Articles
<![CDATA[The Development of ProBSTAD Teaching Materials With Conservation Vision on the Learning of the Nervous System in MA ]]>
<![CDATA[Hanifah, Ishfi Zakiyatul]]>;
<![CDATA[Lisdiana, Lisdiana]]>;
<![CDATA[Nugrahaningsih, Nugrahaningsih]]>
<![CDATA[ Journal of Biology Education Vol 8 No 1 (2019): April 2019 ]]>
Publisher : <![CDATA[FMIPA UNNES ]]>
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DOI: 10.15294/jbe.v8i1.26829
<![CDATA[ProBSTAD teaching materials have the advantage of presenting learning objects in a concrete manner so that it is good to add to the learning experience. The scientific approach links learning the material with everyday life. The nervous system material is closely related to the real life of living things. This study aims to develop ProBSTAD teaching materials with conservation vision with valid, feasible and effective criteria. This research was carried out at MA Nurul Islam Kriyan. The research subjects consisted of 37 students. The results showed the validation scores by the media and material experts were 92% and 94% with very valid criteria. The results of teacher and student responses were obtained on average 94% and 755 with very good and good criteria. Cognitive learning outcomes of students with N-gain obtained an average of 0.76 with high criteria for planting attitudes of class XI students obtained an average score of 84% in very high criteria. Based on the results of the study, it can be concluded that the teaching material of ProBSTAD with conservation vision has been valid, feasible, and effectively applied to the learning of nervous system material in MA.]]>
<![CDATA[IDENTIFIKASI APOPTOSIS DENGAN METODE TUNEL PASCA PEMBERIAN EKSTRAK SAMBILOTO DAN PENGARUHNYA TERHADAP VOLUME TUMOR ]]>
<![CDATA[Nugrahaningsih, Nugrahaningsih]]>;
<![CDATA[Yuniastuti, Ari]]>
<![CDATA[ Sainteknol : Jurnal Sains dan Teknologi Vol 12, No 2 (2014): December 2014 ]]>
Publisher : <![CDATA[Universitas Negeri Semarang ]]>
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DOI: 10.15294/sainteknol.v12i2.5415
<![CDATA[Apoptosis adalah kematian sel terprogram (programed cell death) yang bertujuan untuk mempertahankan kestabilan populai sel. Kegagalan pengaturan apoptosis dapat menyebabkan sel membelah tanpa terkendali, yang disebut sebagai kanker. Peningkatan apoptosis merupakan suatu upaya yang dikembangkan sebagai terapi kanker. Pemeriksaan apoptosis dengan metode TUNEL(Terminal deoxyribonucleotidyl transferase dUTP nick end labeling) dapat memberikan gambaran proses apoptosis pada tingkat sel tunggal sehingga lebih spesifik dan memiliki akurasi tinggi. Sambiloto merupakan salah satu tanaman obat tradisional yang digunakan sebagai anti kanker. Beberapa penelitian yang dilakukan secara in vitro menunjukkan pengaruh andrografolid yang diisolasi dari sambiloto terhadap apoptosis sel kanker pada kultur. Hasil tersebut masih memerlukan penelitian lebih lanjut, terutama pengaruhnya bila diberikan secara oral. Penelitian ini dilakukan untuk membuktikan pengaruh ekstrak sambiloto terhadap apoptosis dan volume tumor bila diberikan secara oral dan diidentifikasi dengan metode TUNEL. Penelitian dilakukan dengan desain Randomized post test control group. Sebanyak 24 ekor mencit C3H yang telah tumbuh kanker mamma dibagi secara acak menjadi 4 kelompok masing-masing 6 ekor. Diberikan ekstrak sambiloto dengan dosis 5, 10 dan 15 mg per ekor per hari, dan kelompok kontrol. Pemberian ekstrak sambiloto dilakukan secara oral selama 14 hari. Pengukuran volume tumor dilakukan pada hari ke 1, 4, 8, 12 dan 15. Pada hari ke 15 mencit dimatikan dengan menggunakan eter. Jaringan kanker dibuat blok parafin untuk pemeriksaan apoptosis dengan metode TUNEL. Hasil Penelitian menunjukkan adanya peningkatan signifikan sel apoptosis (p=0,000), dengan dosis terbaik 15 mg/hari. Ada beda yang bermakna pada rerata kelipatan penambahan volume tumor (p=0,049). Hasil uji post hoc menunjukkan bahwa perbedaan terletak antara kelompok kontrol dengan kelompok dosis 10 mg/hr. Dapat disimpulkan bahwa pemberian ekstrak sambiloto secara oral meningkatkan sel yang mengalami apoptosis dengan pemeriksaan TUNEL namun belum dapat menurunkan volume tumor.]]>
<![CDATA[The Influence of Predict Observe Explain (POE) Learning Model on Student Learning Outcomes ]]>
