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Diana Holidah
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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GREEN TEA EXTRACT EFFECT ON BLOOD GLUCOSE LEVEL AND LIVER HISTOPATHOLOGY IN DIABETIC MICE Diana Holidah; Fransiska Maria Christianty; Wilda Zidni Ilma
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Diabetes mellitus is a disorder of hyperglycemia andglucose intolerance due to insulin deficiency,impaired of insulin receptor or both (Unwin et al.,2009). There are generally two types of diabetes aretype 1 diabetes (pancreatic beta cell damage causedabsolute insulin deficiency) and type 2 (acombination of a lack of insulin production andsecretion and sensitivity to insulin receptor) (Dipiroet al, 2008).Diabetes mellitus disease is increasing rapidly inworlwide. The incidences in 2010 were about 285million people and It has been estimated that by theyear 2025, the global incidence of diabetes wouldincrease to 350 million (International diabetesfederation, 2006).In diabetes, activation of hepatic gluconeogenesisenzymes can increase glucose production and thuscontribute to increase blood glucose which coulddeteriorate diabetes (Sundaram et al., 2013). Thestate of diabetes characterized by decreased insulinsensitivity is the major cause of NAFLD (Non -Alcoholic Fatty Liver Disease), because in diabetesstate occurs disorders of glucose metabolism and fatso that could result in fibrosis, infiltration,necroinflamation, to acute liver disease (Marchesiniet al., 2001).Treatment of diabetes mellitus is chronic and longlife, causing undesirable side effects (Unwin et al.,2009). Metformin is an oral hypoglycemic agent,which belongs to the class known as the biguanides.Metformin is now widely used as one of themainstays in the management of type 2 diabetes.Metformin reduces fasting plasma glucoseconcentration by reducing rate of hepatic glucoseproduction via gluconeogenesis and glycogenolysis.Metformin improves glycemic control asmonotherapy and in combination with other oralantidiabetic agents, such as sulfonylureas andthiazolidinediones (Frendell et al. 2003).Several plant extracts are known to have antidiabeticproperties and a large number of compounds fromplant extracts have been reported to have beneficialeffects for treatment of diabetes mellitus (Anhauser,2003). Tea (Camellia sinensis L.) is one of plant thatcan decrease blood glucose. Green tea is producedby enzymatic inactivation of the leaves of Camelliasinensis followed by rolling or comminution anddrying. In the manufacturer of green tea, theenzymatic inactivation achieved by steam or panfiring treatment to preserve natural polyphenolswith respect to the health promoting properties.Green tea derived products are mainly extracts ofgreen tea in liquid or powder form varying in theproportion of polyphenols (45-90%) and caffeinecontent (0.4-10%). The polyphenolic fraction ofgreen tea, has been reported to have multiplepharmacological actions (Sano et al., 1995).Green tea is an excellent source of polyphenolantioxidants, known as green tea catechins. Theimportant catechins of green tea are epicatechin(EC), epicatechin-3-gallate (ECG), epigallocatechin(EGC) and epigallocatechin-3-gallate (EGCG). Thepolyphenolic fractions of green tea have beenreported to have multiple pharmacological actions.They exhibit potent antioxidant activity in vitro andin vivo. Epidemiologic observation and laboratorystudies have indicated that polyphenolic compoundspresent in the tea may reduce the risk of a variety ofillnesses, including cancer and coronary heartdisease (McKay and Blumberg 2002).Some studies suggest that green tea extract loweredcholesterol levels and blood glucose on mice and rat(Yang et al., 2001). Green tea extract at dose of300mg /kg /day can lower blood glucose in diabeticrats and was also able to reduce the lipids in heartdefects (Babu et al., 2006). Blood glucose loweringactivity of green tea was greater and totalpolyphenol content was higher when compared withblack tea and oolong tea (Holidah et al., 2015).
Profil Lipid dan Gambaran Histopatologi Aorta Tikus Hiperlipidemia dengan Pemberian EKSTRAK Kopi Hijau Fransiska Maria Christianty; Diana Holidah; Fifteen Aprila Fajrin; Monica Cinuradha Aura Salsabina; Andrean Roni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.056 KB) | DOI: 10.35814/jifi.v18i1.718

