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Pengaruh Pemberian Ekstrak Pare(Momordica Charantia,L)Terhadap Struktur Histologi Testis dan Epididimis Tikus Jantan (Rattus Norvegicus) Spraque DawleyÂ® Siti Cholifah; Arsyad Arsyad; Salni Salni
Majalah Kedokteran Sriwijaya Vol 46, No 2 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i2.2697

Senyawa aktif yang terdapat dalam pare yaitu kukurbitasin yang termasuk golongan glikosida tripenoid diduga bekerja menghambat perkembangan sel spermatogenik melalui efek sitotosikÂ dan melalui efek hormonal.Tujuan Penelitian untuk mengukur dan menganalisis berat serta struktur histologis testis dan epididimis tikus jantan(Rattus Novergicus) Sprague DawleyÂ® akibat pemberian ekstrak pare (Momordica charantia, L). Penelitian ini dilaksanankan pada bulan Maret sampai Agustus tahun 2013 di Laboratorium Bersama PPSUnsri dan membuat preparat histopatologi di laboratorium Patologi Anatomi Rumah Sakit RK. Charitas Â Palembang sementara untuk hasil pengamatannya dilakukan di Bagian Biologi Kedokteran Universitas Sriwijaya.Rancangan penelitian yang dipakai adalah Random Alokasi Desain, menggunakan 24 ekor tikus jantan yang dibagi menjadi 4 kelompok perlakuan yang masing-masing kelompok terdiri atas 6 tikus jantan. Setiap kelompok diberi perlakuan ekstrak Pare 15mg/100gBB, 25mg/100gBB, 50mg/100gBB dan utk kelompok kontrol diberi saline fisiologis, pemberian dilakukan dengan cara sonde oral. Hasil penelitian menunjukkan adanya penurunan rata-rata berat testis dan epididimis, penurunan rata-rata diameter tubulus seminiferus, penurunan rata-rata tebalÂ epitel germinal tubulus seminiferus serta penipisan ketebalan epitel epididimis antara kelompok kontrol dengan kelompok yang diberi ekstrak pare. Tebal epitel germinal tubulus seminiferus pada hasil uji pos hoct tes antara kelompok kontrol dan kelompok perlakuan sama-sama sebesar 0,000 artinya ada perbedaan yang sangat signifikan tebal epitel germinal tubulus seminiferus antara kelompok kontrol dan kelompok perlakuan. Begitupun pada tebal epitel epididimis, pada hasil uji pos hoct test didapatkan nilai p 0,000. Hal ini menunjukkan bahwa perlakuan ekstrak pare dapat menurunkan diameter tubuli dan tebal epitel germinal tubulus seminiferus serta tebal epitel epididimis secara bermakna (p= 0,000). Dari hasil penelitian dapat disimpulkan bahwa ekstrak pare dapat menurunkan berat testis, berat epididimis,Â diameter tubulus seminiferus, tebel epitel germinal tubulus seminiferus dan tebal epitel epididimis. Hasil signifikan terlihat pada dosis 25mg/100 gBB dan 50mg/100gBB.

Antibacterial Activity of The Secondary Metabolites Produced by Endophytic Fungi Isolated from Acanthus ilicifolius Plant Gusti Ayu Widayanti; Hary Widjajanti; Salni Salni
Indonesian Journal of Environmental Management and Sustainability Vol. 3 No. 4 (2019): December
Publisher : Research Centre of Inorganic Materials and Complexs

Twelve endophytic fungi were isolated from the Acanthus ilicifolius plant. Two of them have the best antibacterial activity, namely Culvularia lunata and Diaporthe phaseolorum. Fungi can produce secondary metabolites that have the potential as antibacterial compounds. This study aims to isolate antibacterial compounds using column chromatography methods and test the antibacterial activity using diffusion methods to use paper discs. Isolation of secondary metabolites produces 27 eluates. From TLC, it is known that the endophytic fungi Culvularia lunata produce an active compound as an antibacterial that is phenol compound. Endophytic fungi Diaporthe phaseolorum produces three types of active compounds as antibacterial namely phenol, terpenoids, and alkaloids, each component of the active compound are tested for sensitivity to bacterias Escherichia coli, Staphylococcus aureus, Shigella dysenteriae, and Salmonella typhi. MIC values ??of terpenoid compounds with concentrations of 125-250 ppm are antibacterial compounds with good activity against Escherichia coli, Staphylococcus aureus, Shigella dysenteriae, and Salmonella typhi.

