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All Journal VALENSI Farmaka Indonesian Journal of Pharmaceutical Science and Technology Journal of Community Development Indonesian Journal of Cancer
Holis Abdul Holik, Holis Abdul
Fakultas Farmasi Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Pemanfaatan Tanaman Eceng-Ecengan (Ponteridaceae) sebagai Agen Fitoremediasi dalam Pengolahan Limbah Krom Putri, Yola Desnera; Holik, Holis Abdul; Musfiroh, Ida; Aryanti, Anisa D.
Indonesian Journal of Pharmaceutical Science and Technology Vol 1, No 1 (2014)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2252.638 KB) | DOI: 10.15416/ijpst.v1i1.7510

Abstract

Permasalahan pencemaran air yang disebabkan oleh limbah krom industri penyamakan kulit di kawasan Sukaregang, Kabupaten Garut perlu diolah dengan teknik fitoremediasi dengan tanaman dari keluarga Ponteridaceae. Penelitian ini perlu dilakukan untuk mengetahui kadar penyerapan tanaman eceng-ecengan dan menentukan eceng mana yang paling efektif menyerap krom. Penelitian ini dilakukan dengan tahap pengumpulan bahan dan determinasi tanaman eceng-ecengan, pengolahan limbah dengan fitoremediasi selama 21 hari, dan analisis kadar krom dengan spektrofotometer serapan atom. Kapasitas penyerapan Eichhornia crassipes Solm., Heteranthera peduncularis, dan Monochoria vaginalis adalah 1,5395; 0,5728; dan 0,1057 µg/g. Berdasarkan uji Duncan, disimpulkan bahwa Eichhornia crassipes Solm. merupakan tanaman eceng paling efektif yang memiliki kemampuan paling tinggi dalam menyerap logam krom limbah penyamakan kulit. Kata kunci: Eichhornia crassipes Solm., fitoremediasi, Heteranthera peduncularis, krom, Monochoria vaginalis
Edukasi Hidup Sehat Tanpa Diabetes Dengan Pemanfaatan Tanaman Obat Bagi Masyarakat Desa Mekarjaya Banjaran Musfiroh, Ida; Megantara, Sandra; Holik, Holis Abdul; Susilawati, Yasmiwar; Wilar, Gofarana
Journal of Community Development Vol. 3 No. 3 (2023): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v3i3.113

Abstract

Diabetes mellitus in Indonesia now ranks 5th with the highest number of diabetes mellitus sufferers in the world. At present, the prevalence has increased from 6.2% compared to 2019. Diabetics need to get effective and safe drugs in order to avoid various complications. In addition to using pharmacological therapy, it is also necessary to carry out non-pharmacological therapy. One type of medicinal plant that is known to be effective in reducing sugar is ginger and cinnamon, but there has not been much reported on its processing other than in the form of a decoction or marinade. The purpose of carrying out this PPM activity is to increase the knowledge and understanding of the people of Mekarjaya Banjaran Village regarding the use of medicinal plants as anti-diabetics, and provide knowledge about making ginger-cinnamon instant powder drinks. The activity method is carried out in 3 stages, namely the planning, implementation, evaluation and follow-up stages. The results of this PPM activity show that the community has a better understanding of efforts to be healthy in preventing diabetes through the use of ginger-cinnamon medicinal plants, and how to process them through instant powders. The evaluation is carried out based on the results of the initial test and the final test as a method for measuring the achievements of this PPM activity.
Radiolabeling and In-Silico Study of 131I-(4-fluorobenzoyl-3-methylthiourea) as Radiopharmaceuticals for Breast Cancer Theranostics Pratama, Febby; Ruswanto, Ruswanto; Nofianti, Tita; Pratita, Anindita Tri Kusuma; Daruwati, Isti; Susilo, Veronika Yulianti; Holik, Holis Abdul
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.34258

