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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia Science and Technology Indonesia Medical Laboratory Technology Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Conferences of Medical Sciences Dies Natalis Jurnal Pengabdian Pada Masyarakat
Soilia Fertilita
Fakultas Kedokteran Universitas Sriwijaya Palembang
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Potency of Pulai (Alstonia Scholaris) As an Immunostimulant Antania Phelia Zen; Soilia Fertilita
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.167

Abstract

South Sumatera is one of provinces in Indonesia with broad peat soil ecosystem. Pulai or Alstonia scholaris is an evergreen plant commonly grow in peat soil ecosystem dan can be found in numerous areas in South Sumatera. Pulai has been globally used as traditional medicine to treat various kinds of disease ranging from gastrointestinal disorder, skin diseases, to anti-cancer. Therefore, researchers have been intrigued to analyze pharmacological aspect of Pulai. Several prior studies have found a large number of compounds within Pulai and a handful of them have been proved to function as anti-oxidant, anti-inflammation, anti-malaria, and even as immunomodulator. The present article is aimed to give preferences around the potential of Pulai or Alstonia scholaris as immunostimulant.
MOLECULAR DOCKING ANALYSIS OF THE BIOACTIVE COMPOUND EMODIN WITH VEGFR2 IN CERVICAL CANCER Innayah Rania Farzana; Rara Inggarsih; Ziske Maritska; Ayeshah Augusta Rosdah; Soilia Fertilita
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 2 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/z96yxv93

Abstract

Cervical cancer remains a leading cause of cancer-related mortality among women and represents the third most common cancer globally. Elevated VEGF expression in cervical cancer is associated with poor prognosis, highlighting the relevance of anti-VEGF therapeutic strategies. Several studies have shown that emodin, a natural anthraquinone derivative mainly isolated from Rheum palmatum, inhibits VEGF-stimulated proliferation, migration, and formation of endothelial cells. This study aims to characterize the interaction between emodin and the VEGF receptor in cervical cancer through in silico molecular docking. The workflow included preparation of the compound structure, preparation of the target protein structure, docking protocol validation, and docking of the compound to the receptor. Lower binding energy reflects a stronger and more stable interaction. The docking analysis showed that the emodin–VEGFR2 complex exhibits a binding energy of −7.78 kcal/mol, forming three hydrogen bonds with GLU915, CYS917, and LEU838, as well as three van der Waals interactions with PHE916, GLY920, and VAL846. These findings demonstrate a stable interaction between emodin and VEGFR2 and suggest its potential as a lead compound for further development of VEGFR2-targeted inhibitors, underscoring the need for subsequent in vitro and in vivo validation.
Co-Authors Angga Febriyanto Antania Phelia Zen Antania Phelia Zen Astari Rahayu Afifah Ayeshah A Rosdah Chris Alberto Amin Dwi Handayani Eka Febri Zulissetiana Fadhilatul Hilda Herlina Herlina Indah Solihah Innayah Rania Farzana Isnani Nur I Krisna Murti Mardiyanto Mardiyanto Muhammad Farhan Nelda Aprilia Salim Oktia Charmila Phey Liana Raissa Nurwany Rara Inggarsih Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Rianasari Puspita Rasyid Rohan Sabloak Shafa Larasaty Shaum Shiyan Suprabawati, Desak Gede Agung Susilawati Susilawati Susilawati Susilawati Tri Suciati Tungki Pratama Umar Venny Larasati Venny Larasati Veny Larasati Verdiansah Verdiansah Willy Sandhika Wresnindyatsih Wresnindyatsih Zen Hafy Ziske Maritska