Effect Of Pomegranate (Punica granatum L.) Fraction In Reducing Total Blood Cholesterol Levels and Triglyceride in Mice (Mus muscullus L.) Nurlaily Agustini; Arum Setiawan; Salni Salni
Indonesian Journal of Environmental Management and Sustainability Vol. 4 No. 1 (2020): March
Publisher : Research Centre of Inorganic Materials and Complexs

Pomegranate (Punica granatum L.) will be examined by looking at the ability between pomegranate extracts or fractions, which are more effective in lowering total blood cholesterol and triglyceride levels in mice. This study aims to determine the active pomegranate fraction that can reduce the total cholesterol levels and triglyceride in mice. The research method used was an experimental method with a Completely Randomized Design (CRD) which was divided into 6 treatment groups, and test animals divided into 6 treatment groups namely negative control given aquades, positive control fed a high-fat diet, given simvastatin, given 25 mg/grBB of pomegranate methanol fraction, given 50 mg/grBB of pomegranate methanol fraction, given 100 mg/grBB of pomegranate methanol fraction, each treatment group will be divided into 4 male mice.Based on the results of this study that the active fraction that has an effect in reducing blood cholesterol levels and mice triglycerides is the treatment given 100mg/grBB of pomegranate water methanol fraction.

Antifungi Effect of Keghenyat Leaves Fraction (Acmella uliginosa) In Vitro Study Agustina Septi Hijir; Salni Salni; Joko Marwoto; Triwani Triwani; Sri Nita; Mgs Irsan Saleh; Ziske Maritska; Nita Parisa; Evi Lusiana; Nia Savitri Tamzil; Ayeshah Augusta Rosdah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.5

Introduction Candida is a yeast fungus classes most commonly found in the oral cavity, gastrointestinal tract, reproductive tract and skin, especially the species Candida albicans. Alternative medicines such as herbs are easily available and affordable by the community, such as keghenyat leaves (Acmella uliginosa). Aim of StudyTo determine the activity of Keghenyat leaves fraction (Acmella uliginosa) compared to Nystatin against Candida albicans in vitro. MethodsIn vitro study was held in Laboratory of Genetics and Biotechnology Department of Biology, Faculty of Science and Medical Faculty, Sriwijaya University in December 2015 and January 2016. Research stages: extraction, fractionation, sensitivity test using Nystatin and Candida albicans, fractions antifungal activity test, the determination of minimum inhibitory concentration (MIC), bioautografi test and determination of compound classes. One final stages of testing the active fraction Keghenyat leaves (Acmella uliginosa) with Nystatin. Data were analyzed using ANOVA and Post Hoc Duncan test and linear regression using SPSS 20. ResultsHexane faction of Keghenyat leaves (Acmella uliginosa) is active against the fungus Candida albicans, has a Minimum Inhibitory Concentration (MIC) of 0.625% (6250Î¼l) against the fungus Candida albicans antifungal contain active compounds that terpenoids and flavonoids, amounting to 84.68 mg / ml equivalent to 1 mg / ml Nystatin against the fungus Candida albicans. ConclusionThere is a significance different MIC between hexane fraction of Keghenyat leaves (Acmella uliginosa) and Nystatin, Nystatin have more high activity.

The Efficacy of Red Ginger Fraction (Zingiber officinale Roscoe var. rubrum) as Insecticidal Aedes aegypti Chairil Anwar; KM Yahya Syukur; Dalilah Dalilah; Salni Salni; Novrikasari Novrikasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.40

Aedes aegypti is a vector of Dengue Hemoragic Fever. The use of synthetic chemical insecticide is the most common way to control Ae. aegypti. However, since it can cause resistency if it is used in a wide scale with high frequency and continously, it requires an alternative way. Red ginger (Zingiber officinale Roscoe var. rubrum) is one of natural insecticide which is safe to be used to control Ae. aegypti. This research aims was to determine the activity of active fraction of red ginger to mortality of Ae. aegypti. It was a quasi-experiment research with post test only control design. Twenty Ae. aegypti Liverpool strain were the sample of this research with 5 concentration for each and 4 times repetition. The result showed that concentration 0.5%, 1.0%, 1.5%, 2.0% and 2.5% causing mortality percentage of 32.5%, 33.8%, 51.3%, 58.8% and 65.0% respectively. One way Anova test showed p-value < alpha ± (0.00 < 0.05). It was concluded that there was a significant difference of various concentration of active fraction n-heksan of red ginger extract to the mortality of Ae. aegypti. The lethal concentration (LC50) was 2.409%. It was suggested to continue this research with reppellant or bio-assay test method. Key words: Toxicity, extract, fraction, Aedes aegypti, Insecticidal

