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Nurwidodo, Nurwidodo
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Social Sciences Other

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Journal : Jurnal Mangifera Edu

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Blood glucose levels in hyperglycemic white rats administered various preparations of bay leaves Zaenab, Siti; Nurwidodo, Nurwidodo
Jurnal Mangifera Edu Vol 10 No 1 (2025): Jurnal Mangifera Edu
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/mangiferaedu.v10i1.230

Abstract

Elevated blood glucose levels, known as Hyperglycemia, are a key feature of diabetes mellitus (DM), which remains a primary global health challenge. The rising prevalence of type 2 diabetes and the side effects of synthetic drugs have led to interest in natural alternatives. Bay leaves (Syzygium polyanthum), commonly used in Indonesian cuisine, contain bioactive compounds such as flavonoids, tannins, and terpenoids that may have antidiabetic properties. This study examined the effect of bay leaves preparations—decoction, tea, and filtrate—on blood glucose levels in hyperglycemic white rats and identified the most effective form. A proper experimental design involved 25 male rats, divided into five groups: a negative control, a positive control (alloxan only), and three treatment groups (decoction, tea, and filtrate). Hyperglycemia was induced using alloxan (150 mg/kg BW), and treatments were given orally twice daily for 30 days. Blood glucose levels were measured before and after treatment using a GlucoDr glucometer. Data were analyzed using one-way ANOVA and the LSD test (α = 0.05). Significant differences were observed among groups (Fhit = 16.61 > Ftab = 2.87). The decoction group had the most considerable glucose reduction (112.4 mg/dL), closely followed by the negative control (118 mg/dL), while the tea and filtrate groups showed lesser effects. Decoction proved most effective, likely due to better compound extraction. These findings highlight the potential of bay leaves decoction as a natural remedy for hyperglycemia, warranting further clinical research.
Co-Authors AA Sudharmawan, AA Abdulkadir Rahardjanto, Abdulkadir Ahmad Fauzi Ali Djamhuri Arina Mufrihah Azizul Ghofar Candra Wicaksono, Azizul Ghofar Candra Dini Fithria Nurul Aisyah Dwi Setyawan Dwi Sulistiarini Dwi Sulistiarini, Dwi Eka Susy Lestari Elly Purwanti Endah Wardani Endah Wardani, Endah Eri Sarimanah Fauzi Ahmad Muda Fendy Hardian Permana Feni Nur’ain, Feni Feni Nur’ain Fitriani, Dhita Fuad Jaya Miharja Herlina Herlina Husamah Husamah I Dewa Putu Eskasasnanda, I Dewa Putu Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Iffah, Anna Harizatul Iin Hindun Iriani, Dwi Lilis Wahyuningrum, Lilis Lise Chamisijatin Mas’odi, M. Mashuri Mashuri Mas’odi Mas’odi Mimien Henie Irawati Misbahul Munir Moh. Mirza Nuryady Mr Sumar Hendayana Muhammad Mifta Fausan Mulyono , M. Nikmah, Hurrun In Novita Adiqka Putri Novita Adiqka Putri, Novita Pratiwi, Ambar Rahardjanto, Abdulkadir Reni Mega Sari Samsun hadi Selvy Yulia Paradila Siti Zaenab Siti Zaenab Sri Wahyuni Sri Wahyuni Tria Rosiana Utami, Inggita Wilujeng, Elok Catur Yuni Pantiwati Yuni Pantiwati Pantiwati Yuniarti, Fenti Nur