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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dental Journal (Majalah Kedokteran Gigi) Journal of Case Reports in Dental Medicine MDJ (Makassar Dental Journal) Indonesian Journal of Dental Medicine Denta: Jurnal Kedokteran Gigi Odonto dental journal

Hening Tuti Hendarti

Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Airlangga, Surabaya, Jawa Timur

Author-ID : 3197037

Dentistry Health Professions Medicine & Pharmacology

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Reccurent trauma-induced aphthous stomatitis in adjustment disorder patients Y. Yuliana; Saka Winias; Hening Tuti Hendarti; Bagus Soebadi
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 3 (2019): September 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p163-167

Background: Adjustment disorder is a temporary psychological condition related to emotional responses or behaviour in reaction to stress resulting from certain changes in a specific period of an individual’s life yet which does not significantly affect his/her daily life. Recurrent aphthous stomatitis (RAS) constitutes recurrent inflammation of the oral mucosa, in the form of an ulcer, frequently associated with psychological stress. Occasionally, a patient does not realise that she/he is suffering from a psychological disorder until the emergence of clinical symptoms, among them recurrent ulcers the causes of which are unknown. Purpose: This article presents a case of adjustment disorder diagnosed from symptoms observable in the oral cavity. Case: The case involved a 21-year-old student who presented with the symptoms of large, painful ulcers on her tongue, the inside of her cheek, and the floor of her mouth. These symptoms had been observable for one month but remained untreated. The patient only ate once a day or even once every two days. An introverted personality, she did not associate with other people. Case management: The procedure covered anamnesis, clinical examination, blood laboratory tests, total immunoglobulin E (IgE), an Antinuclear Antibody (ANA) test, bacterial and fungal culture in ulcus, questionnaire screening on psychological disorders, cortisol level examination and referral to a psychiatrist. Symptomatic therapy administered to the patient led to recovery of the ulcer in 29 days. Conclusion: RAS can be triggered by psychological stress which induces changes in the immune system and oral mucosa tissue.

Stomatitis aftosa yang diperparah oleh iritasi kimiawi obat tradisional Ayu Fresno Argadianti; Yuliana Yuliana; Hening Tuti Hendarti; Desiana Radithia
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.53046

Stomatitis aftosa adalah suatu kondisi inflamasi dengan etiologi yang belum diketahui, ditandai dengan ulserasi sangat nyeri di mukosa rongga mulut selama 7 hingga 14 hari. Berbagai faktor berpengaruh dalam pembentukannya, salah satunya adalah trauma lokal. Perawatan diberikan untuk meredakan nyeri, mengeliminasi sumber trauma, dan penyembuhan ulserasi. Tujuan laporan kasus ini adalah untuk melaporkan stomatitis aftosa yang diperparah oleh iritasi kimiawi obat tradisional. Seorang laki-laki berusia 64 tahun mengeluh sariawan pada gusi kiri bawah terasa nyeri sejak kurang lebih 1 minggu yang lalu. Pasien mengoleskan suatu obat cair tradisional untuk meredakan rasa nyeri tapi kemudian rasa nyeri timbul kembali dan belum mereda. Tanda vital normal kecuali skor VAS (visual analog scale) nyeri mulut 6/10. Pemeriksaan ekstra oral normal, pemeriksaan intra oral didapatkan ulkus soliter berukuran 1x1,5 cm pada lipatan bukal regio 34, 35 dengan peninggian tanpa indurasi dan nyeri. Tata laksana meliputi anamnesis untuk mengetahui faktor yang memperparah, pemeriksaan klinis, debridement lesi untuk menghilangkan jaringan nekrotik dan aplikasi obat topikal gel mengandung klorin dioksida. Pasien diinstruksikan untuk berhenti mengoleskan obat tradisionalnya dan menggunakan obat yang diresepkan. Lesi sembuh dalam waktu 13 hari. Stomatitis aftosa dapat diperparah oleh iritasi kimiawi. Anamnesis, pemeriksaan klinis, debridement lesi dan pemberian obat yang tepat dapat membantu tata laksana dan penyembuhan yang efektif.

