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All Journal Althea Medical Journal Global Medical and Health Communication Biology, Medicine, & Natural Product Chemistry Jurnal Kesehatan Vokasional Majalah Sainstekes Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Science Midwifery Medicra (Journal of Medical Laboratory Science/Technology) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Junior Medical Journal Advance Sustainable Science, Engineering and Technology (ASSET)
Nunung Ainur Rahmah
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Perbedaan Morfologi Kelenjar Mammae Dan Jaringan Ikat Pada Kanker Payudara Dan Fibrokistik Di Rumah Sakit Islam Jakarta Triana Intan Sari; Saffa Hasanah; Muhammad Arsyad; Nunung Ainur Rahmah; Yulia Suciati
Majalah Sainstekes Vol 9, No 1 (2022): JUNI 2022
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1011.722 KB) | DOI: 10.33476/ms.v9i1.2650

Abstract

Kanker payudara adalah keganasan yang berasal dari epitel duktus maupun lobules di jaringan payudara. Di sisi lain, penyakit fibrokistik adalah benjolan teraba di payudara dan terkait dengan siklus menstruasi. Karena gejala awal yang mirip, pada pemeriksaan klinis, penyakit fibrokistik sering salah didiagnosis sebagai kanker payudara. Oleh karena tingginya kasus kanker payudara di Indonesia, penentuan stadium klinis dan pemeriksaan histopatologi diperlukan untuk menentukan diagnosis dan tata laksana lebih lanjut.Penelitian ini bertujuan untuk mengetahui bagaimana perbedaan kepadatan jaringan ikat dan perbedaan luas sel pada kanker payudara dan penyakit fibrokistik.Jenis penelitian ini adalah eksperimen dengan rancangan penelitian cross sectional. Sampel dalam penelitian ini adalah blok paraffin pasien kanker payudara dan penyakit fibrokistik di Rumah Sakit Islam Cempaka Putih Jakarta. Pengumpulan data ini dilakukan dengan data primer sediaan biopsi eksisi atau mastektomi pasien kanker payudara dan penyakit fibrokistik dan diolah menjadi sediaan slide menggunakan pewarnaan masson’s trichrome dan Hematoxylin Eosin. Analisis dilakukan menggunakan uji komparatif dua sampel yang tidak berpasangan dan distribusi tidak normal dengan uji Kolmogorov Smirnov.Penelitian ini menunjukkan bahwa rerata luas morfologi kelenjar pada kanker payudara lebih besar dibandingkan penyakit fibrokistik (226,324 um : 60,522 um). Berdasarkan hasil uji analisis didapatkan perbedaan yang bermakna secara statistik antara luas morfologi kelenjar pada kanker payudara dan penyakit fibrokistik. Semenetara jumlah jaringan ikat pada fibrokistik lebih banyak dibandingkan kanker invasif payudara. Kepadatan rata-rata jaringan ikat pada fibrokistik payudara sebesar 52%. Sedangkan kepadatan rata-rata jaringan ikat pada kanker payudara sebesar 29,17%. Berdasarkan hasil uji analisis Kolmogorov Smirnov didapatkan hasil yang signifikan secara statistik antara variabel kepadatan jaringan ikat pada kanker payudara dan penyakit fibrokistik (p kurang dari 0.05).Terdapat perbedaan bermakna jaringan ikat antara kanker payudara dengan penyakit fibrokistik. Sementara luas morfologi kelenjar pada kanker payudara lebih besar dibandingkan penyakit fibrokistik
Clinical Manifestation and Diagnosis of Cryptosporidiosis in Adult Infected with HIV Nunung Ainur Rahmah; Ening Krisnuhoni; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 4, ISSUE 3, December 2003
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/43200396-99

