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All Journal Sport and Fitness Journal METAMORFOSA Journal of Biological Sciences E-Jurnal Medika Udayana Health Notions Aktiva : Jurnal Akuntansi dan Investasi ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Ners Bali Anatomy Journal Indonesian Andrology and Biomedical Journal
I Gusti Ayu Widianti
Department Of Anatomy, Medical Faculty, Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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The Addition of SNAGS is Faster to Reduce Pain and Disability Comparing with Conventional Therapy Only among HNP Lumbar Grade I and II Asrul Sani; Susy Purnawati; Sugijanto Sugijanto; DPG Purwa Samatra; IPG Adiatmika; IG Ayu Widianti
Health Notions Vol 6, No 8 (2022): August
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn60802

Abstract

Herniated nucleus pulposus is a rupture of the annulus fibrosus intervertebral disc which can compression the excitatory tissue of the lumbar that comes out of the intervertebral foramen, causing radicular pain, and ultimately causing lumbar disability. This study aims to prove that the addition of SNAGS to conventional therapy is faster in reducing pain and disability in grade I and II lumbar HNP. This research was a experimental study with a control times series design which was carried out at dr. La Palaloi Hospital, Bhayangkara Hospital and Inggit Medical Clinic Makassar. The population was 50 samples with each group was consists of 20 people according to pocock formula and each group had given 2 times exercises a week for 6 weeks, simple random sampling using consecutive sampling method with lottery technique. The primary outcomes measured were pain and disability used VAS and ODI that were performed every week. Data analysis using Kruskall-Wallis and Wilcoxon showed the change in the mean VAS before the intervention was 5.84±1.17 and the mean VAS after the third week of intervention was 4.90±1.04 with p-value = 0.000 and a change in the mean The ODI before the intervention was 40.60±9.21 and the mean ODI after the fourth week of intervention was 32.90±6.79 with p-value = 0.0000. While the treatment group showed a change in the mean VAS before the intervention was 5.68±1.00 and the mean VAS after the second week of intervention was 4.57±0.79 with p-value = 0.000 and change in the mean ODI before intervention was 40.50±8.43 and the mean ODI after the third week of intervention was 28.60±6.23 with p-value = 0.000 which means that the control group was effective for changes in pain in the third week and effective for changes in disability in the fourth week, while the study group was effective for changes in pain in the second week and effective for changes in disability in the third week. There was a significant difference in pain changes in the control group and the treatment group in the second week with p-value = 0.014 and a significant difference in the change in disability in the control group and the treatment group in the third week with p-value = 0.011. It was concluded that the addition of SNAGS to conventional therapy was faster in reducing pain in the second week and disability in the third week in cases of grade I and II lumbar HNP. Keywords: pain; disability; HNP lumbar grade I and II; conventional therapy; SNAGS
The Relationship Between Varicocele in Infertile Male and Intrauterine Insemination Success at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar Andhika Bhayangkara Putra Anak Agung Gde; I Gusti Ngurah Pramesemara; Yukhi Kurniawan; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 3 No. 2 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v3i2.35877

Abstract

Background: Assisted Reproductive Technology (ART), such as intrauterine insemination (IUI), can be an option for infertile couples who are expecting a pregnancy. However, the success of IUI can be influenced by various factors, one of which is varicocele.   Objective: This study aims to determine the association between varicocele and IUI success. Methods: This study is an analytical cross-sectional study using patient medical records. The sample of this study was male patients aged 25-45 years with infertility and undergoing IUI in the period April to June 2021 at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar. The sampling technique used, purposive sampling, was selected based on inclusion and exclusion criteria. Based on the criteria, this study selected 32 samples. Result: From 32 participants, 5 had varicocele (15.6%), and 27  were without varicocele (84.4%). In this study, we found 12 success pregnancy after IUI (37.5%), with 3 participants having varicocele (9.4%) and 9 participants without varicocele (28.1%). The chi-square analysis carried out obtained the results (p>0.05), and the calculation of the relative risk got the result (RR=0.600). Conclusion: This study showed no significant association between varicocele in infertile men and the success of IUI. The RR calculation showed that varicocele was not a risk factor for IUI failure.
Sperm Agglutination in Infertile Men and The Success Rate of Intrauterine Insemination in Rumah Sakit Ibu dan Anak Puri Bunda Denpasar Anak Agung Sintya Padma Dewi; I Gusti Ngurah Pramesemara; Yukhi Kurniawan; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 4 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v4i1.42110

