofen, liquisolid, non volatile solvent, hydrophilic polymer.
Ibuprofen salt production and its application in tablet dosage form Lannie Hadisoewignyo
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.59 KB) | DOI: 10.14499/indonesianjpharm0iss0pp141-150

Abstract

Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.
Effect of Various Concentration of Vegetable Protein in Hair Mask on The Hair Texture Ivony Helen; Idajani Hadinoto; Lannie Hadisoewignyo; Lisa Soegianto
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss1pp159-168

Abstract

Effect of various concentrations of vegetable protein in hair mask on the hair texture including hair smoothness, hair shining, hair strength, and morphology of hair had been studied. Concentrations of vegetable protein are made 5%, 7.5%, and 10%. The hair mask was evaluated such as organoleptic, pH, viscosity, and allergy test. Hair mask used in six subjects that have damage hair for 8 times every 2 days. Then, the hair mask was evaluated such as hair smooth and hair shine that used tree trained panel and analyzed using non parametric method Q Cochran. Hair strength was evaluated using autograph then the results were  analyzes using ANOVA test (p<0.05), while hair morphology was evaluated using scanning microscope electron (SEM). The experimental results showed that vegetable protein in hair mask increased hair smoothness, hair strength, and morphology of damaged hair but did not give effect for hair shining. Various concentrations of vegetable protein (5%, 7.5%, and 10%) on hair mask given the same effect in hair texture (hair smoothness, hair strength, and hair morphology).Keywords: vegetable protein, hair mask, hair texture
Pembuatan, modifikasi dan pemanfaatan material nano-pori Sandy Budi Hartono; Lannie Hadisoewignyo; . Antaresti
Widya Teknik Vol. 16 No. 2 (2017)
Publisher : Fakultas Teknik, Universitas Katolik Widya Mandala Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/wt.v16i2.1664

Abstract

Pemanfaatan Teknologi-Nano (Nanotechnology) dalam pembuatan berbagai jenis nanoparticles (partikel berukuran nanometer atau material nano) mengalami perkembangan yang sangat pesat. Aplikasi dari material nano telah meluas di berbagai bidang antara lain: katalis, pangan dan farmasi. Material nano dengan ukuran partikel antara 100 sampai 1000 nm memiliki keunggulan terutama pada luasan permukaan yang sangat besar dibandingkan dengan bulk material. Material nano-pori (MNP) sebagai bagian dari material nano memiliki karakteristik khusus dengan keberadaan struktur pori pada bahan tersebut. Salah satu jenis yang banyak dipelajari adalah Material Nano-Pori berbahan dasar silika (MNPS). Keunggulan dari (MNPS) terletak pada luasan permukaan yang sangat besar (dapat mencapai 1000 m2/g), ukuran pori yang dapat dirubah serta karakternya yang mudah untuk dimodifikasi. Penulisan artikel ini bertujuan untuk memberikan gambaran singkat tentang beberapa contoh MNPS, modifikasi dari MNPS serta pemanfaatannya. Aplikasi Material Nano-Pori ini meliputi gene delivery dan juga drug delivery diantaranya ibuprofen dan kurkumin. Materi dari review singkat ini berasal dari penelitian penulis serta dari beberapa artikel terkait di bidang MNPS yang dibuat oleh peneliti lain.
Pembekalan Aspek Kewirausahaan dalam Pembuatan Sediaan Jamu Instan Wedang Pokak Bagi Petugas Kebersihan Hadisoewignyo, Lannie; Prasetyo, Jefri; Darsono, Farida Lanawati; Sinansari, Restry; Hadinugroho, Wuryanto; Soeliono, Ivonne
Jurnal Masyarakat Madani Indonesia Vol. 4 No. 3 (2025): Agustus
Publisher : Alesha Media Digital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59025/t68w8415