Abstract

Cryptosporidiosis is a rare infection caused by a coccidian parasite, Cryptosporidium, which could cause diarrhea in humans, especially those who are immunocompromised Cryptosporidiosis could cause self- limited diarrhea infection in immunocompetent hosts, but in immunocompromised hosts, especially those with AIDS, the diarrhea can be chronic and severe. To date, no known effective therapeutic agents have been identified. The following is one case report of cryptosporidiosis of a 27 year-old male admitted with chronic diarrhea since 2 months. Endoscopy of the ileum and colon showed hyperemia, erosion and edema, and biopsy was performed. Histopathological examination of ileum showed an atrophic villous and atypical degeneration. There was a number of circular cryptosporidium lining up along the surface of epithelium. There was inflammatory cell infiltration, consisting of lymphocytes, eosinophils and a few neutrophils in the lamina propria. Serological examination revealed an HIV-positive result. Keywords: Cryptosporidiosis, HIV, diarrhea
Hepatocellular Carcinoma in an Infant due to HBV Vertical Transmission Nunung Ainur Rahmah; Wirasmi Marwoto; Vera Yuwono; Ening Krisnuhoni; Diah Rini Handjari; Darmawan Kartono; David Handojo Muljono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 1, April 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/101200929-32

Abstract

Hepatocellular carcinoma (HCC) is one of the common tumors in the world. The incidence of HCC generally increases with age in all population but there is a tendency of decreasing incidence in the elderly and it is very rare in children. This is a case report of HCC in a 9-month-old boy, who was admitted to the hospital with palpable abdominal mass in the right upper quadrant. Imaging modality by ultrasonography could not adequately demonstrate definite findings demonstrating that the tumor was derived from liver, and the diagnosis was neuroblastoma. Intra-operatively, the tumor mass appeared to be derived from the surface of the posterior edge of the liver, so it was a pedunculated tumor. The histopathological examination revealed a pedunculatedhepatocellular carcinoma grade 3. The Victorian blue staining and immunohistochemical staining were done afterward, which showed HBsAg positive result as found in non-tumor lesion as well as inneoplastic lesion of liver tissue.Keywords: hepatocellular carcinoma, pedunculated HCC, infant HCC, occult hepatitis B virus infection
The Influence of Anxiety Levels Facing Medical Exams to Urinary Incontinence in YARSI University Medical Students Class of 2019 and 2020, and A Review Through Islamic Perspectives Muhammad Achmad Yani; Nunung Ainur Rahmah; Citra Fitri Agustina; Firman Arifandi
Junior Medical Journal Vol 1, No 7 (2023)
Publisher : Junior Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v1i7.3206

Abstract

Background: Urinary incontinence is the involuntary excretion of urine at any given condition. Medical exams experienced by medical students could induce anxiety, which could lead to urinary incontinence. Through an Islamic viewpoint, individuals suffering from urinary incontinence are constantly unclean and require certain ways to practice worship. This study aims to determine the relationship between anxiety levels and age; anxiety levels and gender; the correlation between anxiety levels and urinary incontinence; identifying anxiety levels; and the severity of urinary incontinence symptoms within YARSI University Medical Students Class of 2019 and 2020, as well as how to pray and ablute for individuals with urinary incontinence.Method: This study is qualitative research done as an analytical observational study with cross-sectional study design. The research instrument used the Urogenital Distress Inventory questionnaire (UDI-6) and the Hamilton Anxiety Rating Scale (HARS). The research was conducted on YARSI University Medical Students Class of 2019 and 2020 with a sample size of 209 participants. Data analysis utilized Kruskal Wallis, Kolmogorov-Smirnov, and Spearman Correlation statistical tests.Results: The level of anxiety experienced by most students is a mild level of anxiety. The highest severity of urinary incontinence symptoms was experienced by students with moderate to severe anxiety levels. No significant relationship was found between age and gender with anxiety levels. There is a positive correlation with moderate strength between the level of anxiety and urinary incontinence.Conclusion: No relationship was found between anxiety levels facing medical exams with age nor gender and a positive correlation with moderate strength was found between anxiety levels medical exams and urinary incontinence within YARSI University Medical Students Class of 2019 and 2020.
The Formulation, Evaluation and Physical Stability Test of Aloe Vera (Aloe vera L.) Extract Gel Preparations with the Addition of Sodium Metabisulfite Wiji Purnamasari, Yulia; Juniarti; Rahmah, Nunung Ainur
Medicra (Journal of Medical Laboratory Science/Technology) Vol 7 No 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1737

