Article Per Year (5 Year)
p-Index From 2021 - 2026
2.083
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Bandung Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Paediatrica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Acta Biochimica Indonesiana MEDICINUS JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Yuditiya Purwosunu
Department Of Obstetric And Gynecology Faculty Of Medicine, Universitas Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
Management of a Giant Ovarian Mucinous Cyst in Late Pregnancy: A Combined Surgical Approach Arya Ady Nugroho; Yuditiya Purwosunu
MEDICINUS Vol. 39 No. 6 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/m47k9074

Abstract

Background: Adnexal masses complicating pregnancy are relatively rare, with an incidence of 1–5% of all pregnancies. Most are benign and may regress spontaneously; however, large or persistent cysts require careful management because of risks such as torsion, rupture, obstruction of labor, and malignancy. Ovarian mucinous cystadenomas are particularlyuncommon but may grow to giant sizes, causing maternal discomfort and fetal complications, including malpresentation. The optimal timing and mode of surgery depend on gestational age and tumor characteristics. In late pregnancy, concurrent cesarean section and adnexal surgery is considered safe and effective, minimizing the need for repeated laparotomy. Case presentation: We report a 30-year-old gravida 3, para 1, abortus 1 woman at 38 weeks of gestation with a giant right ovarian cyst suspected to be mucinous cystadenoma. The patient presented with a transverse fetal lie without acute complications. Ultrasonography demonstrated a multilocular homogeneous cyst extending to the xiphoidprocess without solid components, classified as O-RADS 3, with a risk of malignancy index (RMI) 39. Tumor markers levels were within benign ranges. At term, the patient underwent spinal anesthesia and Pfannenstiel laparotomy during cesarean section. A healthy male infant weighing 2,720 g was delivered, with Apgar scores of 8 and 9 at 1 and 5 minutes respectively. Right salpingo-oophorectomy was also performed. The estimated blood loss was 600 ml, urine output was 300 ml, with uneventful postoperative recovery. The contralateral adnexa were normal. Conclusions: This case highlightsthe challenges of managing a giant ovarian mucinous cyst during pregnancy. Concurrent cesarean section and salpingooophorectomyat term provided an optimal approach, to ensure maternal and neonatal safety while preventing recurrence risk. Multidisciplinary planning and individualized surgical decisions making remain essential for achieving favorable outcomes in such complex cases.
Expression and correlation of endoglin, sEndoglin, and MMP-14 on preeclampsia placenta Febriana Catur Iswanti; Ninik Mudjihartini; Reni Paramita; Yuditiya Purwosunu; Ani Retno Prijanti
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.179

Abstract

Background: Hypertensive disorders, particularly preeclampsia, are major contributors to maternal mortality and neonatal morbidity. Angiogenic imbalance plays a critical role in placental ischemia, a hallmark of preeclampsia. Purpose: This study aimed to investigate the roles of endoglin, soluble endoglin (sEndoglin), and matrix metalloproteinase-14 (MMP-14) in the angiogenic imbalance observed in preeclampsia placentas compared to normal-term placentas. Method: A cross-sectional study was conducted using 68 placental samples: 34 from normal-term pregnancies and 34 from preeclampsia cases. Concentrations of endoglin, sEndoglin, and MMP-14 were measured using the sandwich ELISA method, and protein levels were determined using the Christian Warburg method. Data were analyzed using SPSS version 20. Results: The concentration of endoglin in preeclampsia placentas was slightly higher (1.37 [0.2–2.2] ng/μg protein) compared to normal placentas (1.12 [0.6–14.1] ng/μg protein), although the difference was not statistically significant. In contrast, sEndoglin (0.05 [0.0–0.01] ng/μg protein vs. 0.02 [0.0–0.3] ng/μg protein) and MMP-14 (0.14 [0.1–0.6] ng/μg protein vs. 0.11 [0.1–1.3] ng/μg protein) concentrations were significantly higher in preeclampsia placentas compared to normal placentas. All parameters showed a gradual decrease with advancing gestational age. sEndoglin and MMP-14 demonstrated a strong positive correlation (r = 0.658, p < 0.001), while endoglin and MMP-14 exhibited a moderate positive correlation (r = 0.554, p < 0.001). Conclusion: Endoglin, sEndoglin, and MMP-14 were differentially expressed in preeclampsia placentas, with sEndoglin and MMP-14 significantly elevated. These findings highlight their potential role in angiogenic imbalance and may provide insight into the pathophysiology of preeclampsia.
Placental Vitamin D, Oxidative Stress, and Senescence Markers in Spontaneous Preterm Birth: A Comparative Cross-Sectional Study Yudianto Budi Saroyo; Noroyono Wibowo; Damar Prasmusinto; Yuditiya Purwosunu; Rima Irwinda; Mohammad Adya Firmansha Dilmy; Atikah Sayogo Putri; Arya Ivan Mahendra; Lysandra Olivia Prasanti Putri
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2928

