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All Journal BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Majalah Kedokteran Andalas Jurnal Aisyah : Jurnal Ilmu Kesehatan JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Jurnal Implementa Husada Jurnal Pandu Husada JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Pengabdian Ilmu Kesehatan

Nuralita, Nanda Sari

UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Author-ID : 3333035

Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Perbedaan Jenis Kelamin Terhadap Simtom Depresi Pasien Skizofrenia Di Rumah Sakit Jiwa Prof.Dr.M.Ildrem Kota Medan Sumatera Utara Pada Tahun 2017 Siti Andira; Nanda Sari Nuralita
Buletin Farmatera Vol 3, No 2 (2018)
Publisher : Universitas Muhammadiyah Sumatera Utara

Abstract: Depressive symptoms in schizophrenia are important not only because they contribute significantly to the suffering caused by the illness, whether positive psychotic symptoms are active or quiscent, but also because they exacerbate deficits in psychosocial functioning and commonly precede attempted and completed suicide. Depressiv symptoms in man often shows itself very differently from female depression, this means that they feel the same difficult emotion but their expression of them is notably different. Depression symptom in woman often express feeling of sadness and hopelessness, depression symptom in male often complain about the physical symptoms of depression, mask their depression with alkoholism or subtance abuce. This study was observational with cross sectional. Population in this study from outpatients in September-October 2017 in Psychiatric hospital Prof.Dr.M.Ildrem Medan, North Sumatera. The sample of the study consisted 113 patients which filtrated from inclusion and exclusion criteria, measuring depression symptom with Beck Depression Inventory II (BDI II), data analyzed with person correlation using Mann-Whitney Test. The result was there has significant differences depression symptom between male (64,19) and female (40,97) patients schizophrenia. Depression symptoms in male schizoprenia patients is more serious p:0,01 (P:<0,05). The conclusion was there has significant differrences depression symptom between male and female patients schizophrenia.Keywords: Depression Symptom, Schizophrenia

Sindrom Rett Nanda Sa Sari Nuralita
Buletin Farmatera Vol 1, No 2 (2016)
Publisher : Universitas Muhammadiyah Sumatera Utara

Perkembangan yang terlambat sering digunakan untuk menggambarkan anak-anak dibawah umur 5 tahun dengan menunjukkan keterlambatan secara signifikan dalam menunjukkan kemampuan ketrampilan motorik kasar dan halus, kemampuan berbicara dan bahasa, fungsi kognisi, sosial, ketrampilan pribadi, dan kemampuan untuk melakukan kegiatan sehari-hari.1Istilah retardasi mental sering disinonimkan dengan perkembangan yang terlambat, tetapi juga harus divalidasi dengan intellegence test (tes IQ). Retardasi mental mempengaruhi sekitar 1 sampai 2 persen dari populasi umum. Penyebab gangguan retardasi mental yang berat, dapat diidentifikasi pada 60 hingga 70 persen dari kasus dan kebanyakan berhubungan dengan kelainan genetik yang mengubah perkembangan dan fungsi otak, sehingga menimbulkan penyimpangan pada fungsi kognitif, tingkah laku, dan fisik. Gangguan retardasi mental yang sering ditemui antara lain fragile x, sindrom rett, dan sindrom prader-wili.1Sindrom rett sejauh ini hanya dilaporkan terjadi pada anak perempuan, yang telah dirinci dasar onsetnya, perjalanan penyakitnya, serta pola gejalanya. Secara khas ditemukan bahwa di samping suatu pola perkembangan awal yang normal atau mendekati normal terdapat suatu kehilangan ketrampilan gerakan tangan yang telah didapat, sebagian atau menyeluruh dan kemampuan berbicara, bersamaan dengan terdapatnya kemunduran/ perlambatan pertumbuhan kepala, yang biasanya terjadi sekitar usia 7 sampai 24 bulan.2 Gejala yang khas adalah, gerakan tangan seperti memeras sesuatu yang strereotipik, hiperventilasi, serta hilangnya kemampuan untuk gerakan tangan yang bertujuan. Perkembangan fungsi sosialisasi dan bermain terhenti pada usia 2 atau 3 tahun pertama, tetapi perhatian sosial cendrung untuk tetap dipertahankan. Pada usia menengah anak terdapat ataksia tubuh, apraksia, disertai skoliosis atau kifoskoliosis, dan kadang terdapat koreoatetosis. Selalu terjadi suatu dampak gangguan jiwa yang berat, pertama berkembang pada masa kanak awal atau menengah.2,3.