Abstract

Aloe vera (Aloe vera L.) is a plant that has many benefits, such as anti-inflammatory, anti-fungal, antibacterial, and moisturizing the skin. Gel preparations are easily contaminated by bacteria and fungi, so it is necessary to consider adding sodium metabisulfite as a preservative. The aim of this research is to prove the effectiveness of using sodium metabisulfite as a preservative for aloe vera extract gel preparations. The aloe vera plant (Aloe vera L.) was extracted using the maceration method for 3x24 hours using methanol solvent. This research used 5% aloe vera (Aloe vera L.) extract, and in the evaluation and stability test used 4 variation formulations using a carbomer base, only gel base (F1), gel base with the addition of sodium metabisulfite (F2), gel base with 5% aloe vera extract (F3), and gel base with 5% aloe vera extract and sodium metabisulfite (F4). The evaluations carried out were organoleptic tests, pH tests, viscosity tests, and ALT (Total Plate Number) tests and AKK (Yeast Mold Number) tests. The physical stability test is carried out for 3-14 days. The extract yield test results obtained were 4.892%. Organoleptic tests on F1, F2, F3 and F4 did not show changes in color, odor and texture, whereas on day 14 changes in color, odor and texture began to occur in the F3 preparation. The pH test showed pH results of 4.67 (F1), 4.9 (F2), 5 (F3) and 5.1 (F4). The viscosity test shows the gel has a viscosity of 2760 cps (F1), 2650 cps (F2), 2590 cps (F3), and 2575 cps (F4). The ALT and AKK tests showed that there was an increase in the value of the F3 preparation. So based on these results it can be concluded that the best gel preparation is F4
Potential of Soursop Leaf Extract as an Antioxidant in MCF-7 Cells Mustofa, Muhammad Samsul; Hadi, Restu Syamsul; Rahmah, Nunung Ainur; Pendrianto, Pendrianto
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.265-269

Abstract

The frequency of breast cancer tends to increase. Malondialdehyde (MDA) is a marker of oxidative stress as an end product from the chain reaction of lipid peroxidation. The use of traditional medicine soursopleaf (Annona muricata L.) has been reported for a long time because of its bioactivity as an antioxidant. This study analyzes the relationship between MDA levels and glutathione enzymes in MCF-7 cells given the methanol extract of soursop leaves. The methanol extract of soursop leaves was carried out by infusion method. The methanol extract of soursop leaves was given to cancer cells at several doses with an incubation of 24 hours. The cytotoxic test was carried out using the MTT method. Measurement of MDA levels was carried out using the thiobarbituric acid reactive substance (TBARS/TBA) reactivity test method. GSH measurements used the colorimetric method. The results showed that the ethanol extracts of soursop leaves have cytotoxic activity in the MCF-7 breast cancer cell line with IC50 values of 23.96 ppm. Ethanol extract of soursop leaves increased levels of MDA inhibition and GSH level. Soursop leaf extract could increase MDA inhibition GSH level in human breast cancer cells MCF-7.
The Effect of Course Schedule Density and Assignment Frequency on Burnout Syndrome in Students of The Faculty of Medicine YARSI University in 2019 And 2020 and Their Review According to Islam Rostiana, Ajeng Nita; Rahmah, Nunung Ainur; Royhan, Aan; Arifandi, Firman
Junior Medical Journal Vol. 2 No. 2 (2023): Oktober 2023
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v2i2.3009

