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All Journal Journal of Food and Pharmaceutical Science JPSCR : Journal of Pharmaceutical Science and Clinical Research JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Journal of Food and Pharmaceutical Sciences
Ungsari Rizki Eka Purwanto
Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Orally Disintegrating Tablet Formulation of Avicennia Fruit Ethanol Extract (Avicennia marina) Ungsari Rizki Eka Purwanto; Maria Caecilia Nanny Setiawati; Ika Puspitaningrum; Siti Munisih
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2488

Abstract

The fruit produced from Avicennia tree (in the form of ethanol extract) has the property of reducing blood glucose levels (oral antidiabetic mellitus) with an effective dose of 10 mg / 50 kg human body weight. Most of the elderly with diabetes mellitus in Indonesia are aged 60-74 years (83.3%) who have a decreased ability to swallow drugs. In addition, antidiabetic drugs are expected to be able to produce fast action, so that it can reduce blood sugar levels immediately. Therefore, the Avicennia fruit ethanol extract formulated in the form of Orally Disintegrating Tablet (ODT). The aim of this study was to determine the effect of Starch 1500 and Crospovidone as a superdisintegrant in either single or combination use in the Avicennia fruit ethanol extract ODT formulation. The ODT was made by direct compression. There were three formulas that was carried out in this study : FI with 10 mg of Starch 1500, FII with 10 mg of Crospovidone and FIII with a combination of superdisintegrant Starch 1500 and Crospovidone (7 mg and 3 mg). In this study it could be conclued that the best compatible superdisintegrant in ODT for Avicennia fruit ethanol extract was Crospovidone, not combination with Starch 1500.
Edukasi Pemanfaatan Kosmetik Herbal Dan Pembuatan Sabun Beras Pada Kader PKK Desa Ungsari Rizki Eka Purwanto; Mutmainah; Siti Munisih; I Kadek Bagiana; Yuvianti Dwi Franyoto; Aries Koes Soendoro; Maria Caecilia Nanny Setiawati H; Sri Haryanti; Lia Kusmita; Ika Puspitaningrum
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 2 No 2 (2023): April
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v2i2.100

Abstract

Latar belakang: Desa Dukuh, kecamatan Delanggu merupakan salah satu Desa di Kabupaten Klaten, Jawa Tengah yang terkenal akan produksi berasnya. Inovasi yang dapat diberikan untuk meningkatkan potensi dan nilai tambah dari beras adalah diformulasikan ke dalam sediaan sabun beras herbal. Tujuan: Memperkenalkan metode pengolahan beras dan tanaman herbal hingga menjadi produk sabun beras herbal yang dapat menciptakan peluang usaha desa. Metode: Kegiatan ini dilakukan melalui tiga tahapan yaitu tahapan pertama tahapan perencanaan dan persiapan kegiatan, tahapan kedua adalah pelaksanaan meliputi sosialisasi dan pelatihan pembuatan sabun beras herbal dan tahap ketiga adalah evaluasi akhir. Hasil: Hasil pelaksanaan kegiatan pengabdian masyarakat diterima dengan antusias dan seluruh peserta aktif dalam kegiatan sosialisasi mengenai kosmetik herbal dan pelatihan pembuatan sabun beras herbal. Lebih dari 90% peserta memahami sosialisasi dan pelatihan yang diberikan. Kesimpulan: Kegiatan pengabdian masyarakat yang berlangsung sukses dan lancar. Peserta pengabdian juga berharap kelanjutan kegiatan pelatihan kontrol kualitas sediaan sabun dan pelatihan pemasaran produk. Kata Kunci: beras, herbal, Klaten, sabun __________________________________________________________________________________________ Abstract Background: Dukuh Village, Delanggu sub-district is one of the villages in Klaten  Regency, Central Java which is famous for its rice production. An innovation that can be given to increase the potential and added value of rice is to formulate it into herbal rice soap preparations. Objective: To introduce methods of processing rice and herbal plants to become herbal rice soap products that can create village business opportunities. Method: This activity is carried out through three stages, namely the first stage is the planning stage, the second stage is the socialization and training stage for making herbal rice soap and the third stage is the final evaluation. Result: The results of the implementation of community service activities were enthusiastically received and all participants were active in socialization activities regarding herbal cosmetics and training in making herbal rice soap. More than 90% of the participants understood the socialization and training provided. Conclusion: Community service activities that took place successfully and smoothly. The participants also hope to continue the quality control training activities for soap preparations and product marketing training. Keywords: rice, herbs, Klaten, soap
Orally Disintegrating Tablet Formulation of Avicennia Fruit Ethanol Extract (Avicennia marina) Ungsari Rizki Eka Purwanto; Maria Caecilia Nanny Setiawati; Ika Puspitaningrum; Siti Munisih
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2488

