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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional JFIOnline Jurnal Kesehatan Rajawali Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia
Anjar Mahardian Kusuma
Fakultas Farmasi Universitas Muhammadiyah Purwokerto
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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The Cytoprotective and Cell Recovery Properties of Apple Extracts on H2O2 induced-NIH3T3 Cells: An Anti Aging Candidate Nunuk Aries Nurulita; Anjar Mahardian Kusuma; Darsini Darsini; Weny Delvia; Veby Tri Yulianti
Indonesian Journal of Cancer Chemoprevention Vol 9, No 2 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss2pp78-85

Abstract

Apple contains high concentration of phenolic compounds that protect cells from oxidative stress. The prolong exposure of free radicals may induce cell damage and premature cell aging. Both local and imported apple contain flavonoid, saponin, tannin, steroid, and terpenoid. The extract of local and imported apples showed low toxicity on NIH3T3 fibroblast cells, with IC50 value of 529 and 463 µg/mL, respectively. Both apple extracts (50 – 250 µg /mL) protected three-day-H2O2 induced-cell damage and cell death. Protective effect was observed as the viability increase of treated cells compared to untreated ones. The protective effect of both extracts were higher than the effect of vitamin C as standard antioxidant at this study. Both apple extracts could reverse cell damage caused by three-hour-high concentration H2O2 exposure, similar with vitamin C. Low concentration of both extracts (50 µg /mL) induced the increase of fibroblast cells’ proliferation kinetics. The extract of imported apple showed higher properties of protective, cell recovery and proliferation of fibroblast cells tha local apple, but not statistically significance. This study concludes that the extract of local and imported apples have high potency in cytoprotective effect and cell recovery of damaged cells caused by free radicals induction. Both apple extracts have high potency to be developed the candidate of antiaging and cells’ regeneration agent.Keywords : antiaging, cell recovery, cytoprotective, NIH3T3 cells
Aktivitas Penghentian Pendarahan Luar Ekstrak Etanol Daun Berenuk (Crescentia cujete L) Secara In-Vivo Kusuma, Anjar Mahardian; Sulistyo, Adri Nurrakhmat; Susanti, Susanti; Sabikis, Sabikis
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Crescenti cujete L. or better known as calabash is a plant that thrives in Indonesia. Calabash has a great potential as an herbal remedy, but there is only some scientific research conducted on this plant, one of which is antibacterial against Bacillus subtilis and Escerichia coli on 2006 by Susanti. The method in this research was an experimental activities of the cessation external bleeding with 3 dose variation of calabash leaf extract 80%, 60%, and 40% by counting the bleeding time at base of the tail in mice. As a result, all groups of external bleeding cessation activities have better outcomes than negative controls (p < 0,05).
Efek Ekstrak Bawang Dayak (Eleutherine palmifolia (L.)Merr) dan Ubi Ungu (Ipomoea batatas L) terhadap Penurunan Kadar Kolesterol dan Trigliserida Darah pada Tikus Jantan Kusuma, Anjar Mahardian; Asarina, Yupin; Rahmawati, Yeni Indah; Susanti, Susanti
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2925

Abstract

Bawang Dayak (Eleutherine palmifolia (L.)Merr) and Ubi Ungu (Ipomoea batatas L.) are potential medicinal plant in lowering cholesterol. This study aims to measure the effect of bawang dayak extract and ubi unggu extract on lowering cholesterol and triglyceride blood levels in male rats fed with 10 ml/Kg BW quail egg yolk. The cholesterol and triglyceride blood levels of rats were measured with 50, 100 and 200 mg/Kg BW dose variations for each extract for 14 days. Cholesterol and triglyceride levels were measured at day 15th by ‘Multicare’. As controls were rats fed with 1,26 mg/Kg BW simvastatin, 1 % (b/v) Na-CMC, and normal diet. The data was analyzed by Anova statistical tests and LSD (α = 0,05). The result shows that both extracts can reduce cholesterol and triglyceride blood levels with 200mg/Kg BW dose. Bawang dayak extract can reduce cholesterol and triglyceride blood levels to 80.8 ± 9.2 mg/dL and 95 ± 7.9 mg/dL, respectively. Ubi ungu extract can reduce cholesterol and triglyceride blood levels to 72 ± 8.2 mg/dL and 86.4 ± 4.3 mg/dL, respectively.
The physical properties and stability of purple yam (Ipomoea batatas (L.) Lam ) lipstick Susmiatun, Susmiatun; kusuma, Anjar mahardian; Budiman, Arif; Hapsari, Indri
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.6834

