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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) e-Journal Pustaka Kesehatan The Journal of Pure and Applied Chemistry Research STOMATOGNATIC- Jurnal Kedokteran Gigi Al-Kimia BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Nasional (JPN) Indonesia Borneo Journal of Pharmacy Journal of Agropharmacy
Dian Agung Pangaribowo
Fakultas Farmasi Universitas Jember
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Journal : e-Journal Pustaka Kesehatan

 1 
Label Pintar untuk Pemonitoran Kesegaran Daging Ayam pada Kemasan Novialda Nitiyacassari; Bambang Kuswandi; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 9 No 2 (2021): Volume 9 No.2, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i2.10974

Abstract

Chicken meat is one of the commodities consumed by most Indonesian people and has a pH range of 5,5 – 6,0. The smart label has been applied as a chicken meat freshness detector. As dual indicator freshness, two pH indicators have been used, i.e., bromothymol blue (BTB) and methyl red (MR). The objective of this research was to determine chicken meat freshness using a smart label at room temperature. The color change of the smart label was examined by ImageJ software to determine freshness degree using the mean RGB value. The chicken meat was examined every 2 hours for pH and TVB analysis during the 24 hours storage at room temperature. The result showed that color indicator would change according to chicken meat freshness, BTB turned from yellow to blue (mean RGB 210,591 ± 0,376), and MR turned from red to yellow (mean RGB 208,146 ± 0,390). Chicken meat freshness at room temperature decreased as pH increase from 5,68 to 6,11 along with a color change of smart label. Furthermore, the color would change when 0.022 %N of TVB has been reached. Therefore, chicken meat freshness can be determined by using a smart label based on a dual indicator of bromothymol blue and methyl red at room temperature.
Uji Sitotoksisitas dan Proliferasi Senyawa 1-(4- Trifluorometilbenzoiloksimetil)-5-Fluorourasil terhadap Sel Kanker Payudara MCF-7 (Cytotoxicity and Proliferation Assay of 1-(4- Trifluoromethylbenzoyloxymethyl)-5-Fluorouracil) On MCF-7 Breast Cancer Cell Puspita Arum Wijayanti; Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil (TFU) is a derivative compound of anticancer agent, 5-fluorouracil (5-FU). TFU has been synthesized by Ernawati to increase the anticancer activity of 5-FU. However, the cytotoxic and antiproliferative effect of TFU had not been carried out. This study aimed to evaluate the cytotoxic and antiproliferative activity of TFU compared to 5-FU on MCF-7 breast cancer cell line using MTT method. The citotoxicity study was done for 24 hours. The antiproliferative study was done for 24, 48, and 72 hours. The cytotoxic effect was determined based on IC50 value while the antiproliferative effect was determine based on the doubling time value. The results showed that TFU had better cytotoxicity on MCF-7 with IC50 value 401.03 ± 0.370 µM compared to 5-FU with IC50 value 4216.32 ± 800.28 µM. The doubling time value of TFU at concentration of ½ IC50, IC50, and 1½ IC50 were 359.66; 364.39; and 448.40 hours respectively, while 5-FU were 184.45; 214.00; and 220.63 hours. The doubling time value indicated that TFU compound was able to prolong the doubling time of MCF-7 cell line compared to 5-FU. Keywords: cancer, cytotoxicity, proliferation,1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil, MCF-7
Sintesis dan Uji Aktivitas Antibakteri Senyawa N-Fenil-3,4-Diklorobenzamida (Synthesis and Antibacterial Activity Assay of N-Phenyl-3,4-Dichlorobenzamide) Vinastika Gita Yualanda; Indah Purnama Sary; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6610

Abstract

In this research, the synthesis of N-phenyl-3,4-diklorobenzamida was carried out by reacting 1,3-diphenylthiourea and 3,4-dichlorobenzoil chloride via bimolecular nucleophilic substitution reaction (SN2). The assays for the obtained compound product were purity test (tested by TLC and melting point tester), chemical and physical characterization (shape, color, and solubility), confirmation of the compound and structure (performed by UV-Vis spectrophotometer, FTIR spectrometer, 1H-NMR and 13C-NMR). The result showed that the compound was synthesized successfully with a yield of 42%, then the in vitro test of antibacterial activity against Staphylococcus aureus ATCC 6538 and Pseudomonas aeruginosa ATCC 27853 was conducted by well diffusion method. The compound N-phenyl-3,4-dichlorobenzamida did not have antibacterial activity which showed by the absence of inhibition diameter. Keywords: 1,3-diphenylthiourea, N-phenyl-3,4-dichlorobenzamide, nucleophilic substitution, antibacterial
Uji Sitotoksisitas dan Proliferasi Senyawa 1-(4-nitrobenzoiloksi- metil)-5-fluorourasil terhadap Sel Kanker Payudara MCF-7 (Cytotoxicity and Proliferation Studies of 1-(4-nitrobenzoyloxy- methyl)-5-fluorouracil) on Breast Cancer Cells MCF-7) Eka Mustika Wati; Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

