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All Journal EKSAKTA: Journal of Sciences and Data Analysis CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Majalah Farmaseutik Indonesian Journal of Chemistry Proceeding of International Conference Health, Science And Technology (ICOHETECH)

Ritmaleni, Ritmaleni

Faculty Of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia.

Author-ID : 2920924

Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 18 Documents Claim Missing Document

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Articles

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SYNTHESIS OF TETRAHYDROHEXAGAMAVUNON-5 AND TETRAHYDROHEXAGAMAVUNON-7 Ritmaleni Ritmaleni; Ian Praditya; Haryono Wibowo; Sardjiman Sardjiman
Indonesian Journal of Pharmacy Vol 26 No 2, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Synthesis of Tetrahydrohexagamavunon-5 (THHGV-5) and Tetrahydrohexagamavunone-7 (THHGV-7) were prepared by catalytic hydrogenation reaction on Hexagamvunon-5 (HGV-5) and Hexagamavunone-7 (HGV-7) by using gas H2 as source of hydrogen gas, Pd/C 10 % as metal catalyst and methanol as solvent at room temperature. The products were characterized by IR Spectroscopy, Gas Chromatography-Mass Spectroscopy (GCMS), 1D-NMR (1H-NMR and 13C-NMR) and 2D-NMR (1H-13C HMQC) Spectroscopy to determine the product structure molecules. According to the data of IR, GC-MS, 1H-NMR, 13C-NMR and 1H-13C HMQC spectra, the products are THHGV-5 and THHGV-7 as white crystalline powders. Key words:Tetrahydrohexagamavunon-5, Tetrahydrohexagamavunone-7, Hexagamvunon-5, Hexagamavunone-7

Synthesis and cytotoxicity test of LR-2 on breast cancer cell line T47D Ritmaleni Ritmaleni; Dina Anitasari; Sinta Susanti; Sismindari .
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

LR-2 is a compound analog of monastrol, an anticancer agent, which has been succesfully synthesised through the application of Biginelli reaction and one of LR compound series that synthesised in Faculty of Farmacy, Universitas Gadjah Mada. This reserach was aimed to synthesized the LR-2 compound and to investigate the cytotoxicity of LR-2 on breast cancer cell line. The reaction was carried out by using the one pot reaction method. In this reaction benzaldehyde, 2-indanone and thiourea were reacted together for 6hours in acid catalyst. The cytotoxicity test was carried by using breast cancer cell line the MTT assay method and the LC50 was ditermined by using the probit analysis with Miller and Tainter method. The product was isolated by using preparative TLC in 54 % yield. The structure was elucidated by spectroscopymethods (UV-Vis, H-NMR, IR and GC-MS).The LC50 is 159 µM.Keywords : LR-2, benzaldehyde, 2-indanone, thiourea, T47D

Synthesis of Phenethyl-aza-ß-Lactam (1,2-Dimethyl4(R,S)-Phenethyl-[1,2]Diazetidin-3-One) Ritmaleni Ritmaleni; Varinder K Anggarwal
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Racemic spiro-epoxide, (7RS, 1RS, 3RS)-phenethyl-10-oxa-1,3-dithiaspiro[6,7]octane 1,3-dioxide 12, can be synthesised in four step reactions, sequences starting from the commercially available 1,3-dithiane 8. The synthesis of aza ß-lactam, 1,2-dimethyl-4(R,S)-phenethyl-[1,2]diazetidin-3one 13, was successfully carried out by opening the epoxide by 1,2-dimethyl hydrazine salt in moderate yield. Keywords : epoxide, aza-ß-lactam

