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All Journal JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Pharmacology and Clinical Pharmacy Research JFIOnline Narra J Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia
Slamet Ibrahim
Sekolah Farmasi ITB Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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The polymorphismof amoxicillin has been identified after freeze drying process. The freeze dried amoxicillin have some specific physical properties different from their raw material, that was proved by DSC, XRD, and polarize microscope. Exothermal curve from DSC thermogram changes to endothermal curve, diffractogram XRD changes to different profile, and the crystal shows different habit. All of data showed that freeze drying process improve amoxicillin to different crystal form which has higher melting oxidation point and lower hydrate. The improvement of the crystal structure might be impact to change physical-pharmaceutical properties like dissolution, absorption, and change it antibiotic potency.
Evaluation of phenolic compounds as cross-linkers to improve the qualities of halal gelatin from milkfish scales (Chanos chanos) Hamzah, Nursalam; Ibrahim, Slamet; Tjahjono, Daryono H.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.907

Abstract

Gelatin is a versatile substance extensively used in medical and pharmaceutical industries for many applications, including capsule shells, X-ray film, infusion for plasma substitute, and the fabricating of artificial tissue. Fish scale gelatin is a profitable alternative source as a halal material despite its inferior quality. An addition of phenolic cross-linker may enhance the qualities of fish scale gelatin. The aim of this study was to determine the ability of phenolics to act as cross-linkers for fish scale gelatin and to identify the factors affecting this process. Gelatin production from fish scales (Chanos chanos) was carried out through basic pre-extraction and acidic pre-extraction. Thereafter, the gelatin was reacted with 10 different phenolics (phenol, pyrocatechol, resorcinol, α-naphthol, vanillin, L-tyrosine, curcumin, gallic acid, quercetin, and tannic acid). The resultant gelatins were characterized by infrared spectrum, X-ray diffraction pattern, swelling index, degree of cross-linking, viscosity, gel strength, mechanical profile, thermal profile, and water vapor permeability. Gelatin with the most favorable characteristics was further investigated for the effects of acidity (pH 4, 7, and 10) and cross-linker concentrations (2.5–10%). The findings revealed the formation of cross-linkage through shifted vibrational peaks of amide A, amide B, and amide II in the infrared spectrum. Shifted X-ray diffraction peaks in the gelatin with phenol addition also indicated the formation of cross-linkage. Significant improvement in the gelatin characteristics, such as swelling index, degree of cross-linking, viscosity, gel strength, mechanical profile, thermal profile, and water vapor permeability, could be attributed to the addition of phenolics cross-linkers. The highest improvement was observed in gelatin added with basic tannic acid 10%. Gelatin cross-linked with basic tannic acid 10% had a moisture content of 9.24±0.14%, swelling index of 323±17%, degree of cross-linking of 69.99±0.84%, viscosity of 8.48±0.23 cP, gel strength of 151.5±6.9 Bloom, melting temperature of 213.5°C, tensile strength of 7.00±0.54 N.cm-2, elongation at the break of 114.08±14.63%, elastic modulus of 58.45±8.20 N.cm-2 and water vapor permeability of 0.57±0.07 g.mm.m-2.h-1. kPa-1. The qualities of tannic acid-cross-linked gelatin films and film-forming gel increased when manufactured under basic conditions in comparison to acidic or neutral conditions. Furthermore, increasing the quantity of tannic acid to 10% improved the overall characteristics as compared to non-cross-linked gelatin. In conclusion, tannic acid has the ability to cross-link the fish gelatin, thereby enhancing its qualities.
Synthesis and Characterization Molecularly Imprinted Polymers for Analysis of Dimethylamylamine Using Acrylamide as Monomer Functional Amin, Saeful; Damayanti, Sophi; Ibrahim, Slamet
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.330

Abstract

A selective separation techniques with Molecularly Imprinted Polymer (MIP) for High-Performance Liquid Chromatography (HPLC) has been developed for the assay of Dimethylamylamine (DMAA) doping compounds. Molecular imprinted polymer (MIP) is a technique to produce a polymer having the cavity due to the disposal of the templates, in which the cavity serves to recognize the molecules of the same size, structure, chemical and physical properties. The selectivity and affinity of the templates itself will increase, while the concentration value is increasing. MIP is made by DMAA as template, acrylamide as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linking, azobisisobutyronitrile (AIBN) as the initiator and chloroform as a porogen solvent; using bulk method. The aim of research are conduct the MIP for the DMAA compound analysis, then the formed MIP is characterized by using Fourier Transform Infra Red (FTIR) and Scanning Electron Microscopy (SEM) to find out the polymer complexes formed and the morphological form of the MIP. The MIP formed then was analyzed by using High-Performance Liquid Chromatography (HPLC) to know the amount of the DMAA, the adsorption capacity, and the adsorption condition found in the MIP. The result of analysis on the content of DMAA in the MIP by using UV-Vis Spectrophotometer is 1.957 mg. Scanning Electron Microscopy (SEM) shows that the MIP has irregular and rough morphological structure; while the NIP has irregular morphology structures and smooth surfaces shape
Co-Authors Abdul Mutalib Ahmad Muhtadi Aliya Nur Hasanah Daryono H. Tjahjono Eli Halimah, Eli Entris Sutisna, Entris Fikri, Fauzan H.Tjahjono, Daryono H.Tjahjono, Daryono Ida Musfiroh, Ida Ilma Nugrahani Jutti Levita Kartasasmita, Rahmana E Kartasasmita, Rahmana E Mursadad, Amir N.S, Sundani Nawawi, Asari Nursalam Hamzah Nursamsiar Nursamsiar Nursyamsiah, Tresna Nursyamsiah, Tresna Rahmana Emran Kartasasmita Saeful Amin Saeful Amin, Saeful Saptarini, Nyi M. Sophi Damayanti Sukmadjaja Asyarie Sumiwi, Sri A. Sundani Nurono Soewandhi