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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Putri Lestari
Sekolah Tinggi Ilmu Farmasi Riau
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Isolasi dan Uji Aktivitas Antioksidan Ekstrak Metanol Dari Buah Senduduk Bulu (Clidemia hirta (L.) D. Don) Haiyul Fadhli; Ihsan Ikhtiarudin; Putri Lestari
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.9846

Abstract

A study on isolation and antioxidant activity of secondary metabolit of methanol extract of fruit of Senduduk Bulu (Clidemia hirta (L.) D. Don) has been carried out. Senduduk bulu is used for folk medicine to many diseases. Flavonoid and phenolic has been reported to its activity as antioxidant. The aim of this research was to find antioxidant compound and antioxidant activity of this fruit. Isolation works were conducted using Vacuum Liquid Chromatography and Column Chromatography method. Antioxidant activity was determined using DPPH free radical scavenging methods. The isolation works afforded 10 mg of pure compound CHP1 which was obtained as white crystal, with its melting point of 165–167ºC, soluble in chloroform and slightly soluble in methanol. This compound gave positive reaction with Liebermann-Burchard (LB) reagent and concluded as terpenoid. Based on it UV spectrum, this compound showed a λ max of 316 nm. Its FT-IR spectrum showed appearence of some functional groups of OH, C-H aliphatic, C=O ester,C=C alkene, CH bending and C-O. The 1H-NMR spectrum showed the alkene protons and methyl protons which is a characteristic of terpenoid compounds. The pure compound (CHP1) provided a weak antioxidant activity with the IC50  of 327,01µg/mL.
A Literature Review On the Formulation, Characterization, and Stability of Cinnamomum burmannii Emulgel Extract as an Antioxidant and Sunscreen Rodhia Ulfa; Ferdy Firmansyah; Fenny Khairunnisa; Putri Lestari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9126

Abstract

Emulgel is a pharmaceutical formulation that integrates the characteristics of both emulsions and gels, resulting in a semisolid product. The utilization of emulgel formulations has been shown to enhance the efficacy of drug delivery by facilitating deeper skin penetration and subsequently augmenting its pharmacological activity. The antioxidant and sunscreen properties of cinnamon bark extract make it suitable for incorporation into an emulgel formulation. Variations in the concentration of extracts and gelling agents can have an impact on the physical properties, stability, and pharmacological efficacy of the emulgel. The objective of this review is to ascertain the optimal concentrations of extracts and gelling agents in emulgel formulations for enhanced efficacy. The employed methodology entails conducting a comprehensive review of scholarly articles pertaining to emulgel formulations containing cinnamon bark extract. These formulations encompass a range of concentrations of both the extract itself and gelling agents, while also possessing antioxidant and sunscreen properties. The formulation that is recommended is one that satisfies the criteria pertaining to its physical attributes, stability, and pharmacological efficacy. The emulgel formulation that best meets the specified criteria consists of a 1% concentration of cinnamon bark extract in combination with the gelling agent Viscolam MAC 5%.
In Vitro Evaluation of Sunscreen Activity of Extract and Fraction of Kedabu Fruit (Sonneratia ovata Backer) : Uji Aktivitas Tabir Surya Ekstrak dan Fraksi Buah Kedabu (Sonneratia ovata Backer) Secara In Vitro Lestari, Putri; Furi, Mustika; Fernando, Armon; Amin, Syahrul; Irfan, Nawwar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.17347

Abstract

The Kedabu fruit, scientifically known as Sonneratia ovata Backer, is a mangrove plant commonly found in Indonesia. This fruit is valued for its antioxidant properties and shows potential as a natural sunscreen. This study was conducted to determine the in-vitro activity of the extract and fractions of Kedabu fruit (Sonneratia ovata Backer) as a sunscreen, with the potential for development into a natural sunscreen preparation. Experiments were conducted on extracts and various fractions, including n-hexane, ethyl acetate, n-butanol, and water. The extracts and fractions of Kedabu fruit were prepared at concentrations of 200, 400, 600, 800, and 1000 µg/mL. Their absorbance was then measured in the UV A (320-375 nm) and UV B (290-320 nm) wavelength ranges. The n-butanol fraction, at a concentration of 1000 µg/mL, appears to be the most effective sunscreen, demonstrating a %Te value of 8.369% and %Tp of 50.345%. This performance places it in the standard Suntan range for UV B protection. Additionally, it has an SPF value of 10.58, categorizing it within the highest level of sun protection.
Co-Authors Amin, Syahrul Armon Fernando Fenny Khairunnisa Ferdy Firmansyah Furi, Mustika Haiyul Fadhli Ihsan Ikhtiarudin Irfan, Nawwar Rodhia Ulfa