Abstract

The fruit produced from Avicennia tree (in the form of ethanol extract) has the property of reducing blood glucose levels (oral antidiabetic mellitus) with an effective dose of 10 mg / 50 kg human body weight. Most of the elderly with diabetes mellitus in Indonesia are aged 60-74 years (83.3%) who have a decreased ability to swallow drugs. In addition, antidiabetic drugs are expected to be able to produce fast action, so that it can reduce blood sugar levels immediately. Therefore, the Avicennia fruit ethanol extract formulated in the form of Orally Disintegrating Tablet (ODT). The aim of this study was to determine the effect of Starch 1500 and Crospovidone as a superdisintegrant in either single or combination use in the Avicennia fruit ethanol extract ODT formulation. The ODT was made by direct compression. There were three formulas that was carried out in this study : FI with 10 mg of Starch 1500, FII with 10 mg of Crospovidone and FIII with a combination of superdisintegrant Starch 1500 and Crospovidone (7 mg and 3 mg). In this study it could be conclued that the best compatible superdisintegrant in ODT for Avicennia fruit ethanol extract was Crospovidone, not combination with Starch 1500.
Nanoemulgel Formulation of Marjoram (Origanum majorana L.) Essential Oil with Potential as Anti-Inflammatory and Anti-Hyperuricemia Ungsari Rizki Eka Purwanto; Mighfar Syukur; Tris Harni Pebriani; Anissa Nursofiatun
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.78668

Abstract

The prevalence of hyperuricemia has increased in several countries, including Indonesia. Uric acid will continuously be deposited in the form of crystals in the joint cavity, which can cause inflammation. One natural ingredient potentially treating this problem is marjoram essential oil (Origanum majorana L.). Marjoram essential oil (MEO) contains various terpene compounds that have the potential to reduce pro-inflammatory mediators and uric acid levels. Terpene compounds are known to be able to be delivered through the skin, but their penetration levels are still very limited. The development of pharmaceutical preparations such as nanoemulgel is needed to enhance the penetration of the active components in marjoram essential oil. This research aimed to optimize the components that make up nanoemulgel, namely polysorbate 80 surfactants and PEG 400 co-surfactant, to produce a nanoemulgel preparation of marjoram essential oil with optimum physical characteristics and potential as an anti-inflammatory and anti-hyperuricemia in the rat. The optimum composition of Polysorbate 80 surfactant and PEG 400 co-surfactant is 9.958: 6.042. It resulted in the optimal formula for MEO 1% nanoemulsion, which had an average globule size of 22.94 nm with a polydispersity index of 0.65 and MEO 2% nanoemulsion: 142.4 nm with a polydispersity index of 0.91. MEO nanoemulsion could be dispersed into a gel base and become an MEO nanoemulgel, which has inhibitory power against xanthine oxidase, whereas 2% MEO nanoemulgel has an IC 50 of 25.30+2.57 ppm and has greater anti-inflammatory power than 1% MEO nanoemulgel. 
Co-Authors Anissa Nursofiatun Aries Koes Soendoro Franyoto, Yuvianti Dwi I Bagiana Ika Puspitaningrum Ika Puspitaningrum Lia Kusmita Maria Caecilia Nanny Setiawati Maria Caecilia Nanny Setiawati H Mighfar Syukur Mutmainah Siti Munisih Sri Haryanti Tris Harni Pebriani