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All Journal Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Health Sains eJournal Kedokteran Indonesia Makara Journal of Health Research
Junita Indarti
Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Association Between High-risk HPV Infection and Cervical Precancerous Lesions indarti, Junita; Bonifasius, Bonifasius; Wiguna, Sandra
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 2 April 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i2.2937

Abstract

AbstractIntroduction: More than 70% of cervical cancer cases are associated with high-risk HPV infections, especially those of type 16/18. Persistent high-risk HPV infection can cause cervical lesions and develop into cancer; therefore, early detection of HPV infection is important. Screening using HPV DNA tests, either as a single test or combined with a cervical cytological test, is recommended. This study aimed to determine the association between high-risk HPV infection and the development of cervical precancerous lesions.Methods: This cross-sectional study was conducted on 104 patients at RSUPN Dr. Cipto Mangunkusumo in 2020-2022 using secondary data from HPV DNA test results with the DiagCor GenoFlow Human Papilloma Virus Array Test and cervical cytology results from liquid-based cytology. The data were presented in tables and analyzed using SPSS version 26.Results: The prevalence of high-risk HPV infection was 30.8%, with the most common genotypes being HPV 18 & 52 (15.6%), HPV 51 (12.5%), and HPV 58 (9.4%). Cytological results from the high-risk HPV types showed that 16 out of 32 (50%) were abnormal. High-risk HPV caused 11 (78.6%) low-grade squamous intraepithelial lesions and 5 (83.3%) high-grade squamous intraepithelial lesions. It is known by the statistical analysis test that there was a significant relationship between high-risk HPV infection and cervical precancerous lesions (p=0.000).Conclusion: A significant association was observed between the occurrence of high-risk HPV infection and the development of cervical precancerous lesions. Appropriate management and supervision can be carried out in accordance with risk stratification based on screening results.Keywords: cervical precancerous lesions, high-risk HPV infection, screening
Risk Factors of Intrauterine Fetal Death in Cipto Mangunkusumo General Hospital, Indonesia Indarti, Junita; Mardhatillah, Syifa; Alda, Kristian; Vitasatria, Arresta; Solihin, Affan; Sumulyo, Ganot; Ikhsan, Muhammad; Agassi Antoniman, Mohammad
Jurnal Health Sains Vol. 5 No. 11 (2024): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i11.1394

Abstract

Intra Uterine Fetal Death ( IUFD ) results from various disorders of the mother, fetus, and placenta. This study aimed to explore factors contributing to IUFD, knowing the risk factors will prevent this case in the future time. In 2016-2018, patients diagnosed with IUFD at 22 weeks of gestation were included. One hundred twenty-five patients with IUFD and 125 controls with alive fetuses were enrolled. Data were collected from the medical records of participants. Factors that may have contributed to IUFD were explored. Comparisons between various risk factors and outcomes of the two groups were made. P-value was statistically significant if ≤0.05. We found several factors that contribute to IUFD. Some factors like BMI, ANC provider, referred from tertiary health facility, and congenital anomaly increased the risk of IUFD by 2.86, 5.86, 6.26 and 9.45 times respectively. In contrast, some factors like a number of ANC ≥ 6 times and gestational age >36 weeks decrease the risk of IUFD. Regular and intensive ANC ≥ 6 times during pregnancy, number of pregnancy and gestational age ≥ 36 weeks significantly decreases the risk of IUFD with OR 0.12, 0.4, and 0.23 respectively. High-quality ANC to identify IUFD risk factors may lead to a significant decrease in its occurrences. Some factors like BMI, ANC provider, referred from tertiary health facility, and congenital anomaly increased the risk of IUFD, but Number of ANC≥ 6 times, number of pregnancy ≥2 and gestational age ≥36 weeks can reduce risk of IUFD.
Age at Sexual Debut as a Determinant of HPV Infection in Women with Clinically Normal Cervix in Indonesia Utami, Tofan Widya; Nuranna, Laila; Purwoto, Gatot; Indarti, Junita; Firdaus, Najmarani Devi; Oktalia, Arisda; Sulastri, Nuni; Kekalih, Aria
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2745

Abstract

Objectives: This study examined the association between sexual debut and HPV infection in Indonesian women with a clinically normal cervix, contextualized within the Sustainable Development Goals (SDGs). Methods: This prospective cohort study utilized primary data from structured interviews and gynecological exams conducted by the Female Cancer Program (FCP) team across public and private health providers in Jakarta (January 2012–July 2018). Cervical cancer risk factors, including early sexual debut, were analyzed using odds ratios (ORs). Results: A total of 1,390 women with a clinically normal cervix were enrolled in this study, with 52 (3.7%) testing positive for HPV-DNA. Statistical analysis indicated an odds ratio (OR) of 1.176 (95% CI: 0.598–2.316, p = 0.601) for early sexual debut. Conclusion: This study showed that there was an insignificant association between sexual debut and HPV infection in clinically normal cervix. According to the SDGs, early sexual debut and cervical cancer are highly associated. In order to meet the SDGs by 2030, more research is required to validate this finding and assess additional co-factors connected to cervical cancer.
Co-Authors Abror Irsan Aditya, Reyhan Adri Dwi Anggayana Affan Solihin Agassi Antoniman, Mohammad Alda, Kristian Aldri Frinaldi Alida Harahap Andi Yasmon Aria Kekalih Arietta Pusponegoro Arini Setiawati Ario B. Hanggono Arresta V. Suastika Bambang Sutrisna Bethy Suryawati Boeyoeng E.A.P Dalimunte Bonifasius, Bonifasius Budidarmo, Utomo Caroline Caroline Chakti A. Swastika Cherysa Rifiranda Dalri Suhartomo David Eka Prasetya Diana Natalia Diana Natalia Ditha Loho Dwiana Ocviyanti Dwiyana Ocviyanti Dyah P. Wardhani Effiana Effiana Effiana, Effiana Erda Ayu Umami Firdaus, Najmarani Devi Fitriyadi Kusuma Gatot Purwoto Handika Zulimartin Hanny Nilasari Hari Sandi Henny S. Wonodihardjo Imam Rahmadi Iwan Darmansjah Jan Susilo Kristian Alda Kristian Alda Laila Nuranna Lisnawati Rachmadi Lucas Christiawan Maemonah, Maemonah Mardhatillah, Syifa Mardhia, Mardhia Mardhia, Mardhia Mohammad A.F Dilmy Mohammad F. Aziz Muhammad Ikhsan Muhammad T. Ramadhani Natasya Prameswari Nova V. Wijaya Nuryati C. Siregar Ocviyanti, Dwiyana Oktalia, Arisda Prasetyo, Sandy Pratama, Yuven S Quamila F. Afdi Rahmadhany, Rizky Raymond Surya Reyhan Aditya Riyan H Kurniawan Riyan H Kurniawan, Riyan H Rizky Rahmadhany RR. Ella Evrita Hestiandari Sari Rahmayanti Shinta Pangestu Siti R.F Harun Solihin, Affan Sulastri, Nuni Sumulyo, Ganot Surya, Ilham Utama Syaharutsa, Danny Maesadatu Syifa M. Syafitri Utami, Tofan Widya Vitasatria, Arresta Wiguna, Sandra