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Pengaruh Ekstrak Daun Sirsak (Annona Muricata L.) terhadap Histologi Kulit dan Penyembuhan Luka Sayat pada Penderita Diabetes Melitus Mariana, Siska; Purwanti, Dewi; Kuswani, Lili
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.735

Diabetes memperlambat penyembuhan luka dan regenerasi jaringan, terutama di kulit. Penelitian ini meneliti efek ekstrak daun sirsak (Annona muricata L.) pada penyembuhan luka insisi dan histopatologi kulit pada tikus Wistar jantan penderita diabetes melitus. Percobaan ini menggunakan tikus Wistar jantan penderita diabetes yang diinduksi streptozotocin. Pada dosis yang berbeda, ekstrak daun sirsak diberikan kepada tikus dalam kelompok kontrol dan perlakuan. Setiap tikus memiliki luka insisi di punggungnya, dan pengukuran kontraksi luka dan analisis histologis jaringan kulit pada fase penyembuhan yang berbeda digunakan untuk melacak penyembuhan. Pada tikus penderita diabetes, ekstrak daun sirsak meningkatkan kontraksi luka dan kualitas jaringan dibandingkan dengan kelompok kontrol. Histopatologi menunjukkan regenerasi jaringan yang lebih besar, deposisi kolagen, dan penurunan peradangan pada kelompok terapi. Pada penderita diabetes, ekstrak daun sirsak dapat mempercepat penyembuhan luka dan meningkatkan pemulihan jaringan kulit. Ekstrak daun sirsak dapat membantu penyembuhan luka diabetes, tetapi penelitian lebih lanjut diperlukan untuk memahami jalur molekuler.

Analysis of factors influencing re-visit intention of diabetes mellitus patients at dr. Pirngadi General Hospital Loren, Jeff; Zannah, Rafika; Hutauruk, Magdalena Julianni; Kuswani, Lili; Delfian, Taufik; Haryadi, Haryadi; Lumban Tobing, Andrico Napolin; Sopacua, Erwin; Arviandi, Rizki; Cisca, Anita Merry; Nadapdap, Faskanita Maristella; Putra, Kriswandy
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7444

Diabetes mellitus is a non-communicable disease that requires a long treatment so that patients have to take medication or visit the hospital more often, interest in repeat visits is a behavior that appears in response to objects that indicate a customer's desire to make a repeat purchase. The aim of the study was to find out whether the factors that determine interest in returning to diabetes mellitus patients at Pirngadi Hospital in Medan City in 2023. The research method uses a correlative descriptive design with a cross-sectional approach. The results showed that most of the respondents were male, namely 23 (51.1%), the education level of respondents who were high and medium had the same proportion, namely 18 (40%), the employment status of respondents was 30 (66.7%) working. Quality of service as many as 33 (73.3%) and as many as 28 (62.2%) families get high support. The results of the statistical chi-square test found that there was no significant relationship between gender and intention to revisit (p=0.155), there was no relationship between education and intention to revisit (p=0.371), there was no relationship between work and intention to revisit (p=0.828), there is a relationship between quality of service and interest in repeat visits (p=0.000). There is no relationship between family support and interest in repeat visits (p=0.000). This research is expected to be an evaluation material in improving health services related to the determinants of interest in repeat visits of patients with diabetes mellitus.

Early menopause and type 2 diabetes: A cross-sectional study at Royal Prima Hospital Waren, N Wignes; Wijaya, Johanna Fransisca; Dalimunthe, Siti Aisyah; Kuswani, Lili; Riskaldy, Riskaldy; Munadi, Munadi
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5606

Type 2 diabetes mellitus (T2DM) is a metabolic disease affecting various organs and causing hormonal disorders. Estrogen deficiency can alter a woman's menstrual cycle and trigger menopause, which affects reproductive health, fat distribution, lipid profiles, and the nervous system. This study aimed to assess the relationship between T2DM and menopausal age in women in the menopausal phase. The research method used was observational with a cross-sectional design, using 120 medical records of menopausal women from the period 2020-2022 at the Royal Prima Hospital. To explore the relationship between menopausal age and T2DM, bivariate analysis was performed, including the Chi-square test or Fisher's Exact Test for categorical variables, as well as t-test or Mann-Whitney U test for numerical variables. The results showed that the age range of 51-60 years constituted the largest group of 120 T2DM patients (29.17%). The most common age of onset of menopause was between 46-50 years, and showed a significant influence on the risk of T2DM (sig value 0.026 and t value 2.257). Blood pressure, which varied from 81 mmHg to 283 mmHg, showed no significant association with T2DM. It can be concluded that age at the onset of menopause was significantly associated with the risk of T2DM, whereas blood pressure had no significant effect on T2DM in this study. These findings highlight the importance of health monitoring in women with early menopause to prevent the development of T2DM.

Analysis of factors influencing re-visit intention of diabetes mellitus patients at dr. Pirngadi General Hospital Loren, Jeff; Zannah, Rafika; Hutauruk, Magdalena Julianni; Kuswani, Lili; Delfian, Taufik; Haryadi, Haryadi; Lumban Tobing, Andrico Napolin; Sopacua, Erwin; Arviandi, Rizki; Cisca, Anita Merry; Nadapdap, Faskanita Maristella; Putra, Kriswandy
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7444

Diabetes mellitus is a non-communicable disease that requires a long treatment so that patients have to take medication or visit the hospital more often, interest in repeat visits is a behavior that appears in response to objects that indicate a customer's desire to make a repeat purchase. The aim of the study was to find out whether the factors that determine interest in returning to diabetes mellitus patients at Pirngadi Hospital in Medan City in 2023. The research method uses a correlative descriptive design with a cross-sectional approach. The results showed that most of the respondents were male, namely 23 (51.1%), the education level of respondents who were high and medium had the same proportion, namely 18 (40%), the employment status of respondents was 30 (66.7%) working. Quality of service as many as 33 (73.3%) and as many as 28 (62.2%) families get high support. The results of the statistical chi-square test found that there was no significant relationship between gender and intention to revisit (p=0.155), there was no relationship between education and intention to revisit (p=0.371), there was no relationship between work and intention to revisit (p=0.828), there is a relationship between quality of service and interest in repeat visits (p=0.000). There is no relationship between family support and interest in repeat visits (p=0.000). This research is expected to be an evaluation material in improving health services related to the determinants of interest in repeat visits of patients with diabetes mellitus.

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