Abstract

The purple yam (Ipomoea batatas (L) Lam) has a useful anthocyanin as a natural dye which safer compare to the synthetic dyes. Anthocyanins have the antioxidant effect that can capture free radicals. The purpose of this study was to assess the effect of purple yam extract in various concentrations on the physical properties and physical stability of lipstick. Lipstick was made in three formulas that is L01, L02, L03. To evaluate the quality of the product, the physical properties, and stability test for purple yam lipsticks were conducted. Physical properties test consisted of organoleptic tests, melting point test, hardness test, homogeneity test, the Pap test, and pH test. Lipstick stability tests were performed by stored lipstick for 30 days at room temperature 25 °C, then observed the change of shape, color, and odor during storage. “W” a top market leader lipstick in Indonesia was used as a control. Observed data of melting point, strength, and pH of lipstick were analyzed using One Way ANOVA and continued with Tukey. Organoleptic data, homogeneity, topicality and lipstick stability were described descriptively. The results showing no significant differences between lipstick L01, L02, L03 in organoleptic, homogeneity, pH and lipstick physical stability. However, when comparing with W lipstick, there is a significant difference in the melting, hardness and smearing points between L01, L02, L03 lipstick with W lipstick. It was concluded that purple yam extract may influence the physical properties of lipstick in particular melting point and hardness of lipstick. Although it has no effect on the stability of purple yum lipstick.
PENGARUH PEMBERIAN SEDIAAN CURCUMA DALAM SUSU DAN EMULSI TERHADAP PARAMETER FARMAKOKINETIKA PARASETAMOL Kusuma, Anjar Mahardian; Rahayu, Wiranti Sri; Maryati, Siti; Sobarani, Rini Afini
Media Farmasi: Jurnal Ilmu Farmasi Vol. 10 No. 2: September 2013
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v10i2.1169

Abstract

Penggunaan lebih dari satu macam obat dapat menimbulkan terjadinya interaksi. Pemberian multivitamin dan susu yang mengandung kurkumin, apabila diberikan dengan parasetamol secara bersamaan dimungkinkan dapat menimbulkan interaksi yang dapat berpengaruh terhadap parameter farmakokinetika parasetamol. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pemberian curcuma emulsi dan susu curcuma yang mengandung kurkumin terhadap parameter farmakokinetika parasetamol pada tikus jantan wistar. Jenis metode penelitian yang digunakan yaitu jenis eksperimental dengan rancangan penelitian posttest only control group design dan metode analisis data yang digunakan adalah one way anova. Parameter farmakokinetika pada tiap kelompok mengalami perubahan. Nilai Cpmax untuk kelompok I dengan pemberian parasetamol peroral dosis 150 mg/kgBB yaitu 4,129 µg/ml, kelompok II dan III dengan pemberian parasetamol dosis 150 mg/kgBB dan curcuma emulsi dosis 0,9 mg/kgBB dan 1,8 mg/kgBB yaitu 3,904 µg/ml dan 3,894 µg/ml, pada kelompok IV dan V dengan pemberian parasetamol dosis 150 mg/kgBB dan susu curcuma dosis 0,9 mg/kgBB dan 1,35 mg/kgBB yaitu 3,942 µg/ml dan 3,916 µg/ml. Nilai klirens mengalami penurunan, yaitu pada kelompok I 88 ml/menit, pada pemberian curcuma emulsi kelompok II dan III 87 ml/menit dan 84,8 ml/menit, pada kelompok IV dan V dengan pemberian susu curcuma yaitu 87 ml/menit dan 85,2 ml/menit. Penurunan klirens menyebabkan terjadinya peningkatan nilai AUC kelompok II, III, IV dan V. Hasil secara statistika menunjukkan perbedaan yang tidak signifikan (p>0.05). 
Pengaruh Short Message Service Terhadap Kepatuhan Pengobatan Dan Gaya Hidup Pasien Diabetes Melitus di RSUD Dr. M. Ashari Pemalang Rahmah, Pradnya Aulia; Galistiani, Githa Fungie; Kusuma, Anjar Mahardian
Media Farmasi: Jurnal Ilmu Farmasi Vol. 13 No. 1: Maret 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v13i1.5746