Aphrodisiac Effects of Areca Fruit in Erectile Dysfunction Rat Model Nita Parisa; Muhammad Totong Kamaluddin; Salni Salni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 3 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i3.90

Abstract. Erectile Dysfunction (ED) cases are quite high in both women and men and increase with age. Areca fruit, ginseng and purwoceng are plants that have been traditionally used to increase male vitality. This in vivo experimental research study with pre and post-test control group design located in the laboratory of animal house and the biomolecular laboratory Faculty of Medicine Sriwijaya University. The subjects of this study were albino rats (Rattus norvegicus), Wistar strains, divided into 6 groups are negative control, Sildenafil, Areca Fruit Extract (AFE) 50 mg/kgBW, AFE 100 mg/kgBW, Combination of Areca Fruit, Ginseng and Purwoceng (AGP) 50 mg/kgBW and AGP 100 mg/kgBW. Female rat was injected by giving 500 mg/100 g of subcutaneous progesterone and 10 Î¼g/100 g of BB benzoate 48 hours before mating so that female mice enter the esterus phase. In this study it was found that Combination of Areca fruit, Ginseng and Purwoceng (AGP) group 50mg/kgBW significantly improved testosterone levels compared to sildenafil, while single areca fruit (AFE) dose 50mg/kgBW increased FSH and LH levels as well as sildenafil statistically. Keywords: areca fruit, erectile dysfunction, FSH, ginseng, LH, purwoceng, testosteron.

Antifungi Effect of Keghenyat Leaves Fraction (Acmella uliginosa) In Vitro Study Agustina Septi Hijir; Salni Salni; Joko Marwoto; Triwani Triwani; Sri Nita; Mgs Irsan Saleh; Ziske Maritska; Nita Parisa; Evi Lusiana; Nia Savitri Tamzil; Ayeshah Augusta Rosdah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.5

Introduction Candida is a yeast fungus classes most commonly found in the oral cavity, gastrointestinal tract, reproductive tract and skin, especially the species Candida albicans. Alternative medicines such as herbs are easily available and affordable by the community, such as keghenyat leaves (Acmella uliginosa). Aim of StudyTo determine the activity of Keghenyat leaves fraction (Acmella uliginosa) compared to Nystatin against Candida albicans in vitro. MethodsIn vitro study was held in Laboratory of Genetics and Biotechnology Department of Biology, Faculty of Science and Medical Faculty, Sriwijaya University in December 2015 and January 2016. Research stages: extraction, fractionation, sensitivity test using Nystatin and Candida albicans, fractions antifungal activity test, the determination of minimum inhibitory concentration (MIC), bioautografi test and determination of compound classes. One final stages of testing the active fraction Keghenyat leaves (Acmella uliginosa) with Nystatin. Data were analyzed using ANOVA and Post Hoc Duncan test and linear regression using SPSS 20. ResultsHexane faction of Keghenyat leaves (Acmella uliginosa) is active against the fungus Candida albicans, has a Minimum Inhibitory Concentration (MIC) of 0.625% (6250Î¼l) against the fungus Candida albicans antifungal contain active compounds that terpenoids and flavonoids, amounting to 84.68 mg / ml equivalent to 1 mg / ml Nystatin against the fungus Candida albicans. ConclusionThere is a significance different MIC between hexane fraction of Keghenyat leaves (Acmella uliginosa) and Nystatin, Nystatin have more high activity.

