Articles
<![CDATA[The Effectivenes of Red Rice to Decrease Total Cholesterol in Type 2 DM Patients ]]>
<![CDATA[Wydi Ulfa Pradini]]>;
<![CDATA[Ancah Caesarina Novi Marchianti]]>;
<![CDATA[Rini Riyanti]]>
<![CDATA[ Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017) ]]>
Publisher : <![CDATA[Faculty of Medicine, University of Jember ]]>
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DOI: 10.19184/ams.v3i1.4091
<![CDATA[Diabetes mellitus (DM) is a group of metabolic diseases with hyperglycemia characteristic that happens because anomaly of insulin secretion or insulin activity. Insulin deficiency in type 2 DM caused dislipidemia. Red rice are contain fiber, essential fatty acid and Gamma Amino Butiric Acid (GABA). This research intended to know the effectiveness of red rice to decrease total cholesterol levels of patient with type 2 DM. Clinical test with quasi experimental and research design non randomized control-group pretest-postest design was used for the research method. Total samples of this research are 36 samples. The treated group was given the red rice during 6 days on breakfast and dinner, while the control group did not have any intervention. The research showed that average cholesterol levels in the beginning and finale of treated group was 235,69 mg/dL and 198,56 mg/dL, while average cholesterol levels in the beginning and finale of control group was 235,72 mg/dL and 256,50 mg/dL. From this research, red rice has effective to decrease total cholesterol levels of patients with type 2 DM.Keywords: Diabetes mellitus, Red Rice, Cholesterol total levels]]>
<![CDATA[The Correlation between Knowledge Level and Personal Hygiene with Scabies Occurrence in Miftahul Ulum Islamic Boarding Schools Jember Regency ]]>
<![CDATA[Anthia Ayu Nandira]]>;
<![CDATA[Yunita Armiyanti]]>;
<![CDATA[Rini Riyanti]]>
<![CDATA[ Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021) ]]>
Publisher : <![CDATA[Faculty of Medicine, University of Jember ]]>
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DOI: 10.19184/ams.v7i1.19151
<![CDATA[Scabies is caused by infestation and sensitization of Sarcoptes scabiei hominis varieties. Scabies is easily transmitted to individuals who live in groups such as boarding schools. Knowledge of scabies that is lacking and low in individual hygiene among student causes a transmission to be faster and wider. The purpose of this study was to determine the relationship between the characteristics, level of knowledge and individual hygiene of the student with the occurrence of scabies at the Miftahul Ulum Islamic Boarding School in Kalisat District, Jember Regency. This study used an observational analytical method with cross-sectional. Of the population of 358 students, 229 students were willing to become respondents. The results showed that 105 students (45.9%) suffered from scabies. The chi-square test results showed the characteristics of respondents such as gender, pruritus complaints, pruritus onset when entering the hut, treatment history was associated with the incidence of scabies (p <0.05). Risk factors for individual hygiene in the form of using towels alternately and washing towels together were also associated with the incidence of scabies (p <0.05). Bivariate analysis at the level of individual knowledge and hygiene as a whole showed no significant association with the incidence of scabies (p> 0.05). The result of multiple logistic regression test showed 2 variables, namely, sex and pruritus onset when entering the lodge significantly associated with the incidence of scabies (p <0.05). Keywords : scabies, knowledge level, personal hygiene]]>
<![CDATA[The Correlation between Ferritin Levels and Glutation (GSH) Levels in Major Beta Thalassemia Patient at dr. Soebandi Jember Hospital ]]>
<![CDATA[Amalia Nur Zahra]]>;
<![CDATA[Rini Riyanti]]>;
<![CDATA[Elly Nurus Sakinah]]>
<![CDATA[ Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018) ]]>
Publisher : <![CDATA[Faculty of Medicine, University of Jember ]]>
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DOI: 10.19184/ams.v4i1.6322
<![CDATA[Repeated blood transfusions in patient with Major Beta Thalassemia leads to iron overload marks by the increased of serum ferritin levels. Free iron caused the change of H2O2 to oxidants by fenton reaction and caused oxidative stress. These oxidants will be counteracted by GSH as antioxidants. The purpose of this study was to investigate the correlation between ferritin levels with GSH in patients with major beta thalassemia in RSD dr. Soebandi hospital Jember. The samples of this study are fifteen (15) patients age 1-18 years who were regularly transfused. Serum ferritin levels were measured by Enzyme-Linked Fluorescent Immuno Assay (ELFA) and plasma GSH levels were measured by Ellman method. Data was analyzed using Pearson correlation test. Serum feritin levels were increased in Major Beta Thalassemia children with average of 3540,46 ± 3925,37 ng/mL. The mean of GSH is 10,46 ± 2,58 µmol. We found significant and negative correlation between serum ferritin and GSH with p value=0,000 and r=-0,951 in Major beta thalassemia patient at RSD dr. Soebandi Jember. Keywords: Thalassemia, Oxidative stress, Feritin, GSH]]>
