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All Journal Buletin Veteriner Udayana Buletin Udayana Mengabdi Jurnal Veteriner Journal of Global Pharma Technology
Made Suma Anthara
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Toksisitas Ekstrak Daun Sirih Merah pada Tikus Putih Penderita Diabetes Melitus (TOXICITY OF RED BETEL EXTRACT IN DIABETIC WHITE RAT ) Anak Agung Sagung Kendran; Ketut Tono Pasek Gelgel; Ni Wayan Linda Pertiwi; Made Suma Anthara; Anak Agung Gde Oka Dharmayuda; Luh Dewi Anggreni
Jurnal Veteriner Vol 14 No 4 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The aim of this research was to study the toxicity of red betel  (Piper crocatum) extract in diabeticwhite rat based on ALT and AST activities. This research used 20 male white rats, which randomlydivided into five groups, P1: given only aqua; P2: given alloxan 120mg/kg bw; P3: given alloxan 120 mg/kgbw and red betel leaf extract 50 mg/kg bw; P4: given alloxan 120 mg/kg bw and red betel leaf extract 100mg/kg bw; P5: given alloxan 120 mg/kg bw and glibenclamide suspension 1 mg/kg bw. ALT and ASTactivities were measured by using reflovet plus Machine. The collected data were analyzed by usinganalysis of covariance. The result showed no significant  effect (P>0.05) was observed on giving red betelleaf extract in diabetic white rat for ALT and AST activities.  It can be concluded that red betel leaf extractis potential for diabetic treatment in white rat  and it is not toxic for the rat’s ALT and AST activities.
The Vermicidal Effectivity of Wudani Leaf Extract (Quisqualis indica Linn) in Treating Infection caused by Gastrointestinal Worms in Cattle Ida Bagus Komang Ardana; Made Suma Anthara; Dan Anak Agung Gde Oka Dharmayudha; DK Harya Putra
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The present study was aimed to study whether application of 100% extract of wudani leaf (Quisqualis indica Linn) was able to kill gastrointestinal worms Strongylus Sp. (vermicidal effect). In order to make comparation with commercial drug commonly used, one group was treated with Rheindazol (100 ml of Rheindazol contain 10 gram of albendazol) at a single dose of 10 mg/kg of body weight (BW). The other 3 groups were subjected to a single treatment with 100% wudani leaf extract at 10 mg, 15 mg, and 20 mg/kg of BW, respectively. Assessment on its vermicidal effect was carried out by conducting fecal egg count reduction (FECR). The results showed that the vermicidal property of 100% wudani leaf extract given at 10mg/kg BW was 100% and this was significantly (P < 0.01) higher than that of dose of 15 kg/kg BW (92.4%), 20 mg/kg BW (96%) and even compared to that of albendazol treatment (96%). Thus, from the present in vivo study, it can be concluded that 100% wudani leaf extract due to its vermicidal property can be effectively used to cure gastrointestinal worm infection and, therefore, can be subsequently applied to overcome worm infection in cattle. Keywords: Gastrointestinal worm, Wudani leaf extract, Vermicidal property.
Co-Authors Anak Agung Gde Oka Dharmayuda Anak Agung Gde Oka Dharmayudha Anak Agung Sagung Kendran Gunawan, I Wayan Nico Fajar I B. Komang Ardan I Dewa Ketut Harya Putra I Gusti Ngurah Kade Mahardika I Gusti Ngurah Narendra Putra I Ketut Angga Yuda I Made Sukada I Nyoman Suartha I Wayan Wirata Ida Bagus Dimas Kusumadarma Ida Bagus Komang Ardana Kadek Karang Agustina Ketut Tono Pasek Gelgel Luh Dewi Anggreni Luh Made Sudimartini Ni Made Rita Krisna Dewi Ni Made Ritha Krisna Dewi Ni Wayan Linda Pertiwi Yesy Febnica Dewi Yoana Pratiwi Clara Pakpahan