Kandidiasis oral sebagai penanda infeksi HIV/AIDS: laporan kasus Oral candidiasis as a warning sign of HIV/AIDS infection: case report Nur Asmi Usman; Neken Prasetyaningtyas; Adiastuti Endah P.; Hening Tuti Hendarti; Bagus Soebadi
Makassar Dental Journal Vol. 6 No. 2 (2017): Vol 6 No 2 Agustus 2017
Publisher : Makassar Dental Journal PDGI Makassar

Latar belakang: Kandidiasis oral merupakan infeksi oportunistik yang sering ditemukan pada penderita yang terinfeksi human immunodeficiency virus (HIV) atau acquired immune deficiency syndrome (AIDS) ditandai dengan adanya penurunan jumlah CD4 + . Tujuan: Melaporkan kandidiasis oral pada pasien yang terinfeksi HIV/ AIDS. Kasus: Pasien wanita 40 tahun mengeluh langit-langit dan lidahnya terasa panas dan sakit sejak 3 bulan lalu. Gambaran klinis menunjukkan pseudomembran putih dapat dikerok, daerah sekitar kemerahan pada palatum kanan dan lidah, nodul multipel warna kemerahan pada palatum kanan dan kiri. Pemeriksaan jamur menunjukkan bentukan yeast dan pseudohifa. Pemeriksaan darah lengkap menunjukkan penurunan jumlah limfosit. Kandidiasis oral yang meluas ke orofaring disertai penurunan jumlah limfosit menimbulkan kecurigaan adanya infeksi HIV/AIDS sehingga dilakukan pemeriksaan CD4 + dan anti HIV. Hasil uji laboratorium menunjukkan jumlah CD4 + = 95 sel/mL, dan anti HIV reaktif. Pasien kemudian dirujuk ke Unit Perawatan Intermediate Penyakit Infeksi (UPIPI) RSUD Dr Soetomo untuk mendapatkan perawatan dengan anti retroviral (ARV). Kandidiasis oral dirawat menggunakan obat antijamur sistemik golongan azole. Simpulan: Kandidiasis oral yang telah diderita pada pasien dewasa muda dalam jangka waktu lama, sulit disembuhkan dan melibatkan daerah orofaring dapat menjadi penanda adanya infeksi HIV/AIDS.

Kebiasaan merokok dan konsumsi alkohol pada pasien dengan diagnosis oral lichen planus: Laporan kasus: Smoking habits and alcohol consumption in patients diagnosed with oral lichen planus: Case report Dian Angriany; Meilia Aquina; Hening Tuti Hendarti; Bagus Soebadi
Makassar Dental Journal Vol. 8 No. 1 (2019): Volume 8 No 1 April 2019
Publisher : Makassar Dental Journal PDGI Makassar

Pendahuluan: Oral lichen planus (OLP) merupakan suatu penyakit inflamasi kronis yang dimediasi oleh sel T sitotoksik CD8 + pada rongga mulut. Daerah yang sering terkena adalah mukosa bukal. Salah satu faktor predisposisi terjadinya OLP adalah merokok dan konsumsi alkohol. Penggunaan kortikosteroid secara topikal merupakan pilihan dalam pengobatan lichen planus, karena efek memodulasi inflamasi dan respon imunologi yang dapat mengendalikan lichen planus. Kasus: Pasien laki-laki usia 24 tahun mengeluhkan sariawan pada mukosa bukal kanan dan kiri yang muncul kembali setelah sembuh + 3 tahun yang lalu. Terdapat riwayat merokok sejak 7 tahun yang lalu dan konsumsi alkohol sejak 6 tahun yang lalu. Diskusi: Biopsi untuk pemeriksaan histopatologi dilakukan untuk menegakkan diagnosis klinis, utamanya untuk mengecualikan atipia epitel dan tanda-tanda keganasan. Simpulan: Diagnosis OLP dilakukan melalui anamnesis, pemeriksaan klinis dan penelitian. Kolaborasi multidisiplin juga dibutuhkan pada saat perawatan dan diagnosis OLP.

Multidisciplinary Management of Recurrent Aphthous Stomatitis Triggered by Severe Depression Nur Tsurayya Priambodo; Hening Tuti Hendarti; Azimatul Kharimah
Denta Journal Kedokteran Gigi Vol 15 No 1 (2021): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v15i1.6

