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All Journal Jurnal Akuakultur Indonesia Jurnal Perikanan Universitas Gadjah Mada Indonesian Aquaculture Journal Aquacultura Indonesiana SIGANUS: Journal of Fisheries and Marine Science Journal of Multidisciplinary Applied Natural Science
ALIM ISNANSETYO
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics

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Extraction and Fractionation of Anti-Cholesterol Compounds from Water Chestnut (Eleocharis dulcis) Putra, Hemi Adi; Husni, Amir; Isnansetyo, Alim
Jurnal Perikanan Universitas Gadjah Mada Vol 27, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfs.106066

Abstract

Cholesterol is a significant contributor to mortality rates worldwide. The quest for effective cholesterol treatments continues, aiming to develop preventive agents with minimal adverse effects. This study seeks to elucidate the anti-cholesterol properties of extracts and components fractionated from water chestnut (Eleocharis dulcis). The research encompassed several phases, including sampling, extraction and fractionation, qualitative and quantitative flavonoid analysis, anti-cholesterol activity assays, and gas chromatography-mass spectrometry (GC-MS) analysis. The quantitative flavonoid assessment revealed that the highest flavonoid concentration was present in the ethyl acetate:methanol (5:5) fraction, totaling 79.224 mg/mL. The water chestnut extract demonstrated notable anti-cholesterol activity with an IC50 value of 13016.27 ± 5648.31 ppm, whereas the water chestnut fraction exhibited enhanced anti-cholesterol activity with an IC50 value of 42.22 ± 9.79 ppm, comparable to simvastatin. The bioactive compounds in water chestnut attributed to its anti-cholesterol effects include 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, n-Hexadecanoic acid, Octadecanoic acid ethyl ester, 9-Octadecenamide (Z)-, 9,12,15-Octadecatrienoic acid, 2,3-dihydroxypropyl ester, 3,4-Dimethoxycinnamic acid, and 2H-1-Benzopyran-2-one, 7-methoxy-. These findings suggest that the fraction derived from E. dulcis exhibits significant anti-cholesterol activity and holds promise for further development in the treatment of hypercholesterolemia.
Co-Authors Abdullah, Faisal Zain Amir Husni Angela Mariana Lusiastuti Anshory, Lutfi Buana Basir Condro, Sri Laksono Esti Handayani Hardi Gina Saptiani Halim, Aldi M. Hariyadi, Dimas Rizky Ign. Hardaningsih INDAH ISTIQOMAH Irpani, Husni Mubarok Ismail, Norshida Jabbar, Firmansyah Bin Abd Kim, Sung Sam Kristiani, Theresia Adven Dea Lusiana, Lusiana Mira Mawardi Mukhlisnah Djalil Murwantoko . Niklani, Andi Noer Kasanah Putra, Hemi Adi Rahayu, Widianingsih Rarastoeti Pratiwi Rina Puji Astuti Rudy Agung Nugroho SUWARNO HADISUSANTO Tito Arya Nugraha Triastutik, Gemi Triyanto Triyanto Wahyudi Wahyudi Wulansari, Tyas Ayu Yasa, Ngurah Sedana Yasa, Ngurah Sedana Zafran, Zafran