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All Journal Jurnal Anestesiologi Indonesia Jurnal Anestesi Perioperatif Majalah Anestesia dan Critical Care Journal of Anaesthesia and Pain Indonesian Journal of Life Sciences Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Journal of General Procedural Dermatology and Venereology Indonesia
Ristiawan Muji Laksono
Brawijaya University Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Medicine & Pharmacology Nursing Public Health

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Manajemen Nyeri Post-Operative untuk Pasien COVID-19 di Indonesia Ristiawan Muji Laksono
Journal of Anaesthesia and Pain Vol 1, No 2 (2020): May
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jap.2020.001.02.01

Abstract

Manajemen nyeri post-operative menjadi salah satu fokus utama dalam perawatan pasien COVID-19. Minimnya jumlah publikasi tentang pilihan terapi post-operative untuk pasien COVID-19 di Indonesia membuat masih dibutuhkannya informasi mengenai pilihan obat-obatan atau teknik manajemen nyeri post-operative untuk pasien COVID-19. Manajemen nyeri post-operative pada pasien COVID-19 positif atau terduga pasien COVID-19 perlu mempertimbangkan ha-hal sebagai berikut.
Hubungan Faktor Sosiodemografi dengan Angka Kejadian Nyeri Kronik pada Pasien Pasca Operasi Bedah Mayor di Rumah Sakit Dr. Saiful Anwar Malang Trianna Mailawati; Ristiawan Muji Laksono; Arie Zainul Fatoni
Journal of Anaesthesia and Pain Vol 1, No 1 (2020): January
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jap.2020.001.01.01

Abstract

Latar belakang: Nyeri kronik pasca bedah mayor merupakan komplikasi bermakna pada sebagian besar pasien.  Faktor sosiodemografi menjadi salah satu perhatian dalam prevalensi kejadian nyeri kronik pasca bedah mayor dan belum ada data mengenai angka kejadian nyeri kronik dan faktor yang mempengaruhinya di Indonesia, khususnya di Malang. Penelitian ini bertujuan untuk mengetahui hubungan faktor sosiodemografi seperti usia, jenis kelamin, pendidikan, dan tingkat pendapatan terhadap angka kejadian nyeri pasca bedah.Metode: Penelitian ini tergolong penelitian epidemiologi analitik dengan metode cross sectional pada 123 pasien yang menjalani operasi elektif bedah mayor di RS Dr. Saiful Anwar Malang periode Juli-Desember 2018. Penelitian dilaksanakan dengan metode wawancara pada responden. Variabel penelitian ini yaitu usia, jenis kelamin, tingkat pendidikan dan  tingkat pendapatan. Data yang diperoleh dianalisa dengan menggunakan uji korelasi Spearman pada SPSS 25.0.Hasil: Sebanyak 66 subjek tidak mengalami nyeri kronik dan 57 subjek mengalami nyeri kronik pasca bedah mayor. Tingkat pendidikan memiliki hubungan yang signifikan dengan dengan angka kejadian nyeri kronik (p=0,038). Akan tetapi hubungan yang terjadi bersifat lemah  (koefisien korelasi Spearman =0,187). Faktor sosiodemografi di antaranya usia, jenis kelamin dan pendapatan tidak berhubungan dengan angka kejadian nyeri kronik pasca bedah mayor (p>0,05).Kesimpulan: Faktor tingkat pendidikan memiliki hubungan yang bersifat lemah dengan angka kejadian nyeri kronik pasca operasi bedah mayor. Akan tetapi, faktor sosiodemografi seperti usia, jenis kelamin, dan pendapatan tidak berhubungan dengan angka kejadian nyeri kronik pasca operasi bedah mayor.
Social Service of Pain Management for Patients Unresponsive to Conservative Treatment Ristiawan Muji Laksono; Taufiq Agus Siswagama; Buyung Hartiyo Laksono; Aswoco Andyk Asmoro; Priscilla Tulong; Emilia Tiara Shantikaratri; Haffidz Wahyu Aji; Yudhistira Yuliandra; Dadik Prasetya Hutama; Candra Aditiarso
Journal of Anaesthesia and Pain Vol 3, No 3 (2022): September
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jap.2022.003.03.01