<![CDATA[Prabawati, Reni]]>;
<![CDATA[W.H., Nugrahaningsih]]>;
<![CDATA[Alimah, Siti]]>
<![CDATA[ Journal of Biology Education Vol 9 No 1 (2020): April 2020 ]]>
Publisher : <![CDATA[FMIPA UNNES ]]>
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DOI: 10.15294/jbe.v9i1.38065
<![CDATA[This study aims to analyze the influence of Predict Observe Explain (POE) model on student’s learning outcomes. This research was conducted using Quasi Experimental design with Pretest-Posttest Control Group Design. Population of this research is all of XI grade students at MA Al Asror Semarang. The sample that were used are XI IPA 1 as control class and XI IPA 2 as experimental class taken by simple random sampling. The result showed that the learning outcomes experiment class are better than control class in term of cognitive, affective, and psychomotor aspects. The result of N-gain t-test shows there is significant difference of posttest-pretest value between experiment class and control class. The level of affective and psychomotor aspects of the experimental class is better than the control class. This is supported by the responses of teachers and students who respond well to learning with POE model applied. Based on the results of the study concluded that the learning of Predict Observe Explain (POE) model applied have a significant effect on students’s learning outcomes.]]>
<![CDATA[The Development of ProBSTAD Teaching Materials With Conservation Vision on the Learning of the Nervous System in MA ]]>
<![CDATA[Hanifah, Ishfi Zakiyatul]]>;
<![CDATA[Lisdiana, Lisdiana]]>;
<![CDATA[Nugrahaningsih, Nugrahaningsih]]>
<![CDATA[ Journal of Biology Education Vol 8 No 1 (2019): April 2019 ]]>
Publisher : <![CDATA[FMIPA UNNES ]]>
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DOI: 10.15294/jbe.v8i1.26829
<![CDATA[ProBSTAD teaching materials have the advantage of presenting learning objects in a concrete manner so that it is good to add to the learning experience. The scientific approach links learning the material with everyday life. The nervous system material is closely related to the real life of living things. This study aims to develop ProBSTAD teaching materials with conservation vision with valid, feasible and effective criteria. This research was carried out at MA Nurul Islam Kriyan. The research subjects consisted of 37 students. The results showed the validation scores by the media and material experts were 92% and 94% with very valid criteria. The results of teacher and student responses were obtained on average 94% and 755 with very good and good criteria. Cognitive learning outcomes of students with N-gain obtained an average of 0.76 with high criteria for planting attitudes of class XI students obtained an average score of 84% in very high criteria. Based on the results of the study, it can be concluded that the teaching material of ProBSTAD with conservation vision has been valid, feasible, and effectively applied to the learning of nervous system material in MA.]]>
<![CDATA[The Influence of Predict Observe Explain (POE) Learning Model on Student Learning Outcomes ]]>
<![CDATA[Prabawati, Reni]]>;
<![CDATA[W.H., Nugrahaningsih]]>;
<![CDATA[Alimah, Siti]]>
<![CDATA[ Journal of Biology Education Vol 9 No 1 (2020): April 2020 ]]>
Publisher : <![CDATA[FMIPA UNNES ]]>
Show Abstract
|
Download Original
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Original Source
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Check in Google Scholar
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DOI: 10.15294/jbe.v9i1.38065
<![CDATA[This study aims to analyze the influence of Predict Observe Explain (POE) model on student’s learning outcomes. This research was conducted using Quasi Experimental design with Pretest-Posttest Control Group Design. Population of this research is all of XI grade students at MA Al Asror Semarang. The sample that were used are XI IPA 1 as control class and XI IPA 2 as experimental class taken by simple random sampling. The result showed that the learning outcomes experiment class are better than control class in term of cognitive, affective, and psychomotor aspects. The result of N-gain t-test shows there is significant difference of posttest-pretest value between experiment class and control class. The level of affective and psychomotor aspects of the experimental class is better than the control class. This is supported by the responses of teachers and students who respond well to learning with POE model applied. Based on the results of the study concluded that the learning of Predict Observe Explain (POE) model applied have a significant effect on students’s learning outcomes.]]>
