Article Per Year (5 Year)
p-Index From 2021 - 2026
1.606
P-Index
This Author published in this journals
All Journal Jurnal Media Gizi Indonesia (MGI) Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Indonesian Journal of Cardiology JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Heart Science Journal Indonesian Andrology and Biomedical Journal
Andrianto
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine Airlangga University - RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 15 Documents
Search

 1   2 
Immature Platelet Fraction as A Potential Marker To Differentiate Types of Acute Coronary Syndrome Endah Indriastuti; Yetti Hernaningsih; Yulia Nadar Indrasari; Andrianto Andrianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1609

Abstract

Acute Coronary Syndrome (ACS) includes ST-Elevation Myocardial Infarction (STEMI), non-ST Elevation Myocardial Infarction (NSTEMI), and Unstable Angina (UA). Platelet plays an essential role in ACS pathogenesis. Immature Platelet Fraction (IPF) and platelet indices can predict platelet activations. Platelet indices consist of platelet count, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), plateletcrit (Pct). This study aimed to analyze the differences of IPF and platelet indices among ACS patients. This study was an observational analytical cross-sectional study conducted in Dr. Soetomo Hospital during May-September 2019. The subjects consisted of 30-STEMI, 25-NSTEMI, and 24-UA patients. The EDTA-samples were measured for platelet indices and IPF using Sysmex XN-1000. The differences between IPF and platelet indices among STEMI, NSTEMI, and UA patients were analyzed using Kruskal-Wallis and Mann-Whitney test. The IPF values were significantly higher in STEMI patients than NSTEMI and UA patients. The IPF values of NSTEMI patients were higher than UA patients. The MPV, PDW, and P-LCR were significantly higher in STEMI and NSTEMI compared to UA. The MPV, PDW, and P-LCR values of NSTEMI patients were significantly higher than UA patients. The significant differences between STEMI and NSTEMI toward UA might be caused by the more severe thrombotic conditions in myocardial infarction patients than UA. The IPF values were significantly different among each type of ACS patients gave an opportunity using this parameter to differentiate the ACS types. The MPV, PDW, and P-LCR were significantly higher in myocardial infarction patients than UA patients, which also allowed them to use those parameters to differentiate both conditions.
Gene Expression of SOX2, OCT4, and Nanog by Small Molecule Compound VC6TFZ on Peripheral Blood Mononuclear Cell Rizka Amalia; Budi Susetyo Pikir; Andrianto Andrianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1759

Abstract

Peripheral blood mononuclear cells are a potential source of cells to be induced into pluripotent stem cells because the collection procedure is easy, minimally invasive, and can be stored in a frozen form. Small molecule compound VC6TFZ consisting of valproic acid (VPA), CHIR990210 (CHIR), 616452, Tranylcypromine, Farsokline, 3-deazaneplanocin (DZnep) and TTNPB has been shown to induce pluripotency in mouse fibroblasts, but this has not been proven in peripheral blood cells. This chemical reprogramming strategy has the potential to be used in producing the desired functional cell types for clinical applications. This study aims to determine whether the small molecule compound VC6TFZ can induce pluripotency of peripheral blood mononuclear cells to become induced pluripotent stem cells. Mononuclear cells were isolated from peripheral venous blood by density gradient centrifugation method. The cells are grouped into 4 groups. Group 1 was the control group, which was not exposed to the small molecule. Groups 2-4 were experimental groups exposed to different doses of the small molecule VC6TFZ. Identification of induced pluripotent stem cells was carried out by identifying colony morphology and pluripotent gene expression of Octamer-binding transcription factor-4 (OCT4), Sex-determining region Y-box 2 (SOX2), and Nanog using Real-Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Colonies with a round shape, large, cobble stone like, and clear boundaries resembling pluripotent stem cell colonies appeared on the 9th day of the induction process. OCT4 and Nanog gene expression were significantly increased in the treatment group compared to the control.
Non-HDL Cholesterol and LDL Cholesterol as Main Risk Factors for Coronary Heart Disease: Meta-Analysis Ravell Hansen Untono; Jusak Nugraha; I. Gde Rurus Suryawan; Andrianto Andrianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.2006

Abstract

Coronary heart disease is a highly frequent illness in both developed and developing nations. Non-HDL cholesterol (n-HDL-c) and LDL cholesterol (LDL-c) stages are biomarkers that doctors frequently utilize to assess the risk of Coronary Heart Disease (CHD). This study was a systematic review and meta-analysis to assess the association between n-HDL-c and LDL-c as major risk factors for CHD. Cochrane, PubMed, and Science Direct searches were conducted using the keywords "LDL cholesterol," "non-HDL cholesterol," and "coronary heart disease." Any research that describes the analysis of LDL-c and n-HDL-c as key risk factors for CHD and all studies involving patients diagnosed with CHD are included in the literature. A total of seven papers were involved in the qualitative analysis (systematic review), while five studies were included in the quantitative analysis (meta-analysis). The English-language research includes two RCTs, four case-control studies, and one cohort study, with a total of 68,713 individuals. LDL-c parameters were obtained (MD = 8.45; 95 percent CI = 7.03-9.87 p=0.001) and n-HDLc (p=0.001) (MD = 35.57; 95 percent CI = 33.27-37.88). n-HDL-c may be a more significant parameter of CHD risk because it has a higher MD value.
MEDICATION ADHERENCE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH CORONARY HEART DISEASE Shafiero Muhammad Elsya Putera; Sony Wibisono; Andrianto; Hermina Novida
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.109-117