Abstract

Pain is one of the most common complain encountered in outpatient clinic. Inadequate pain management has been widely reported. As an anesthesiologist and pain physician, we perform a social service of pain management for patients unresponsive to conservative treatment. The social service  was held from April - June 2022. We enrolled thirty-two patients from other physician reference and Primary Health Care in several districts around Malang city to come to Brawijaya University Hospital with the age range of 30-80 years old. The pain interventions given to the participants mainly include prolotherapy, pulsed radiofrequency (PRF), and others. The pain measurement of the patients were assessed with Numerical Rating Scale (NRS), pre and post-intervention. The social service is performed on 32 patients (male 34,37%, female 65.62%), majority aged 60 years od and older (34.37%) with low back pain become the major complaint (43.75%). The majority of patients receive prolotherapy (68%). The mean NRS decrease from 6.19 ± 0.18 (before treatment) to 2.69 ± 0.10 (after treatment). After this social service, most patients (96.875%) have obtained better pain control after given pain interventions. 
Combination of Femoral and Parasacral Sciatic Nerve Block as Multimodal Pain Management in Post Hemiarthroplasty Surgery Patient Faundra Arieza Firdaus; Ristiawan Muji Laksono
Journal of Anaesthesia and Pain Vol 4, No 1 (2023): January
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jap.2023.004.01.03

Abstract

Background: The prevalence of femoral neck fractures is high in geriatric patients with a high mortality rate. Many geriatric patients have comorbidities and find it difficult to tolerate general or neuraxial anesthesia during hip hemiarthroplasty. A more safe technique in lower extremities using peripheral nerve blocks is preferred. The combination of sciatic nerve blocks and psoas compartments can supply adequate anesthesia for hip surgery thus reducing mortality. Femoral nerve blocks decrease the incidence of complications than psoas compartment blocks.Case: A 88-year-old female patient, 70 kg, with distal femoral subtrochanteric fracture accompanied by dislocation, hypertension emergency, hyperplasia heart disease (HHD), and heart failure stage B Fc II were undergoing hemiarthroplasty with regional anesthesia sciatic nerve block and femoral block. After surgery, a block was performed using regional anesthesia sub-arachnoid block bupivacaine 0,5% 7mg + fentanyl 25 µg + Morphin 0,1 µg, post-operative pain with ultrasound, the patient received 0.375% naropin and 50 mg trilac total volume 20 cm3. Then femoral block was done with 0.375% and 50 mg trilac total volume 20 cm3.  Patients were observed for pain scale during hospitalization, time of mobilization, and length of stay. Post-operative hemodynamic was stable, the pain scale using VAS assessment was 0-1 during hospitalization without additional opioid analgesia, active mobilization began on the 2nd day, and the length of stay was 3 days.Conclusion: The combination of a femoral and sciatic nerve block to the proximal part of the skin incision can supply adequate pain compliance for hip hemiarthroplasty.
The effectivity of ultrasound-guided platelet-rich plasma perineural injection in improving leprosy sensory peripheral neuropathy Brahmanti, Herwinda; Widiatmoko, Arif; Widasmara, Dhelya; Sari, Diane Tantia; Kurniawan, Shahdevi Nandar; Santoso, Widodo Mardi; Laksono, Ristiawan Muji; Gofur, Abdul
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Sensory nerve damage is the earliest leprosy sign which can lead to disability. Previous studies showed that autologous platelet-rich plasma (PRP) perineural blind injection can stimulate leprosy sensory nerve regeneration. Our study provided a safer and more accurate PRP agent delivery method through ultrasound-guided injection and was the first to compare PRP versus standard neuropathy treatment, the neurotropic vitamin. This study aimed to determine the effectiveness of combination therapy of ultrasound-guided PRP perineural injection and oral vitamin B complex compared to single oral vitamin B complex in sensory peripheral neuropathy of posterior tibial nerve in leprosy patients.
Effective Communication Training for Palliative Volunteers’ Motivation for Providing Psychosocial Support to Breast Cancer Patients Astari, Asti Melani; Supriati, Lilik; Ilhamuddin, Ilhamuddin; Laksono, Ristiawan Muji; Alasiry, Sharifa
Jurnal Keperawatan Soedirman Vol 20 No 2 (2025): Jurnal Keperawatan Soedirman (JKS)
Publisher : Fakultas Ilmu-ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jks.2025.20.2.14947