Background: Recurrent Aphthous Stomatitis (RAS) is an inflammation of the oral mucosa in the form of a single or more ulcer that occurs repeatedly. One of the predisposing factors that contribute to the onset of RAS is depression. Depression is a mood that is not happy or sadness that is experienced as part of the pattern of life. Objective: Discuss multidisciplinary management in cases of 65-year-old women with large multiple ulcers with depression-triggering factors. Case: Women aged 65 years complained of recurrent canker sores. The frequency of RAS increased by 10 years due to economic and household problems. It has been treated with topical non-steroidal anti-inflammatory drugs but does not heal. Does not have a history of systemic diseases. Case Management: Do investigations are complete peripheral blood examination, Depression Anxiety Stress Scale (DASS), Refer patients to the psychiatric specialist. Multidisciplinary treatment is performed by a psychiatric specialist. Treatment of oral mucosa with topical anti-inflammatory steroid drugs. Conclusions: in accordance with the treatment that has been given, this case has recovered after day 14. So it can be concluded that proper multidisciplinary management and elimination of triggering factors are the main roles to prevent recurrence and reduce the frequency of recurrent aphthous stomatitis.

CORRELATION OF Ki67 EXPRESSION TO DEGREE OF DYSPLASIA IN LINGUAL EPITHELIAL DYSPLASIA IN Rattus norvegicus EXPOSURED BY CIGARETTE SMOKE (Hubungan Ekspresi Ki67 Terhadap Derajat Displasia Pada Epitel Mukosa Lidah Rattus norvegicus yang Dipapar Asap Rokok) Rina Kartika Sari; Hening Tuti Hendarti; Bagus Soebadi; Priyo Hadi; Desiana Radithia; Adiastuti Endah P
Odonto : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Dysplasia is malignant transformation of stratified squamous epithelium characterized by cellular atypia and loss of stratification and maturation. It can caused by cigarette smoke. Measuring the activity of cell proliferation as the beginning of dysplasia is very useful to know the development of malignancy. One of proliferation marker is Ki67 that expressed in all cell cycle phase except G0.Methods: 30 male wistar rats divided into: control grup (n=10), exposed to cigarette smoke for 4 weeks (n=10), 8 weeks (n=10) as much as 20 cigarettes/group/day/exposure used smoking pump. Specimen were stained HE to see dysplasia and Ki67 expression seen immunohistochemically. Statistical analyzed by Spearman correlation.Result: There was an increase in mean of Ki67 expression and significant differences between groups (p=0,000) and also significant difference of degree of dysplasia between groups (p=0,000). There was a strong correlation between Ki67 score to degree of dysplasia (p=0.001).Conclusion: Increased of Ki67 expression proportional to the Increase in degrees of dysplasia

TATALAKSANA STOMATITIS ALERGICA PADA PENDERITA YANG MENGALAMI STRESS (Management of Allergic Stomatitisin Patient with Stress) Raziv Ganesha; Diah Savitri E; Hening Tuti Hendarti
Odonto : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Introduction: Allergic stomatitisis ahypersensitivity reaction caused by allergens, such as drugs, food, and dental materials. Manifestation allergic reaction to food in oral cavity can be recurrent ulcer. Purpose: This case report pupose to report management allergic stomatitis in Stress condition.Case: female was a 44-year-old with complaintmany stomatitis in oral cavity. Patients say often since ± 6 years ago without knowing the cause. Stomatitis often moving location but also in the same site. On intra oral examination found ulcer multiple, variant size, irregular shape, paintfull.Management: the patient performed examination of total IgE with a result of 642.98 (normal<150), skin prick test in patients results positive on dust house, dog hair, cotton, beef, cow's milk, chicken egg yolk, shrimp, milkfish, pindang, chocolate, and peanuts.Patients given aloe vera extract oral rinse at the first visit, then after skin prick test was given methylprednisolone, hepaprotector caplet, multivitamin B-Complex plus Zinc. Patients are also given education and instruction to avoid a food become allergic. Conclusion: Allergic Stomatitis diagnosis requires a complete history and supportive examination. In this case, the treatment requires good cooperation between the patient and the dentist so that treatment can be done thoroughly.

Managementof squamos cell carcinoma of tongue in young men: case report Israyani, Israyani; Argadianti, Ayu F.; Hendarti, Hening Tuti; P, Adiastuti E.
Journal of Case Reports in Dental Medicine Vol 1, No 1 (2019)
Publisher : Hasanuddin University

Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap

White sponge nevus as a hereditary disease: A brief narrative review Mahdani, Fatma Yasmin; Puspasari, Karlina; Manuaba, Ida Bagus Pramana Putra; Putri, Salsabila Fitriana; Ayunnisa, Naqiya; Ernawati, Diah Savitri; Hendarti, Hening Tuti
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.49-52