Abstract

The chemicals produced from thiourea are actively being studied as anticancer possibilities. In complexes with radionuclides like Iodine-131, the 1-(4-Fluorobenzoyl)-3-methyl thiourea is a promising ligand for theragnostic applications. This study aimed to label 1-(4-fluorobenzoyl-3-methylthiourea) with iodine-131 and observe its interaction with breast cancer receptors. The radiolabeling of 131I-(4-fluorobenzoyl-3-methylthiourea) uses the radioiodination method with Chloramine-T, and an in-silico investigation of breast cancer receptors was conducted. According to the results of molecular docking using AutoDockTools, this radiopharmaceutical molecule has the best activity on the HER2 receptor (PDB ID: 3PP0) compared to the native ligand and control positive, with a binding affinity of -6.13 kcal/mol and a Ki value of 32.05 mM. According to the molecular dynamics data using Desmond, the radiopharmaceutical molecule 131I-(4-Fluorobenzoyl-3-methylthiourea) displays good stability starting from the 50ns range. The indirect radioiodination method has successfully labeled 1-(4-Fluorobenzoyl-3-methylthiourea) with iodine-131.
Studi In Silico Senyawa 5-BOTP dan ADPB sebagai Senyawa Pembawa Radioteranostik terhadap LAT-1 Holik, Holis Abdul; Elaine, Angela Alysia; Sitinjak, Bernap Dwi Putra; Qolbina, Shofura Marsa; Ibrahim, Faisal Maulana; Achmad, Arifudin; Sudarmanto, B.S. Ari; Kartamihardja, Achmad Hussein Sundawa
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.55077

Abstract

Kompleksitas patogenesis kanker membuat kanker sulit untuk menemukan target terapi yang tepat, sehingga tingkat keberhasilan obat baru dalam uji klinis rendah. Oleh karena itu, studi pengembangan teknik intervensi yang baru untuk pasien kanker sangat penting. Large-type Amino Acid Transporter 1 (LAT-1) diekspresikan secara berlebihan dalam sel kanker jika dibandingkan dengan sel normal, hal ini menjadikannya salah satu target molekuler khusus untuk terapi kanker. Fungsi LAT-1 adalah memberikan nutrisi pada sel kanker untuk berkembang biak secara masif sehingga penghambatan LAT-1 dapat dijadikan alternatif terapi kanker. Penelitian ini bertujuan untuk mendapatkan senyawa potensial yang akan digunakan untuk radioteranostik dengan dua senyawa inhibitor LAT-1 sebagai senyawa pembawa, yaitu 5-Benzyloxytryptophan (5-BOTP) dan asam (S)-2-amino-4-(3,5-diklorofenil) butanoat (ADPB) yang dikonjugasikan dengan senyawa linker dan berbagai agen pengkelat bifungsional (BFCA) terhadap situs antiporter LAT-1. Metode penelitian terdiri dari mode pengikatan senyawa 5-BOTP dan ADPB terkonjugasi dengan LAT-1, simulasi penambatan molekuler, dan analis pre-ADMET. Hasil penelitian menunjukkan bahwa 5-BOTP-6AHA-H2CB-DO2A dan ADPB-6AHA-H2CB-DO2A memiliki afinitas terbaik dan kompleks pengikatan yang terbaik dengan LAT-1 sehingga keduanya berpotensi sebagai agen radioteranostik kanker dengan menghambat LAT-1.Kata kunci: Kanker, radioteranostik, LAT-1, 5-Benzyloxytryptophan, asam (S)-2-amino-4-(3,5-diklorofenol) butanoat.
ANALISA KESESUAIAN ASPEK BANGUNAN DI SALAH SATU PEDAGANG BESAR FARMASI (PBF) KOTA BANDUNG TERHADAP CDOB 2020 Pangestu, Lauren; Holik, Holis Abdul
Farmaka Vol 22, No 3 (2024): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i3.54962