Abstract

AbstractObjective: To evaluate the associations between vitamin D metabolism markers and biomarkers of oxidative stress and placental senescence among women with spontaneous preterm labor compared with those with term labor. Methods: We conducted a comparative cross-sectional study between 2017 and 2019 in two hospitals in Jakarta, Indonesia. Maternal serum and placental samples were collected from women with term labor and spontaneous preterm labor. Markers of the vitamin D pathway 25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D? (1,25[OH]?D?), vitamin D receptor (VDR), and CYP27B1 along with oxidative stress (8-hydroxy-2--deoxyguanosine [8-OHdG]) and placental senescence markers (GLB1 and HMGB), were measured using ELISA, LC–MS/MS, and ICP–MS. Between-group comparisons were performed using parametric or nonparametric tests, as appropriate, and correlations were assessed using Pearson’s or Spearman’s correlation coefficients. Results: A total of 67 women were included (term labor, n = 34; spontaneous preterm labor, n = 33), and both groups were vitamin D deficient. Placental 1,25(OH)?D? levels were significantly lower in the preterm group than in the term group (4.58 ± 2.90 vs 5.57 ± 3.50 pg/ng, p = 0.037). Placental VDR levels also differed significantly between groups {21.70 (6.06–73.40) vs 16.48 (1.87–74.67), p = 0.041}. Across all participants, 8-OHdG and placental senescence markers were negatively correlated with placental 25(OH)D and 1,25(OH)?D? levels and positively correlated with placental CYP27B1 and VDR expression. Conclusion: In this comparative cross-sectional cohort, placental vitamin D metabolites were associated with lower levels of oxidative stress and placental senescence biomarkers, whereas VDR and CYP27B1 showed positive associations with these biomarkers. These patterns may reflect compensatory regulatory mechanisms in the context of maternal vitamin D deficiency. These findings are hypothesis-generating and warrant confirmation in prospective studies and mechanistic investigations. Keywords: oxidative stress, placental senescence, spontaneous preterm labor, vitamin D.
Co-Authors Agus Firmansyah Anggia Widyasari Ani Retno Prijanti Arya Ady Nugroho Arya Ivan Mahendra Atikah Sayogo Putri Budiman, Jenica Xaviera Damar Prasmusinto Dilmy, Mohammad Adya Firmansha Elfikri Asril Fahmi Rusnanta Fairuz, Vycka Fikriyani Febriana Catur Iswanti Fita Maulina Fita Maulina Irene Sinta Febriana Islamah, Rachelya Nurfirdausi Lysandra Olivia Prasanti Putri Munasir, Zakiudin Ninik Mudjihartini Noroyono Wibowo Nunki Febriastuti Nurida M. Siagian Putri Maharani Tristanita Marsubrin Putri, Ruth Widhiati Raharjo Reni Paramita Rima Irwinda Rinawati Rohsiswatmo Rumondang, Amanda Salsabila Putri, Cut Tisya Sandhy Prayudhana Saroyo, Yudianto Budi Susie Susilawati Tetty Yuniati Yudi B. Saroyo