Abstract

The high prevalence and risk of death from cardiovascular disease has led to the development of alternative treatments derived from nature. Green coffee has not undergone a roasting process. The product is claimed as a weight loser, even though the cardiovascular effects are still controversial. This study aim was to determine the impact of green coffee bean extract on rat lipid profiles and aortic histopathology. Green coffee bean extract made by a re-maceration method using 96% ethanol. Rats were induced with high-fat diet then treated with green coffee bean extract at a dose of 200; 400; and 800 mg/kg BB. Rats were sacrificed, blood was taken for lipid profile measurements and observations were made on histopathological preparations of rat aorta. The results showed that administration of green coffee bean extract (especially doses of 200 mg/kg BW) for 14 days in hyperlipidemic mice could significantly improve lipid profiles, except HDL levels. Microscopic observations showed that green coffee bean extract could enhance the rat aorta histopathology even though it did not match normal conditions. We can conclude that green coffee bean extract has potential effects to be developed as an alternative to traditional medicine that has antihyperlipidemic effects and cardiovascular protective effects.
POTENSI BIJI SAGA (Abrus precatorius) SEBAGAI KONTRASEPSI PRIA Siti Muslichah; Wiratmo Wiratmo; Diana Holidah; Fifteen Aprilia Fajrin
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 11 No. 02 Desember 2014
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v11i2.836

Abstract

ABSTRAK Saga (Abrus precatorius) merupakan salah satu tanaman yang dikenal mempunyai banyak aktivitas farmakologi. Biji saga digunakan oleh pengobat tradisional Ayurveda sebagai bahan kontrasepsi oral. Tujuan dari penelitian ini adalah untuk mengetahui potensi fraksi biji n-heksana, fraksi kloroform, dan fraksi biji saga sebagai bahan kontrasepsi pria. Fraksi-fraksi tersebut diberikan secara oral dengan dosis masing-masing 75 mg/kg bb selama 20 hari. Sebanyak 20 ekor tikus jantan dengan berat badan 200-250 g berumur 2-2,5 bulan dikelompokkan menggunakan Rancangan Acak Lengkap. Hasil penelitian menunjukkan terjadinya penurunan jumlah, motilitas, viabilitas serta peningkatan abnormalitas spermatozoa yang signifikan dibandingkan kontrol. Hasil tersebut menunjukkan bahwa ekstrak biji saga mempunyai efek terhadap reproduksi pria yang menunjukkan potensi tanaman ini sebagai pengatur kesuburan pria. Kata kunci: biji saga, kontrasepsi pria, kualitas sperma, jumlah sperma. ABSTRACT Saga (A. precatorius) is a medicinal plant having various pharmacological activities. A. precatorius seed was used by Ayurvedic practitioners as an oral contraceptive. The present study was aimed to evaluate the contraceptive potentials of hexane, chloroform and methanolic fractions of precatory seed as male contraceptive. The organic fractions were administered orally with the dose of 75 mg/kg body weight for 20 days. Twenty five male rats weight 200-250 g of 2-2.5 month old are grouped using Complete Random Design. A significant decline in sperm count and viability, total inhibition of sperm motility, and increased numbers of sperm abnormalities were observed after 20 days of treatment. The result showed that A. precatorius seed extract affected male reproduction, suggesting the potential role of this plant in the regulation of male fertility. Key words: Abrus precatorius, male contraceptive, sperm quality, sperm count.
SKINCARE LEARNING YOUTH EDUCATION PROGRAM FOR KNOWLEDGE IMPROVEMENT AT SMA NEGERI 1 SUBOH SITUBONDO Ika Puspita Dewi; Diana Holidah; Mochammad Amrun Hidayat
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Teenagers' lack of knowledge of cosmetics causes the risk of using dangerous or illegal products. Students at SMA Negeri 1 Suboh Situbondo have never received special material regarding the selection and use of beauty products. The outcome of this educational program is to increase the knowledge of SMA Negeri 1 Suboh students about how to use and choose the right and safe skincare. This program is carried out by offline method at SMA Negeri 1 Suboh Situbondo and online method with the Zoom Meeting. The materials given to students are various teenage skin problems, introduction to skincare ingredients, and choosing the right skincare. The results of the survey related to the skin characteristics of the participants showed that most of the skin types owned by students of SMA Negeri 1 Suboh were oily (38.09%), with most of them having skin problems (79.37%), and the majority problem was acne (42.68%), while 79.37% of participants had used skincare. The results of the post-test showed that the average score of the participants was 88.57, which indicates most of the participants had understood the materials given. This program has succeeded in providing information about the correct, appropriate, and safe use of skincare to the students of SMA Negeri 1 Suboh Situbondo. Keywords: knowledge, skincare, SMA Negeri 1 Suboh Situbondo, teenager
SOSIALISASI TANAMAN BERKHASIAT SEBAGAI PELANCAR ASI (AIR SUSU IBU) DI KECAMATAN ARJASA SITUBONDO Diana Lady Yunita Handoyo; Sri Nur Atiqah; Nur Diana Kholidah; Mutmainnatus Solihah
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 2: Juli 2022
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v2i2.2642

