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All Journal Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Kesehatan Rajawali Asian Journal of Health and Applied Sciences Generics: Journal of Research in Pharmacy International Journal of Health and Pharmaceutical (IJHP) Journal of Pharmaceutical and Sciences. Prosiding SIMKESNAS Generics : Journal of Research in Pharmacy
Purwaeni Purwaeni
Program Studi Sarjana Farmasi, Fakultas Farmasi Institut Kesehatan Rajawali, Bandung Barat, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Effectiveness of X Herbal Medicine On The Reducing Blood Sugar In A Diabetic Mice Model Purwaeni, Purwaeni; Fentiani Siahaan, Nurbaiti; Windy Astuty, Meilinda
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025 ( Indonesia - Thailand)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.494

Abstract

The prevalence of Diabetes Mellitus in Indonesia is estimated to reach 21.3 million people by 2030. Treatment with oral antidiabetic drugs carries the risk of myocardial infarction and congestive heart failure, while modern therapy of NIDDM has adverse side effects. WHO recommends researching traditional methods, especially plants with hypoglycemic effects. Efficacy claims in herbal medicines, especially herbal medicines, are rarely reported, so it is necessary to test antidiabetic activity to ensure their use. To determine the antidiabetic activity of herbal medicine product X on blood sugar levels in aloxane-induced mice (Mus Musculus), determine the most effective dose, and determine the decrease in GDP after the administration of herbal medicine X on days 7 and 14. Experimental research uses male mice (Mus Musculus) as test animals. Blood glucose levels were measured before and after treatment, with a negative control of CMC-Na of 0.5% and a positive control of glibenclamide of 0.65mg/Kg BB. The optimal dose of herbal product X is determined by a ratio of doses of 52 mg/KgBB, 104 mg/KgBB, and 156 mg/KgBB for 7 to 14 days. Herbal Medicine X at doses of 52mg/KgBB, 104mg/KgBB, and 156mg/KgBB succeeded in reducing aloxan-induced blood sugar levels in mice. The dose of 156mg/KgBB was found to be the optimal dose based on the Mann-Whitney test with Sig<0.05. The most significant decline on day 14 was based on the Kruskal Wallis test with Sig<0.05. Herbal Medicine X was effective in lowering blood sugar levels in mice, with an optimal dose of 156mg/Kg BB and a significant decrease on day 14.
Evaluasi Penggunaan Obat Triheksifenidil Sebagai Terapi Adjuvan Pada Pasien Fangguan Afektif Bipolar Di Rumah Sakit Jiwa Provinsi Jawa Barat Cantika, Erika; Putri, Fitria Sulistia; Purwaeni, Purwaeni; S, Encep; Nur, Ice Laila
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p51-56

Abstract

Background: Bipolar affective disorder is a mental disorder that attacks the psychological condition, characterized by mood swings in the form of mania and depression. The high number of mental health cases in Indonesia is one of the challenges of treatment, especially in the pharmaceutical world. Evaluation of drug use is a structured quality assurance program, and provides assurance that the drugs given are appropriate, safe, and effective. Objective: This study aims to evaluate the use of trihexyphenidyl in patients with bipolar affective disorder at the West Java Provincial Mental Hospital. Methods: The research design used was a retrospective observational study with a descriptive cross-sectional approach. The data source used in the study was written information in the medical records of mental patients diagnosed with bipolar affective disorder who received trihexyphenidyl drug therapy at the West Java Provincial Mental Hospital. Results: Based on the results of the study, 93 patients diagnosed with bipolar affective disorder using trihexyphenidyl were obtained, the results of the ANOVA test on the evaluation of drug use showed a significance value of 0.021 <0.05 so that it can be concluded that the data has differences from the research variables. Conclusion: Based on the results of the study, it can be concluded that the evaluation of the use of trihexyphenidyl drugs in patients with bipolar affective disorder is appropriate and in accordance with the rationality of drug use.
Co-Authors Aulia, Reza Nurul Cantika, Erika Carla, Natasya Cintya Cep Wahyu Deti Kurnia Diani Aliansy Fadhila, Feldha Fadilah, Tyas Ismi Farhan Baehaki Farhan, Dicky Fentiani Siahaan, Nurbaiti Hesti Yulia Ningsih Jaojah, Siti Karimah, Haniefatul Liah Kodariah Mega Nuryanti Meilasari, Rika Nur Ni'matul Murtafi'ah Nur, Ice Laila Nurhamidah, Yeni Nurkamal, Elsa Nuryanti, Mega Pertiwi, Dini Yulianti Putri, Fitria Sulistia Raisya Amira Shabira Rifani Shalsadila S, Encep Shalsadila, Rifani Siahaan, Nurbaiti Fentiani Windy Astuty, Meilinda