<![CDATA[Effects of Herbal Forte Rice as Replacement of Carbohydrate to Insulin Resistance in Patients with Type 2 Diabetes in Sumbersari Health Center Jember ]]>
<![CDATA[Dina Faizatur Rahmah]]>;
<![CDATA[Ancah Caesarina Novi Marchianti]]>;
<![CDATA[Rini Riyanti]]>
<![CDATA[ Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017) ]]>
Publisher : <![CDATA[Faculty of Medicine, University of Jember ]]>
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DOI: 10.19184/ams.v3i2.5064
<![CDATA[The population of type 2 diabetes mellitus sufferer continuously increases due to the increase of insulin resistance characterised by the rise of the secretion insulin. Insulin resistance is affected by several factors such as the lack of physical activity, obesity, and unhealthy diet. One of the characteristics of the unhealthy diet is the high consumption of carbohydrates.Whereas Indonesian prefers to have carbohydrate sources from food which has high glycemic index such as rice so thatit makes the glucose in the blood increased rapidly. This condition causes more and faster insulin secretion and can affect insulin resistance. The purpose of this study is to know the effectiveness of herbal forte rice as a substitute of the main carbohydrate in the state of hyperinsulinemia suffered by 15 patients of type 2 diabetes mellitus in Puskesmas (community health center) Sumbersari Jember. This study is a clinical trial with a quasi experimental method and crossover design. In this study, the sample is interviewed by characteristics (age, gender) and the early consumption patterns using 24-hour food recall three times at different times. Samples acted as a control group once the experimental group. The control group did not receive any treatment, while the experimental group received the herbal forte rice as much as 100 grams for 7 consecutive days in the morning (at 06.30 am). After washing out period for 9 days, experimental group switched into control group. At the end of the period (7 days), data of fasting blood glucose and fasting insulin were collected then counted by HOMA-IR formula. The result of the study based on the paired t test p=0.001 in comparison to the state of the control and experimental group. The conclusion of this study is there is a changing state of insulin resistance with the replacement of food based on glycemic index.]]>
<![CDATA[UJI CEPAT (RAPID TEST) ANTIBODI IgM TERHADAP Salmonella typhi DEMAM TIFOID ]]>
<![CDATA[Rini Riyant]]>;
<![CDATA[Prihatini .]]>;
<![CDATA[Siti Rochmatoen]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v14i3.935
<![CDATA[Typhoid fever is caused by Salmonella typhi. The definitive diagnosis can be made by isolation of Salmonella typhi from blood, bone marrow or other body fluids. To support the clinical diagnosis of typhoid fever in Indonesia, where most hospitals and health centres haveno facilities for cultures, a rapid test for the detection of lipopolysaccharides (LPS) Salmonella typhi-specific IgM antibodies was evaluatedon serum samples from patients with typhoid fever. This study is proposed to know the rapid test diagnostic value for the detection oflipopolysaccharides (LPS) Salmonella typhi-specific IgM antibodies. A cross sectional, observational analytical study on 27 typhoidfever and 25 dengue hemorrhagic fever patients of the Dr. Soetomo Hospital, Dr. M Soewandhi General Hospital and Gotong-RoyongClinic has been conducted from January – May 2007. The diagnosis of typhoid fever patients was based on positive gall culture whilethe diagnosis of dengue hemorrhagic fever was based on negative gall culture, positive serology examination for dengue hemorrhagicfever and a recovery from dengue hemorrhagic fever with standard treatment. The sera from patients were examined using a rapid testfor the detection of lipopolysacharides (LPS) Salmonella typhi specific IgM antibodies from Amgenix Onsight of the first blood samples(collected on admission to the hospital) the rapid test for IgM antibodies showed the following: sensitivity 70.4%, specificity 80.0%,positive predictive value 79.2%, negative predictive value 71.4%, diagnostic efficiency 75% respectively. Of the second blood samples(collected 2–3 weeks during the illness) therapid test for IgM antibodies showed the following: sensitivity 88.9%, positive predictive value 82.8%, negative predictive value 87.0%, and diagnostic efficiency 84.6% respectively. The rapid test for IgM antibodies has a high diagnostic value for typhoid fever. The assay uses stabilized components which can be stored at room temperature; the test does notrequire special equipment and may be used in health centres that have no facilities for culture.]]>