Abstract

The use of efficacious plants as breast milk has been known for a long time by the people of Arjasa District Situbondo Regency The use of these plants has been used for a long time and passed down from generation to generation. However, with the passage of time, public knowledge related to the efficacy of plants as breast milk carriers has begun to become scarce and is only known by a certain group of people. The purpose of this community service activity (PKM) is to socialize to the community about plants that can be used as breast milk carriers based on the results of previous ethnobotany studies. PKM activities carried out in the form of socialization to breastfeeding mothers and productive mothers as many as 20 people. The results of the PKM stated that 100% of the socialization participants stated that this activity was very beneficial to the participants, especially in terms of knowledge about the use of herbal plants as breast milk promoters
Pola Peresepan Obat pada Pasien Diare Anak di Instalasi Rawat Inap RSUD dr. Abdoer Rahem-Situbondo Ninda Titis Ainorrochma; Ema Rachmawati; Diana Holidah
Pustaka Kesehatan Vol 11 No 1 (2023): Volume 11 No.1, 2023
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v11i1.16608

Abstract

Diarrhea is defined clinically as increased bowel movements more than three times a day, accompanied by changes in stool consistency (becoming liquid) with or without blood within 24 hours. This disease often occurs in patients aged under five to children - children, usually lasts for several days, so that the body can lose important fluids such as water and salt needed for survival. Most patients die from diarrhea due to severe dehydration and fluid loss. This research was conducted to determine the pattern of drug prescription in pediatric diarrhea patients which includes the types and classes of drugs and how to administer the drug. The research method used was purposive sampling and using a retrospective descriptive approach. The sample of this study was diarrhea patients for children aged 0 months to 1 year who received treatment at the inpatient installation at RSUD dr. Abdoer Rahem Situbondo from January to December 2019. The treatment of diarrhea treatment included rehydration, antidiarrheal, antimicrobial, analgesic-antipyretic and other drug classes such as antacids, anticonvulsants and mucolytics. From 108 samples of pediatric diarrhea patients found 82 patients (75.96%) used antimicrobial drugs.
THE EFFECT OF SUGARCANE LEAF EXTRACT ON MALONDIALDEHYDE PLASMA LEVELS IN CARBON TETRACHLORIDE-INDUCED RATS Dewi, Ika Puspita; Ulinnuha, Jihan Ulya; Holidah, Diana
Jurnal FARMASIMED (JFM) Vol 5 No 1 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i1.1340

Abstract

Peroksidasi lipid akibat radikal bebas dapat menyebabkan kematian sel yang dapat merusak berbagai organ, termasuk liver. Hal ini dapat ditandai dengan peningkatan kadar malondialdehid. Pengukuran parameter ini pada darah dan organ digunakan sebagai penanda adanya stres oksidatif. Radikal bebas akibat peroksidasi lipid dapat diredam dengan senyawa antioksidan. Beberapa penelitian telah membuktikan aktivitas antioksidan tebu (Saccharum officinarum). Daun tebu dan jus tebu dari varietas yang berbeda-beda telah menunjukkan sifat antioksidan yang baik. Penelitian ini dilakukan untuk mengetahui efek ekstrak etanol tebu dengan berbagai dosis terhadap kadar malondialdehid plasma tikus yang diinduksi stress oksidatif dengan karbon tetraklorida (CCl4). Daun tebu diekstraksi dengan maserasi dengan pelarut etanol 96%. Pembuatan kurva baku malondialdehid dilakukan dengan seri larutan 1,1,2,2-tetraethoxypropane. Pengujian dilakukan terhadap hewan uji tikus Wistar yang dibagi menjadi beberapa kelompok. Pembagian kelompok meliputi kelompok normal tanpa induksi CCl4 diberikan CMC-Na 1%; kontrol negatif diberikan CMC-Na 1%; kontrol positif diberikan Silybum marinum yang 100 mg/kgBB; kelompok dosis yang terdiri atas 300, 400, dan 500 yang masing-masing diberikan ekstrak etanol daun tebu dosis dengan dosis 300 mg/kgBB, 400 mg/kgBB dan 500 mg/kgBB berturut-turut. Tikus diperlakukan sepanjang 14 hari lalu diambil sampel plasmanya pada hari ke-15 untuk pengukuran kadar malondialdehid. Hasil ekstraksi daun tebu mendapatkan rendemen sebesar 16,05%. Kurva baku yang digunakan untuk mengukur malondialdehid plasma tikus adalah y = 0,0059x + 0,0238. Hasil menunjukkan pemberian ekstrak daun tebu semua dosis memiliki nilai malondialdehid yang lebih rendah dibandingkan kontrol negatif. Dosis 400 mg/kgBB tidak memiliki perbedaan signifikan dengan kontrol positif, sedangkan dosis 500 mg/kgBB lebih rendah dibanding dengan kontrol positif. Hal ini diduga karena metabolit sekunder seperti flavon yang terdapat pada ekstrak yang dapat meredam radikal bebas. Ekstrak etanol daun tebu dapat berperan sebagai antioksidan dengan menurunkan kadar malondialdehid darah tikus terinduksi CCl4.
Drug Interaction Study in Type 2 Diabetes Mellitus with Hypertension Patients at X Hospital, Jember Regency Afifah, Hanin; Dewi, Ika Puspita; RACHMAWATI, Ema; HOLIDAH, DIANA; NORCAHYANTI, IKA
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.2051