Abstract

Highlights                                                                                                                                      Type 2 diabetes mellitus (T2DM) that is not appropriately handled can result in macro- or micro-complications. Medication adherence is one of the most important efforts to do to prevent complications in chronic diseases such as T2DM. Abstract Background:  Diabetes medication non-adherence can aggravate the patient's condition and raise the chance of acquiring diabetes complications such as coronary heart disease. Medication adherence can help prevent micro- and macrovascular problems. Objective: This study aimed to investigate the medication adherence of type 2 diabetic patients with coronary heart disease. Material and Method: This research used a systematic literature review for the research design, with a PRISMA chart as a guideline. Researchers searched 3 databases using predefined keywords: PubMed, Google Scholar, and ScienceDirect. Result:  The search yielded 3.373 pieces of literature, and six pieces that fit the requirements were chosen. The total number of people who responded was 9.950. More men over 60 years old who have had diabetes for more than 5 years, who are taking oral medication, insulin, or combination treatment, and who are ex-smokers were shown to have characteristics of people with type 2 diabetes mellitus and coronary heart disease. Results from a systematic literature review revealed five kinds of literature with low medication adherence levels and one literature with a high medication adherence rate. Conclusion:  Medication adherence differs among type 2 diabetic patients with coronary heart disease. More research, however, has revealed that the level of medication adherence in type 2 diabetic patients with coronary heart disease remains low.
Clinical Patterns of Pharmacotherapy Administration in Acute Heart Failure at a Tertiary Hospital in Indonesia Nadhifa Ainur Rohmah; Andrianto Andrianto; Sundari Indah Wiyasihati; Anudya Kartika Ratri
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 1 (2026): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I12026.68-73

Abstract

Highlights: Diuretics were the most commonly administered therapy for AHF patients. Pharmacotherapy administration adhered to the existing European Society of Cardiology (ESC) and the Indonesian Heart Association (PERKI) guidelines.   Abstract Introduction: Acute heart failure (AHF) has long been the leading cause of hospitalizations among the elderly. In Indonesia, AHF poses a significant challenge due to its high rates of hospitalization and mortality, with the number of cases continuing to rise annually. This study aimed to characterize the clinical pharmacotherapy patterns of AHF patients during hospitalization at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, providing valuable insights into therapeutic approaches in this tertiary care setting. Methods: This retrospective descriptive study utilized secondary data from medical records of AHF patients admitted to Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, between January and December 2023. This study included 52 patients aged 18 years and older with complete medical records. All statistical procedures were performed using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 25.0 to support systematic and reproducible evaluation of the dataset. Results: This study categorized AHF treatment based on clinical manifestations, etiology, and ejection fraction. Diuretics were the most commonly used medication across all categories. Patients with acute decompensated heart failure (ADHF) and acute pulmonary edema primarily received diuretics and vasodilators, while inotropes were administered for isolated left ventricular failure. Patients with cardiogenic shock were treated with vasopressors and inotropes. Treatment patterns highlighted the tailored use of additional therapies, including vasodilators and vasopressors, according to specific clinical presentations and ejection fraction profiles. Conclusion: All medications administered to AHF patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2023 adhered to existing guidelines.
Co-Authors Alanna Sari Pratikto Amelia Arindanie Annisa Trissatharra Anudya Kartika Ratri Anudya Kartika Ratri Arifta Devi Anggraeni Budi Susetio Pikir Budi Susetyo Pikir Budi Wicaksono Dian Paramita Kartikasari Dibya Arfianda Eka Prasetya Budi Mulia Fita Triastuti Hanestya Oky Hermawan Hanestya Oky Hermawan Hermina Novida, Hermina Indriastuti, Endah Ivana Purnama Dewi Jusak Nugraha Khanisyah Erza Gumilar Meity Ardiana Mohammad Satya Bhisma Nadhifa Ainur Rohmah Primasitha Maharany Harsoyo Putri Rachmawati Dewi Ravell Hansen Untono Rejeki, Purwo Sri Rizka Amalia Rurus Suryawan Shafiero Muhammad Elsya Putera Sony Wibisono Sony Wibisono Sundari Indah Wiyasihati Suryawan, I Gde Rurus Ula Nur Pramesti Karman Veithzal Rivai Zainal Yetti Hernaningsih Yulia Nadar Indrasari