Abstract

Susahnya menumbuhkan jiwa wirausaha pada masyarakat Indonesia pada zaman sekarang termasuk yang dialami oleh peserta pengabdian kami yaitu petugas kebersihan di bawah PT. ISS Indonesia yang bekerja kampus Universitas Katolik Widya Mandala Surabaya. Hal itu disebabkan karena sebagian besar petugas kebersihan tersebut masih belum mendapatkan pembekalan dalam hal berwirausaha secara mandiri. Oleh sebab itu, pada kegiatan pengabdian ini, petugas kebersihan akan dibekali dengan ilmu berwirausaha dalam bentuk kegiatan pelatihan pembuatan produk minuman jamu yang dikemas secara modern dalam bentuk granul instan wedang pokak yang siap minum dan mudah diterapkan serta diimplementasikan secara sederhana. Keberhasilan kegiatan pembekalan menggunakan indikator perolehan nilai pre-test dan post-test. Hasil dari pembekalan yaitu para petugas kebersihan mampu meningkatkan pengetahuan dan wawasan tentang komponen bahan alam dalam formula jamu wedang pokak. Berdasarkan hasil evaluasi yang telah dilakukan, dapat disimpulkan bahwa kegiatan pengabdian yang dilakukan telah berhasil diterima dengan baik oleh para peserta yang dibuktikan melalui peningkatan pengetahuan berdasarkan nilai pre-test dan post-test yaitu sebesar 41%. Selain itu, kegiatan pengabdian ini telah berhasil dalam meningkatkan wawasan dan menambahkan ide bisnis bagi para peserta dalam berwirausaha dengan cara membuat sediaan jamu dalam bentuk granul instan wedang pokak secara mandiri yang memiliki nilai jual.
Efek Fraksi Air Daun Salam (Syzygium polyanthum) Terhadap Imunitas Alami Tikus Wistar Jantan Tamayanti, Wahyu Dewi; Soegianto, Lisa; Nurak, Elisabeth; Hadisoewignyo, Lannie; Ervina, Martha
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.702

Abstract

Pemberian fraksi air daun salam (Syzygium polyanthum) terhadap jumlah netrofil dan kadar IL-6 tjkus Wistarjantan yang telah diinduksi Staphylococcus aureus telah dilakukan. Tikus Wistar jantan dibagi dalam 3 ckelompok, masing-masing terdiri dari 5 ekor tikus, yaitu kelompok kontrol negatif (perlakuan NaCI 0,9%) kelompok uji (perlakuan fraksi air daun salam 200 mg/kg BB) dan ~elompok kontrol positif (perlakuan suspensi ibuprofen 400 mg/kg BB). Tikus dengan perlakuan dikorbankan satu jam setelah induksi Staphylococcus aureus, dan diambil darahnya. Perhitungan jumlah netrofil darah dilakukan .di bawah mikroskop dan penentuan kadar IL-6 dilakukan dengan metode ELISA. Hasil ana lisa data dengan anava satu arah mengindikasikan bahwa daun salam tidak menurunkan jumlah netrofil darah maupun IL-6 pada tikus Wistar jantan yang terinduksi Staphylococcus aureus.
Optimasi Formula Tablet Floating Metformin Hidroklorida Menggunakan Polimer Guar Gum Elim, Siska; Hadisoewignyo, Lannie; Sukarti, Emi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2345

Abstract

Metformln hydrochloride Is an orally administered blguanlde derivative drug and functions as an anti hyperglycemic In patient with type 2 diabetes mellitus with bioavallablllty between 50-6096. Floating system Is the one method to enhance absorption and bioavallablllty of metformln hydrochloride. The purpose of this research was to determine the effect of guar gum concentration and concentration effervescent components and Interactions of both components on physical properties of tablets, floating lag time, floating time, and dissolution rate constant and get the optimum formula with drug release pattern according to zero order kinetics. In this research using factorial design with two factors Is concentrations factor of guar gum at 15-2096 and concentrations factor of effervescent components Is citric acid and sodium bicarbonate (1:1) at 5-1096. The method used Is direct compression method. Concentration of guar gum have a significant effect on floating lag time and dissolution rate constant but do not have a significant effect on tablet hardness. While the concentration of effervescent components not have a significant effect on tablet hardness and dissolution rate constant but a significant effect on floating lag time. Interaction between guar gum concentration and concentration effervescent components not have a significant effect on tablet hardness, floating lag time, and dissolution rate constant Based on Design - Expert program optimization, the optimum formula obtained Is formula with combination 19,596 guar gum concentration and 5,596 concentration effervescent components which resulting 11,43 Kp hardness, floating lag time 8,69 min and K dissolution 0,324 mUmln.
Co-Authors . Antaresti Achmad Fudholi Elim, Siska Emi Sukarti, Emi Evania hadi Farida Lanawati Darsono Fudholi, Achmad Handayani, Elok Tri Hartono, Sandy Budi Henny Dwi Arini Hestianah, Eka Pramhyrta Idajani Hadinoto Idajani Hadinoto Ivonne Soeliono Ivony Helen Ivony Helen Lisa Soegianto Lisa Soegianto Lucia Hendriati Mahanani, Sri Rahayu Martha Ervina Muchalal, M. Nehru Wibowo Nurak, Elisabeth Prasetyo, Jefri Pratiwi, Melinda Sandy Budi Hartono Sinansari, Restry Sumargo, Fredy Teguh Widodo Teny, Gracesya Florensya Wahyu Dewi Tamayanti, Wahyu Dewi Wuryanto Hadinugroho Yunita, Beby