Abstract

Background: Burnout syndrome is a measure of physical exhaustion and mental stress that is driven primarily by pressure and job requirements. The academic demands experienced by medical students, such as busy class schedules, practicum materials, group discussions, clinical skills, final exams, to organizational activities are some of the factors that make the duties and obligations as students pile up, triggering to the Burnout syndrome. According to the Islamic view, patience and trustworthiness are a way to deal with fatigue in studying. Method: This type of research is quantitative which is done in an analytical observational manner with a cross sectional design. Questionnaires were distributed via Google form to YARSI University Medical Faculty students in 2019 and 2020. The sample in this study was 224 respondents. The statistical test uses the Chi-Square test. Results: In the study it was found that there were 125 (55%) students who had moderate burnout syndrome. Based on the results of statistical tests, there is no effect between schedule density and the frequency of assignments on burnout syndrome. Conclusion: There is no effect of the density of schedules and the frequency of assignments on burnout syndrome
Cytotoxicity of Combination Doxorubicin and Garcinia picrorrhiza Fruit Extract on Fibroblast Cell Utami, Sri; Endrini, Susi; Batubara, Lilian; Rahmah, Nunung Ainur; Syarif, Irfan; Nafik, Said; Arrahmani, Betharie Cendera; Novianto, Agung; Kusuma, Hanna Sari Widya; Widowati, Wahyu
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.10985

Abstract

Combining chemotherapeutic agents such as doxorubicin with herbal products or other compounds that can enhance cytotoxicity without side effects is required. Thus, we aimed to observe the cytotoxicity of doxorubicin and sesoot (Garcinia picrorrhiza) fruit ethanolic extract (GpKar) on human fibroblast cells, BJ. This study used a post-test-only control randomized group design with n=3 and a number group of 5. The method used in this research is cell number, and viability was measured with (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Treatments consisted of a combination of doxorubicin (0.02 μg/ml) and GpKar of 66.47 µg/ml (DES1), 132.94 µg/ml (DES2) and 265.89 μg/ml (DES3). The data were analyzed using a one-way ANOVA and Duncan post hoc tests. DES3 showed the lowest viability among treatments (89.32%). DES1 and DES2 showed high viability (>90%), 97.93%, and 95.08%, respectively. Thus, the combination of doxorubicin (0.02 μg/ml) and GpKar (66.47 µg/ml) was considered safe for further use in the following assay. In summary, the combination of doxorubicin and GpKar showed high viability in normal fibroblast cells.
ANALISIS GAMBARAN GASTROSKOPI DAN HISTOPATOLOGI GASTRITIS PADA PENDERITA SINDROMA DISPEPSIA DI RS YARSI JAKARTA Syafruddin A. R. Lelosutan; Nunung Ainur Rahmah; Ari Fahrial Syam
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.237

Abstract

ABSTRAK Prevalensi Helicobacter pylori (HP) di Indonesia bervariasi sesuai lokasi daerah dan etnis. Di RS YARSI Jakarta kasus Sindroma Dispepsia (SD) cukup banyak mendapat prosedur tindakan Esofagogastroduodenoskopi (EGD) dan biopsi mukosa lambung (BML) dengan hasil histopatologi berupa sejumlah gambaran positif adanya HP. Mendapatkan angka prevalensi infeksi HP serta hasil analisis hubungan infeksi bakteri HP dengan gambaran diagnosis makroskopis EGD dan histopatologi hasil BML di RS YARSI, Jakarta. Studi retrospektif kasus SD yang mengalami prosedur tindakan EGD dan sekaligus pengambilan spesimen BML selama 1 tahun (2023‒2024) Data dipilih sesuai kriteria inklusi dan eksklusi. Pengolahan statistik memakai SPSS versi 26 dan uji analisis data menggunakan uji Chi-Square dalam batas kemaknaan 0,05 dan interval kepercayaan 95%. Sebanyak 72 subyek memenuhi kriteria. Prevalensi bakteri HP di RS YARSI Jakarta sebesar 18.0%. Ada hubungan antara infeksi bakteri HP dengan gambaran makroskopis (EGD) jaringan mukosa lambung (Gastritis hiperemikum-eritematousa, Gastritis erosif, dan Gastritis ulseratif) dan dengan kerusakan histologis mukosa lambung (Gastritis kronik aktif/GKA dan Gastritis kronik inaktif/GKI) yang signifikan masing-masing dengan p = 0,003 (p < 0,05) dan p = 0,004 (p < 0,05). Frekuensi kerusakan jaringan mukosa lambung akibat infeksi bakteri HP berupa GKA (Gastritis kronik aktif) dan GKI (Gastritis kronik inaktif) masing-masing sebesar 8,3% dan 9,7% dari keseluruhan Subyek. Ada hubungan infeksi bakteri HP dengan gambaran diagnosis makroskopis EGD dan histopatologi hasil BML di RS YARSI, Jakarta.
Dietary almonds and peanuts improve metabolic health and reduce oxidative stress in wistar rats Mukhtar, Diniwati; Rahmah, Nunung Ainur; Royhan, Aan; Yusnidar, Amirah
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1856