Abstract

Background: Every human being, especially a married couple, wants children. Obstacles to obtaining children are called infertility. One of the Assisted Reproductive Technology (ART) procedures used for treating infertility is intrauterine insemination (IUI), a non-invasive procedure with affordable costs. The success of IUI is influenced by many factors, one of which is sperm agglutination. Objective: This study determined the relationship between sperm agglutination and the success rate of the IUI procedure. Methods: The study is a descriptive-analytic study with a cross-sectional approach. The sample collection technique uses non-probability. The data used were medical records of male patients diagnosed with infertility, aged 25-45 years, and undergoing IUI procedures at the Rumah Sakit Ibu dan Anak Puri Bunda Denpasar from January to July 2022. Results: Of the 91 samples obtained, 9 people experienced sperm agglutination (9,9%), and 82 people did not experience sperm agglutination (90,1%). The success rate of the IUI procedure was 29 people (31,9%), 1 person (11.1%) experiencing sperm agglutination, and 28 people (34,1%) not experiencing sperm agglutination. Fisher's Exact test carried out has obtained a result (p=0.263). And the value of the odds ratio (OR) obtained=0.241) Conclusion: This study concluded that there is no significant relationship between sperm agglutination in infertile men and the success rate of the IUI procedure. The value of OR showed sperm agglutination is not included in the factors that affect the success rate of IUI. Keywords: Sperm Agglutination, Intrauterine Insemination, Male Infertility
Leukospermia in Infertile Men and Successful Intrauterine Insemination at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar Anak Agung Ngurah Perdana Anantadiva; I Gusti Ngurah Pramesemara; Yukhi Kurniawan; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 4 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v4i1.41761

Abstract

Infertility is a condition after a year of regular sexual intercourse, without the use of contraceptives, and ends with the absence of pregnancy. Intrauterine Insemination (IUI) is a procedure that is widely used in fertility clinics and is usually the first treatment option in patients who are experiencing infertility disorders, diagnosis of infertility due to cervical factors, diagnosis of factor infertility in men, and diagnosis of unexplained infertility. the cause. IUI is also a simple, inexpensive, and quite effective infertility treatment. One of the factors that can influence the success of IUI is leukospermia. This study is an analytical study using a cross-sectional design and using medical records of patients diagnosed with infertility, aged from 25 to 45 years, and undergoing IUI procedures from January to June 2022 at the RSIA Puri Bunda Denpasar. The sampling method in this study used a purposive sampling method which was selected based on inclusion and exclusion criteria. In this study, 53 samples were obtained. Of the 53 samples that have been collected, 13 people experienced leukospermia (24.5%), 40 people were non-leukospermic (75.5%). The success of IUI in this study was 17 people (32.1%) consisting of 3 leukospermic (23.1%) and 14 non-leukospermic (35.0%). The results of the Fisher's Exact test obtained, namely the p value = 0.511, it can be concluded that leukospermia with the success of IUI does not have a significant relationship. Calculation of odds ratio (OR) obtained a figure of 1.759 (CI95% 0,423-7,610).
Post-Preparation Total Motile Sperm Count in Infertile Men and The Success Rate of Intrauterine Insemination at Rumah Sakit Kasih Ibu Denpasar in 2022 Wibawa, I Kadek Sadam; I Gusti Ngurah Pramesemara; I Made Oka Negara; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 5 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i1.53777

