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All Journal BALI MEDICAL JOURNAL (BMJ) E-Jurnal Medika Udayana E-Jurnal Udayana Medica Indonesian Journal of Urology Syntax Literate: Jurnal Ilmiah Indonesia JBN (Jurnal Bedah Nasional) ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Journal of Anesthesiology and Clinical Research Journal of Global Pharma Technology Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute E-Amal: Jurnal Pengabdian Kepada Masyarakat Folia Medica Indonesiana
Gede Wirya Kusuma Duarsa
Bagian Bedah Urologi Fakultas Kedokteran Universitas Udayana
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Comprehensive Histopathological Properties of Dartos Tissue Associated with Hypospadias Severity and Chordee: A Prospective Study Raharja, Putu Angga Risky; Birowo, Ponco; Rachmadi, Lisnawati; Wibowo, Heri; Kekalih, Aria; Duarsa, Gede Wirya Kusuma; Wahyudi, Irfan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.243

Abstract

Background: The cause of chordee in hypospadias is not fully understood. Dartos fascia resection has been shown to correct penile curvature, suggesting its potential involvement. This study aimed to evaluate the histopathological properties of dartos tissue and their association with hypospadias severity and chordee.Methods and Materials: Dartos tissue samples were collected from 37 children with hypospadias and ten controls undergoing circumcision between March and October 2024. Histopathological analysis using hematoxylin-eosin and Masson’s trichrome staining assessed for collagen, smooth muscle, and vascular density. Assessment and quantification of all histopathological components were blinded. Results: The hypospadias group showed lower collagen density (60.85±6.75% vs. 67.31±4.61%; p=0.003) and higher smooth muscle density (7.34±4.92% vs. 2.51±2.24%; p<0.001) compared to controls, with no significant difference in vessel density. Sub-analysis showed severe chordee was linked to lower collagen density compared to mild (Mean Difference [MD] -6.24±2.41%; p=0.014) and moderate chordee (MD -5.73±2.54%; p=0.031). Conclusions: The dartos tissue in hypospadias patients exhibited lower collagen density and higher smooth muscle density, with chordee severity specifically linked to decreased collagen density.
Co-Authors 'Azmy, Ahmad Farid Anak Agung Gde Oka Aria Kekalih Bharata, Made Bagus Sastrapramaya Bramastha A Rosadi, Bramastha A Cita Rosita Sigit Prakoeswa Citra Gading Dea Emmanuel Djodi Sidartha Donny Oktavius Gde Oka, A A Gede Andi Aditya Gede Hendra Wijaya Gede Wirata Gede Wirya Diptanala Putra Duarsa Gede Wirya Diptanala Putra Duarsa Gede Wirya Diptanala Putra Duarsa Gede Wirya Diptanala Putra Duarsa Gusti Ayu Putu Nilawati Heri Wibowo I Gde Raka Widiana I Gusti Ayu Irma Vitriani I Gusti Ayu Putri Purwanthi I Gusti Bagus Dharma Prakasa Musti I Ketut Wiargitha I Ketut Widiana I Made Nugraha Gunamanta Sabudi I Nengah Wiadi I Nyoman Semadi I Wayan Niryana I Wayan Yudiana I.G. Darma-Kusuma Ida Bagus Putra Manuaba Ida Bagus Putra Pramana Irfan Wahyudi Kadek Budi Santosa Ketut Putu Yasa Krishna, I Komang O. Lisnawati Rachmadi Marleen Nurhaen - Nyoman Golden Nyoman Khrisna Dharmawan Oka Udrayana Oka, AA Gde Oka, Anak A.G. Paksi Satyagraha Pande Made Wisnu Tirtayasa Pande Putu Yuli Anandasari Paulina Magdalena Ponco Birowo Pontisomaya Parami Pradiptha, I Nyoman Tri Pramana, Putu Bagus Gin Gin Prayudi, I Nyoman Gede Putra, Bismantara Aditya Putu Anda Tusta Adiputra Putu Astri Novianti Putu Kurnia Darma Pratama Putu Primeriana Nugiaswari Raharja, Putu Angga Risky Rika Lesmana, Rika S. F. Laura, S. F. Soetojo Soetojo Sri Maliawan Sugianto, Ronald Suryawisesa, Ida Bagus Made Teguh Dwi Nugroho, Teguh Dwi Tjokorda Gde Agung Senapathi Tjokorda Gde Bagus Mahadewa Udiyana, Nyoman Dwi Maha Wayan Sudana Yenny Kandarini