Abstract

Metabolic syndrome characterized by insulin resistance, atherogenic dyslipidemia, and hypertension, is a significant health concern often associated with obesity and Diabetes Mellitus. Regular consumption of nuts has been suggested to mitigate some of these conditions. This study investigates the effects of almond and peanut consumption on oxidative stress, plasma lipids, body weight, glucose, and blood pressure in Wistar rats. Wistar rats were divided into four dietary groups: standard diet (ST), high-fat diet (HF), high-fat diet with almonds (HFA), and high-fat diet with peanuts (HFP). The treatment lasted for 8 weeks, during which body weight was monitored weekly. Blood pressure measurements and retro-orbital blood samples were collected before and after the treatment. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured using ELISA and TBARS methods. Blood lipid profiles and glucose levels were analyzed using enzymatic methods. Statistical tests used the oAnova followed by Posthoc LSD. The HF group exhibited significant increases in body weight, blood glucose, cholesterol, triglycerides, MDA, and blood pressure, with reduced SOD levels. Conversely, the HFA and HFP groups showed moderated increases in these parameters compared to the HF group. Both nut-supplemented groups had significantly lower MDA levels and higher SOD activity, indicating reduced oxidative stress and enhanced antioxidative defenses. Almonds and peanuts can reduce body fat, improve lipid profiles, and stabilize blood glucose levels, suggesting their potential role in promoting metabolic health and reducing cardiovascular risk. Further research should explore the long-term benefits and the specific bioactive compounds responsible for these effects.
Co-Authors Aan Royhan Agung Novianto, Agung Agustin, Rika Alivia Ahmad Rusdan Utomo Ari Fahrial Syam Arifandi, Firman Arrahmani, Betharie Cendera Batubara, Lilian Chandra Prasetyo Utomo Citra Fitri Agustina Damayanti, Ndaru Andri Darmawan Kartono David Handojo Muljono Dewa Nyoman Murti Adyaksa Diah Rini Handjari Diah Rini Handjari Dianti, Sry Vhina Dinda, Salsabila Chyllia Diniwati Mukhtar Elan Suherlan Ening Krisnuhoni Firman Arifandi Haddad, Desi Ariyani Hanna Sari Widya Kusuma, Hanna Sari Widya Hutabarat, Andrea Ivana Allicia INDRA KUSUMA Irfan Syarif, Irfan Irwandi, Nurmayani Janah, Lulu Ah Juniarti Juniarti Juniarti Linda Weni Manik, Sabarina Elfrida Marsiati, Himmi Muhamad Fathurachman Muhammad Achmad Yani Muhammad Arsyad Mustofa, Muhammad Samsul Nafik, Said Nashuha Insani Neng Suhaeni Nursabur, Bistamy Muhammad Patrisha, Milaviza Pendrianto Pendrianto, Pendrianto Pratiwi, Nike Puspita, Switania Putri Restu Syamsul Hadi Rostiana, Ajeng Nita Saffa Hasanah Sri Utami Sri Wuryanti Susi Endrini Susmiarsih, Tripanjiasih Syafruddin A. R. Lelosutan Taslim, Siti Ghadira Inayah Thamrin, Nabila Pyrenina Triana Intan Sari Vera Yuwono WAHYU WIDOWATI Wiji Purnamasari, Yulia Wirasmi Marwoto Wirasmi Marwoto Yulia Suciati Yusnidar, Amirah