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All Journal Abdimas Sainteknol : Jurnal Sains dan Teknologi Proceeding International Conference on Global Resource Conservation Jurnal Pendidikan Biologi Indonesia Journal of Tropical Biodiversity and Biotechnology BIOMA Journal of Biology Education Universa Medicina Biosaintifika: Journal of Biology & Biology Education Indonesian Journal of Biology Education Jurnal Ilmu Kefarmasian Indonesia Journal of Innovative Science Education Jurnal Abdidas Proceeding Biology Education Conference Jurnal Kedokteran Hewan Jurnal Ilmu Hayat
Nugrahaningsih Nugrahaningsih
Universitas Negeri Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Ekspresi VEGF Sel Adenokarsinoma Mamma Pada Pemberian Oral Ekstrak Andrographis paniculata NUGRAHANINGSIH NUGRAHANINGSIH; SARJADI SARJADI; EDI DHARMANA; HERTANTO WAHYU SUBAGIO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.677 KB)

Abstract

Angiogenesis was needed to fulfill nutrition and oxygen demand for tumor growthh and its metastase. Vascular endothelial growth factor (VEGF) was a potential proangiogenic factor of angiogenesis process. In vitro study of Andrographis paniculata extract showed decreasing tend of VEGF level serum on PC-3 cancer cell line. The aim of this study was to prove the effect of oral administered Andrographis paniculata extract on VEGF expression of adenocarcinoma mammae C3H mice. Twenty four mice was transplanted with adenocarcinoma mammae randomly to four groups. Andrographis paniculata extract at dose 5, 10, and 15 mg/day were given on mice group along 14 days. One group another as a control. VEGF expression were examined use immunohistochemistry staining. Anova test showed difference VEGF expression among reseach groups (p=0,000, r=-0,953). The highest of VEGF expression index 24,8 was found on control group, and the lowest 19,4 was found on group which received 15 mg/day. We concluded that oral administration of Andrographis paniculata extract decreased VEGF expression of adenocarcinoma mamme C3H mice.
Developing an Organic Liquid Fertilizer Booklet to Support The Sustainable Reserve Food Garden (SRFG) Program at Tunggak Cerme, Wonomerto, Probolinggo Novi Wulandari; Mimien Henie Irawati; Nugrahaningsih Nugrahaningsih
Indonesian Journal of Biology Education Vol 1, No 1 (2018): INDONESIAN JOURNAL OF BIOLOGY EDUCATION
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.826 KB) | DOI: 10.31002/ijobe.v1i1.1019

Abstract

The aim of this study is to develop and test organic liquid fertilizer booklet to support SRFG program. This study used ADDIE model which consists of analyze, design, develop, implement, and evaluation. The product tests are validity test and practicality test. The validity test result by the material expert, media expert, and field practitioner are 95,5%, 98,5%, 97,9%, showed that the booklet is valid. The practicality test result is 91,1%, showed that the booklet is practical.
POTENSI EKSTRAK ETANOL LABU SIAM (Sechium edule) UNTUK PERBAIKAN KERUSAKAN SEL BETA PANKREAS DAN KADAR NITROGEN OKSIDA PADA TIKUS YANG MENGALAMI DIABETES MELITUS (The Potenty of Sechium edule Ethanolic Extract to Repair Beta Pancreas Cells and Nitrogen Oxide Concentration in Streptozotocin-induced Diabetic Rat) Betty Lukiati; Siti Imroatul Maslikah; Nugrahaningsih N
Jurnal Kedokteran Hewan Vol 10, No 1 (2016): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.589 KB) | DOI: 10.21157/j.ked.hewan.v10i1.3365

Abstract

The objectives of this research were to examine the effect of Sechium edule ethanolic extract to repair beta pancreas cells damage and tomeasure nitrogen oxide (NO) concentration in streptozotocin-induced rats. Type I diabetic rats were obtained by intraperioneally injected therats with multiple low dose streptozotocin (MLD-STZ) for 5 days. In this research, rats were assigned into 5 treatment groups: untreated rats ingroup 1 were considered as negative control, while MLD-STZ induced type 1 diabetic rats in group 2 were considered as positive control. Inanother 3 groups, type 1 diabetic rats were orally treated with three doses of Sechium edule ethanolic extract (14, 28, 42 mg/kg bw) respectivelyfor 7 consecutive days. Repairing of beta pancreas cells were analyzed descriptively whereas concentration of NO were analyzed using one wayANOVA and continued with LSD test (α= 0.01). The result showed that the administration of Sechium edule ethanolic extract significantlydecreased NO concentration (P0.01) up to 67.9 µM and repaired beta pancreas cells damage. Dose of 42 mg/kg bw of Sechium edule ethanolicextract is the effective dose for diabetic rat therapy. Key words: Sechium edule extract, diabetic mellitus, rat, beta pancreas cells
Protein Jaringan Otot Ayam Broiler (Gallus gallus domesticus) pada Waktu Inkubasi yang Berbeda Nindya Ulfa Wardhani; Umie Lestari; Nugrahaningsih Nugrahaningsih
Jurnal Ilmu Hayat Vol 1, No 1 (2017)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um061v1i12017p35-42

