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All Journal Jurnal Anestesiologi Indonesia JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Journal of Dedicators Community Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JURNAL USM LAW REVIEW
Edward Kurnia Setiawan Limijadi
Department Of Clinical Pathology, Faculty Of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang
Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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RELATIONSHIP BETWEEN FASTING BLOOD GLUCOSE LEVELS AND LDL CHOLESTEROL LEVELS IN PATIENTS WITH TYPE-2 DIABETES MELLITUS IN DIPONEGORO NATIONAL HOSPITAL Muhammad Fakhrul Aditya Duta Pradana; Edward Kurnia Setiawan Limijadi; Kusmiyati Tjahjono; Banundari Rachmawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.32715

Abstract

Background: Diabetes Mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels above the normal range. Type-2 diabetes mellitus can cause lipid metabolism disorder. This study analyzed the relationship between fasting blood glucose and LDL cholesterol levels in type-2 diabetes mellitus patients.Aim: To prove the correlation between fasting blood glucose levels with LDL cholesterol levels in patients with type-2 diabetes mellitus.Methods: This research is an observational analytical study with cross-sectional design on 40 subjects. The secondary data for this research was obtained from diabetic patients at Diponegoro National Hospital. The correlation analysis was done using Spearman Rank test.Results: Spearman Rank analysis showed no significant association between fasting blood glucose levels with LDL cholesterol levels in patients with type-2 diabetes mellitus (p = 0,119 and r = 0,250).Conclusion: There was no significant correlation between fasting blood glucose levels with LDL cholesterol levels in patients with Type-2 Diabetes Mellitus.
The Differences of N–Acetyl–β–Glucosaminidase and β2 Microglobulin levels in Patients with and without Early Diabetic Nephropathy Cynthia Citra; Edward Kurnia Setiawan Limijadi; Banundari Rachmawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1836

Abstract

Diabetic Nephropathy (DN) is becoming the most serious microvascular complication, which be marked by the presence of persistent albuminuria. N–asetil–β–glucosaminidase is dominant lyzosom enzyme in the renal tubule epitel. β2 microglobulin is low molecular weight protein which produced by major histocompatibility complex class 1 (MHC-1) expressed cell in all nucleated cell. N–asetil–β–glucosaminidase and β2 microglobulin could be new usefull marker for early DN. Analytic observational study with cross sectional approach was conducted in May – July 2019 involving 27 non diabetic patients (K1), 27 diabetic patients without DN (K2) and 27 diabetic patients with early DN (K3) at the Clinical Pathology department of Faculty of Medicine, Diponegoro University and Diabetic Clinic. Data include age, gender, fasting blood glucose, blood preasure and urine albumin creatinine ratio. N–asetil–β–glucosaminidase level between groups were analyzed using Anova, β2 microglobulin level between groups using Kruskal Wallis, p<0.05 were considered significant. There are significant differences in levels of N–asetil–β–glucosaminidase between K1 and K2 (p =0.01), K1 and K3 (p =< 0.01), K2 and K3 (p = 0.03) and β2 microglobulin  between K1 and K2 (p = 0.02), K1 and K3 (p =< 0.01), K2 and K3 (p< 0.01). N-acetyl-β-glucosaminidase and β2 microglobulin levels were higher in K2 compared to K1 and increased higher in K3 compared to K1 and K2. N-acetyl-β-glucosaminidase and β2 microglobulin can be used as an alternative marker for early DN. 
Co-Authors Adrian Stefanus Herawan Agnes Widanti Soebiyanto Ajeng Kurnia Wardhani Ariosta Ariosta Asri Ragil Kemuning Banundari Rachmawati Banundari Rachmawati C O Harahap Cynthia Citra Djuara P Lubis Dodik Pramono Donna Hermawati Doso Sutiyono Dwi Retnoningrum Herniah Asti Wulanjani Herniah Asti Wulanjani Himawan Sasongko Indranila Kustarini Samsuria Kartika Rizky Aulia Kusmiyati Tjahjono Lusiana Batubara Maria Petronela W.M Meita Hendrianingtyas Muhammad Fakhrul Aditya Duta Pradana Nyoman Suci Widyastiti Purwanto Adipireno Ria Triwardhani Satrio Adi Wicaksono Theresia Ilyan Yetty Movieta Nency Yuliana Yuliana