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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indian Journal of Forensic Medicine & Toxicology

Hari Sukanto, Hari

Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya

Author-ID : 3287368

Immunology & microbiology Public Health

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The Description of Dermoscopy and Wood’s Lamp on Melasma Ryski Meilia Novarina; Rahmadewi Rahmadewi; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Melasma is an acquired hypermelanosis disorder occurred symmetrically on the sun exposure area, predominantly on the face and neck. Melasma classification based on Wood’s light examination does not always have positive correlation with the histopathologic examination. Dermoscopy is a new non-invasive modality for examining melasma. Purpose: To evaluate melasma classification based on dermoscopy and Wood’s lamp examination. Methods: This is a descriptive observational cross sectional study, the subjects are melasma patients in Cosmetic Division of Dermatology and Venereology Outpatient Clinic of Dr. Soetomo hospital. This research was conducted for 2 months with a total of 100 samples that had been performed dermoscopy and Wood’s lamp examinations. Results: Conformity melasma examination results in this study obtained three clinical types of melasma, the vast majority were melasma mixture (72 samples). On dermoscopic examination obtained dermal melasma amount of 17 samples (17%) and telangiectasis structure 38%. In addition dermoscopy can also be used to detect ochronosis on the melasma lesions (7 of 100 samples) with the characteristics are arciform curvilinear (worm-like pattern) and teleangiectasis, dot/globuler bluish brown-black, greyish/bluish brown diffuse amorphic structure, and structureless area. Conclusions: Dermoscopic examination revealed more detailed structure and color of melanin deposit in the superficial dermis, teleangiectasis and early detection of ochronosis. Histopathology still the gold standard diagnosis of melasma and ochronosis lesion.

Association of Serum Testosterone with Various Severity of Acne Vulgaris in Adult Women Umi Miranti; Diah Mira Indramaya; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne Vulgaris (AV) is a chronic and obstructive inflammatory skin disease of the pilosebaceous unit. Testosterone is main androgen hormone that have a role in the pathogenesis of AV. Pevious researches have shown controversial results regarding serum testosterone levels in AV. Purpose: To evaluate the association of serum testosterone levels with AV severity in adult women in Dermatovenereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya. Methods: This is an analitic observational study, with 37 patients based on the inclusion and exclusion criteria. Results: Mean serum testosterone level in mild AV group was 39.16 + 24.18µg/dL, moderate AV group was 39.75 + 23.75 µg/dL, and severe AV group was 52.46 + 24.00 µg/dL. These results indicate that serum testosterone level in severe AV group was higher than moderate and mild AV groups. But there was no statistically significant correlation between serum testosterone levels and the severity of AV. Conclusions: Serum testosterone levels in patients with severe AV was higher than moderate and mild AV. No correlation between serum testosterone levels with AV severity in adult women. Further research ruled out confounding factors is needed to determine hormonal role in the pathogenesis of AV.

Severe Cutaneous Adverse Drug Reaction Damayanti Damayanti; Sylvia Anggraeni; Cita Rosita SP; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Cutaneous adverse drug eruption (CADR) are frequently found. A systematic review showed, the incidence of severe CADR (SCADR) ranging from 0-8%. Few studies have assessed the severe form of CADR, which has high mortality rate. The epidemiological study was needed to show the profile of SCADR, especially in the setting of general hospital. Purpose: To evaluate clinical and epidemiological profile of SCADR in Dermatology and Venereology Ward Dr. Soetomo Hospital Surabaya. Methods: All SCADR patients in the period of January 2015–January 2016 was evaluated clinically and epidemiologically. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic reaction (DRESS) cases were included in the study. Results: There were 14 patients in this study, consist of 10 SJS cases (71.4%), 2 TEN patients, and 2 AGEP patients. The highest frequency of age group was 25-29 years old (57.1%). Man to woman ratio was 3:4. The most common offending drug was paracetamol (50%), followed by amoxicillin (28.6%). Antibiotic was the highest frequent offending drug-group (64.3%), followed by antipiretics (50%). In this study, all patients got systemic corticosteroid and the mortality was 0%. Conclusion: The most common type of SCADR was SJS. The most common offending drug was paracetamol, and antibiotic was the highest frequent offending drug-group. Systemic corticosteroid therapy showed good result in severe CADR management.

Profile of Melasma Patients: A Retrospective Study Alfrid Asditya; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Melasma is a common hypermelanotic condition that can be frustrating to patients, thus appropriate diagnosis and management of melasma is required. Purpose: To evaluate patient’s profile, diagnosis, and management of melasma. Methods: Retrospective study of new patient in Cosmetic Division, Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital, Surabaya from January 2011 until December 2013. Result: Total new patient of melasma in Cosmetic Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 2011 until December 2013 (3 years) is 869 patients. Conclusion: Appropriate diagnosis, treatment, and education is needed to manage melasma because of the chronicity and progressivity of this disease.

