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All Journal HAYATI Journal of Biosciences Jurnal Sain Veteriner Buletin Peternakan Biologi Edukasi : Jurnal Ilmiah Pendidikan Biologi Jurnal Kedokteran Brawijaya Jurnal Biologi Tropis Jurnal Ilmu Alam dan Lingkungan JURNAL KAJIAN VETERINER BIOEDUPAT: Pattimura Journal of Biology and Learning Berkala Penelitian Hayati Biofaal Journal TROPICAL GENETICS Pakem : Jurnal Pengabdian Kepada Masyarakat Tropical Genetics BAKTI : Jurnal Pengabdian Kepada Masyarakat
Pieter Kakisina
Jurusan Biologi Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Pattimura, Ambon
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Journal : BIOEDUPAT: Pattimura Journal of Biology and Learning

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Decreasing SGPT level and macrophage activity through CD68 expression in the Balb/c mice (Mus musculus) liver infected with Salmonella typhi after treating with atung seeds (Parinarium glaberimmun Hassk) Eifan Boyke Pattiasina; Pieter Kakisina; Ferymon Mahulette
BIOEDUPAT: Pattimura Journal of Biology and Learning Vol 1 No 1 (2021): Bioedupat : Pattimura Journal of Biology and Learning
Publisher : Program Studi Pendidikan Biologi, Pascasarjana, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.827 KB) | DOI: 10.30598/bioedupat.v1.i1.pp17-23

Abstract

Normally macrophages are always in the body and spread in various body tissues such as liver tissue (Kupffer cells). Macrophages in tissue can be identified by the expression of several markers, in humans the marker is CD68. The increase and decrease in macrophage activity in the liver can also be indicated by an increase in SGPT levels so that atung seeds have the ability to inhibit the growth of S. tyhpi bacteria which contain tannin compounds which can damage microbial cell walls and form bonds with microbial functional proteins so that bacterial growth is inhibited. The purpose of this study was to determine the SGPT levels and macrophage activity. The method used is laboratory experiment. The results showed an increase in SGPT levels in the positive control (87.00 ± 2,915) and a concentration of 25% (84.20 ± 3,962) and a decrease in SGPT levels in the negative control (50.80 ± 2.168 *), 50% concentration (78.20 ± 3.114 *) and concentrations. 75% (58.20 ± 3,834), decreased macrophage activity in the liver also occurred at a concentration of 50% and at a concentration of 75%, the liver was normal, which was indicated by the resulting brown expression
Co-Authors Abdu Mahid Ukratalo Adrien Jems Akiles Unitly Amos Killay Bambang Poernomo Chomsa Ditasari Umi Baszary Baszary Eifan Boyke Pattiasina Ferymon Mahulette Fredrik Manuhutu, Fredrik Hasan Tuaputty Healthy Kainama Lakoan, Milda Rianty Linda Linda Mainassy, Meilissa C Maman Rumanta Mardi Santoso Marlyn Wattimena Martha Kaihena Marthinus Usmany Marthinus Usmany Meigy N Mailoa Moniharapon, Mechiavel Pagaya, Joseph Picarima, Reynita Rasyad Indra Rony Kunda Rony Marsyal Kunda Sahertian, Dece Elisabeth Salamor, Reinhard Seumahu, Cecelia Anna Slamet Diah Volkandari Sri Fatmawati Taslim Ersam Tuhumuri, Evelin Ukratalo, Abdul M Win Darmanto