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Association between Platelet-Lymphocyte Ratio and Troponin-I in NSTE-ACS Patient Riyanti, Rini; Sutejo, Ika Rahmawati; Arif, Dina Rizky Amalia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2166

Non-ST segment elevation acute coronary syndrome (NSTE-ACS) accounts for 2/3 of cases of acute coronary syndrome in the hospitals in United States. Acute coronary syndrome causes myocardial ischemia, which results in the release of cellular elements like cardiac troponin into interstitial and intravascular spaces. Troponin-I is a marker of heart muscle damage with high sensitivity and specificity. Researchers were interested in analyzing the relationship between Troponin-I and the inflammatory biomarkers Platelet-Lymphocyte Ratio (PLR). Complete blood count is a routine test, which provides information about red and white cells as well as platelets and lymphocytes. This study aimed to determine the correlation between PLR and Troponin-I in a patient presenting NSTE-ACS using cross-sectional design and medical records data of patients presenting NSTE-ACS at Slamet Martodirdjo Hospital, Pamekasan from January to December 2022. The correlation between variables was analyzed using Spearman correlation tests. The Spearman test results showed a p-value of 0.132, indicating a very weak positive correlation between PLR and Troponin-I in NSTE-ACS patients at Slamet Martodirdjo Hospital (r= 0.150, very weak correlation). Receiver Operating Characteristic (ROC) curve analysis of PLR to determine infarct (NSTEMI) in NSTE-ACS patients showed a cut-off of 139.5 for PLR with a sensitivity of 57.9% and a specificity of 59.3%.

Exploring the Role of Self-Efficacy in Antiretroviral Therapy Adherence Among HIV Patients in Regional General Hospital Wahyuni, Ika Sri; Rondhianto; Riyanti, Rini; Rohkmah, Dewi; Suharsono
International Journal of Contemporary Sciences (IJCS) Vol. 2 No. 3 (2025): January 2025
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i3.13629

This study investigates the role of self-efficacy in antiretroviral therapy (ART) adherence among HIV patients at RSUD Blambangan Banyuwangi using a qualitative case study approach. Data were collected from 36 purposively sampled HIV patients through in-depth interviews, direct observation, and document analysis. Thematic analysis was conducted through data reduction, coding, categorization, and conclusion drawing, with validity ensured via triangulation, member checks, and prolonged engagement. Findings reveal that higher self-efficacy enhances ART adherence by fostering consistent medication routines, resilience, and proactive communication with healthcare providers. Emotional stability, family and peer support, and medical staff guidance were identified as key factors influencing self-efficacy. The study highlights the need to integrate psychological support and self-efficacy enhancement programs into HIV care services to improve treatment adherence.

Relationship between PLR Value and Severity of Dengue Infection in Pediatric Patients in the Aster Room at RSUD dr. Soebandi Jember Gianevan, Nicholas Jirezra; Riyanti, Rini; Shodikin, Muhammad Ali; Rachmania, Sheilla; Dewi, Rosita
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.50026

Dengue infection is a disease caused by dengue virus infection and transmitted by the Aedes mosquito, and is a major health problem in children, especially in developing countries. The Platelet to Lymphocyte Ratio (PLR) is a novel inflammatory biomarker that has recently been frequently studied and plays a role in the assessment of viral infectious diseases, and the use of PLR in viral infectious diseases has previously found greater potential compared with the Neutrophil-Lymphocyte Ratio (NLR). It is hoped that PLR can become a new biomarker for predicting the severity of dengue infection which is suitable for use in developing countries because PLR â€‹â€‹is a cheap biomarker and is available in all clinical conditions. This research is a correlative analytical observational study using a cross-sectional approach. This research design was carried out by collecting data from children diagnosed with dengue infection as well as data on platelets and lymphocytes on the first day of admission to the hospital. This research uses stratified random sampling. Data were analyzed using Spearman correlation with a confidence level of 99%. The results of Spearman's correlation analysis showed a strong significant relationship with p<0.01 (p=0.000) and a correlation coefficient of -0.753. In conclusion, there is a significant and strong relationship between the Platelet-to-Lymphocy Ratio (PLR) value and the severity of dengue infection in pediatric patients in the Aster ward of RSUD Dr. Soebandi Jember. If the PLR â€‹â€‹value increases, the severity of dengue infection will be lower or decrease and vice versa. Keywords: PLR; dengue infection; children; platelets; lymphocytes

The effects of consuming coconut milk on SGOT and SGPT levels of rats serum (Rattus norvegicus strain Wistar) fed with High Fat Diet (HFD) Sari, Yuhanita Tyara; Wahyudi, Septa Surya; Febianti, Zahra; Riyanti, Rini; Prasetyo, Aris
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 13 ISSUE 5, 2025
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2025.13(5).324-334