Abstract

Diabetes melitus dan hipertensi merupakan penyakit yang saling berkaitan dan mempengaruhi satu sama lainnya. Hipertensi berkontribusi terhadap perkembangan dan perkembangan komplikasi mikrovaskular dan makrovaskular pada diabetes. Pasien diabetes melitus tipe 2 dengan komplikasi hipertensi dapat memperoleh banyak obat (polifarmasi). Hal ini berisiko menimbulkan Drug Related Problem, salah satunya interaksi obat. Adanya interaksi obat dapat menyebabkan kegagalan terapi. Tujuan penelitian ini adalah untuk menganalisis risiko terjadinya interaksi obat pada pasien DM tipe 2 dengan komplikasi hipertensi. Metode penelitian menggunakan deskriptif non eksperimental secara retrospektif. Pengambilan data dilakukan dengan menggunakan rekam medis pasien rawat inap rumah sakit X di Jember. Sebanyak 32 pasien memenuhi kriteria inklusi selama durasi satu tahun data pengobatan. Hasil penelitian menunjukkan pasien paling banyak adalah pasien wanita dengan rentang usia 45 – 54 tahun dan 55 – 64 tahun dan penyakit penyerta paling banyak adalah peptic ulcer. Pengobatan diabetes paling banyak menggunakan terapi tunggal insulin short-acting, sedangkan terapi hipertensi menggunakan kombinasi candesartan dan amlodipin. Analisis potensi interaksi obat antara antidiabetes dan antihipertensi menunjukkan interaksi obat terjadi pada 17 pasien dengan kejadian tertinggi yaitu interaksi insulin short-acting dengan candesartan sebanyak sembilan kasus dengan tingkat interaksi mayoritas moderat.
Aliskiren, Obat Antihipertensi Baru dengan Mekanisme Penghambat Renin Diana Holidah
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 3 (2011): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i3.34

Abstract

Hypertension is a chronic disease with a prevalence reaching 1 billion people around the world. Hypertension is the major treatable risk factor for cardiovascular disease, which remains the leading cause of death in the industrialized world. Despite the risks associated with the condition, the majority of patients with hypertension across the world do not have their blood pressure (BP) controlled to recommended target levels. RAAS is a main target, although, in total inhibition of RAAS can not be obtained with ACEI and ARB class of drugs because of the feedback mechanism. As a solution, we could inhibit the early stages of the mechanism, that is renin. Previous studies have indicated that the renin inhibitor class of drugs effective as antihypertensive and well tolerated, both as monotherapy and in combination with other drugs. Based on researched to aliskiren and the success of antihypertensive drug class of ACEI and ARB in reducing morbidity and mortality in patients with hypertension, it is rational if the expected drug classes like renin inhibitor aliskiren would provide the same benefits. Whether the benefits are equal, larger or even smaller than another RAAS inhibitor, we needed long research to find supporting data. Key word: Aliskiren, hypertension, renin ABSTRAK Hipertensi merupakan salah satu penyakit kronis dengan prevalensi mencapai 1 milyar jiwa di seluruh dunia. Hipertensi yang menginduksi penyakit kardiovaskular merupakan penyebab utama kematian di dunia. Pengaturan tekanan darah hingga optimal masih sulit untuk dicapai di semua Negara. RAAS merupakan target utama, walaupun begitu, penghambatan RAAS secara total tidak dapat diperoleh dengan penggunaan obat golongan ACEI dan ARB karena adanya mekanisme umpan balik. Sebagai solusinya, dapat dilakukan penghambatan pada tahap awal dari mekanisme tersebut yaitu pada renin. Penelitian sebelumnya sudah mengindikasikan bahwa obat golongan renin inhibitor efektif sebagai antihipertensi dan dapat ditoleransi dengan baik, baik sebagai monoterapi maupun dikombinasi dengan obat lain. Berdasarkan penelitian yang sudah dilakukan terhadap aliskiren serta keberhasilan obat antihipertensi golongan ACEI dan ARB dalam menurunkan angka morbiditas dan mortalitas pada penderita hipertensi, maka sangat rasional jika diharapkan obat golongan renin inhibitor seperti aliskiren akan memberikan manfaat yang sama. Apakah manfaat tersebut sama, lebih besar atau justru lebih kecil daripada yang ditunjukkan oleh inhibitor RAAS yang lain, maka diperlukan penelitian lain yang panjang untuk mencari data pendukung. Kata kunci: Aliskiren, hipertensi, rennin
Hepatoprotective Effect of Caesalpinia sappan L. Ethanolic Extract on Alloxan Induced Diabetic Rats: Efek Hepatoprotektif Ekstrak Etanol Caesalpinia sappan L pada Tikus Diabetes Terinduksi Aloksan Holidah, Diana; Dewi, Ika Puspita; Siregar, Iskandar P. A.; Aftiningsih, Dwi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 1 (2022): (March 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i1.15601

