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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Global Medical and Health Communication Journal of Medicine and Health Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science Journal of Medicine and Health
Sadeli Masria
Universitas Islam Bandung
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Karakteristik Pasien dan Gambaran Indeks Platelet pada Pasien Leukemia Limfoblastik Akut di Rumah Sakit Al-Islam Kota Bandung Periode 2020-2022 Amalia Salima; Yani Triyani; Sadeli Masria
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12418

Abstract

Abstract. Acute lymphoblastic leukemia (ALL) is the most common blood cancer in children in Indonesia. The latest data regarding the characteristics of ALL patients at Al-Islam Hospital Bandung City is currently not available. Apart from that, there are 27 blood parameters released by the hematology analyzer, but there are still values that have not been used optimally in helping to diagnose ALL, namely the platelet index. This study aims to determine the characteristics and features of platelet indices in acute lymphoblastic leukemia patients before and after chemotherapy. The method used is descriptive using medical record data from ALL patients aged 0–18 years for the period 2020–2022. This research was carried out at Al Islam Hospital Bandung during November 2023 and the data collection technique used total sampling. The data is processed using Statistical Product and Service Solutions (SPSS) software. In this study, 1040 medical record data were obtained and 292 of them met the inclusion criteria. The most frequent cases of ALL occurred in 2022 with 384 patients, aged 18 months–10 years in 721 patients (79%), male gender in 569 patients (55%), type of diagnosis was remission in 149 patients (51%). In addition, the hemoglobin level was 7.00–11.00 g/dL in 179 patients (63%), the leukocyte count was <10,000 mm3 in 209 patients (73%), and the platelet count was >100,000 mm3 in 181 patients (65%). In conclusion, the characteristics of most ALL patients are male, age 18 months–10 years, and type of diagnosis in remission. Abstrak. Leukemia limfoblastik akut (LLA) merupakan kanker darah yang paling banyak terjadi pada anak di Indonesia. Data terbaru mengenai karakteristik pasien LLA di RS Al-Islam Kota Bandung saat ini belum tersedia. Selain itu, terdapat 27 parameter darah yang dikeluarkan hematology analyzer, tetapi masih ada nilai yang belum digunakan secara optimal dalam membantu penegakan diagnosis LLA yaitu indeks platelet. Penelitian ini bertujuan mengetahui karakteristik dan gambaran indeks platelet pada pasien leukemia limfoblastik akut sebelum dan sesudah kemoterapi. Metode yang digunakan adalah deskriptif yang menggunakan data rekam medik pasien LLA usia 0–18 tahun periode tahun 2020–2022. Penelitian ini dilaksanakan di Rumah Sakit Al Islam Bandung selama bulan November 2023 dan teknin pengambilan data menggunakan total sampling. Data tersebut diolah menggunakan perangkat lunak Statistical Product and Service Solutions (SPSS). Pada penelitian ini didapatkan 1040 data rekam medik dan yang memenuhi kriteria inklusi sebanyak 292. Kasus LLA paling sering terjadi pada tahun 2022 sebanyak 384 pasien, usia 18 bulan–10 tahun pada 721 pasien (79%), jenis kelamin laki-laki 569 pasien (55%), jenis diagnosis remisi pada 149 pasien (51%). Selain itu, kadar hemoglobin 7,00–11,00 g/dL pada 179 pasien (63%), jumlah leukosit <10.000 mm3 pada 209 pasien (73%), dan jumlah platelet >100.000 mm3 pada 181 pasien (65%). Simpulan, karakteristik pasien LLA terbanyak laki-laki, usia 18 bulan–10 tahun, dan jenis diagnosis remisi.
The Probiotic Effect towards Aspirin-induced Gastric Ulcer Healing Process as Measured by Mucous Thickness, Reepithelization, Gastric Glands Formation, and Angiogenesis in Animal Model Teresa Lucretia; Achadiyani Achadiyani; Sadeli Masria
Journal of Medicine and Health Vol 1 No 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i4.533

Abstract

Gastric Ulcer is a common side effect of Non-Steroid Anti Inflammatory Drugs (NSAIDs) use such as Aspirin. Probiotic has many benefits especially for the alimentary system, but the effect on gastric ulcer have yet to be explored. In this research we aimed to find the probiotic effect on histological structure changes during aspirin induced gastric ulcer healing process in animal model. This was simple random sampling animal experimental laboratory, that divided Wistar Rats into two main groups. Both groups were induced with Aspirin (300mg/Kg BW) per oral, once daily for three consecutive days,and subsequently the test group were given probiotic suspension (cfu >108/gr) per oral, once daily, for 14 days. Each subgroups were sacrified serially at day 0, 3, 7, 14. The gaster were collected and processed for histology examination. Better histological structures were shown in the test group at day 14. MANOVA result showed probiotic's effect in enhancing histological structure changes during gastric ulcer healing process. Better histological structure changes were observed in mucus thickness; reepitelization, gastric glands formation, and angiogenesis process of the test group. As a conclusion, probiotic enhanced mucus thickness, reepitelization, glands remodelling, and angiogenesis in Aspirin induced gastric ulcer healing process in animal model. Key words: probiotic, gastric ulcer, histological structure, aspirin, healing process
Co-Authors Achadiyani Aditya Pradipta Lantik Aisyah Putri Rejeki Amalia Salima Astuti, Ratna Dewi Indi Chrysanti Chrysanti Dione Margareth Setiawan Dyana Eka Hadiati Fajar Awalia Yulianto Fauzan Rahman Latama Fauzia Andrini Fayza Amelina Fitriyani Ghin Ghin Anugrah Herry S. Sastramihardja Hildan Hadian Hilmi Sulaiman Rathomi Imam Supardi Imam Supardi Jusuf Sulaeman Effendi Lelly Yuniarti Luthfi Rahinajati Maya Tejasari Mohamad Daffa Putra Utama Noeradiana Mohamad Daffa Putra Utama Noeradiana Mohamad Dias Agustian Mohammad Rizki Akbar Nanda Fadilah Zainuddin Nova Triandini Purnomo R. Anita Indriyanti Rahmawaty, Ike Salma Nur Afina Sunarjati SA Sunarjati Sudigdoadi Susanti Dharmmika Teresa Lucretia Teresa Lucretia, Teresa Titik Respati Tjoekra Roekmantara Uci Ary Lantika Usep Abdullah Husin Wida Purbaningsih Yani Triyani Yani Triyani Yuwono, -