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All Journal Jurnal Penelitian Saintek JBIO: jurnal biosains (the journal of biosciences) Biogenesis: Jurnal Ilmiah Biologi EduChemia: Jurnal Kimia dan Pendidikan Meditory : The Journal of Medical Laboratory Jurnal Media Analis Kesehatan Klinikal Sains (Jurnal Analis Kesehatan) Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Borneo Journal of Medical Laboratory Technology Journal Of Applied Food And Nutrition Jurnal Kesehatan Rajawali Jurnal Kesehatan
Suci Rizki Nurul Aeni
Institut Kesehatan Rajawali
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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EFFECT OF GROUND AND NON-GROUND BAY LEAF (Syzygium polyanthum) ON AORTIC THICKNESS IN WISTAR RATS Suci Rizki Nurul Aeni; Fitri Nurmahamidah; Hafizah Ilmi Sufa; Syaeful Bahri
Meditory : The Journal of Medical Laboratory Vol. 14 No. 1 (2026): Meditory, Volume 14 No. 1 Tahun 2026
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v14i1.4876

Abstract

Background: Hypercholesterolemia promotes aortic wall thickening and increases cardiovascular risk. Although Syzygium polyanthum (bay leaves) has antioxidant and hypocholesterolemic properties, evidence comparing crushed and non-crushed decoctions remains limited. Objective: This study aimed to compare the effects of crushed and non-crushed bay leaf decoctions on aortic wall thickness in hypercholesterolemic Wistar rats (Rattus norvegicus). Methods: A randomized post-test only control group study was conducted using 40 male Wistar rats assigned to eight groups. Bay leaf decoctions (crushed or non-crushed; 0.52%, 0.72%, and 0.92%) were administered orally for 14 days. Aortic wall thickness was assessed histologically and analyzed using the Kruskal–Wallis and Dunn's tests. Results: A significant difference in aortic wall thickness was observed among the groups (p = 0.040). The lowest mean aortic wall thickness was observed in the 0.92% crushed bay leaf decoction group (92.00 ± 29.20 μm), which was lower than that of the hypercholesterolemic control group (188.00 ± 29.24 μm). Conclusions: Crushed bay leaf decoction, especially at 0.92%, more effectively reduced aortic wall thickness than the non-crushed preparation. Further studies are needed to confirm the underlying mechanisms.
Co-Authors Ani Haerani Ansori, Ikhsan Faisal Ayu Nuralifah Anggraeni Aziz Ansori Wahid Diani Aliansy Dika Adhi Sriwiguna Dwi Safanida Erika Setyowati Farhan Baehaki Farhan Baehaki Fitri Nurmahamidah Gita Nur Fajriani Hafizah Ilmi Sufa Handarini Handarini Haruniati, Zakiyah Aulia Ira Prima Sari Lina Rahmawati Mahmudatul Istiqomah Mira Miraturrofi'ah Mira Miraturrofi’ah Miraturrofi’ah, Mira Muhammad Iqbal Alfirmansyah Muhtar, Putri Mutiara Murtafi’ah, Ni’matul Ni'matul Murtafi'ah NI'MATUL MURTAFI'AH Novi Andriani, Novi Nurdin, Nurdin Ramadianti, Dwi Anjani Rismayani Solihat Sapta Nisa Andini Silva Oktriana Syaeful Bahri Syifa Zayna Muwahiddah Viky Cahyo Handoko Yuningsih, Rima Zahratul Zakiah