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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Kedokteran Gigi Indonesia Essential: Essence of Scientific Medical Journal Indonesian Journal of Biomedicine and Clinical Sciences
Oktarina, Dyah Ayu Mira
Department Of Dermatology And Venereology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr Sardjito Hospital, Yogyakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Berkala Ilmu Kesehatan Kulit dan Kelamin

 1 
Pseudolimfoma Kutis: Laporan Kasus Kartika Kemala; Wening Setyani; Dyah Ayu Mira Oktarina; Yohanes Widodo Wirohadidjojo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (525.073 KB) | DOI: 10.20473/bikk.V30.3.2018.275-278

Abstract

Latar Belakang: Pseudolimfoma kutis adalah proses limfoproliferatif jinak poliklonal pada kulit, yang menyerupai limfoma kutis secara klinis dan atau histopatologi. Pseudolimfoma kutis bermanifestasi dalam bentuk nodul atau plak keunguan pada wajah. Pada kasus yang dicurigai sebagai pseudolimfoma kutis, bagian terpenting adalah diagnosis untuk membedakan lesi tersebut jinak atau ganas. Diagnosis memerlukan kombinasi antara pemeriksaan klinis, histopatologis, dan imunohistokimia. Tujuan: Melaporkan satu kasus pseudolimfoma kutis yang menitikberatkan pada masalah penegakan diagnosis. Kasus: Seorang wanita usia 27 tahun, datang dengan keluhan nodul asimptomatik berwarna merah pada pipi sejak 2 bulan yang lalu. Pemeriksaan histopatologi didapatkan sebukan limfosit padat membentuk folikel limfoid dengan centrum germinativum yang sebagian mendestruksi kelenjar appendices kulit dan meluas hingga jaringan lemak subkutis. Pemeriksaan imunohistokimia menunjukkan hasil positif dengan pewarnaan cluster of differentiation (CD) 20+, CD3+, dengan dominasi pada CD3+. Pewarnaan CD4+ menunjukkan hasil positif dan CD8+ dengan hasil negatif. Penatalaksanaan: Pasien diterapi dengan injeksi triamsinolon asetonid 10 mg/ml intralesi, dan memberikan hasil yang memuaskan setelah 3 kali injeksi. Simpulan: Berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan histopatologi, dan imunohistokimia, telah ditegakkan kasus pseudolimfoma kutis pada seorang wanita 27 tahun. Terapi dengan injeksi triamsinolon asetonid 10 mg/ml intralesi memberikan hasil yang memuaskan.
The Role of Connexin in Cutaneous Adverse Drug Reactions (CADRs) in Patients with Increasing Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Dyah Ayu Mira Oktarina; Gilang Baswara; Hardyanto Soebono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.123-128

Abstract

Background: The occurrence of Cutaneous Adverse Drug Reactions (CADRs) is relatively rare but can be fatal when causing organ failure, especially in the liver. The supporting examinations to determine liver injury are aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Connexin-32 (Cx32) and connexin-43 (Cx43) are gap junction proteins that can be found in the liver and allegedly have a role in the mechanism of liver injury. To date, correlations between the level of connexin and aminotransferases enzyme in humans with CADRs cases are still unclear. Purpose: To determine the correlations between Cx32/Cx43 and AST/ALT levels in CADRs cases. Methods: This was a retrospective study, data collected from inpatient and outpatient’s medical records, Department of Dermatology and Venereology of Dr. Sardjito Hospital, from 2011–2015. Result: A total of 25 patients with CADRs and 35 healthy controls were included in this study. The levels between Cx32 and AST, Cx32 and ALT, Cx43 and AST, and Cx43 and ALT were not significantly correlated in CADRs cases (p>0.05). Both Cx32 and Cx43 were not significantly different between patients with and without CADRs (p>0.05). Confounding factors such as gender were not associated with this study (p>0.05). Conclusion: There was no correlation between levels of Cx32/Cx43 and increasing AST/ALT in CADRs cases. Therefore, further study is necessary to conclude the correlation between connexin and aminotransferase enzyme in CADRs patients.
A Five-Year Review of Adverse Cutaneous Drug Reaction in a Tertiary Care Hospital in Yogyakarta, Indonesia Dyah Ayu Mira Oktarina; Maria Sophiati; Erinda Maharani Rambu Moha; Fajar Waskito; Hardyanto Soebono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.150-155

Abstract

Background: The prevalence of adverse drug reactions is likely to increase, and it is associated with increased usage of various drugs. Adverse Cutaneous Drug Reaction (ACDR) is the most frequent adverse drug reaction (30–45%). In Indonesia, the study on the prevalence of ACDR is still limited. Purpose: This study investigated the prevalence, clinical features, causative agents, and mortality rate of ACDR with a type-IV hypersensitivity reaction among patients attending the Department of Dermatology and Venereology in Dr. Sardjito Hospital, Yogyakarta. Methods: This retrospective study was conducted examining medical records undertaken for five years (2011–2015). Of 68,375 patients medicated in the Department of Dermatology and Venereology, 397 patients were diagnosed as ACDR with a type-IV hypersensitivity reaction. Detailed history, including age, sex, past history, and family history of drug reaction taken by the patient, were obtained. Patch testing was done wherever feasible. Result: Of 68,375 patients, 397 patients were included in ACDR with type-IV hypersensitivity (0.58%), giving a 5% of mortality rate. The mean age of the patients was 40.42 years (±16.30; range 18 to 89 years). The female to male ratio was 1.1: 1. The Maculopapular rash was the most common ACDR manifestation (50.88%), followed by Stevens-Johnson Syndrome (13.85%), Fixed Drug Eruption (12.85%), and Drug Reaction with Eosinophilia and Systemic Symptoms (10.08%). The most common causative agents were beta-lactam (16.55%), NSAIDs (12.18%), and acetaminophen (8.62%). Conclusion:  Prescription of those drugs should be considered carefully so the incidence of ACDR can be reduced.
Co-Authors Agnes Sri Siswati Andayani, Raden Roro Rini Anggatama, Marcella Anindya Intan Ardanari Dahlia Herawati Dewi Kartikawati Paramita Diovani, Sonia Erinda Maharani Rambu Moha Fajar Waskito Fitri Yuniawati Gilang Baswara Hanggoro Tri Rinonce Hardyanto Soebono Harsono, Erliana Tantri Indra Wahono Iwan Dwiprahasto Kartika Kemala Khalidah, Miya Kwartarini Murdiastuti Maria Sophiati Muthia Fahiratunnisa Amany Niken Trisnowati Nunuk Purwanti Rita Cempaka Rizkiani, Dwinanda Almira Roihan Mohamad Iqbal Saihas Sauda Satiti Retno Pudjiati Satiti Retno Pudjiati Siti Isya Wahdini Wening Setyani Yohanes Widodo Wirohadidjojo Zubairi Djoerban