ABSTRAK Latar Belakang: Pola makan tinggi lemak merupakan pemicu utama terjadinya obesitas dan penyakit kardiometabolik. Akumulasi lemak yang berlebihan menyebabkan peningkatan Reactive Oxygen Species (ROS) melalui hidrokarbon aromatik polisiklik (PAH), yang bermanifestasi dalam peningkatan kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT). Santan mengandung kandungan polifenol yang dapat menghambat mekanisme ROS. Penelitian sebelumnya menyebutkan bahwa pemberian MCFA dan polifenol pada tikus Wistar yang diinduksi hiperkalori tidak memberikan efek hepatoprotektif dan mengindikasikan adanya peningkatan kadar SGOT dan SGPTTujuan: Penelitian ini bertujuan untuk membuktikan pengaruh pemberian santan terhadap kadar SGOT dan SGPT pada tikus yang diinduksi diet tinggi lemak (HFD).Metode: Penelitian ini merupakan penelitian true eksperimental dengan rancangan posttest control group design. Sampel terdiri dari 25 ekor tikus wistar (Rattus norvegicus) jantan dibagi menjadi 5 kelompok secara acak. Pengukuran SGOT dan SGPT dilakukan sesuai standarisasi IFCC (International Federation of Clinical and Chemistry and Medical Laboratory) dengan mengumpulkan sampel serum yang dilanjutkan dengan pemeriksaan menggunakan Spektrofotometer Biolyzer 100 untuk menganalisis kadar SGOT dan SGPT setelah 45 hari perlakuan. Analisis data menggunakan uji ANOVA.Hasil: Hasil penelitian menunjukkan bahwa, peningkatan dosis santan makin menurunkan kadar baik SGOT/SGPT. Hasil uji Anova menunjukkan hasil yang signifikan secara statistik. Perbandingan LSD Post-hoc antara kelompok K dan P3 menunjukkan signifikansi terhadap SGPT (0,276) dan SGOT (0,707). Pemberian santan dosis 10 mL/kg berat badan/ hari pada tikus yang diinduksi HFD secara statistik, dapat menghambat peningkatan SGOT dan SGPT.Kesimpulan : Berdasarkan hasil tersebut disimpulkan bahwa pemberian santan mampu mencegah peningkatan kadar SGOT dan SGPT.KATA KUNCI: diet tinggi lemak;santan kelapa;SGOT;SGPT ABSTRACTBackground: High-fat diets contribute to obesity and cardiometabolic diseases by increasing Reactive Oxygen Species (ROS)levels. Coconut milk's polyphenols may counteract ROS effects which manifests in increasing levels of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). Coconut milk contains polyphenols which can inhibit the ROS mechanism. Previous research stated that administration of MCFA and polyphenols to Wistar rats induced by hypercalories did not provide a hepatoprotective effect and indicated an increase in SGOT and SGPT levels.Objectives: This study aimed to prove the influence of coconut milk administration on the levels of SGOT and SGPT in rats induced by High Fat Diet (HFD).Methods: The study was a true experimental research employing a posttest control group design. It involved 25 male Wistar rats (Rattus norvegicus) split into 5 randomly assigned groups. SGOT and SGPT measurements were carried out according to IFCC standards by collecting serum samples followed by examination using the photometric method to analyze SGOT and SGPT levels after 45 days of treatment. Data analysis used the ANOVA test using SPSS Statistics V21.0Results: The results of research on both SGOT and SGPT levels showed that increasing the dose further reduces both SGOT and SGPT levels. The Anova test results show statistically significant results. Post-hoc LSD comparison between groups K and P3 showed significance for SGPT (0.276) and SGOT (0.707).Conclusions: Based on these results, it can be concluded that high-dose coconut milk administration was able to prevent the increase in SGOT and SGPT levels KEYWORDS: coconut milk; high fat diet; SGOT; SGPT

ADHERENCE DETERMINANT ANALYSIS OF PLHIV ON ARV (ANTIRETROVIRAL) THERAPY IN SITUBONDO DISTRICT: Analisis Determinan Kepatuhan ODHA dalam Menjalani Terapi ARV (Antiretroviral) di Kabupaten Situbondo Wulandari, Winda Cindy; Syafriadi, Mei; Riyanti, Rini; Sugih Utami, Wiwien; Rondhianto, Rondhianto
Jurnal Berkala Epidemiologi Vol. 12 No. 1 (2024): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V12I12024.44-53

Background: Human Immunodeficiency Virus (HIV) infection causes Acquired Immune Deficiency Syndrome (AIDS), a collection of symptoms arising from the deteriorating immunity. The number of people living with HIV worldwide continues to increase year-by-year. Those infected with HIV need antiretroviral (ARV) therapy to suppress the amount of HIV in the body. Purpose: This study aimed to investigate the determinants of adherence in people living with HIV/AIDS (PLHIV) undergoing ARV therapy in Situbondo Regency. Methods: This study employed a quantitative analytic observational approach with a cross-sectional design. Data analysis involved both descriptive and multivariate analysis. The population for this study consisted of 328 individuals, from which 212 were selected as samples, all being PLHIV on ART as of April 2022, sourced from ARV treatment services in Situbondo district. Results: The research analysis was based on predisposing factors, measured using three indicators: work, knowledge, and belief in ARVs. Supporting aspects were measured by two factors: ownership of health insurance and adherence counselling. Reinforcing factors were measured using two indicators: family support and stigma in the community. Conclusion: The study concluded that predisposing and reinforcing factors significantly influenced PLHIV adherence to antiretroviral therapy. However, supporting factors did not show a significant influence on adherence in PLHIV undergoing antiretroviral therapy in the Situbondo District.