Background: White sponge nevus (WSN) is an autosomal dominant hereditary genetic disorder characterized by thickened keratin in the oral mucosa that appears folded, wavy, spongy, thick, and rough. WSN do not have the potential to become malignant, but an accurate diagnosis is still needed to prevent unnecessary treatment and reduce potential remissions and exacerbations due to infection. Purpose: to provide a detailed description of white sponge nevus as a hereditary disease by means of narrative review. Review: A literature search using ScienceDirect and PubMed yielded results between 2012 and 2024. The keywords of the search strategy were “hereditary disease” and “white sponge nevus” or “Cannon’s disease” or “white folded gingivostomatitis” or “leukokeratosis.”. White sponge nevus (WSN) was first discovered by Hyde in 1909 and usually occurs in children and people under 20 years old. The main etiology of WSN is an autosomal dominant hereditary genetic disorder; KRT4 and KRT13 are specific keratin encoders that cause WSN, and there are predisposing factors such as bacterial infection, smoking, and alcohol consumption. Conclusion: In determining the diagnosis of WSN, it is necessary to carry out blood tests, subjective examinations, objective examinations, and supporting examinations in the form of exfoliative cytology and biopsies. As well as the need for comprehensive treatment, even though the prognosis of this disorder is good.

Effect of freeze-dried platelet-rich plasma on FGF-2 and type I collagen expression in traumatic ulcers of diabetes mellitus: An in vivo study Riskayanti, Ni Putu; Radithia, Desiana; Maharani, Annissaqiella; Hendarti, Hening Tuti; Rahayu, Retno Pudji; Surboyo, Meircurius Dwi Condro; Ernawati, Diah Savitri
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p361-366

Background: Diabetes mellitus is a chronic disease characterized by the pancreas’s inadequate production of insulin or the body’s impaired utilization of insulin, resulting in dysregulation of blood sugar levels. Diabetes mellitus causes prolonged wound healing due to decreased growth factors, including fibroblast growth factor 2 (FGF-2) and type I collagen. Purpose: This research analyzes the effect of topical administration of freeze-dried platelet-rich plasma (FD-PRP) on the healing process of traumatic ulcers in diabetic Wistar rats by increasing FGF-2 and type I collagen expression. Methods: Allogenic FD-PRP was obtained from the blood of 35 Wistar rats and 2% carboxymethyl cellulose (CMC) was added to make a gel formulation. Diabetes was induced in 30 Wistar rats using streptozotocin, followed by the creation of traumatic ulcers on the lower labial mucosa using a hot burnisher. The traumatic ulcers were then topically treated with FD-PRP gel in the treatment group and 2% CMC gel in the control group. Analysis of FGF-2 and type I collagen expression was performed through indirect immunohistochemical methods following treatment for 3, 5, and 7 days. Results: The expression of FGF-2 and type I collagen in the FD-PRP was higher than in the control group (p < 0.05). Conclusion: Topical application of FD-PRP plays an important role, especially in increasing the FGF-2 and type 1 collagen expression, in the healing process of traumatic ulcers in diabetic Wistar rats.

Co-Authors Adiastuti Endah P Adiastuti Endah P. Adiastuti Endah Parmadiati Adiastuti Endah Permadiati Argadianti, Ayu F. Ayu Fresno Argadianti Ayunnisa, Naqiya Azimatul Kharimah Bagus Soebadi Bagus Soebadi Bagus Soebadi Bagus Soebadi Desiana Radithia, Desiana Diah Savitri E Diah Savitri Ernawati Dian Angriany Dian Angriany Dorisna Prijaryanti Erawati, Satrya Ayu Erawati, Satrya Ayu Fatma Yasmin Mahdani Grahania Octaviono Mahardika Hendri Susanto Israyani, Israyani Iwan Hernawan Maharani Laillyza Apriasari Maharani, Annissaqiella Manuaba, Ida Bagus Pramana Putra Meilia Aquina Neken Prasetyaningtyas Nur Asmi Usman Nur Tsurayya Priambodo Nurhilailah Nurhilailah Nurina Febriyanti Ayuningtyas P, Adiastuti E. Priyo Hadi Priyo Hadi Puspasari, Karlina Putri, Salsabila Fitriana Raziv Ganesha Retno Pudji Rahayu Rina Kartika Sari Rina Prabajati Riskayanti, Ni Putu Rosnah Binti Zain Saka Winias Selviana Tampoma, Selviana Surboyo, Meircurius Dwi Condro Tampoma, Selviana Y. Yuliana Yuliana Yuliana

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