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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional JFIOnline Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia
Anjar Mahardian Kusuma
Fakultas Farmasi, Universitas Muhammadiyah Purwokerto
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Aktivitas Penghentian Pendarahan Luar Ekstrak Etanol Daun Berenuk (Crescentia cujete L) Secara In-Vivo Kusuma, Anjar Mahardian; Sulistyo, Adri Nurrakhmat; Susanti, Susanti; Sabikis, Sabikis
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Crescenti cujete L. or better known as calabash is a plant that thrives in Indonesia. Calabash has a great potential as an herbal remedy, but there is only some scientific research conducted on this plant, one of which is antibacterial against Bacillus subtilis and Escerichia coli on 2006 by Susanti. The method in this research was an experimental activities of the cessation external bleeding with 3 dose variation of calabash leaf extract 80%, 60%, and 40% by counting the bleeding time at base of the tail in mice. As a result, all groups of external bleeding cessation activities have better outcomes than negative controls (p < 0,05).
Efek Ekstrak Bawang Dayak (Eleutherine palmifolia (L.)Merr) dan Ubi Ungu (Ipomoea batatas L) terhadap Penurunan Kadar Kolesterol dan Trigliserida Darah pada Tikus Jantan Kusuma, Anjar Mahardian; Asarina, Yupin; Rahmawati, Yeni Indah; Susanti, Susanti
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2925

Abstract

Bawang Dayak (Eleutherine palmifolia (L.)Merr) and Ubi Ungu (Ipomoea batatas L.) are potential medicinal plant in lowering cholesterol. This study aims to measure the effect of bawang dayak extract and ubi unggu extract on lowering cholesterol and triglyceride blood levels in male rats fed with 10 ml/Kg BW quail egg yolk. The cholesterol and triglyceride blood levels of rats were measured with 50, 100 and 200 mg/Kg BW dose variations for each extract for 14 days. Cholesterol and triglyceride levels were measured at day 15th by ‘Multicare’. As controls were rats fed with 1,26 mg/Kg BW simvastatin, 1 % (b/v) Na-CMC, and normal diet. The data was analyzed by Anova statistical tests and LSD (α = 0,05). The result shows that both extracts can reduce cholesterol and triglyceride blood levels with 200mg/Kg BW dose. Bawang dayak extract can reduce cholesterol and triglyceride blood levels to 80.8 ± 9.2 mg/dL and 95 ± 7.9 mg/dL, respectively. Ubi ungu extract can reduce cholesterol and triglyceride blood levels to 72 ± 8.2 mg/dL and 86.4 ± 4.3 mg/dL, respectively.
The physical properties and stability of purple yam (Ipomoea batatas (L.) Lam ) lipstick Susmiatun, Susmiatun; kusuma, Anjar mahardian; Budiman, Arif; Hapsari, Indri
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.6834

Abstract

The purple yam (Ipomoea batatas (L) Lam) has a useful anthocyanin as a natural dye which safer compare to the synthetic dyes. Anthocyanins have the antioxidant effect that can capture free radicals. The purpose of this study was to assess the effect of purple yam extract in various concentrations on the physical properties and physical stability of lipstick. Lipstick was made in three formulas that is L01, L02, L03. To evaluate the quality of the product, the physical properties, and stability test for purple yam lipsticks were conducted. Physical properties test consisted of organoleptic tests, melting point test, hardness test, homogeneity test, the Pap test, and pH test. Lipstick stability tests were performed by stored lipstick for 30 days at room temperature 25 °C, then observed the change of shape, color, and odor during storage. “W” a top market leader lipstick in Indonesia was used as a control. Observed data of melting point, strength, and pH of lipstick were analyzed using One Way ANOVA and continued with Tukey. Organoleptic data, homogeneity, topicality and lipstick stability were described descriptively. The results showing no significant differences between lipstick L01, L02, L03 in organoleptic, homogeneity, pH and lipstick physical stability. However, when comparing with W lipstick, there is a significant difference in the melting, hardness and smearing points between L01, L02, L03 lipstick with W lipstick. It was concluded that purple yam extract may influence the physical properties of lipstick in particular melting point and hardness of lipstick. Although it has no effect on the stability of purple yum lipstick.
PENGARUH PEMBERIAN SEDIAAN CURCUMA DALAM SUSU DAN EMULSI TERHADAP PARAMETER FARMAKOKINETIKA PARASETAMOL Kusuma, Anjar Mahardian; Rahayu, Wiranti Sri; Maryati, Siti; Sobarani, Rini Afini
Media Farmasi: Jurnal Ilmu Farmasi Vol. 10 No. 2: September 2013
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v10i2.1169