<![CDATA[Developing of instructional media-based animation video on enzyme and metabolism material in senior high school ]]>
<![CDATA[Muhammad Mustofa Yusuf]]>;
<![CDATA[Mohamad Amin]]>;
<![CDATA[Nugrahaningsih Nugrahaningsih]]>
<![CDATA[ JPBI (Jurnal Pendidikan Biologi Indonesia) Vol. 3 No. 3 (2017): NOVEMBER ]]>
Publisher : <![CDATA[University of Muhammadiyah Malang ]]>
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DOI: 10.22219/jpbi.v3i3.4744
<![CDATA[The research aimed to product a learning material related to animation video on enzyme and metabolism material for high school student which is validated by media and material experts, educational practition and student legibility. Research and development model is ADDIE with quantitative-qualitative data analyzing methode. Data collection was obtained from validation results by media and material experts, educational partition and student legibility. The validation results were scores and suggestion. The percentage of product from expert media validation (100%), expert material validation (89,58%), educational practition (84,61%), and student legibility (81,91%) showed valid of the criteria and feasible to use after revision.]]>
<![CDATA[The Role of Sechium edule Fruits Ethanolic Extract in Insulin Production and Malondialdehyde Level in Stz-Induced Diabetic Rat ]]>
<![CDATA[Betty Lukiati]]>;
<![CDATA[Nugrahaningsih Nugrahaningsih]]>;
<![CDATA[Siti Nur Arifah]]>
<![CDATA[ Journal of Tropical Biodiversity and Biotechnology Vol 4, No 1 (2019): April ]]>
Publisher : <![CDATA[Universitas Gadjah Mada ]]>
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DOI: 10.22146/jtbb.33948
<![CDATA[The objectives of this research were to examine the effect of Sechium edule ethanolic extract in insulin and Malondialdehyde (MDA) levels in streptozotocin (STZ) induced diabetic rats. Type 1 diabetic rat were obtained by intraperitonially injected with multiple low dose STZ (MLD-STZ) 20 mg/kgBW for 5 days. The animals were divided into 5 groups: untreated rats in group (K) were considered as negative control, MLD-STZ induced type 1 diabetic rats in group (S) were considered as positive control. In another 3 group (A, B, C) type 1 diabetic rats were orally treated with three doses of S. edule ethanolic extract (14, 28, 42 mg/kg BW) for 7 days. The animals were sacrificed in two days after last treatment, serum were collected for measuring of the insulin concentration by ELISA method. Level of MDA on kidney, liver and pancreas were measured by TBA method. The treatment with S. edule ethanolic extracts unable to increase of insulin yet but the treatment with 42 mg/kg BW of S. edule ethanolic extract showed significantly decreased MDA levels on liver but not significant on kidney and pancreas.]]>
<![CDATA[Andrographis paniculata extract induced apoptosis of adenocarcinoma mammae in C3H mice ]]>
<![CDATA[Nugrahaningsih Nugrahaningsih]]>;
<![CDATA[Sarjadi Sarjadi]]>;
<![CDATA[Edi Dharmana]]>;
<![CDATA[Hartanto Wahyu Subagio]]>
<![CDATA[ Universa Medicina Vol. 32 No. 2 (2013) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Trisakti ]]>
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DOI: 10.18051/UnivMed.2013.v32.99-107
<![CDATA[BACKGROUNDApoptosis plays an important role in tumorigenesis. Induction of apoptosis is a strategy for developing cancer therapy. In vitro study found that andrographolide isolated from Andrographis paniculata has anticancer activity by an apoptotic mechanism in cancer cell lines. The aim of the present study was to prove theeffect of Andrographis paniculata extract administered orally on apoptosis of mammary adenocarcinoma in C3H mice.METHODSThis study was of post test randomized control group design. Twenty four C3H mice with transplanted mammary adenocarcinomas were divided into four groups. To three groups Andrographis paniculata extract was administered orally for14 days, at doses of 5, 10 and 15 