ATTEMPTED SYNTHESIS OF BIS-SPIROEPOXIDE DITHIANEDIOXIDE Ritmaleni Ritmaleni; Varinder K. Aggarwal
Indonesian Journal of Pharmacy Vol 23 No 3, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The bis-spiroepoxide dithiane dioxide has been attempted to be synthesised as its role as an intermediate in the synthesis of diaminopimelic acid (DAP). The first method was carried out by reacting the 3-dithiane-2-diethylphosphonate 4 with an aqueous solution of the commercially available glutaraldehide resulting the bis-ketene dithiane dioxide 5. The second alternative method was involving the ozonolysis of cyclopentene 7 in the synthesis of bis-ketene dithiane dioxide 5 in four step reactions which gave moderate to good yield. Unfortunately, epoxidation process for the bis-ketene dithiane dioxide 5 was still unsuccess yet.Key words: synthesis, diaminopimelic acid, bis-spiroepoxide dithiane dioxide

OXIDATION KINETICS AND QUANTIFICATION METHOD OF CHOLESTEROL USING CHOLESTEROL OXIDASE ENZYME CATALYST Iip Izul Falah; Ritmaleni Ritmaleni; M. Utoro Yahya
Indonesian Journal of Chemistry Vol 10, No 1 (2010)
Publisher : Universitas Gadjah Mada

In view of health, cholesterol is believed as one of many sources can raise several diseases. Hence, both of research in quantification and developing simple, rapid and accurate analysis method of cholesterol in a sample is very important. Aim of this research was to investigate cholesterol oxidation kinetics and its quantification method based on oxidation of cholesterol and formation complex compound of hexathiocyanato ferat(III), {Fe(SCN)6}-3. The kinetics analysis and quantification, involved cholesterol oxidation in 0.1 M and pH 7.0 phosphate buffer solution to produce cholest-4-en-3-one and hydrogen peroxide, in the presence of cholesterol oxidase enzyme. The formed hydrogen peroxide was used to oxidize iron(II) ion, which was reacted furthermore with thiocyanate ion to raise the red-brown complex compound. Results of the study showed that the complex was stable at 10-120 min since the reaction was started, with maximum wavelength of 530-540 nm. While the kinetics analysis gave first order oxidation reaction with a reaction rate constant, kapp = 5.22 x 10-2 min-1. Based on this kinetics data, cholesterol analysis method could be developed i.e. by oxidizing cholesterol within 1.5 h using cholesterol oxidase as a catalyst, and then reacted with Fe2+, in a solution containing thiocyanate ion. Absorbencies of solutions of the complex compound, measured at wavelength of 535 nm, were linearly proportional to their cholesterol concentrations, in the range of 50-450 ppm.

N-(2-chlorobenzyl) formamide, a Novel Synthesized Antituberculosis Evaluation by Microplate Alamar Blue Assay Desy Ayu Irma Permatasari; Ritmaleni
Proceeding of International Conference on Science, Health, And Technology Proceeding of the 1st International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

The multicomponent amidoalkylation reaction is done by mixing three compounds simultaneously. This method develops in the area of anti-tuberculosis. Tuberculosis (TB) is an infectious disease caused by M. tuberculosis. A novel N-(2-chlorobenzyl) formamide was synthesized by reacted with formic acid or NaBH4. The synthesized compounds were identified by structural elucidation using spectroscopic methods (1H-NMR, 13C-NMR, FTIR) and GC-MS. The antituberculosis activity test used the Microplate Alamar Blue Assay (MABA) method with a concentration series of 1000-1,954 µg / mL against M. tuberculosis bacteria strain H37Rv. The results showed that the product was successfully synthesized using a multicomponent reaction with formic acid. N-(2-chlorobenzyl)formamide has MIC value 1000 μg / mL for its evaluation on antituberculosis activity with MABA method but are less potent than INH (2 μg / mL) as drug control.

Formulasi dan Uji Stabilitas Fisik Sediaan Krim Tabir Surya Pentagamavunon-5 Serta Uji Aktivitasnya Secara In Vitro Zulkarnain, Abdul Karim; Syach, Muhammad Ferdian; Ritmaleni, Ritmaleni
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.95459