Cholesterol Levels in Angiotensin Converting Enzyme Gene Polymorphisms in Schizophrenia Patients Isra Thristy; Nanda Sari Nuralita; Debby Mirani Lubis
Buletin Farmatera Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i2.8330

Abstract: Angiotensin-converting enzyme (ACE) is widely distributed on the surface of endothelial and epithelial cells. The renin-angiotensin system in the brain has implications for various functions, including cerebral blood circulation and brain protection, stress, depression, and the aetiology of schizophrenia. ACEs and angiotensin receptors can be found on dopaminergic neurons in the basal ganglia. Elevated levels of triglycerides and cholesterol can also be found in schizophrenic patients related to treatment and duration of the course of the disease. The purpose of this study was to determine the relationship between ACE gene polymorphism and cholesterol levels in schizophrenia patients. The design of this study was observational analytic with a cross-sectional approach. The sample in this study was schizophrenia patients who sought treatment at Madani Medan Hospital with a total of 42 people. The data obtained is then processed with the ANOVA one-way test. The results of the study were obtained from 42 samples, the most types of ACE gene polymorphisms were type II (76.2%), followed by the type of DD polymorphism (19%) and the least was the type of ID polymorphism (4.8%). The average value of cholesterol levels of the sample was 235.40 mg/dl with a standard deviation value of 47.618. Statistical test results of ACE gene polymorphism with cholesterol levels with p = 0.770 (p 0.05). It can be concluded that there is no relationship between the polymorphism of the ACE gene and the cholesterol levels of schizophrenic patients.

Differences in Sleep Quality of Schizophrenia Patients Based on Gender at Madani Hospital Medan, North Sumatra Zulhilmi, Zulhilmi; Nuralita, Nanda Sari; Rizaldi, Aril; Asfur, Robitah
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.16340

Abstract: Schizophrenia is a severe mental disorder, this disorder is characterized by delusions, hallucinations, thought disorder, restlessness, strange or hostile behaviour, feeling (affect) dull or flat, interest away from social interactions, little emotional contact (quiet, difficult to talk to), passive, apathetic or indifferent, difficult to think abstractly and lose of motivation. Sleep disturbances have been assessed in various studies in patients with schizophrenia, using subjective (ie daily interviews, sleep diaries) and objective (ie, polysomnography and actigraphy) parameters. Compared with healthy controls, patients with schizophrenia exhibit longer sleep onset latency, decreased sleep efficiency, more nighttime awakenings, increased daytime dysfunction due to sleep deprivation, poorer overall sleep quality, and a higher proportion of sleep disturbances. Previous studies have suggested that poor sleep quality is associated with female gender in schizophrenic patients. This study aims to determine the difference in sleep quality of schizophrenia patients based on gender at Madani Hospital Medan, North Sumatra. This study is an analytical descriptive with a cross-sectional study approach, sampling method using a purposive sampling technique. The data of this study were obtained from primary data using questionnaire instruments and patient medical records. Data analysis using Chi-Square test. The results showed that the sleep quality of male research respondents with disturbed sleep quality was found in 18 people (51.4%), and undisturbed sleep quality was found in 17 people (48.6%). Of female research respondents, 22 people (62.9%) had disturbed sleep quality and 13 people (37.1%). The p-value was found to be 0.334 (p0.05), which means that there was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra. There was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra.

The Relationship of Cognitive Function to Nutritional Status and Blood Pressure in the Tegal Sari Mandala Village, Medan City Nuralita, Nanda Sari; Damayanti, Amelia Eka
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.3316

Cognitive function is an intellectual function that plays a role in carrying out daily activities. The main risk factor for impaired cognitive function is hypertension. In addition, nutritional status also influences cognitive function disorders. Currently, in Indonesia, people with increased blood pressure and unbalanced nutritional status are often found, and without realizing it can have a bad influence on cognitive function. This is a categorical analytic study with a cross-sectional method, the sampling method is non-probability sampling with consecutive sampling types, with a sample of 40 people. There is a significant difference between the difference in blood pressure on cognitive function and there is also a significant difference between nutritional status on cognitive function with a P-value = 0.001. There is a significant difference between cognitive function on blood pressure and weight gain