Abstract

Background: Every married couple hopes to have children, but not all can fulfil that desire. A married couple finds themselves unable to achieve pregnancy after 12 months of regular unprotected sexual intercourse, which can be called infertility. Infertility can also occur in men. In dealing with infertility, intrauterine insemination (IUI) is a cost-effective and non-invasive Assisted Reproductive Technology (ART) procedure. The condition of male infertility can be detected through semen analysis. One of the parameters in semen analysis is the total motile sperm count (TMSC). Objective: This research seeks to establish the relationship between post-preparation TMSC and the success rate of the IUI procedure. Methods: This research adopts a descriptive-analytical design employing a cross-sectional methodology. Non-probability sampling was utilized as the sampling technique, and the data analyzed were secondary data from the medical records of male patients aged 25 to 45 years old diagnosed with infertility. The subjects had undergone IUI at Rumah Sakit Kasih Ibu Denpasar from January 1 to December 31, 2022. Results: From the 35 obtained samples, 12 individuals (34.3%) had a post-preparation TMSC of ≥10 í— 106, while 23 individuals (65.7%) had a post-preparation TMSC of <10 í— 106. The success rate of the Intrauterine Insemination (IUI) procedure was 17.1%, with 4 couples (33.3%) having a post-preparation TMSC of ≥10 í— 106 and 2 couples (8.7%) with a post-preparation TMSC of <10 í— 106. The Fisher's Exact test carried out has obtained a result (p=0.151), while the value of the odds ratio (OR) obtained (OR=5.250) Conclusion: Based on statistical analysis, it can be concluded that there is no significant association between post-preparation TMSC in infertile men and the success rate of IUI procedures (p > 0.05). The odds ratio (OR) obtained is 5.250 (95% CI 0.799-34.496).
Pengaruh Ekstrak Etanol Kubis Ungu terhadap Kadar Malondialdehida, Superoksida Dismutase dan Derajat Steatosis Hati pada Tikus Model NAFLD Ni Made Gita Kusuma Dewi; I Wayan Sugiritama; I Gusti Ayu Widianti; I Nyoman Gede Wardana; Desak Ketut Ernawati; I Putu Bayu Mayura
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.43013

Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) adalah gangguan hati kronis yang ditandai dengan akumulasi lemak berlebih dalam hepatosit dan berkaitan dengan sindrom metabolik. Stres oksidatif berperan dalam progresi NAFLD, dengan kadar malondialdehida (MDA) dan aktivitas superoksida dismutase (SOD) sebagai biomarker. Kubis ungu (Brassica oleracea var. capitata L.) memiliki kandungan antosianin tinggi yang bersifat antioksidan, namun efek hepatoprotektifnya terhadap NAFLD masih perlu diteliti lebih lanjut. Penelitian ini bertujuan untuk mengevaluasi efek hepatoprotektif ekstrak etanol kubis ungu terhadap kadar MDA dan SOD serta derajat steatosis hati pada tikus Wistar jantan yang diinduksi dengan diet tinggi lemak dan karbon tetraklorida (CCl₄). Studi ini menggunakan desain post-test only control group dengan empat kelompok: kontrol negatif dan tiga kelompok perlakuan yang menerima ekstrak etanol kubis ungu dengan dosis 100 mg/kg BB, 200 mg/kg BB, dan 400 mg/kg BB. Analisis menggunakan ANOVA dan uji post-hoc Tukey HSD menunjukkan bahwa ekstrak kubis ungu secara signifikan mencegah peningkatan kadar MDA (p < 0,05), mencegah penurunan aktivitas SOD (p < 0,05), serta mencegah peningkatan derajat steatosis, dengan dosis paling efektif 200 mg/kg BB. Hasil ini menunjukkan bahwa ekstrak etanol kubis ungu memiliki efek hepatoprotektif dan berpotensi sebagai agen terapeutik alami untuk pencegahan NAFLD.
Co-Authors Adhitya Bayu S Aditya Permana Adriyanto Amelia Heryanto Anak Agung Ngurah Perdana Anantadiva Anak Agung Sintya Padma Dewi Andhika Bhayangkara Putra Anak Agung Gde Archana Laxmi Pathmanathan Asrul Sani Bagus Komang Satriyasa Desak Ketut Ernawati Dewa Putu Gede Purwa Samatra Elisabeth Matrona Sintia Pareira Gusti A Putu Mentari Saga P I Dewa Putu Sutjana I Gusti Ngurah Pramesemara I Gusti Ngurah Pramesemara I Made Krisna Dinata I Nyoman Adi Putra I Nyoman Gede Wardana I Nyoman Mangku Karmaya I P G. Adiatmika I Putu Bayu Mayura I Wayan Sugiritama Made Oka Negara Merlynda Ayu Rara Dini Mohd Fauzan Arif Bin Mat Nudin Muhamad Baidhowi Primadi Ni Made Gita Kusuma Dewi Nur Fitriyah Putu Susilawati Sawitri, Anak Agung Sagung Sugijanto Sugijanto Susy Purnawati Wahyuddin, Wahyuddin Wibawa, I Kadek Sadam Yukhi Kurniawan