Abstract

Perubahan pola konsumsi masyarakat yang sadar akan pentingnya gizi dan kesehatan, menyebabkan konsumsi ayam ras pedaging cenderung meningkat. Ayam ras pedaging yang paling banyak dikonsumsi adalah jenis Ayam Broiler. Salah satu kandungan tertinggi pada daging ayam broiler selain lemak adalah protein. Daging ayam mudah mengalami penurunan kualitas selama penyimpanan. Penelitian ini bertujuan untuk mengetahui pengaruh waktu inkubasi terhadap konsentrasi protein jaringan otot ayam broiler serta mengetahui profil protein jaringan otot ayam broiler pada waktu inkubasi yang berbeda. Berdasarkan hasil uji Anava, waktu inkubasi berpengaruh terhadap konsentrasi protein jaringan otot ayam broiler. Hasil uji Post-Hoc Duncan menunjukkan jaringan otot Ayam Broiler yang disimpan mulai 1 jam, 3 jam, 5 jam, 7 jam, 9 jam dan 11 jam konsentrasi proteinnya menurun dan berbeda nyata dibandingkan dengan inkubasi 0 jam. Visualisasi protein memperlihatkan adanya perbedaan ketebalan pita protein setelah jaringan otot ayam disimpan selama 1 jam hingga 11 jam, adanya pita protein dengan BM 53 kDa yang hilang setelah jaringan otot ayam disimpan selama 11 jam serta adanya pita protein dengan BM 60 kDa yang muncul setelah jaringan otot disimpan selama 7 jam.
Pengaruh Penambahan Serbuk Cangkang Telur Ayam terhadap Pertumbuhan Tanaman Sirih (Piper betle L.) Septiria Listiya Warhani; Nugrahaningsih Nugrahaningsih; I Wayan Sumberartha
Jurnal Ilmu Hayat Vol 2, No 2 (2018)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um061v2i22018p95-101

Abstract

Tanaman sirih (Piper betle L.) merupakan tanaman budidaya yang bermanfaat sebagai obat, kosmetik, pasta gigi, dan sabun. Tanaman sirih merupakan tanaman yang membutuhkan unsur hara yang tercukupi untuk menghasilkan produksi yang maksimal. Salah satu unsur hara yang dibutuhkan yaitu kalsium. Kalsium dibutuhkan untuk menetralkan pH media tanam sehingga unsur hara tersedia sebagai pendukung pertumbuhan organ vegetatifnya. Penelitian ini bertujuan untuk mengetahui pengaruh serbuk cangkang telur ayam terhadap pertumbuhan tanaman sirih (Piper betle L), menggunakan Rancangan Acak Kelompok (RAK), yang terdiri dari 6 taraf perlakuan dan 4 kali ulangan. Teknik analisis data yang digunakan adalah analisa variansi (ANAVA) tunggal, setelah itu dilanjutkan Uji Duncan. Hasil penelitian menunjukkan bahwa serbuk cangkang telur berpengaruh sangat signifikan terhadap pertumbuhan tanaman sirih (Piper betle L.). Konsentrasi 25 gram serbuk cangkang telur menunjukkan pengaruh baik terhadap panjang batang, Konsentrasi 10 gram serbuk cangkang telur menunjukkan pengaruh baik terhadap jumlah daun dan luas daun tanaman sirih (Piper betle L.). 
Association of TCF7L2 Gene Polymorphism With Non Obesetype 2 Diabetes Mellitus in Javanese Population Yuniastuti, Ari; Susanti, R; Nugrahaningsih, Nugrahaningsih; R, Rahmatika Saputri
Bioma : Jurnal Ilmiah Biologi Vol 12, No 2: October 2023
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v12i2.15365

Abstract

Type 2 diabetes is characterized by insulin deficiency due to inadequate insulin secretion or decreased tissue response to insulin at one or more points. Three important factors that influence the pathogenesis of type 2 DM are individual factors or ethnic genetics, factors of pancreatic β cell damage and insulin resistance factors. The TCF7L2 gene is a gene that codes for TCF7L2 protein, a group of proteins that act as transcription factors in the Wnt signal pathway. TCF7L2 gene polymorphism occurs when cytosine is replaced with thymine in the intron 3 position in wild-type due to alternative splicing.The purpose study was to determine the frequency of TCF7L2 gene polymorphism in Javanese type 2 non-obese DM patients in Semarang. Detection of TCF7L2 gene polymorphism was carried out on 49 people with type 2 non-obese DM patients and 38 people not with type 2 DM using the PCR-RFLP method. The restriction enzyme used is Rsa1. The allele frequency of TCF7L2 gene polymorphism was analyzed by Chi-square and analysis of sample characteristics was carried out with Odds Ratio. The results showed that there were significant differences in the allele frequency of TCF7L2 gene polymorphism and in the characteristics of age, KGD and systole between case subjects and control subjects. From this study it was concluded that TCF7L2 gene polymorphism is associated with the type 2 DM through interactions between genetic factors (T allele) and life style.
Co-Authors Andri Zainal Angga Ari Wibowo Ari Yuniastuti Balqis Balqis Betty Lukiati Dewi Mustikaningtyas Edi Dharmana EDI DHARMANA Enni Suwarsi Rahayu Farikhul Ulum Fitri Arum Sasi, Fitri Arum Frida Kunti Setiowati Hanifah, Ishfi Zakiyatul Hanifah, Ishfi Zakiyatul Hartanto Wahyu Subagio Hertanto Wahyu Subagio I Wayan Sumberartha Lisdiana Lisdiana Martien Herna Susanti Mimien Henie Irawati Mohamad Amin Muhammad Mustofa Yusuf Muhammad Rifqi Hariri Nihayah, Durrotun Nindya Ulfa Wardhani Noor Aini Habibah Novi Wulandari Prabawati, Reni R, Rahmatika Saputri Sabdhosih, Has Sagala, Gaffar Hafz Sarjadi Sarjadi SARJADI SARJADI Septiria Listiya Warhani Simatupang, Nurhayati Siti Alimah Siti Imroatul Maslikah Siti Nur Arifah Siti Nur Chasanah, Siti Nur Sitorus, Mido Ester Talitha Widiatningrum Tyas Agung Pribadi Umie Lestari Wiwi Isnaeni Yusuf, Muhammad Mustofa Zunikhah Zunikhah