mg/day, respectively, whereas to the control group no Andrographis paniculata extract was administered. On day 15 the mice were terminated. The mammary adenocarcinomas were examined by the terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL) method. The values of the apoptotic index were expressed as mean±SD and analyzed using ANOVA and Pearson’s correlation test.RESULTSThe mean apoptotic index values differed significantly among the experimental groups (p=0.001). The highest value was found in the group receiving Andrographis paniculata extract 15 mg/day, while the lowest was in the control group, the values being significantly correlated (r=0.974).CONCLUSIONSOral administration of Andrographis paniculata extract induced apoptosis in C3H mice with mammary adenocarcinoma]]>
<![CDATA[Identifikasi dan Manfaat Tanaman Obat Keluarga di Masyarakat Desa Sukorejo Gunungpati, Semarang ]]>
<![CDATA[Ari Yuniastuti]]>;
<![CDATA[Nugrahaningsih Nugrahaningsih]]>;
<![CDATA[Noor Aini Habibah]]>;
<![CDATA[Talitha Widiatningrum]]>;
<![CDATA[Tyas Agung Pribadi]]>;
<![CDATA[Fitri Arum Sasi]]>
<![CDATA[ Jurnal Abdidas Vol. 2 No. 1 (2021): February, Pages 1-160 ]]>
Publisher : <![CDATA[Universitas Pahlawan Tuanku Tambusai ]]>
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DOI: 10.31004/abdidas.v2i1.233
<![CDATA[Tanaman Obat Keluarga (TOGA) dikenal sebagai apotik hidup merupakan tanaman yang ditanam di halaman rumah. Penanaman TOGA di pekarangan warga RT02/RW05 Sukorejo, Gunungpati, Semarang selama ini belum terlaksana dengan baik. Oleh karena itu dilakukan pengabdian ini untuk meningkatkan pengetahuan dan keterampilan kader PKK dalam identifikasi dan pemanfaatan TOGA melalui penyuluhan, pelatihan dan pendampingan TOGA. Khalayak sasaran adalah kader PKK RT 02/RW05 dan ibu-ibu yang dipilih karena memiliki kemampuan lebih dalam menjalankan kegiatan PKK dan pandai mendesiminasikan hasil pengabdian pada khalayak yang lebih luas. Kegiatan berlangsung selama 6 bulan meliputi persiapan, pelaksanaan, monitoring dan evaluasi meliputi a) penyuluhan potensi tanaman rempah-rempah bagi kesehatan dan perlunya menanam rempah-rempah dalam bentuk Taman Tanaman Obat Keluarga (TOGA) di pekarangan, b). pelatihan bagi kader PKK RT02/RW 05 tentang cara menaman TOGA di lahan minimalis dan c) pelatihan mengolah hasil pasca panennya menjadi berbagai minuman yang berkhasiat bagi kesehatan. Hasil dari kegiatan ini adalah meningkatnya pengetahuan dan keterampilan kader PKK RT 02/ RW 05 tentang pengelolaan dan pemanfaatan taman TOGA, terwujudnya taman TOGA di masing-masing perkarangan halaman depan rumah, serta kemandirian dalam pemenuhan pengobatan tradisonal. Keberlanjutan program ini diharapkan dapat dilakukan dengan memanfaatkan pekarangan rumah sebagai lahan menanam TOGA, sehingga pemanfataan TOGA untuk kesehatan dapat dilakukan secara berkesinambungan dan berdampak pada sosial ekonomi masyarakat.]]>
<![CDATA[Ekspresi VEGF Sel Adenokarsinoma Mamma Pada Pemberian Oral Ekstrak Andrographis paniculata ]]>
<![CDATA[NUGRAHANINGSIH NUGRAHANINGSIH]]>;
<![CDATA[SARJADI SARJADI]]>;
<![CDATA[EDI DHARMANA]]>;
<![CDATA[HERTANTO WAHYU SUBAGIO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Angiogenesis was needed to fulfill nutrition and oxygen demand for tumor growthh and its metastase. Vascular endothelial growth factor (VEGF) was a potential proangiogenic factor of angiogenesis process. In vitro study of Andrographis paniculata extract showed decreasing tend of VEGF level serum on PC-3 cancer cell line. The aim of this study was to prove the effect of oral administered Andrographis paniculata extract on VEGF expression of adenocarcinoma mammae C3H mice. Twenty four mice was transplanted with adenocarcinoma mammae randomly to four groups. Andrographis paniculata extract at dose 5, 10, and 15 mg/day were given on mice group along 14 days. One group another as a control. VEGF expression were examined use immunohistochemistry staining. Anova test showed difference VEGF expression among reseach groups (p=0,000, r=-0,953). The highest of VEGF expression index 24,8 was found on control group, and the lowest 19,4 was found on group which received 15 mg/day. We concluded that oral administration of Andrographis paniculata extract decreased VEGF expression of adenocarcinoma mamme C3H mice.]]>
