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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Tumbuhan Obat Indonesia Jurnal Teknologi Informasi dan Ilmu Komputer JUITA : Jurnal Informatika Mutiara Medika: Jurnal Kedokteran dan Kesehatan Universa Medicina JSFK (Jurnal Sains Farmasi & Klinis) Molekul: Jurnal Ilmiah Kimia Journal of Electronics, Electromedical Engineering, and Medical Informatics Indonesian Journal of Electrical Engineering and Computer Science Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat
Isnatin Miladiyah
Departemen Farmakologi, Fakultas Kedokteran, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Universa Medicina

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Protective effects of Cyclea barbata Miers leaves against aspirin-induced gastric ulcer in mice Siregar, Iskandar Muda; Miladiyah, Isnatin
Universa Medicina Vol 30, No 2 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.88-94

Abstract

One side effect of non-steroidal anti-inflammatory drugs is gastric mucosal irritation, possibly causing gastric ulcers. The aim of this study was to evaluate the protective effect of cincau leaves (Cyclea barbata Miers) on aspirin-induced gastric ulcer in Balb/c mice. Twenty five Balb/c mice (20-30 g, 2-3 months old) were randomly divided into 5 groups. Group I-III were given cincau leave infusion at dosages of 2.5 mg/kg BW, 5 mg/kg BW, and 10 mg/kg BW, respectively, while group IV (positive control) received antacid at a dosage of 20 mg/kg BW, and group V (negative control) one milliliter of distilled water. All interventions were given by the oral route, once daily for seven days. On day 7, the mice were given aspirin (600 mg/kg BW) to induce gastric ulcer. After 30 minutes, all mice were sacrified, and their stomachs examined macroscopically for gastric ulcer, characterized by the presence of ulcer(s) and bleeding. Total ulcer scores were analyzed by one-way Anova to compare between-group protective effect of interventions against aspirin-induced gastric ulcer. Results showed that groups treated with cincau leaf infusion at all dosages experienced a gastric ulcer protective effect. There were significant differences (p=0.002) between treatments, compared to the negative control, but no significant differences (p>0.05) when compared to the positive control. Thus cincau leaves (Cyclea barbata Miers) at dosages of 2.5 mg/kg BW, 5 mg/kg BW, and 10 mg/kg BW, had a protective effect against aspirin-induced gastric ulcer in mice. Higher dosages of cincau leaf infusion have a correspondingly higher gastric ulcer protective power.
Analgesic activity of ethanolic extract of Manihot esculenta Crantz leaves in mice Miladiyah, Isnatin
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.3-10

Abstract

Cassava (Manihot esculenta Crantz) leaves have long been used as a vegetable in many countries and empirically as a febrifuge. The aim of the present study was to evaluate the analgesic activity of an ethanolic extract of cassava leaves in mice. Thirty Balb/c mice (20-30 g, 2-3 months old) were randomly divided into 6 groups. Group I was given distilled water 1 mL as negative control, group II paracetamol 65 mg/kgBW as positive control, and group III-VI received an ethanolic extract of cassava leaves in 4 doses, i.e. 12.8 mg/kgBW, 25.6 mg/kgBW, 51.3 mg/kgBW, and 102.6 mg/kgBW, respectively. All interventions were administered as a single dose by oral route on a given day. Acetic acid 0.6% (w/v) was used as a pain inductor. Analgesic activity was measured by counting the percentage of writhing movements as a measure of the analgesic effect  produced by each intervention. Data were analyzed with one-way Anova to compare analgesic activity between treatment groups. The results showed that groups treated with ethanolic extract of cassava leaves at dosages of 12.8 mg/kgBW, 25.6 mg/kgBW, 51.3 mg/kgBW, and 102.6 mg/kgBW had an analgesic activity of 59.2%; 73.9%; 62.1%; and 55.9%, respectively. On statistical analysis there were significant differences (p=0.00) between these treatments compared to the negative control, but no significant differences (p>0.05) with the positive control (paracetamol). It may be concluded that the analgesic effect of an ethanolic extract of cassava (Manihot esculenta Crantz) leaves in mice was of similar potency as paracetamol.
Ethanolic extract of Anredera cordifolia (Ten.) Steenis leaves improved wound healing in guinea pigs Isnatin Miladiyah; Bayu Rizky Prabowo
Universa Medicina Vol. 31 No. 1 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.4-11

Abstract

BACKGROUNDWound healing is a normal biological process in response to skin injury. Anredera cordifolia (Ten.) Steenis is used  traditionally to treat various diseases, including skin disease, hypertension, inflammation and gout. The aim of this study was to evaluate the wound healing activity of the leaves of binahong or Anredera cordifolia (Ten.) Steenis in guinea pigs. Methods Thirty guinea pigs (1.5-2 kg, 3-4 months old) were randomly divided into 5 groups. Group I was given distilled water (negative control), group II was treated with povidone iodine 10% (positive control), while groups III-V were treated with ethanolic extract of binahong leaves at concentrations of 10%, 20%, and 40%, respectively. Before treatment, a 2 cm long excision wound was made on each animal. All interventions were given by the topical route, twice daily for 15 days. At the end of 15th day, the wound lengths in each group were measured and compared to baseline wound lengths. Data were analyzed with one-way Anova to compare wound healing activity between groups. ResultsThis study showed that groups treated with ethanolic extract of binahong leaves at concentrations of 20% and 40% experienced better wound healing activity than negative and positive controls. There were significant differences (p=0.000) between treatments and negative and positive controls. ConclusionsThis research has succesfully show significance of the Binahong leaf extract has a potential for wound healing in guinea pig.
Co-Authors AGUS RIYANTO Agustina T Alvin Sahroni Aminuyati Annisa Fitria Annisa Fitria Anora, Levina Arnetta Novitalia Bayu Rizky Prabowo Eka Yuliana Farida Juliantina Rachmawaty Fitriani, Hannie Hanafi, Mhd. Hannie Fitriani Hendra Setiawan Iqmal Tahir Irfan Jaen Fathani Iskandar Muda Siregar, Iskandar Muda Jumina Jumina Nurhayati Nurhayati Nuryadi, Satyo Prasetyo, Dono Catur Rahmawati, Riana Sisdarmanto Adinandra, Sisdarmanto Sofia Mubarika Haryana Sofyan, Pramudya Rakhmadyansyah Sri Kusumadewi Syafitri, Indah Trunogati, Pranandito Wiryatun Lestariana, Wiryatun Yandi Syukri