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Pengaruh Herbisida Paraquat Diklorida Oral Terhadap Hati Tikus Putih Muhartono Muhartono; Yolanda Fratiwi; Indri Windarti; Susianti Susianti
Jurnal Ilmu Kedokteran Vol 9, No 1 (2015): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

The use of herbicide paraquat dichloride by farmers, is one of effort to increase the production in agricultural sector.Herbicide paraquat dichloride often used by farmers carelessly and there was caution ignorance. Herbicide causemuch adverse effect to organs, especially in liver through oral. The purpose of this study is to determine the effect oforal herbicide paraquat dichloride to hepatocyte swelling and sinusoidal congestion in liver of male rats (Rattusnovergicus) Sprague dawley strain. In this experimental study, 25 male rats (Rattus novergicus) Sprague dawleystrain are divided randomly into 5 group and treated for 2 days. K1 is group of controlled, K2, K3, K4, K5 are givenherbicide paraquat dichloride 25 mg/kgBW, 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW. The results showedthat the average number of hepatocyte swelling and sinusoidal congestion in liver was increasing. In Kruskal Wallistest and Post Hoc Mann Whitney test found significant difference p=0.000 (p<0.005). There are significant effect oforal paraquat dichloride to hepatocyte swelling and sinusoidal congestion in liver of male rats (Rattus novergicus)Sprague dawley strain.

Correlation of Lymphocyte-Monocyte Ratio with Grading of Breast Cancer Malignancy Muhartono Muhartono; Rizki Hanriko; Suharyani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.139

Introduction: Breast cancer cases are increase and fast becoming the leading cause of oncologic mortality among women worldwide. Delay in management will worsen the prognosis of breast cancer patients. The poor prognosis is correlate with high grade of breast cancer malignancy. Histology can be used as an indicator to assess the grade of breast cancer malignancy. In addition, a high predictive value of lymphocyte-monocyte ratio (LMR) has been suggested to indicate favorable prognosis of various cancer, and used as parameters for assessing breast cancer prognosis. Method: This study is a quantitative research, using an observational approach. Laboratory examination results are collected from 43 breast cancer patients who will conduct treatment at Urip Sumoharjo Hospital from June to September 2019. Data are processed by the Spearman rank test using SPSS 22.0. Results: Correlation test results between lymphocyte-monocyte ratio with histological grading of breast cancer obtained a P value of 0.376. Conclusions: Lymphocytes to monocytes ratio (LMR) value cannot be utilize as a parameter for evaluating prognosis of breast cancer.

SIGNET RING CELL CARCINOMA PADA PAYUDARA Muhartono Muhartono
Majalah Kedokteran Andalas Vol 37, No 2 (2014): Published in September 2014
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakKanker payudara merupakan keganasan yang paling sering ditemukan pada wanita. Kanker payudara jenis signet ring cell carcinoma (SRCC) sangat jarang ditemukan. Kasus SRCC paling banyak ditemukan pada saluran cerna (GIT). Dilaporkan kasus, wanita 46 tahun, terdapat benjolan di payudara. Pemeriksaan ultrasonografi payudara menunjukkan area hypoechoik. Mamografi menunjukkan payudara heterogen padat, distorsi arsitektur atau mikrokalsifikasi. Aspirasi jarum halus sitologi dari jaringan payudara menunjukkan bahwa tumor adalah ganas. Pada pemeriksaan endoskopi gastrointestinal normal. Pemeriksaan Patologi menunjukkan sel-sel neoplastik bentuk bulat, tersebar atau distribusi disertai musin intrasitoplasmik besar menekan inti menuju salah satu kutub sel. Secara klinis, usg, maupun endoskopi tidak ditemukan massa tumor pada GIT. Pada pemeriksaan imunohistokimia SRCC payudara GCDFP15+, ER+, CK7+, MUC1+, CK20-, MUC2- dan SRCC GIT CK20+, MUC2+, GCDFP15-, ER-, CK7-, MUC1-, Simpulan, SRCC payudara adalah tumor ganas yang sangat langka dan harus dibedakan dari metastasis GIT.AbstractBreast cancer is the most common malignancy in women. Breast cancer types signet ring cell carcinoma (SRCC) is very rare. SRCC case most commonly found in the saluran cerna (GIT). Reported cases, female 46 years, there is a lump in the breast. Breast ultrasound examination showed hypoechoic area. Mammography showed heterogeneous dense breasts, architectural distortion or microcalcifications. Fine-needle aspiration cytology (FNAC) of the breast tissue showed that the tumor was malignant. In normal gastrointestinal endoscopy. Pathologic examination menunjukkan neoplastic cells rounded shape, spread or distribution with large intracytoplasmik mucin core pressing toward one pole of the cell. Clinically, ultrasound, and endoscopy was not found in the GIT tumor mass. On immunohistochemical examination breast SRCC on ER+, CK7+, MUC1+, MUC2-, CK20-; GIT SRCC CK20+, MUC2+, ER-, CK7-, MUC1-. Conclusion, breast SRCC is a malignant tumor that is very rare and should be differentiated from metastatic GIT.