The effects of consuming coconut milk on SGOT and SGPT levels of rats serum (Rattus norvegicus strain Wistar) fed with High Fat Diet (HFD) Sari, Yuhanita Tyara; Wahyudi, Septa Surya; Febianti, Zahra; Riyanti, Rini; Prasetyo, Aris
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 13 ISSUE 5, 2025
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2025.13(5).324-334

ABSTRAK Latar Belakang: Pola makan tinggi lemak merupakan pemicu utama terjadinya obesitas dan penyakit kardiometabolik. Akumulasi lemak yang berlebihan menyebabkan peningkatan Reactive Oxygen Species (ROS) melalui hidrokarbon aromatik polisiklik (PAH), yang bermanifestasi dalam peningkatan kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT). Santan mengandung kandungan polifenol yang dapat menghambat mekanisme ROS. Penelitian sebelumnya menyebutkan bahwa pemberian MCFA dan polifenol pada tikus Wistar yang diinduksi hiperkalori tidak memberikan efek hepatoprotektif dan mengindikasikan adanya peningkatan kadar SGOT dan SGPTTujuan: Penelitian ini bertujuan untuk membuktikan pengaruh pemberian santan terhadap kadar SGOT dan SGPT pada tikus yang diinduksi diet tinggi lemak (HFD).Metode: Penelitian ini merupakan penelitian true eksperimental dengan rancangan posttest control group design. Sampel terdiri dari 25 ekor tikus wistar (Rattus norvegicus) jantan dibagi menjadi 5 kelompok secara acak. Pengukuran SGOT dan SGPT dilakukan sesuai standarisasi IFCC (International Federation of Clinical and Chemistry and Medical Laboratory) dengan mengumpulkan sampel serum yang dilanjutkan dengan pemeriksaan menggunakan Spektrofotometer Biolyzer 100 untuk menganalisis kadar SGOT dan SGPT setelah 45 hari perlakuan. Analisis data menggunakan uji ANOVA.Hasil: Hasil penelitian menunjukkan bahwa, peningkatan dosis santan makin menurunkan kadar baik SGOT/SGPT. Hasil uji Anova menunjukkan hasil yang signifikan secara statistik. Perbandingan LSD Post-hoc antara kelompok K dan P3 menunjukkan signifikansi terhadap SGPT (0,276) dan SGOT (0,707). Pemberian santan dosis 10 mL/kg berat badan/ hari pada tikus yang diinduksi HFD secara statistik, dapat menghambat peningkatan SGOT dan SGPT.Kesimpulan : Berdasarkan hasil tersebut disimpulkan bahwa pemberian santan mampu mencegah peningkatan kadar SGOT dan SGPT.KATA KUNCI: diet tinggi lemak;santan kelapa;SGOT;SGPT ABSTRACTBackground: High-fat diets contribute to obesity and cardiometabolic diseases by increasing Reactive Oxygen Species (ROS)levels. Coconut milk's polyphenols may counteract ROS effects which manifests in increasing levels of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). Coconut milk contains polyphenols which can inhibit the ROS mechanism. Previous research stated that administration of MCFA and polyphenols to Wistar rats induced by hypercalories did not provide a hepatoprotective effect and indicated an increase in SGOT and SGPT levels.Objectives: This study aimed to prove the influence of coconut milk administration on the levels of SGOT and SGPT in rats induced by High Fat Diet (HFD).Methods: The study was a true experimental research employing a posttest control group design. It involved 25 male Wistar rats (Rattus norvegicus) split into 5 randomly assigned groups. SGOT and SGPT measurements were carried out according to IFCC standards by collecting serum samples followed by examination using the photometric method to analyze SGOT and SGPT levels after 45 days of treatment. Data analysis used the ANOVA test using SPSS Statistics V21.0Results: The results of research on both SGOT and SGPT levels showed that increasing the dose further reduces both SGOT and SGPT levels. The Anova test results show statistically significant results. Post-hoc LSD comparison between groups K and P3 showed significance for SGPT (0.276) and SGOT (0.707).Conclusions: Based on these results, it can be concluded that high-dose coconut milk administration was able to prevent the increase in SGOT and SGPT levels KEYWORDS: coconut milk; high fat diet; SGOT; SGPT

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