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Achmad Fauzi Kamal
Departmen Orthopaedi Dan Traumatologi Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo/Fakultas Kedokteran Universitas Indonesia,Jakarta
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Journal : Medical Journal of Indonesia

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Adipose-derived mesenchymal stem cells enhance regeneration in a chronic peripheral sciatic nerve injury Sprague-Dawley rat model Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257780

Abstract

BACKGROUND Obtaining optimal functional outcomes in patients with chronic peripheral nerve injuries (PNIs) remains challenging due to the limited regeneration of the neuromuscular junction (NMJ). Adipose-derived mesenchymal stem cells (AD-MSCs) can differentiate into Schwann-like cells, secrete neurotrophic factors, and recruit native Schwann cells. This study aimed to analyze the effects of AD-MSCs on functional outcomes in a chronic PNI model. METHODS An in vivo study was performed using 20 male Sprague-Dawley rats with chronic PNI of the right sciatic nerve. Rats were divided into two groups: the AD-MSC group (n = 10), receiving human AD-MSC injections in the NMJ; and the control group (n = 10), receiving normal saline injections. Walking track analysis and electrophysiological assessments were performed 8 weeks after the nerve repair. Postmortem gastrocnemius muscle weights and immunohistochemical examinations were also performed. RESULTS The AD-MSCs showed significantly larger fiber diameters than the control group (45.54 [13.1] versus 35.46 [6.64]; p = 0.011). While clinical, electrophysiological, and gastrocnemius muscle weight data suggested a trend toward improved outcomes in the AD-MSCs group, the differences were not statistically significant. CONCLUSIONS AD-MSC implantation may enhance nerve regeneration, as demonstrated by a better outcome profile in the AD-MSCs group.
Co-Authors Akbar Nur Antarianto, Radiana Dhewayani Aprilya, Dina APRIZAL, RIZA Aria Kekalih Besral . Canintika, Anissa Feby Dahlia, Debie - Eka Wiratnaya Elfrida Ratnawati Errol Untung Hutagalung Evelina Kodrat Evelina Kodrat Fitri Octaviana HENDRA MASKA, HENDRA Heri Suroto Heru Widyawarman, Heru Idia Indar Anggraeni Ismail Hadisoebroto Dilogo Jessica Fiolin Kurniadi Husodo, Kurniadi Ludwig Andre Pontoh Masfuri - Nurjati Chairani Siregar Priyanto Priyanto Priyanto Puspita Eka Wuyung Rino Pattiata RINO PATTIATA RIZA APRIZAL Saptawati Bardosono Setyowati Sholahuddin Rhatomy THARIQAH SALAMAH, THARIQAH Trevino Aristarkus Pakasi Wahyu Widodo Wahyu Widodo Wulyo Rajabto YOGI PRABOWO Yogi Prabowo YOSHI PRATAMA DJAJA, YOSHI PRATAMA