Pengaruh Pemberian Ekstrak Etanol Rimpang Lengkuas (Alpinia galangal L.Willd) Terhadap Gambaran Histopatologi Ginjal Mencit Jantan (Mus musculus L.) yang Diinduksi oleh Monosodium Glutamat (MSG) Muhartono Muhartono; Mukhlis Imanto; Nadia Rosmalia Dewi
Jurnal Kedokteran Universitas Lampung Vol 2, No 1 (2018): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v2i1.1909

Monosodium Glutamat (MSG) adalah garam natrium glutamat yang digunakan sebagai penambah rasa. Menurut Riset Kesehatan Dasar tahun 2013 sekitar 77,3%. MSG dikonsumsi masyarakat Indonesia. MSG dapat membentuk radikal bebas sehingga menyebabkan kerusakan organ-organ tubuh salah satunya organ ginjal manusia. Rimpang lengkuas adalah salah satu bahan alami yang mengandung antioksidan yang dapat mecegah kerusakan organ akibat radikal bebas. Tujuan daripenelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak etanol rimpang lengkuas terhadap gambaran histopatolgi ginjal mencit yang diinduksi MSG. Desain penelitian ini adalah eksperimental dengan 5 kelompok perlakuan, tiap kelompok terdiri dari 5 ekor mencit (Mus Musculus L.) strain DDY. Kelompok K(-) (kontrol -) tidak diberi perlakuan; kelompok K+(kontrol +) diberikan MSG 4mg/grBB; kelompok P1 (perlakuan 1) diberikan MSG 4mg/kgBB + ekstrrak etanol rimpang lengkuas 14mg/20grBB; kelompok P2 (perlakuan 2) diberikan MSG 4mg/kgBB + ekstrrak etanol rimpang lengkuas 28mg/20grBB; kelompok P3 (perlakuan 3) diberikan MSG 4mg/kgBB + ekstrrak etanol rimpang lengkuas 56mg/20grBB. Berdasarkan hasil uji statistik One Way ANOVA didapatakan hasil yang bermakna dan dilanjutkan dengan uji Post Hoc. Pada uji Post Hoc terlihat adanya pengaruh perlakuan terhadap penurunann degenerasi sel ginjal yang bermakna secara statistikterhadap peningkatan dosis ekstrak etanol rimpang lengkuas. Terdapat pengaruh pemberian ekstrak etanol rimpang lengkuas terhadap gambaran histopatologi ginjal mencit yang diinduksi MSG.Kata kunci: Ekstrak lengkuas, histopatologi ginjal, monosodium glutamat

Minyak Jelantah Menyebabkan Kerusakan pada Arteri Koronaria, Miokardium, dan Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Sprague dawley Muhartono Muhartono; M. Agung Yudistira P; Nindya Tiaz Putri; Tri Novita Sari; Oktafany Oktafany
Jurnal Kedokteran Universitas Lampung Vol 2, No 2 (2018): Jk Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v2i2.1949

Minyak jelantah dapat berakibat buruk pada sistem organ. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian minyak jelantah terhadap gambaran histopatologi arteri koronaria, miokardium, dan hepar. Penelitian ini merupakan studi eksperimental dengan rancangan acak terkontrol dengan pola post test only control group design. Sebanyak 25 ekor tikus putih jantan Sprague dawley, dibagi dalam 5 kelompok perlakuan secara acak. Kelompok K (Kontrol) dan kelompok P1, P2, P3, dan P4 yang masing-masing diberikan minyak 1x, 4x, 8x, dan 12x penggorengan dengan dosis 1,5 mL/hari. Hasil penelitian didapatkan rerata diameter lumen arteri koronaria, K:147,02; P1:134,17; P2:126,16; P3:117,19 dan P4:98,28. Rerata skor kerusakan miokardium, K:0,16; P1:0,48; P2:0,96; P3:1,6; P4:1,84. Rerata skor kerusakan hepar, K:0; P1:0,2; P2:1,76; P3:2,88; P4:3,88. Hasil uji One Way Anova terhadap rerata diameter lumen arteri koronaria didapatkan p=0,001. Hasil uji Kruskal Wallis terhadap rerata kerusakan miokardium didapatkan p=0,003 dan rerata kerusakan hepar didapatkan p=0,001. Simpulan pemberian minyak goreng bekas berpengaruh buruk terhadap arteri koronaria, miokardium dan hepar. Kata kunci: arteri koronaria, hepar, minyak goreng bekas, miokardium