Abstract

Keberhasilan terapi diabetes dipengaruhi oleh pengobatan dan gaya hidup pasien. Ketidakpatuhan menjadi salah satu penyebab dari hasil pengobatan yang buruk, berkembangnya gejala penyakit, serta komplikasi. Perlu adanya perlakuan untuk mencapai hasil terapi yang optimal, salah satunya dengan pemberian Short Message Service (SMS) terkait pengobatan diabetes dan gaya hidup yang baik. Penelitian ini bertujuan untuk mengetahui pengaruh SMS terhadap kepatuhan pengobatan dan gaya hidup pasien diabetes melitus di RSUD dr. M. Ashari Pemalang. Jenis penelitian ini adalah kuasi eksperimental dengan metode pengambilan sampel accidental sampling. Kepatuhan pengobatan diukur dengan kuesioner Medical Prescription Knowledge (MPK) sedangkan gaya hidup dinilai dengan kuesioner Summary of Diabetes Self care Activities (SDSCA). Responden yang berjumlah 81 orang dikelompokan menjadi kelompok kontrol dan intervensi. Sejumlah 41 responden kelompok intervensi diberikan perlakuan berupa SMS untuk mengonsumsi obat diabetes, serta anjuran untuk mematuhi pengobatan dan menjalankan gaya hidup yang baik. Sebanyak 40 pasien dalam kelompok kontrol tidak menerima SMS selama penelitian. Kepatuhan dan gaya hidup diukur sebelum dan setelah perlakuan. Pada penilaian gaya hidup terdapat pengaruh SMS yang diberikan, dilihat dari signifikansi perbedaan skor yang diperoleh pasien pada kedua kelompok. Pada variabel kepatuhan pengobatan belum terdapat pengaruh dari SMS yang diberikan selama penelitian. Kata kunci: Diabetes, kepatuhan pengobatan, gaya hidup, SMS 
Penggunaan Antibiotik Pada Pasien Pneumonia Covid-19: Studi Kuantitatif Pada Rumah Sakit Dr. R. Goeteng Taroenadibrata Purbalingga Suseno, Akhmad Haris; Kusuma, Anjar Mahardian; Galistiani, Githa Fungie; Harima, Gangga
Jurnal Kesehatan Rajawali Vol 14 No 2 (2024): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v14i2.443

Abstract

Covid-19 is a problem for the world and Indonesia. Pneumonia is one of the most common comorbid diseases of Covid-19. The management of Covid-19 pneumonia is using empirical antibiotics. Inappropriate use of antibiotics can lead to antibiotic resistance so it is very necessary to evaluate the use of antibiotics. The purpose of this study was to determine the quantity of antibiotic use in patients with Covid-19 pneumonia at Dr. R. Goeteng Taroenadibrata Purbalingga Hospital. This study used a cross sectional research design using retrospective data with observational research. The method of evaluating antibiotic use uses the ATC/DDD methods. Based on the evaluation using the ATC/DDD method, The DDD/100 patient-days value of antibiotic use was intravenous Azithromicin (52,860 DDD/100 patient-days), Ceftriaxone (42,412 DDD/100 patient-days), peroral Azithromicin (8,582 DDD/100 patient-days), Levofloxacin (6,529 DDD/100 patient-days), Cefixime (2,985 DDD/100 patient-days), Ciprofloxacin (1,243 DDD/100 patient-days), Cefotaxime (2,798 DDD/100 patient-days) and Metronidazole (1,119 DDD/100 patient-days). There are 2 types of antibiotics that meet WHO standards and 6 types of antibiotics that do not meet WHO standards.
Co-Authors Adri Nurrakhmat Sulistyo, Adri Nurrakhmat Agus Siswanto Angga Tiya Warma Sarigih Arif Budiman Aryani, Alyxia Fatma Asarina, Yupin Budiman, Arif Darsini Darsini Diniatik Dodit Ari Wibowo, Dodit Ari Egi Laila Solichati, Egi Laila Erlin Nur Azizah, Erlin Nur G, Githa Fungie Gangga Harima Genatrika, Erza Githa Fungie Galistiani Handayani, Devi Tri Indri Hapsari Indri Hapsari Kristianingrum Kristianingrum, Kristianingrum Maryati, Siti Muhammad Abbas Rifa`i, Muhammad Abbas Mulyani Nur Atikah, Mulyani Nur Mutiara Poetri Nurtanti, Mutiara Poetri Ning Pratiwi, Ning Nunuk Aries Nurulita Nurdiyanti, . Nurdiyanti, . Nur’aeni, Nur’aeni Okti Purwaningrum, Okti Pradnya Aulia Rahmah Pri Iswati Utami Rahmah, Pradnya Aulia Rahmah, Pradnya Aulia Rahmawati, Yeni Indah Retno Wahyuningrum Rihan Basyiruddin Ahmad, Rihan Basyiruddin Rini Afini Sobarani Rini Afini Sobarani Rossy Faizah Nur Utami Sabikis Sabikis, Sabikis Siti Maryati Siti Maryati Sobarani, Rini Afini Sudarso Sudarso Sudarso, . Sudarso, . Susanti Susanti Susanti, Susanti Suseno, Akhmad Haris Susmiatun Susmiatun Susmiatun Susmiatun, Susmiatun susmiatun, susmiatun Titik Aisyah, Titik Tresna Asih Santoso, Tresna Asih Trisna Rohmiyati Try Widyati, Try Tyas Adhyati Novica Umami, Muzayanatul Umami, Muzayanatul Veby Tri Yulianti Wahyu Utaminingrum Weny Delvia Wijayanti, Dwi Nur Wijayanti, Dwi Nur Wiranti Sri Rahayu Wiranti Sri Rahayu Yuni Asih Rustanti, Yuni Asih