Abstract

Background: The complications of Diabetes Mellitus (DM) may lead to other health problems such as heart attack, stroke, kidney failure, leg amputation, vision loss, nerve and liver damage. Increasing free radicals in the hyperglycemic condition in DM can induce inflammation and necrosis that lead to liver damage. This damage causes elevated hepatic enzymes such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Malondialdehyde (MDA) is a biomarker that is often used to evaluate oxidative stress including in vivo experimental models of diabetes. Caesalpinia sappan L. is one of the well-known herbs which has a strong antioxidant effect and has various pharmacology activities, including antidiabetic and hepatoprotective. Objectives: This study is aimed to investigate the effect of Caesalpinia sappan L. ethanolic extract on liver function and antioxidant status in diabetic rats. Material and Methods: Twenty-four diabetic male rats were divided into six groups consisting of the normal control group, negative control, positive control, and Caesalpinia sappan L. extract treatment group at a dose of 50, 100, and 400 mg/kg BW. The diabetic status was induced by alloxan. The animals were given treatment for 14 days, and on the 15th day, their blood and liver were collected to measure the level of AST, ALT, plasma MDA, and liver MDA. Results: The extracts of Caesalpinia sappan L. can decrease the levels of AST and ALP and show a low number of MDA levels both in plasma and liver on diabetic rats induced by alloxan. The dose of 100 mg/kg BW has the best result for lowering AST and ALT levels; meanwhile, the dose of 400 mg/kg BW shows the least value of MDA among all the doses. Conclusions: The Caesalpinia sappan L. ethanolic extract has potential activity as the hepatoprotective and antioxidant in diabetic status.
Co-Authors Afifah, Hanin Aftiningsih, Dwi Andrean Roni Antonius Nugraha Widhi Pratama Arizka, Hawwin Elina Ayik Rosita Puspaningtyas1 Brahmansyah Diar Rosiarto Christianty, Fransiska Diana Lady Yunita Handoyo Ema Rachmawati Endah Puspitasari Evi Umayah Ulfa Fifteen Aprila Fajrin Fifteen Aprila Fajrin Fifteen Aprilia Fajrin Fifteen Aprilia Fajrin, Fifteen Aprilia Firandi, Adelia Fransiska Maria Christianty Gati Dwi Sulistyaningrum Ika Norcahyanti Ika Puspita Dewi Ika Puspita Dewi, Ika Puspita Junaidi Khotib Kusumaningrum , Yunita Dyah Lesti Eko Pangestuti Lestyo Wulandari M Nuril Huda Mochammad Amrun Hidayat Monica Cinuradha Aura Salsabina Mutmainnatus Solihah Nia Kristiningrum Ninda Titis Ainorrochma Putri Aditama, Tiara Sagita Sendika Widi Saputri Shinta Cholifatu Rohma Siregar, Iskandar P. A. Siti Muslichah Sri Nur Atiqah Tanfidz Alishlah, Tanfidz Ulinnuha, Jihan Ulya Wilda Zidni Ilma Wiratmo Wiratmo Wiratmo Wiratmo Yasmin Yasmin Yasmin Yasmin