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All Journal HAYATI Journal of Biosciences Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) Jurnal Ternak Tropika JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Jurnal Medik Veteriner
Muhammad Halim Natsir
Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Veterinary Other

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Journal : HAYATI Journal of Biosciences

 1 
Expression of Immunoglobulin M (IgM) and Immunoglobulin G (IgG) in Normal Wistar Rat Post-Cheral® Administration Asyhari, Firda Nuri; Zulfatim, Heni Sukma; Putri, Nenis Try Melani; Dliyauddin, Moh; Jamil, Ahmad Shobrun; Soewondo, Aris; Natsir, Muhammad Halim; Ibrahim, Mansur; Rahayu, Sri; Djati, Muhammad Sasmito; Rifa’i, Muhaimin
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.1030-1036

Abstract

Maintaining immunoglobulin levels in the body is important to protect the body from exposure to pathogens. One effort can be made by consuming herbs containing immunomodulatory compounds, such as Cheral®, which includes a combination of herbs Phyllanthus niruri and Curcuma longa. This research aims to determine the expression of immunoglobulin M (IgM) and immunoglobulin G (IgG) following the administration of Cheral® to Wistar rats. The study was conducted in vivo, utilizing 24 healthy male Wistar rats for a 90-day treatment period. The research was divided into four treatment groups, including a control group and three dosage groups: Dose 1 (156.25 mg/kg BW), Dose 2 (312.5 mg/kg BW), and Dose 3 (468.75 mg/kg BW). IgM and IgG were isolated from the spleen and analyzed using flow cytometry. Flow cytometry data were analyzed using SPSS with a one-way ANOVA and post hoc test (p-value <0.05). The analysis showed that the relative number of IgM-producing cells in the control group was significantly higher than in the treatment groups, with a difference of 44.40%. In contrast, the relative number of IgG-producing cells in Dose 3 was significantly lower than all other treatment groups, showing a decrease of 29.21%. Overall, the expression of IgG and IgM did not differ substantially across all treatments. The lower IgG and IgM profiles compared to the control group indicate Cheral®'s ability to prevent infections and maintain the immune system of the rats throughout the treatment period.
Genetic External Characteristics of Tukong: Indonesian Rumpless Indigenous Chicken Tribudi, Yuli Arif; Nurgiartiningsih, Veronica Margaretha Ani; Ulfah, Maria; Sari, Aprilianna Putri Zahara Nafsina Luvita; Hariyono, Dwi Nur Happy; Sitaresmi, Pradita Iustitia; Crooijmans, Richard PMA; Natsir, Muhammad Halim; Gusmalawati, Dwi; Ibrahim, Alek
HAYATI Journal of Biosciences Vol. 32 No. 5 (2025): September 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.5.1147-1156

Abstract

Tukong chicken, also known as rumpless chicken due to the absence of a tailbone, is one of the indigenous chicken breeds in Indonesia currently at risk of extinction. Due to its scarcity, genetic information on the Tukong chicken remains limited, and its potential has not been fully explored. Therefore, this study aimed to determine the genetic external characteristics of the Tukong chickens. Data were collected from 205 chickens (52 males; 153 females) raised in Landak and Bengkayang Regency, West Kalimantan. The varieties are based on feather color, plumage color, feather pattern, feather flicker, comb shape, and shank color. The data were used to analyze the rate of the original gene, the frequency of autosomal genes, sex-linked genes, feather pattern, introgression rate, gene frequency, and expected heterozygosity. The majority of the Tukong chickens had colored feathers (88.78%), columbian feather type (47.80%), plain feather pattern (61.46%), silver feather flicker (54.63%), yellow-white shank (62.44%), and pea comb (77.07%), which were controlled by ii, ee, bb, SS, IdId, and P_ genes, respectively. The introgression rate from exotic breeds into Tukong chicken is 53.2%, with the original gene at 46.8%, while the average expected heterozygosity was 0.416±0.025, indicating a high level of genetic diversity of the traits. This observed variation in qualitative morphological characteristics might benefit both the conservation and utilization of the Tukong chicken.
Co-Authors Agus Susilo Ahmad Shobrun Jamil Alek Ibrahim Aris Soewondo Asyhari, Firda Nuri Churriyah, Rosyidatul Crooijmans, Richard PMA Dliyauddin, Moh Dwi Gusmalawati Eny Sri Widyastuti Fionita, Rina Aqila Hariyono, Dwi Nur Happy Hermanto, Feri Eko Junaedi Junaedi Lestari, Suci Puji Mansur Ibrahim Maria Ulfah Marwi, Filoza Moch Sasmito Djati Nurgiartiningsih, Veronica Margaretha Ani Nurul Isnaini Osfar Sjofjan Prihatiningsih Putri, Nenis Try Melani Rifa’i, Muhaimin Sari, Aprilianna Putri Zahara Nafsina Luvita Sitaresmi, Pradita Iustitia SRI RAHAYU Widiati, Aris Sri Yuli Arif Tribudi Yuli Frita Nuningtyas Yusuf, Zaen Zulfatim, Heni Sukma