Ngadiwiyana M.Si. S.Si.
Department Of Chemistry, Faculty Of Science And Mathematics, Diponegoro University Jl. Prof. H. Soedarto SH Tembalang, Semarang 50275, Indonesia

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Journal : Chem Info

Sintesis Etil Sinamat dari Sinamaldehid pada Minyak Kayu Manis (Cinnamomum cassia) dan Uji Aktivitas sebagai Antidiabetes Amalia, Dian; , S.Si., M.Si., Ngadiwiyana; Fachriyah, M.Si, Dra. Enny
Chem Info Journal Vol 1, No 2 (2013)
Publisher : Chem Info Journal

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Abstract

Cinnamon oil is obtained by distillation from the bark of cinnamon. The main component in cinnamon oil is cynnamaldehyde (42-75%). Cynnamaldehyde is a compounds which has aldehyde group that can be modified into the ester group that can be used as an antidiabetic. The synthesis cinnamic esters was oxidation and esterification. This research aims to isolate cynnamaldehyde of cinnamon oil, synthesized cinnamic acid and activities test as antidiabetic. Ethyl cinnamic is obtained from the synthesis of a clear yellow liquid and fragrant with a yield 98.86%. The results of FTIR showed the formation of cinnamic ethyl ester in the presence of CO groups, where as the results obtained by GC-MS abudance of 99.01% ethyl cinnamate. From the antidiabetic test results, ethyl cinnamate coumpounds IC50 values of 215.509 ppm.
SINTESIS ISOPROPIL SINAMAT DARI SINAMALDEHID PADA MINYAK KAYU MANIS (Cinnamomum cassia) DAN UJI AKTIVITAS SEBAGAI ANTIDIABETES Anwar, Finalia Femmy; , S.Si., M.Si., Ngadiwiyana; Fachriyah, M.Si, Dra. Enny
Chem Info Journal Vol 1, No 2 (2013)
Publisher : Chem Info Journal

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Abstract

Has done research on use of synthesis isopropyl cinnamate of cinnamaldehyde in cinnamon oil (Cinnamomum cassia) and test activities as the antidiabetic. The purpose of this study was to isolate cinnamaldehyde of cinnamon oil, synthesis cinnamic acid, cinnamic isopropyl synthesis and test the antidiabetic activity. The method used in this study by using the method of oxidation and esterification through cinnamoil chloride. Analysis of compounds synthesis was using infra red spectrophotometry, gas chromatography-mass pectroscopy. Activity test of anti-diabetic compounds isopropyl cinnamic was with the measurement of inhibition α-glucosidase activity. Cinnamaldehyde which is isolated from cinnamon oil was yellow orange oil and cinnamaldehyde’s yield   1    was up to 76.41% and its purity was 99.87%. Cinnamaldehyde analysis using of infra red spectrophotometer showed carbonyl vibration at 1676 cm-1, C-H aldehyde at 2813.9 cm-1. From mass spectra, it can be known that cinnamaldehyde had M+ 132. Cinnamic acid which is oxidation was a white solid with yield was up to 41,89%. Cinnamic acid analysis using of infra red spectrophotometer showed O-H ad 3433.29 cm-1. Esterification of cinnamic acid chloride sinamoil through using 2-propanol produces brownish yellow liquid with a yield of as much as 84.62% and its purity was 98.43%. Isopropyl cinnamic analysis using of infra red spectrophotometer showed C-O ester at 1165.00 cm-1 and C-O isopropyl at 1111.10 cm-1. From mass spectra, it can be known that isopropyl cinnamic had M+ 190. At concentrations of 74.219 ppm isopropyl cinnamate synthesis results showed activity as antidiabetic of the enzyme that can inhibit α-glucosidase by 96.94% with IC50 value of 45.42 ppm.
Sintesis Butil Sinamat dari Sinamaldehid pada Minyak Kayu Manis (Cinnamomum cassia) dan Uji Aktivitas sebagai Antidiabetes Fajriyah, Amalia Fitriyan; , S.Si., M.Si., Ngadiwiyana; , M.Si, Dra. Dewi Kusrini
Chem Info Journal Vol 1, No 2 (2013)
Publisher : Chem Info Journal

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Abstract

Diabetes Millitus (DM) is a metabolic disorder characterized by high blood sugar levels. Cinnamon oil has an antidiabetic potential. Cinnamaldehyde is the main component of cinnamon oil (78 %) containing of aldehyde group which can be modified into the ester group is expected to be potentially as an antidiabetic. The purpose of this research was to isolate cinnamaldehyde from cinnamon oil, cinnamaldehyde oxidation became cinnamic acid, butyl cinnamate synthesis from cinnamic acid and activities test of butyl cinnamate as an antidiabetic. The method of this research was oxidation and esterification. Butyl cinnamate obtained from the synthesis is orange-yellowish liquid and fragrant smell with it’s yield as big as 97,79 %. The result of FTIR shows that it has been formed butyl cinnamate with absorption of ester (C-O), whereas the results obtained by GC-MS is an abundance of butyl cinnamate as big as 100 %. The result of the antidiabetic test, butyl cinnamate have IC50 value as big as 120,951 ppm.