Abstract

Pedagang Besar Farmasi (PBF) memiliki izin untuk mengadakan, menyimpan, dan menyalurkan obat dalam skala besar dengan berlandaskan Pedoman Teknis Cara Distribusi Obat yang Baik (CDOB) sebagai acuannya. Salah satu aspek penting yang diatur dalam CDOB 2020 yaitu mengenai bangunan yang digunakan oleh PBF harus dirancang dan disesuaikan agar dapat menjamin keamanan dan mutu produk yang disimpan. Oleh karena itu, dilakukan penelitian untuk mengevaluasi penerapan CDOB di salah satu PBF Bandung (PBF X) dengan menggunakan metode observasional deskriptif dan evaluatif yang dilakukan melalui studi literatur, pemantauan langsung dengan formulir checklist, serta wawancara dengan Apoteker penanggung jawab di PBF tersebut. Hasil penelitian menunjukkan bahwa PBF X telah memenuhi persyaratan CDOB dalam hal bangunan dan fasilitas untuk mendukung semua kegiatan distribusi obat secara efisien dan meminimalkan risiko yang dapat mempengaruhi kualitas obat. Keseluruhan aspek penting terkait bangunan telah memenuhi ketentuan dan regulasi yang berlaku, namun diperlukan konsistensi dalam menjaga kesesuaian ini yang didukung oleh kinerja personel PBF untuk menjalankan dan menerapkan setiap aspeknya dengan baik.Kata kunci: CDOB, PBF, Bangunan
Comparative Review of the Potential of 177Lu-PSMA-617 and Docetaxel Chemotherapy in the Treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC) Rahmawati, N. Anna Sakinah Liana; Hutapea, Ezra Calista; Holik, Holis Abdul
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1296

Abstract

Background: Prostate cancer has witnessed a substantial rise in both prevalence and risk over the years. In 2022, it is expected to rank fourth in terms of annual cancer-related mortality.  The treatment of prostate cancer involves the administration of chemotherapy using conventional drugs such as docetaxel. The most recent advancement in treating metastatic castration-resistant prostate cancer (mCRPC) is 177Lu-PSMA-617, a radioligand therapy. This treatment combines radioactive and ligand elements, resulting in exceptionally effective outcomes. This review aims to compare the potential of 177Lu-PSMA and Docetaxel in terms of production, side effects, prostate-specific antigen (PSA) reduction, and associated costs.Methods:  This literature review examines the differences in the therapeutic effectiveness of 177Lu-PSMA-617 and docetaxel monotherapy or in combination in patients with mCRPC.  Relevant research on both treatment options was searched, focusing on human clinical trials and case reports published between 2010 and 2024. Article selection was conducted in databases such as PubMed, Scopus, Springer, Elsevier, and NCBI.Results: Based on the eight articles included in this review, 177Lu-PSMA-617 can be regarded as an alternative therapy for patients with mCRPC. 177Lu-PSMA-617 and docetaxel can both decrease PSA levels by ≥50%. However, it's important to note that 177Lu-PSMA-617 is more expensive than docetaxel. Furthermore, the adverse effects of 177Lu-PSMA-617 are relatively less severe compared to those of docetaxel.Conclusions: The comparative results between docetaxel and 177Lu PSMA demonstrate that both therapies exhibit similar efficacy in reducing PSA levels. The results indicate that radioligand therapy 177Lu-PSMA-617 can be used as an alternative treatment for mCRPC with the potential for cure and minimal side effects. The cost can be minimized by increasing the utilization of radioligand 177Lu-PSMA-617, as higher usage leads to decreased prices.
Co-Authors Achmad, Arifudin Anisa D. Aryanti, Anisa D. Elaine, Angela Alysia Gofarana Wilar Hutapea, Ezra Calista Ibrahim, Faisal Maulana Ida Musfiroh, Ida Isti Daruwati Kartamihardja, Achmad Hussein Sundawa Megantara, Sandra Pangestu, Lauren Pratama, Febby Pratita, Anindita Tri Kusuma Qolbina, Shofura Marsa Rahmawati, N. Anna Sakinah Liana Ruswanto, Ruswanto Sitinjak, Bernap Dwi Putra Sudarmanto, B.S. Ari Tita Nofianti, Tita Veronika Yulianti Susilo Yasmiwar Susilawati Yola Desnera Putri