The Efficacy of Red Ginger Fraction (Zingiber officinale Roscoe var. rubrum) as Insecticidal Aedes aegypti Chairil Anwar; KM Yahya Syukur; Dalilah Dalilah; Salni Salni; Novrikasari Novrikasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.40

Aedes aegypti is a vector of Dengue Hemoragic Fever. The use of synthetic chemical insecticide is the most common way to control Ae. aegypti. However, since it can cause resistency if it is used in a wide scale with high frequency and continously, it requires an alternative way. Red ginger (Zingiber officinale Roscoe var. rubrum) is one of natural insecticide which is safe to be used to control Ae. aegypti. This research aims was to determine the activity of active fraction of red ginger to mortality of Ae. aegypti. It was a quasi-experiment research with post test only control design. Twenty Ae. aegypti Liverpool strain were the sample of this research with 5 concentration for each and 4 times repetition. The result showed that concentration 0.5%, 1.0%, 1.5%, 2.0% and 2.5% causing mortality percentage of 32.5%, 33.8%, 51.3%, 58.8% and 65.0% respectively. One way Anova test showed p-value < alpha ± (0.00 < 0.05). It was concluded that there was a significant difference of various concentration of active fraction n-heksan of red ginger extract to the mortality of Ae. aegypti. The lethal concentration (LC50) was 2.409%. It was suggested to continue this research with reppellant or bio-assay test method. Key words: Toxicity, extract, fraction, Aedes aegypti, Insecticidal

Aphrodisiac Effects of Areca Fruit in Erectile Dysfunction Rat Model Nita Parisa; Muhammad Totong Kamaluddin; Salni Salni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 3 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i3.90

Abstract. Erectile Dysfunction (ED) cases are quite high in both women and men and increase with age. Areca fruit, ginseng and purwoceng are plants that have been traditionally used to increase male vitality. This in vivo experimental research study with pre and post-test control group design located in the laboratory of animal house and the biomolecular laboratory Faculty of Medicine Sriwijaya University. The subjects of this study were albino rats (Rattus norvegicus), Wistar strains, divided into 6 groups are negative control, Sildenafil, Areca Fruit Extract (AFE) 50 mg/kgBW, AFE 100 mg/kgBW, Combination of Areca Fruit, Ginseng and Purwoceng (AGP) 50 mg/kgBW and AGP 100 mg/kgBW. Female rat was injected by giving 500 mg/100 g of subcutaneous progesterone and 10 Î¼g/100 g of BB benzoate 48 hours before mating so that female mice enter the esterus phase. In this study it was found that Combination of Areca fruit, Ginseng and Purwoceng (AGP) group 50mg/kgBW significantly improved testosterone levels compared to sildenafil, while single areca fruit (AFE) dose 50mg/kgBW increased FSH and LH levels as well as sildenafil statistically. Keywords: areca fruit, erectile dysfunction, FSH, ginseng, LH, purwoceng, testosteron.

Refleksi Pedagogis John Dewey dalam Praktik PAK Kontemporer: Meninjau Ulang Peran Guru sebagai Fasilitator Pertumbuhan Iman Sesuai Ajaran 1 Korintus 3:6 Salni Salni; Enjelina Enjelina; Delfiana Putri; Julyanti Napa; Sartika Nipa Patanduk
Sabar : Jurnal Pendidikan Agama Kristen dan Katolik Vol. 2 No. 3 (2025): Juli : Sabar : Jurnal Pendidikan Agama Kristen dan Katolik
Publisher : Asosiasi Riset Ilmu Pendidikan Agama dan Filsafat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/sabar.v2i3.1167

This study explores the philosophical and theological implications of John Dewey's pedagogical thought, particularly his emphasis on reflective practice and experiential learning, within the context of Contemporary Christian Religious Education (PAK). Despite its potential to foster active, student-centered learning, a significant gap exists in deeply examining how Dewey's principles align with or challenge PAK's theological aim of faith formation. This qualitative library research, employing Miles and Huberman's data analysis model, addresses this gap by synthesizing Dewey's pedagogical concepts with the Christian theology of spiritual growth, particularly informed by 1 Corinthians 3:6, which posits that God gives the increase. The findings reveal that Dewey's experiential learning framework can profoundly enrich PAK by shifting the teacher's role from a primary knowledge dispenser to a facilitator who guides students in applying biblical truths to real-life experiences. This approach encourages holistic development encompassing cognitive, affective, and psychomotor domains. However, the implementation necessitates a robust theological filter, maintaining that biblical truth is final and acknowledging God's sovereignty in true spiritual growth. The study concludes that while Dewey's pedagogy provides practical strategies for student engagement and character development, its successful integration into PAK hinges on a clear understanding of its theological boundaries, ensuring that pedagogical flexibility is balanced with doctrinal integrity. This research offers a theoretical foundation for transformative PAK practices, aiming to cultivate knowledgeable Christian students with deep and active faith.

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