Penurunan Skor Melasma Area and Severity Index (MASI) antara Asam Traneksamat Topikal dan Modifikasi Formula Kligman dengan Plasebo Topikal dan Modifikasi Formula Kligman pada Pasien Frea Astrilia Tamarina; Sawitri Sawitri; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Melasma merupakan kelainan pigmentasi yang dapat menyebabkan gangguan kualitas hidup. Modifikasi Formula Kligman digunakan sebagai terapi standar melasma di RSUD Dr. Soetomo Surabaya. Penelitian retrospektif mengenai distribusi kemajuan penyakit melasma berdasarkan skor melasma area and severity index (MASI) di RSUD Dr. Soetomo Surabaya pada periode 2012-2014, menunjukkan jika hanya 44,4% yang mengalami penurunan skor pada kunjungan ulang. Asam traneksamat (AT) telah dilaporkan beberapa studi sebagai terapi adjuvan yang dapat menurunkan skor MASI dan memberikan perbaikan klinis pigmentasi. Penggunaannya secara topikal dianggap aman, tanpa efek samping serius. Tujuan: Mengevaluasi perbedaan selisih penurunan skor MASI antara pemberian AT topikal dan modifikasi Formula Kligman dengan pemberian plasebo topikal dan modifikasi Formula Kligman pada pasien melasma. Metode: Penelitian eksperimental analitik dengan uji klinis acak terkontrol, tersamar tunggal, yang membandingkan AT topikal dan modifikasi Formula Kligman (kelompok perlakuan) dengan plasebo topikal dan modifikasi Formula Kligman (kelompok kontrol), setelah pemakaian minggu ke-4, 8, dan 12 pada pasien melasma. Hasil: Studi melibatkan 14 pasien kelompok perlakuan dan 14 pasien kelompok kontrol. Hasil menunjukkan perbedaan bermakna setelah pemakaian minggu ke-4 (p=0,032) pada selisih penurunan skor MASI antara kelompok perlakuan dan kontrol. Tidak terdapat perbedaan bermakna setelah pemakaian minggu ke-8 (p=0,052) dan minggu ke-12 (p=0,057). Kedua agen memiliki mekanisme kerja yang berbeda dengan titik tangkap yang berbeda. Simpulan: Terdapat perbedaan bermakna setelah pemakaian minggu ke-4 pada selisih penurunan skor MASI antara pemberian AT topikal dan modifikasi Formula Kligman dengan pemberian plasebo topikal dan modifikasi Formula Kligman. Diperlukan penelitian lanjutan untuk membandingkan dan menentukan efikasi dari masing-masing agen.

Clinicoepidemiological Profile of Severe Cutaneous Adverse Drug Reaction: A Retrospective Study Damayanti Damayanti; Menul Ayu Umborowati; Sylvia Anggraeni; Cita Rosita Sigit Prakoeswa; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 1 (2019): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Drug eruption were varied from mild to severe reaction. Few studies have assessed the severe cutaneous adverse drug reaction (SCADR), especially in the setting of general hospital. Purpose: To evaluate clinicoepidemiological profile of SCADR at Dermatology and Venereology Ward Dr. Soetomo Hospital, Surabaya, Indonesia. Methods: All SCADR patients at Dr. Soetomo Hospital, Surabaya, Indonesia in the period of January 2016 – June 2017 was evaluated. Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Acute Generalized Exanthematous Pustulosis (AGEP), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and exfoliative dermatitis cases were included in the study. Results: There were 24 patients in this study, consisted of 11 SJS cases, 1 TEN case, 2 SJS/TEN-overlap cases, 10 exfoliative dermatitis cases. The mean of latent period between drug intake and onset of symptoms was 15.8 days. The most common offending drug was mefenamic acid (20.9%), followed by cefadroxil and phenytoin (each 16.7%). Antibiotics was the highest frequent offending drug-groups (62.5%), followed by non-steroid anti-inflammatory drugs (NSAIDs). Prompt withdrawal of the offending drugs, systemic corticosteroid, and supported therapy were given to all patients, which gave good results in 21/24 patients (87.5%). Conclusion: Antibiotics were the most common offending drug-groups. SCADR might give high mortality rate, but early diagnosis, prompt withdrawal of the suspected drugs, closed monitoring to evaluate complications can improve the prognosis of SCADR.

Co-Authors Afif Nurul Hidayati Alfrid Asditya Anggraeni, Sylvia Antoni Miftah Antoni Miftah, Antoni Cita Rosita Sigit Prakoeswa Cita Rosita SP Damayanti Damayanti Damayanti Damayanti Damayanti Diah Mira Indramaya Dinar Witasari Dinar Witasari Dinar Witasari, Dinar Dwi Murtiastutik Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Frea Astrilia Tamarina I G.A. Kencana Wulan Linda Astari, Linda Lita Setyowatie Marsudi Hutomo Marsudi Hutomo Marsudi Hutomo Menul Ayu Umborowati Menul Ayu Umborowati Pepy Dwi Endraswari, Pepy Dwi Rahmadewi Rahmadewi Ryski Meilia Novarina Sawitri Sawitri Trisniartami Setyaningrum Umi Miranti

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