Pentagamavunon-5 (PGV-5) adalah salah satu senyawa analog kurkumin yang memiliki aktivitas antioksidan yang tinggi yang dapat berpotensi dimanfatkan sebagai bahan aktif tabir surya. Penelitian ini bertujuan untuk mengoptimasikan asam stearat dan parafin cair untuk mendapatkan sediaan tabir surya yang memiliki sifat fisik yang baik serta menghasilkan efek proteksi dari PGV-5 sebagai bahan aktif dengan maksimal. Metode optimasi formula dilakukan dengan mengubah konsentrasi dari asam stearat dan parafin cair. Optimasi dilakukan dengan menggunakan metode Simplex Lattice Design pada Design Expert versi 13 yang dilanjutkan dengan verifikasi formula optimum dan uji sifat fisik serta stabilitas sediaan krim. Data yang diperoleh dilakukan analisis dengan One-Sample t-Test dengan taraf kepercayaan 95% dan IBM SPSS Statistic 26 untuk mengevaluasi stabilitas fisik sediaan. Hasil penelitian menunjukkan bahwa sediaan krim dengan PGV-5 sebesar 0,25% dihasilkan nilai SPF sebesar 40,25; sedangkan SPF basis krim sebesar 6,93. Hasil uji stabilitas fisik sediaan yang disimpan pada suhu ekstrim pada siklus 0, 1, 2, dan 3 tidak terdapat perbedaan yang signifikan dengan nilai signifikansi > 0.05. Hasil penelitian dapat disimpulkan bahwa sediaan memiliki SPF 40,25 dan stabil selama penyimpanan pada suhu ekstrim. Nilai %Te krim PGV-5 24%, sedangkan nilai %Tp adalah 12,69% termasuk dalam kategori sebagai sunblock

Validasi Metode Analisa Penetapan Kadar Glukosa dengan Metode Dubois secara Spektrofotometri Rahmayani, Almira; Marzuki, Ahmad; Ritmaleni, Ritmaleni; Sri Tunjung, Woro Anindito
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.97119

Penetapan kadar glukosa dalam sampel biologis dan makanan sangat penting di berbagai bidanhg khususnya farmasi dan makanan. Ketidakseimbangan kadar glukosa dalam darah dapat menjadi indikator berbagai kondisi kesehatan seperti diabetes mellitus. Penelitian ini bertujuan untuk memvalidasi penetapan kadar glukosa dengan metode Dubois dengan spektrofotometri. Metode ini melibatkan reaksi antara glukosa dengan fenol dan asam sulfat pekat, menghasilkan senyawa berwarna kuning yang dapat terbaca pada panjang gelombang visibel ± 490 nm. Proses validasi mencakup uji spesifisitas, linearitas, LOD-LOQ, akurasi, dan presisi sesuai pedoman ICH Q2(R1). Hasil validasi menunjukkan spesifisitas pada l 488 nm dengan nilai R = 0,999, LOD serta LOQ pada 13,36 ppm dan 44,53 ppm, % perolehan kembali 101,11% dan RSD 1,73%. Berdasarkan parameter validasi yang telah diuji, maka prosedur penetapan kadar glukosa dengan instrumen spektrofotometri telah memenuhi kriteria dan dinyatakan telah valid.

Co-Authors Abdul Karim Zulkarnain Adam Hermawan Afifah, Anis Agung Endro Nugroho Ahmad Marzuki Arifin, Muhammad Fajar Azmi Rahmadani Bambang Sulistiyo Ari Sudarmanto Desy Ayu Irma Permatasari Dina Anitasari Haryono Wibowo Ian Praditya Iip Izul Falah Imaniyyati, Niar Nurul Kazutaka Maeyama M. Utoro Yahya Megawati Parmasari Muthi Ikawati Ni Putu Linda Laksmiani Novrizal Abdi Sahid Nurcahyani, Wahyu Purwanto, Heri Rahmayani, Almira Retno Murwanti Retno Wahyuningrum Rumiyati, Rumiyati Sagiyo, Marrita Langgeng Sardjiman Sardjiman Simbara, Ari Sinta Susanti Sismindari . Sismindari . Sismindari, Sismindari Subagus Wahyuono Syach, Muhammad Ferdian Takushi Kaneko Tatang Irianti Titik Nuryastuti Varinder K Anggarwal Varinder K. Aggarwal Woro Anindito Sri Tunjung Yohanes, Jasson

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