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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JOURNAL LA MEDIHEALTICO Action Research Literate (ARL) Buletin Kedokteran dan Kesehatan Prima
Johnson Hutapea
Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital Jakarta
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : JOURNAL LA MEDIHEALTICO

 1 
The Effect of Binahong Leaf Extract on Reducing Cholesterol and Histopathological Features in the Liver Trisnawati, Risca; Djuang, Michelle Hendriani; Hutapea, Johnson
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1098

Abstract

Being overweight or obese raises your risk of elevated cholesterol, triglycerides, and fatty liver. The liver is crucial to metabolic regulation. Essential to preserve liver health. Maintaining your diet, exercising, and eating antioxidants are all options. Many plants contain antioxidants, like Binahong (Anredera cordifolia). This study examines how Binahong leaf extract reduces cholesterol and improves liver function in high-fat-fed Wistar rats (Rattus norvegicus) and their liver histology. An actual experiment or laboratory experimental study is quantitative. 24 Wistar rats were sampled. Binahong leaf extract was the independent variable, cholesterol levels liver histological features were the dependent variable, and a high-fat diet was the precondition. The test animals were put into four groups: control, groups 2, 3, and 4 with Binahong leaf extract at 30mg/BW, 50mg/BW, and 70mg/BW. SPSS normality, homogeneity, and ANOVA tests. If p > 0.05, research results are generally distributed with 0.200 significance. Significant homogeneity was 0.176 > 0.05. Effective One-Way ANOVA test results (0.000 or <0.05). Post Hoc LSD test analysis yielded important values of 0.000.0001 and 0.024 < 0.05. The phytochemical test found flavonoids, alkaloids, saponins, steroids, and tannins in Binahong leaf extract. Binahong leaf extract at 70 mg/BW reduced cholesterol, body weight, and LDL in hypercholesterolemic male white mice best. The study found that Binahong leaf extract's secondary metabolites—flavonoids, alkaloids, saponins, steroids, and tannins—reduce cholesterol, LDL, and body weight in Wistar strain white rats (Rattus Norvegicus) with hypercholesterolemia.
Different Effects of Hylocecarus Polyrhizus and Hylocecarus Undatus Extract on Reducing Total Cholesterol of Male Rattus Norvegicus Wistar Strain Fahriani, Elviza; Mylano, Tri Adi; Hutapea, Johnson
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1100

Abstract

A chronic ailment that is caused by excessive food consumption and a lack of physical activity, obesity is a condition that may be prevented. The tropical dragon fruit can control cholesterol levels, support the immune system, and give a natural colorant for culinary applications. In a true experimental research, sample with rats were fed red and white dragon fruit extracts to determine the amounts of cholesterol in their bodies. Spectrophotometry was used to determine the rats' blood lipid profiles, cholesterol levels, and body weight after they were fed a meal that was high in fat and contained duck egg yolk. For this study, extracts from red and white dragon fruits were administered to male Wistar rats to determine their effects on cholesterol levels. After fourteen days, both groups had a reduction in high cholesterol levels, with group 4 exhibiting the most significant drop in cholesterol levels. Additionally, the extracts decreased the levels of MDA while simultaneously increasing the levels of SOD. The most significant rise was seen in group 4, given white dragon fruit extract at 140 mg/200 gr BW daily. SPSS was utilized to analyze the effects of dragon fruit on blood cholesterol levels in experimental animals, employing the LSD technique and one-way ANOVA.
Co-Authors Alponso, Rudolf Amir, Dwi Fenny Binarwan Halim Djuang, Michelle Hendriani Elizabeth, Monalisa Fahriani, Elviza Iskandar, Dalmy Kuswani, Lili Lina, Juliana Meilani, Inda Kania Mylano, Tri Adi Nasution, Syamsul Arifin Pakpahan, Estriyana Rahimi, Armon Rajagukguk, Samuel Joshua Hamonangan Tua Rapael Ginting Rosari, Anita Sibagariang, Eva Ellya Silaen, Mangatas Tarigan, Denada Br Trisnawati, Risca Yani, Herlina Yensuari, Yensuari Zahira, Niza