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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Narra J
Kurnia F. Jamil
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Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Effect of rubella vaccine to plasmodium-infected mice parasitemia levels Jonny K. Fajar; H. Harapan; Kurnia F. Jamil; Tjut M. Zanaria
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 2, No 1 (2012): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.662 KB)

Abstract

Malaria, an infectious disease causes by Plasmodium, contribute to 300-900 million morbidities and 1-3 million mortalities, annually. This study aimed to determine the Rubella vaccine potency to inhibit Plasmodium berghei merozoite invasion to erythrocyte which evaluated from parasitemia levels, mortality and mice clinical condition. This study conducted in mice injected Rubella vaccine prior injected with P. berghei. There were four groups: A, B and C injected with 500 µl, 2 µl, and 1 µl rubella vaccine respectively. Group D injected with 500 µl sterile aqua, as control group. After 28 days of vaccination all mice injected with 0.2 ml P. berghei. Furthermore, we observed to parasitemia levels, death, and clinical condition of mice to assess Rubella vaccine effectiveness to inhibit merozoite invasion. The results shown Rubella vaccine did not provide significant effect on parasitemia levels. It might Rubella vaccine dose we used under effective dose and less effective of target site. However, our study shown Rubella vaccine provided significant effect on mice mortality (p0.05). It is probably due to Rubella antigen (213-239 amino acid sequence) and malaria antigen merozoite surface protein (MSP)-119 (sequence amino acid 238) has similar structure, thus it was likely generated cross-immunity. In conclusion, 28 days Rubella vaccination did not provide significant effect on parasitemia levels, however it provided significant effect on mice mortality with infected by P. berghei.
Decline of notified dengue infections in Indonesia in 2017: Discussion of the possible determinants Dhewantara, Pandji Wibawa; Jamil, Kurnia F.; Fajar, Jonny Karunia; Saktianggi, Panji Probo; Nusa, Roy; Garjito , Triwibowo Ambar; Anwar, Samsul; Firzan, Firzan; Megawati , Dewi; Sasmono, R. Tedjo; Mudatsir, Mudatsir
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.23

Abstract

This study was conducted to quantify the trend in dengue notifications in the country in 2017 and to explore the possible determinants. Annual nation-wide dengue notification data were obtained from the National Disease Surveillance of Ministry of Health of Indonesia. Annual incidence rate (IR) and case fatality rate (CFR) in 2017 and the previous years were quantified and compared. Correlations between annual larva free index (LFI), implementation coverage of integrated vector management (IVM), El Niño Southern Oscillation (Niño3.4), Dipole Mode Index (DMI), Zika virus seropositivity and the percent change in IR and CFR of dengue were examined. The change of dengue IR and CFRs were mapped. In 2017, dengue IR was declined by 71% (22.55 per 100,000 population) compared to 2016 (77.96 per 100,000 population) while the CFR was slightly reduced from 0.79% to 0.75%. Reduction in IR and CFR occurred in 94.1% and 70.1% out of 34 provinces, respectively. The trend of dengue IR seems to be influenced by Niño3.4 but there is no clear evidence that Niño3.4 is the main reason for dengue reduction in 2017. It is difficult to elucidate that the reduction of dengue in 2017 was associated with previous Zika outbreaks. In conclusion, there was a significant reduction on dengue notifications in Indonesia in 2017. Further investigation is needed to look at the role of climate on the decline of dengue IR at finer temporal scale. In addition, study on the role of cross-protective immunity generated by Zika infection on dengue incidence is also warranted.
Acute severe hepatitis of unknown etiology in children: A mini-review Frediansyah, Andri; Sallam, Malik; Yufika, Amanda; Sharun, Khan; Iqhrammullah, Muhammad; Chandran, Deepak; Mamada, Sukamto S.; Sallam, Dina E.; Khader, Yousef; Lemu, Yohannes K.; Yusuf, Fauzi; Kretchy, James-Paul; Abdeen, Ziad; Torres-Roman, J. Smith; Acharya, Yogesh; Bondarenko, Anastasia; Ikram, Aamer; Jamil, Kurnia F.; Kotfis, Katarzyna; Koyanagi, Ai; Smith, Lee; Megawati, Dewi; Rademaker, Marius; Emran, Talha B.; Memish, Ziad A.; Vento, Sandro; Nainu, Firzan; Harapan, Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
Quality of life and its predictors among people living with HIV in Muslim majority region: A cross-sectional study in Aceh Hasan, Maryatun; Jamil, Kurnia F.; Darmawi, Darmawi; Syukri, Maimun; Liansyah, Tita M.; Beočanin, Anđelija; Erianza, Dava
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.202

Abstract

Human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) remain significant global health challenges addressed by countries worldwide. The advent of antiretroviral therapy (ARV) has significantly reduced morbidity and mortality of people living with HIV (PLHIV), transforming HIV/AIDS from a fatal disease to a manageable chronic disease. However, the increasing number of elderly individuals with HIV who experience early frailty syndrome presents new challenges and potential for diminished quality of life. The aim of this study was to assess the quality of life and to identify its significant predictors in PLHIV patients who have received ARV therapy in Banda Aceh, a Muslim-majority region in Indonesia. A cross-sectional study was conducted on all PLHIV who received ARV therapy at the voluntary counseling and testing (VCT) polyclinic at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia between January and February 2023. The WHOQOL-HIV BREF instrument, a multi-dimensional tool developed by the World Health Organization (WHO), was used to assess the quality of life of the PLHIV, and potential predictors were assessed. The Chi-squared test was used to determine the predictors associated with the quality of patient’s lives. Our data indicated that the majority of PLHIV were male (88%), 26–35 years old (78%), employed (92%), and unmarried (54%). Poor quality of life was dominant for the physical health (100%) and social relationships (76%) domains. In contrast, good quality of life was observed in aspects of independence, psychology, and spirituality, all reporting 100% results. Significant associations were found between married status (p=0.004) and medication adherence (p<0.001) with higher quality of life among PLHIV. In conclusion, married PLHIVs that received support from their partners regarding adherence to therapy exhibited a better quality of life. These results underscore the significance of sustained support systems and adherence strategies to enhance PLHIV's quality of life.
Co-Authors Abdeen, Ziad Acharya, Yogesh Anak Agung Dewi Megawati, Anak Agung Dewi Andri Frediansyah, Andri Beočanin, Anđelija Bondarenko, Anastasia Chandran, Deepak Darmawi . Emran, Talha B. Erianza, Dava Fajar, Jonny Karunia Fauzi Yusuf, Fauzi Firzan Nainu Firzan, Firzan Garjito , Triwibowo Ambar H. Harapan Harapan Harapan Hasan, Maryatun Ikram, Aamer Iqhrammullah, Muhammad Jonny K. Fajar Khader, Yousef Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Lemu, Yohannes K. Liansyah, Tita M. Maimun Syukri, Maimun Mamada, Sukamto S. Memish, Ziad A. Mudatsir Mudatsir Pandji Wibawa Dhewantara Rademaker, Marius Roy Nusa Saktianggi, Panji Probo Sallam, Dina E. Sallam, Malik Samsul Anwar Sasmono, R. Tedjo Sharun, Khan Smith, Lee Tjut M. Zanaria Torres-Roman, J. Smith Vento, Sandro Yufika, Amanda