Abstract

Penggunaan lebih dari satu macam obat dapat menimbulkan terjadinya interaksi. Pemberian multivitamin dan susu yang mengandung kurkumin, apabila diberikan dengan parasetamol secara bersamaan dimungkinkan dapat menimbulkan interaksi yang dapat berpengaruh terhadap parameter farmakokinetika parasetamol. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pemberian curcuma emulsi dan susu curcuma yang mengandung kurkumin terhadap parameter farmakokinetika parasetamol pada tikus jantan wistar. Jenis metode penelitian yang digunakan yaitu jenis eksperimental dengan rancangan penelitian posttest only control group design dan metode analisis data yang digunakan adalah one way anova. Parameter farmakokinetika pada tiap kelompok mengalami perubahan. Nilai Cpmax untuk kelompok I dengan pemberian parasetamol peroral dosis 150 mg/kgBB yaitu 4,129 µg/ml, kelompok II dan III dengan pemberian parasetamol dosis 150 mg/kgBB dan curcuma emulsi dosis 0,9 mg/kgBB dan 1,8 mg/kgBB yaitu 3,904 µg/ml dan 3,894 µg/ml, pada kelompok IV dan V dengan pemberian parasetamol dosis 150 mg/kgBB dan susu curcuma dosis 0,9 mg/kgBB dan 1,35 mg/kgBB yaitu 3,942 µg/ml dan 3,916 µg/ml. Nilai klirens mengalami penurunan, yaitu pada kelompok I 88 ml/menit, pada pemberian curcuma emulsi kelompok II dan III 87 ml/menit dan 84,8 ml/menit, pada kelompok IV dan V dengan pemberian susu curcuma yaitu 87 ml/menit dan 85,2 ml/menit. Penurunan klirens menyebabkan terjadinya peningkatan nilai AUC kelompok II, III, IV dan V. Hasil secara statistika menunjukkan perbedaan yang tidak signifikan (p>0.05). 
Pengaruh Short Message Service Terhadap Kepatuhan Pengobatan Dan Gaya Hidup Pasien Diabetes Melitus di RSUD Dr. M. Ashari Pemalang Rahmah, Pradnya Aulia; Galistiani, Githa Fungie; Kusuma, Anjar Mahardian
Media Farmasi: Jurnal Ilmu Farmasi Vol. 13 No. 1: Maret 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v13i1.5746

Abstract

Keberhasilan terapi diabetes dipengaruhi oleh pengobatan dan gaya hidup pasien. Ketidakpatuhan menjadi salah satu penyebab dari hasil pengobatan yang buruk, berkembangnya gejala penyakit, serta komplikasi. Perlu adanya perlakuan untuk mencapai hasil terapi yang optimal, salah satunya dengan pemberian Short Message Service (SMS) terkait pengobatan diabetes dan gaya hidup yang baik. Penelitian ini bertujuan untuk mengetahui pengaruh SMS terhadap kepatuhan pengobatan dan gaya hidup pasien diabetes melitus di RSUD dr. M. Ashari Pemalang. Jenis penelitian ini adalah kuasi eksperimental dengan metode pengambilan sampel accidental sampling. Kepatuhan pengobatan diukur dengan kuesioner Medical Prescription Knowledge (MPK) sedangkan gaya hidup dinilai dengan kuesioner Summary of Diabetes Self care Activities (SDSCA). Responden yang berjumlah 81 orang dikelompokan menjadi kelompok kontrol dan intervensi. Sejumlah 41 responden kelompok intervensi diberikan perlakuan berupa SMS untuk mengonsumsi obat diabetes, serta anjuran untuk mematuhi pengobatan dan menjalankan gaya hidup yang baik. Sebanyak 40 pasien dalam kelompok kontrol tidak menerima SMS selama penelitian. Kepatuhan dan gaya hidup diukur sebelum dan setelah perlakuan. Pada penilaian gaya hidup terdapat pengaruh SMS yang diberikan, dilihat dari signifikansi perbedaan skor yang diperoleh pasien pada kedua kelompok. Pada variabel kepatuhan pengobatan belum terdapat pengaruh dari SMS yang diberikan selama penelitian. Kata kunci: Diabetes, kepatuhan pengobatan, gaya hidup, SMS 
Co-Authors Adri Nurrakhmat Sulistyo, Adri Nurrakhmat Agus Siswanto Angga Tiya Warma Sarigih Arif Budiman Arif Budiman Aryani, Alyxia Fatma Asarina, Yupin Darsini Darsini Diniatik Diniatik Dodit Ari Wibowo, Dodit Ari Egi Laila Solichati, Egi Laila Erlin Nur Azizah, Erlin Nur Genatrika, Erza Githa Fungie Galistiani Handayani, Devi Tri Indri Hapsari Indri Hapsari Kristianingrum Kristianingrum, Kristianingrum Maryati, Siti Muhammad Abbas Rifa`i, Muhammad Abbas Mulyani Nur Atikah, Mulyani Nur Mutiara Poetri Nurtanti, Mutiara Poetri Ning Pratiwi, Ning Nunuk Aries Nurulita Nurdiyanti, . Nurdiyanti, . Okti Purwaningrum, Okti Pradnya Aulia Rahmah Pri Iswati Utami Rahmah, Pradnya Aulia Rahmah, Pradnya Aulia Rahmawati, Yeni Indah Retno Wahyuningrum Rihan Basyiruddin Ahmad, Rihan Basyiruddin Rini Afini Sobarani Rini Afini Sobarani Rossy Faizah Nur Utami Sabikis Sabikis, Sabikis Siti Maryati Siti Maryati Sobarani, Rini Afini Sudarso Sudarso Sudarso, . Sudarso, . Susanti Susanti Susanti Susanti Susmiatun Susmiatun Susmiatun Susmiatun, Susmiatun susmiatun, susmiatun Titik Aisyah, Titik Tresna Asih Santoso, Tresna Asih Trisna Rohmiyati Try Widyati, Try Tyas Adhyati Novica Umami, Muzayanatul Umami, Muzayanatul Veby Tri Yulianti Wahyu Utaminingrum Weny Delvia Wijayanti, Dwi Nur Wijayanti, Dwi Nur Wiranti Sri Rahayu Wiranti Sri Rahayu Yuni Asih Rustanti, Yuni Asih