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All Journal Dentika Dental Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Prima Abdika: Jurnal Pengabdian Masyarakat INDONESIAN JOURNAL OF MEDICAL ANTHROPOLOGY The Journal of Society Medicine (JSOCMED)
Ervina Sofyanti
Faculty Of Dentistry, Universitas Sumatera Utara, Medan
Agriculture, Biological Sciences & Forestry Arts Humanities Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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The Role of PAX9 and MSX1 Variants in Non-Syndromic Tooth Agenesis Finna; Ameta Primasari; Sry Suryani Widjaja; Thantrira Porntaveetus; Ervina Sofyanti
Dentika: Dental Journal Vol. 28 No. 2 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i2.20787

Abstract

Non-syndromic tooth agenesis (NSTA) is the congenital absence of teeth without systemic involvement. Genetic polymorphisms in PAX9 and MSX1 are implicated in tooth development, but results vary across populations. Therefore, this study aims to explore the role of PAX9 c.-1031G>A and MSX1 671 T>C polymorphisms with NSTA in individuals from Medan. A total of 13 NSTA patients and 26 control were genotyped using PCR-restriction fragment length polymorphism (PCR-RFLP). The results showed that the AA genotype of PAX9 was absent in NSTA cases but found in 26.92% of controls. The GG genotype was reported to be more common in 38.46% of cases, while the G allele was prevalent in 69.23%. These trends suggested a potential association, but it was not statistically significant. In this study, all patients carried the TT genotype for MSX1. These results show a possible role of PAX9 polymorphisms in NSTA susceptibility and support the need for further studies in larger populations.   Keywords: Non-Syndromic, Tooth Agenesis, PAX9, MSX1
Co-Authors Ameta Primasari Ananto Ali Alhasyimi Ance Marintan D. Sitohang Arifa , Silvia Bina Melvia Girsang Chen Kit Fong Chen Kit Fong Darmayanti Siregar Dewi Kartika Endah Mardiati, Endah Eqlima Elfira Faradilla Farmasyanti, Cendrawasih Andusyana Febe Gracewitha Tampubolon Finna Gio, Prana Ugiana Gunadi, Wachjudi R Haryono Utomo Hery Widijanto Ida Bagus Narmada Ika Astrina Indra Jesslyn Okto Govanny Kirubanandan Sathya Moorthy Kwan Min Fook Lisna FN Manurung, Prans Samuel Antony Maria Novita Helen Sitanggang Maria Purbiati Marya, Anand Michael Dany Narmada , Ida Bagus Rachmawati, Aditya Regoo, Vinoshinie Sitanggang, Maria Novita Helen Siti Bahirrah Sitorus, Marshall Gregory Sutan, Christinawaty Syafruddin Ilyas Tambunan, Mirna Rory Yohanita Thantrira Porntaveetus Trelia Boel, Trelia Veronica Angelia Widjaja, Sry Suryani Yusuf , Muslim