Correlation of Lymphocyte-Monocyte Ratio with Grading of Breast Cancer Malignancy Muhartono Muhartono; Rizki Hanriko; Suharyani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.139

Introduction: Breast cancer cases are increase and fast becoming the leading cause of oncologic mortality among women worldwide. Delay in management will worsen the prognosis of breast cancer patients. The poor prognosis is correlate with high grade of breast cancer malignancy. Histology can be used as an indicator to assess the grade of breast cancer malignancy. In addition, a high predictive value of lymphocyte-monocyte ratio (LMR) has been suggested to indicate favorable prognosis of various cancer, and used as parameters for assessing breast cancer prognosis. Method: This study is a quantitative research, using an observational approach. Laboratory examination results are collected from 43 breast cancer patients who will conduct treatment at Urip Sumoharjo Hospital from June to September 2019. Data are processed by the Spearman rank test using SPSS 22.0. Results: Correlation test results between lymphocyte-monocyte ratio with histological grading of breast cancer obtained a P value of 0.376. Conclusions: Lymphocytes to monocytes ratio (LMR) value cannot be utilize as a parameter for evaluating prognosis of breast cancer.

Peranan Ekstrak Kulit Manggis dalam Memperbaiki Kerusakan Hati Akibat Isoniazid Muhartono Muhartono; Fakhmiyogi Fakhmiyogi; Dewi Nurfiana; Novita Carolia
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 2 No. 2 (2015): Jurnal Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

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Pemberian Isoniazid dalam jangka lama dapat menyebabkan kerusakan hati. Salah satu upaya untuk mencegah kerusakan hati tersebut dengan cara pemberian ekstrak kulit manggis. Ekstrak kulit manggis diduga mempunyai aktifitas antioksidan. Tujuan penelitian ini untuk mengetahui potensi kulit manggis dalam memperbaiki kerusakan hati akibat isoniazid. Pada penelitian ini, 25 tikus jantan dibagi dalam 5 kelompok secara acak dan diberi perlakuan selama 14 hari. K1 diberi aquadest, K2 diberi isoniazid 30 mg/100gBB, K3 diberi ekstrak kulit manggis 20 mg/100grBB dan isoniazid 30 mg/100gBB, K4 diberi ekstrak kulit manggis 40 mg/100gBB dan isoniazid 30 mg/100gBB, dan K5 diberi ekstrak kulit manggis 80 mg/100gBB dan isoniazid 30 mg/100gBB. Hasil penelitian menunjukkan bahwa rerata jumlah pembengkakan sel hepatosit pada K1 3±4,472;K2 96±4,183; K3 61±4,183; K4 42±7,582; dan K5 16±5,477. Simpulan, ekstrak kulit manggis dapat memperbaiki kerusakanhati akibat isoniazid. [J Agromed Unila 2015; 2(2):63-66]Kata kunci: ekstrak kulit manggis, hepar, isoniazid

CHRONIC DIARRHEA WITH CHRONIC GASTRITIS ON ELDERLY WOMEN Elis Sri Alawiyah; Muhartono Muhartono
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 1 No. 2 (2014): Jurnal Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