<![CDATA[PENGUMPULAN DAN BATAS PEMAKAIAN SAMPEL POPOK PADA PERBENIHAN URIN ]]>
<![CDATA[Rini Riyanti]]>;
<![CDATA[Prihatini Prihatini]]>;
<![CDATA[M.Y Probohoesodo]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v12i2.847
<![CDATA[Urinary tract infection diagnosis is based on urine culture, taken from a midstream collection in the morning. Obtaining samplesin this manner is difficult in children less than 3 years. In children less than 3 years, urine is obtained by urine collectors. Using urinecollectors may cause discomfort, and the possibility that the urine collectors may not adhere resulting in contamination. (1) Developinga practical method for urine sample collection. (2) Comparing culture from diapers and urine collectors samples. (3) Knowing the limittime for using diapers acceptable for urine culture. Urine samples were obtained from 20 children less than 3 years, using urine collectorsand diapers used for 1 hour, 2 hours and 3 hours and then cultured. Majority of the urine culture from diapers used for 1 hour and 2hours showed the same result with the urine culture from urine collectors. Contamination was found in the urine culture result fromdiapers used for 3 hours. Urine samples from diapers used for 1 hour and 2 hours can be used as samples for urine culture. The techniqueis easy and can be done in children less than 3 years.]]>
<![CDATA[The EFFECT OF Anti-miRNA 144 AND Anti-miRNA 150 ON THE EXPRESSION OF α GLOBIN CHAINS IN PBMC ]]>
<![CDATA[Rini Riyanti]]>
<![CDATA[ Journal of Stem Cell Research and Tissue Engineering Vol. 6 No. 2 (2022): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING ]]>
Publisher : <![CDATA[Stem Cell Research and Development Center, Universitas Airlangga ]]>
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DOI: 10.20473/jscrte.v6i2.42774
<![CDATA[The excess of unbound α globin chains are the basic pathophysiology of the cause of clinical symptoms in major β thalassemia. Recently there are many alternative therapies by increasing γ globin chains to reduced the effects of unbound α globin chains. Alternative therapies by decreasing α globin chains have not been much noticed. α globin expression involves complex regulatory involving transcription factors and miRNAs. It involves GATA-1, KLFD and MYB transcription factors . It also involves miRNA-144 and miRNA-150. The role of miRNA-144 and miRNA-150 to reduce the α globin chains expression in major β thalassemia patients is an alternative therapy. miRNA-144 and miRNA150 activity need to be known by using anti-miRNA 144 and anti- miRNA 150. Analyzed the effect of anti-miRNA 144 and anti-miRNA 150 on the expression of α globin chains. This study was an experimental study using PBMC of a major β thalassemia patients. PBMC divided into four groups that were not transfected, transfected by anti-miRNA 144, transfected by anti-miRNA 150 and transfected by anti-miRNA 144 and anti-miRNA 150. qPCR examinations to find out expression of miRNA-144 and miRNA-150. Western blot examination to find out the expression of α globin chains. There was significantly lower miRNA-144 expression in PBMC of major β thalassemia patients who had been transfected by anti-miRNA 144 than those not transfected. In line with the result of miRNA-144 expression which was 0.17 times lower than the control group. There was significantly lower miRNA-150 expression in PBMC of major β thalassemia patients who had been transfected by anti-miRNA 150 than those not transfected. In line with the result of miRNA-150 expression which was 0.30 times lower than the control group. There was significantly lower α globin chains expression in PBMC thalassemia patients who had been transfected by anti-miRNA 150 than those not transfected. There was significantly lower α globin chains expression in PBMC thalassemia patients who had been transfected by anti-miRNA 150 and anti-miRNA 144 than those not transfected. This is evidenced by the decreased in the area 10-25 KDa band. Based on this study, the administration of anti-miRNA 150 or anti-miRNA 144 and anti-miRNA 150 is capable of decreasing the expression α globin chains in PBMC of major β thalassemia patients.]]>
<![CDATA[Correlation between Platelets Count and C-reactive Protein in COVID-19 Patient in Jember Regency ]]>
<![CDATA[Rini Riyanti]]>;
<![CDATA[Faliqul Bahar Muhammad]]>;