Abstract

Motivation plays a critical role in enabling palliative volunteers to provide effective psychosocial support to breast cancer patients. The negative psychological problems patients face often pose challenges for volunteers, as each patient requires a personal approach. Thus, good communication skills are essential, and training in effective communication can enhance volunteers' motivation to optimize psychosocial assistance. This study aimed to measure the effect of effective communication training on the motivation of palliative volunteers in supporting breast cancer patients in Batu City, Indonesia. This research employed a pre-experimental design with a pre-and post-test approach. A total of 45 palliative volunteers were recruited for this study. The training, which included role-playing exercises and group discussions, was conducted over a period of five weeks. Data were collected using the Volunteer Functions Inventory (VFI) questionnaire and analyzed using SPSS with the Paired-Samples t-Test. The results showed a significant increase in volunteer motivation after the training. Statistical tests confirmed a significant improvement in motivation scores after the training. This study highlights the positive impact of effective communication training on increasing volunteer motivation. It underscores the importance of nurses collaborating with volunteers to address the psychosocial needs of breast cancer patients through empathetic listening and effective communication.
The F-11 Sensory Neuron Model: A Scalable In Vitro Platform for Neuropathic Pain and Drug Screening Nazwar, Tommy Alfandy; Laksono, Ristiawan Muji; Balafif, Farhad; Wardhana, Donny Wisnu; Balafif, Fachriy
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.290

Abstract

Neuropathic pain remains a major therapeutic challenge, largely due to the translational disconnect between preclinical animal models and clinical efficacy in humans. This review critically evaluates the differentiated F-11 cell line, a hybridoma of mouse neuroblastoma and rat embryonic dorsal root ganglion (DRG) neurons, as a scalable, reproducible, and physiologically relevant in vitro platform for neuropathic pain research and analgesic drug screening. A detailed analysis of differentiation strategies highlights the critical interplay of neurotrophic factors (notably NGF), intracellular signaling modulators (such as cAMP elevators), and extracellular matrix cues in driving neuronal maturation. Functional validation via calcium imaging and electrophysiology confirms capsaicin responsiveness and action potential generation, mirroring native nociceptors. Its compatibility with medium-to-high-throughput screening and mechanistic studies including investigation of silent nociceptor sensitization in chronic pain conditions along with emerging applications in neuropathy models, makes it a valuable tool for de-risking drug candidates before animal studies.
Co-Authors Abdul Gofur Alasiry, Sharifa Arie Zainul Fatoni Asti Melani Astari Aswoco Andyk Asmoro Balafif, Farhad Candra Aditiarso Dadik Prasetya Hutama Devi Ariani Dhelya Widasmara Djudjuk R Basuki Djudjuk Rahmad Basuki Eko Nofiyanto Emilia Tiara Shantikaratri Fachriy Balafif, Fachriy Fardian, Dedy Faundra Arieza Firdaus Haffidz Wahyu Aji Hari Bagianto Herwinda Brahmanti Ilhamuddin Ilhamuddin, Ilhamuddin Isngadi Isngadi Karmini Yupono Laksono, Buyung Hartiyo Lilik Supriati, Lilik Muhammad Irzal Nazwar, Tommy Alfandy Priscilla Tulong Ruddi Hartono Sari, Diane Tantia Shahdevi Nandar Kurniawan, Shahdevi Nandar Taufiq Agus Siswagama Taufiq Agus Siswagama Trianna Mailawati Umi Satiyah Vidya Sulistyawan Vilda Prasastri Yuwono Wardhana, Donny Wisnu Widiatmoko, Arif Widodo Mardi Santoso, Widodo Mardi Yudhistira Yuliandra Yudi Hadinata