1-(4-nitrobenzoyloxymethyl)-5-fluorouracil (4-NFU) is a derivative of anticancer drug 5-fluorouracil (5-FU) which has been substituted by alkyl, ester, benzene, and nitro groups at N1 position. 4-NFU has been synthesized by Kurnia but anticancer study has not been reported. This research aims to compare the cytotoxicity and antiproliferative activity between 4-NFU and 5-FU on MCF-7 cells. The cytotoxicity and antiproliferative activity were studied by MTT method. The cytotoxicity study was done for 24 hours. The antiproliferative study was done for 24, 48, and 72 hours. The result showed that cytotoxicity activity of 4-NFU (IC50 = 134.039 μM) was higher than 5-FU (IC50 = 4211.508 μM) on MCF-7 cells. Based on the unpaired t test, there was a significant difference between IC50 of 4-NFU and 5-FU (α<0.05). The antiproliferative study showed that there was a growth inhibition on MCF-7 cells. The doubling time value of 4-NFU was 290.51 hours at ½ IC50; 350.97 hours at IC50; and 418.2 hours at 1½ IC50. The doubling time value of 5-FU was 185.99 hours at ½ IC50; 214 hours at IC50; and 220.63 hours at 1½ IC50. The doubling time value of 4-NFU was higher than 5-FU so that antiproliferative activity of 4-NFU was higher than 5-FU on MCF-7 cells. Keywords: 1-(4-nitrobenzoyloxymethyl)-5-fluorouracil, cytotoxicity, proliferation, MCF-7
Optimasi Sintesis Asam 3-benzamido-4-metil benzoat (Optimization Synthesis 3-benzamido-4-Methyl Benzoic Acid) Muh Agus Mauluddin; Dian Agung Pangaribowo; Indah Purnama Sa\
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5888

Abstract

Benzoic acid derivative has been developed as new drugs that have antioxidant, antifungal, analgesic, anti-cancer, anti-inflammatory, and anti-herpes simplex virus activity. In this study, a new compound of benzoic acid derivative, 3-benzamido-4-methyl benzoic acid (3-BM) was synthesized by reacting 3-amino-4-methyl benzoic acid with benzoyl chloride. This study used benzoylation reaction with Schotten-Baumann method. Temperature, time, and TLC mobile phase were needed to be optimized to make optimum condition, so the synthetis reaction can be done. The reaction time was 24 hours, the samples were taken at 1,2,3,4,5,6,12,24 hours then spotted on TLC plates and eluated with optimum eluent chloroform: ethyl acetate: acetic acid (100:5:1). 3-BM compound can be synthesized by benzoylation reaction with optimum synthesis condition at room temperature 25-27 °C and 2 hours reaction time. Keywords: synthesis, benzoic acid derivative, 3-benzamido-4-methyl benzoic acid, benzoyl chloride
Co-Authors Al Yazid, Moch. Khofi Ari Satia Nugraha Aulia, Donabella Shefa Ayik Rosita Puspaningtyas1 Azzahra, Bazlina Ashi Azzahro, Elok Zakiya Bambang Kuswandi Dewi, Tyas Cahya Dwi Koko Pratoko Dyanshah, Danny Agus Eka Mustika Wati Esti, Putri Annora Fathunnisa, Fathunnisa Fifteen Aprila Fajrin Firdausy, Camelia Puspita Gutomo, Rafa Bagus Himmah, Anisatul Indah Purnama Sary Indah Purnama Sary, Indah Purnama Indah Purnama Sa\ Jamila, Nur Lailatul Lestyo Wulandari Mohammad Ainul Yaqin, Mohammad Ainul Muh Agus Mauluddin Nabilah, Arfan Nafisa, Lia Wardatun Nayla, Maulidya Putri Nia Kristiningrum Novialda Nitiyacassari Nurud Diniyah Nurwijayanti Pasaribu, Cheryl Areta Prayoga , Neisya Azka Putri Puspita Arum Wijayanti Putra, Dimas Arifiansyah Putri, Rinad Alamanda Sallama, Solihatus Sepdianto, Bagas Nur Syaifullah, Abim Tyascahyani, Callysta Vindi Utomo, Wahyu Priyo Vinastika Gita Yualanda Wardhani, Firdha Aprillia Wijayanti, Pamelia Agnes Yuni Retnaningtyas