<![CDATA[Adelia Handoko]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v29i2.2002
<![CDATA[The laboratory test for Coronavirus disease 2019 (COVID-19) is very important for initial treatment and predicting the prognosis of the patients, but there have been reports of false negative COVID-19 diagnostic test results. Another study reported changes in COVID-19 patient biomarkers, namely platelets count and C-Reactive Protein (CRP) levels. This study investigated the correlation between platelet count and CRP in COVID-19 patients. This study was conducted using a cross-sectional analytic observational method, through secondary data analysis of COVID-19 patients who hospitalized between June – August 2021 at Dr. Soebandi Hospital and Jember Klinik Hospital. Of 30 patients, there were 16 male patients (53%) and 14 female patients (47%); 18 patients in the 46-59 years old age group (60%) and 12 patients in ≤ 4 years old (40%) age group; and there were 8 patients admitted to ICU (26.67%). There was a negative correlation between platelet count and CRP in COVID-19 patients (r = -0.733; p<0.001). A strong correlation between platelet count and CRP is related to prognostic and predictive factors of severity in COVID-19 patients. Further studies about the analysis of other biomarkers in COVID-19 are needed to obtain more prognostic and predictive factors of severity in patient.]]>
<![CDATA[Relationship between Ferritin Levels with Calcium Levels in Patients Thalassemia β Major in Hospital in Jember ]]>
<![CDATA[Fantya Cerebella Aslamy]]>;
<![CDATA[Rini Riyanti]]>;
<![CDATA[Cholis Abrori]]>
<![CDATA[ Journal of Agromedicine and Medical Sciences Vol 9 No 3 (2023) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Jember ]]>
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DOI: 10.19184/ams.v9i3.31435
<![CDATA[Thalassemia β major is a hereditary disorder caused by mutations in the β-globin gene, which regulates the formation of one of the components that make up hemoglobin. This disorder results in the production of β-globin chains being reduced or not formed. The prevalence of thalassemia carriers in Indonesia reached 3.8% of the entire population based on data from the Ministry of Health in 2019. Therapy for thalassemia β major patients is lifelong transfusion, which results in iron overload and triggers hypocalcemia and osteoporosis. The aim of this study was to determine the relationship between ferritin levels and calcium levels in thalassemia β major patients. This study uses an observational analytic research type and a cross-sectional research design. This research was conducted at the RSD dr. Soebandi Jember, Jember Clinic Plantation Hospital, and in December 2019-January 2020. The total sample was 13 patients suffering from thalassemia β major aged 1-18 years. The results of the Pearson analysis showed that p=0.858 showed that there was no ignificant correlation between ferritin levels and calcium levels in Thalassemia β major in Jember. Keywords: Thalassemia β major, ferritin levels, calcium levels, hypocalcemia]]>
<![CDATA[Association between Platelet-Lymphocyte Ratio and Proteinuria in T2DM Patient ]]>
<![CDATA[Riyanti, Rini]]>;
<![CDATA[Putri, Rona Andini]]>;
<![CDATA[Sofiana, Kristianningrum Dian]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v31i1.2214
<![CDATA[Diabetes Mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia and glucose intolerance. Type 2 DM (T2DM) covers over 90% of DM cases. Diabetic nephropathy is a microvascular complication of DM. Proteinuria is as a marker of diabetic nephropathy in DM patients, which reflects disturbances of glomerular filtration and protein reabsorption. Platelet-to-Lymphocyte Ratio (PLR) is a new marker of inflammation and predictor of various medical conditions that is cheap and easy to access through a complete blood count. The pathophysiology of diabetic nephropathy has been reported to be related to chronic inflammation, hypercoagulation, and oxidative stress, which can affect the increase in the number of platelets and decrease in the number of lymphocytes. This study aimed to determine the correlation between PLR and proteinuria in T2DM patients. This cross-sectional study design used medical records data and involved patients presenting T2DM at dr. Soebandi Hospital, Jember from April 2021 to March 2023. The correlation between variables was analyzed using the Spearman correlation test (p <0.05). Based on the result with a subject of 98 T2DM patients, statistical analysis showed a significant correlation between PLR and proteinuria (p=0.000) with moderate strength of correlation (r=0.468). The average PLR value in T2DM patients with proteinuria was higher (255.41) than in T2DM patients without proteinuria (139.85).]]>