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Diarrheal disease is still a public health problem for Indonesia, because of its morbidity and mortality are still high. Morbidity survey conducted by Subdit Diarrhea, Department of Health from 2000 untill 2010 looks inclination incidence. In addition, there are also a number of chronic gastritis gastritis already so high that ranks 10th in the category of most diseases. Ny. N, 60 years old female came to the health center with a history of diarrhea since 3 days ago. Diarrhea more than 6 times a day, intermittent over the past 1 month, the color was yellow, and slimy. This complaint accompanied by nausea, decreased appetite, sometimesaccompanied by fever. Physical examination revealed blood pressure, pulse and breathing are normal but body temperature was 37.6 oC, sunken eyelids, dry lips, abdomen was convex, epigastric tenderness, increased bowel sounds. Diagnosis of these patients are chronic diarrhea and chronic gastritis. Therapy was Cotrimoxazole 2x1 tabs, Oralit (on each diarrhea), Zinc 1x1 tab, Paracetamol 3x1 tab, Antacid 3x1 tab. Chronic diarrhea in these patients caused by infection and non-infectious. While chronicgastritis caused by the bacterium Helicobacter pylory or psychological stress. [J Agromed Unila 2014; 1(2):126-131]Keywords: chronic diarrhea, chronic gastritis

CHARACTERISTIC OF CARSINOMA MAMMAE AT RSUD DR. H. ABDUL MOELOEK BANDAR LAMPUNG 2010-2012 Vicki Lusbiyanti Utami; Muhartono Muhartono; Dewi Nur Fiana; Tri Umiana Soleha
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 1 No. 1 (2014): Jurnal Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

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Background: Tumor is a neoplastic condition, means the local tissue is overgrowth and incoordinated through the stimulus that triggers the growth has ceased. Histopathological examination is the gold standard method to determinate and diagnose tumors. This examination distinguish the degree of malignancy of a tumor, whether leading to a benign or malignant changes. Currently, breast tumor is one of the neoplasm most often found, especially for malignant tumor, and cause high mortality in the world. The aim of study is to find out the histopathological type of the breast tumor.Methods: The method of this descriptive study is cross sectional, which is conducted in the Anatomical Pathology Installastion In Doctor Haji Abdul Moeloek General Hospital, Bandar Lampung. Data collecting procedure was carried out by analyses to each 75 data of medical records of breast tumor histopathology type during 2010-2012, using total sampling method. Histopathological type obtained then grouped by the World Health Organization 2003 classifiation.Results: The results of this study indicate that the type of the most breast tumor histopathology on the Anatomical Pathology Installation in Doctor Haji Abdul Moeloek General Hospital, Bandar Lampung, during 2010-2012 is fibromadenoma mammae as the most benign mammary tumors of 30 people (40%) and malignant tumor which is 45 people (60%).Conclusion: Fibroadenoma mammae is the most benign mammary tumor and invasive ductal carcinoma mammae is the most malignant mammary tumor in Anatomical Pathology Installation at Doctor Haji Abdul Moeloek General Hospital, Bandar Lampung, during 2010-2012. [J Agromed Unila 2014; 1(1):1-7] Keywords: breast tumor, descriptive, histopathology

Korelasi antara Pemakaian Oksitosin Drip pada Ibu dengan Angka Kejadian Hiperbilirubinemia Neonatal Andhika Razannur Harjanto; Muhartono Muhartono
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 2 No. 3 (2015): JURNAL AGROMEDICINE
Publisher : Fakultas Kedokteran Universitas Lampung

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Pemakaian oksitosin drip dalam menginduksi kelahiran sudah menjadi hal yang lumrah dalam ilmu kedokteran obstetrik. Oksitosin merupakan suatu hormon yang diproduksi pada bagian supraoptik dan paraventrikuler dari hipotalamus yang memiliki peran utama sebagai neuromodulator di otak. Salah satu fungsi dari oksitosin adalah untuk menginduksi kelahirandengan cara menimbulkan atau meningkatkan kontraksi/his dari uterus. The Institute for Safe Medication Practices menyatakan oksitosin sebagai obat dengan tingkat kewaspadaan yang tinggi. Terdapat beberapa kekhawatiran bahwa pemakaian dosis tinggi memiliki potensial untuk menimbulkan efek samping yang tidak diinginkan, salah satunya adalahterjadinya hiperbilirubinemia neonatal seperti yang diungkapkan oleh penelitian Sunit Singhi dan Merhaban Singh dari Department of Paediatrics, All-India Institute of Medical Sciences. Hiperbilirubinemia neonatal adalah istilah yang dipakai untuk ikterus neonatorum setelah ada hasil laboratorium yang menunjukkan peningkatan kadar serum bilirubin danmerupakan salah satu penyebab utama dari kerusakan otak pada neonatus yang dapat dicegah. [J Agromed Unila 2015;2(3):278-283].Kata kunci: hiperbilirubinemia neonatus, jaundice, oksitosin

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