Hubungan Tingkat Kecacatan dengan Derajat Depresi pada Penderita Kusta di SiCanang, Belawan, Sumatera Utara Batubara, Dian Erisyawanty; Nuralita, Nanda Sari
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.3329

Leprosy and the disability it causes, have a negative stigma in community; however only a few reports have investigated the link between leprosy and psychiatric morbidity such as depression. This study aimed to asses correlation between leprosy disability grade and depression severity among people with leprosy in Sicanang, Belawan, North Sumatera. This study was unpaired categorical comparative analytic study and 54 participants were enrolled to this study. We found a high percentage of leprosys disability, 88,9% participants were having second grade leprosys disability that means the disability was obviously seen. We found that 29,63% participant suffered from a moderate depression, 14,82% with severe depression and 10,27% suffered from extreme depression. The correlation between disability grade and depression severity was analyzed with chi square test and p value was 0,182 which means that no significant relationship between disability grade and depression severity. Depression severity among people with leprosy in Sicanang was determined by patients self perception, spouse, onset of diagnosis and patients perception about their religion.

Relationship between Polymorphism of Angiotensin Converting Enzyme Gene with Symptoms of Depression in Schizophrenic Patients Nuralita, Nanda Sari; Thristy, Isra; Lubis, Debby Mirani
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.9483

In schizophrenic patients, symptoms of depression are often found which can lead to adverse effects on the treatment process, such as increasing the length of treatment, increasing the possibility of relapse, non-adherence in taking medication, and can also lead to suicide in schizophrenic patients. In schizophrenic patients, the activity of the central angiotensin converting enzyme (ACE) gene is altered and angiotensin II interacts with central dopamine, thereby contributing to the pathophysiology of schizophrenia. In addition, it is likely that the ACE gene variant is also involved in the development of depressive symptoms in schizophrenic patients. This research is a categorical analytic study with a cross sectional method, the sampling method is non-probability sampling with consecutive sampling type, with a total sample of 42 people. There was no significant difference between depression symptoms and ACE gene polymorphisms with P value = 0.746. There was no significant difference between depression symptoms and ACE gene polymorphisms.

The RelationshipBetween Online Game Exposure and Sleep Quality in Students at SMAN 13 Medan City Azzahra, Syifa Nadya; Nuralita, Nanda Sari
Buletin Farmatera Vol 10, No 2 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i2.24505

Abstract: Playing online games done during activities at night can come at the expense of sleep. The quality of a person's sleep is influenced by several aspects such as the duration of sleep, the time it takes to fall asleep, the frequency of waking up, and the level of sleep deprivation. Sleep disorders are a decrease in sleep quality that occurs due to daily activities, especially in adolescents. The quality of sleep can continue to decline with this bad routine continuously. This study aims to find out the effect of exposure to online games on sleep quality. The research is a cross sectional research conducted by filling out questionnaires by 81 students and students at SMAN 13 Medan City. The data obtained will be analyzed with Chi-square. Based on data analysis, P=0.004 was obtained where there was a relationship between exposure to online games and sleep quality at SMAN 13 Medan City. There is a significant relationship between exposure to online games and sleep quality at SMAN 13 Medan City.

Perbandingan Penggunaan Antipsikotik Atipikal Tunggal Dan Antipsikotik Atipikal Kombinasi Terhadap Kadar Ldl Pada Pasien Skizofrenia Toniara, Safriwan; thristy, Isra; Nuralita, Nanda Sari
Buletin Farmatera Vol 11, No 3 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v11i3.28213

Abstract: Schizophrenia is a collection of psychotic disorders with irregularities in the thought process, which have the feeling that they are controlled by external forces, delusions, perceptual disorders and abnormal effects integrated with real situations or reality. The use of antipsychotics in schizophrenic patients is the treatment of this disease, especially the most commonly used atypical antipsychotic users. This study aims to compare LDL (low-density lipoprotein) levels in schizophrenia patients who use single atypical antipsychotics and combination atypical antipsychotics at Madani Hospital Medan, North Sumatra. This type of research is descriptive analytical using a cross-sectional method that takes data on variable-free bound variables at one time, which is housed at the Upt Health Laboratory. North Sumatra Provincial Health Office. The results of the Independent T-Test of the use of single antipsychotics and a combination of atypical antipsychotics on LDL levels in schizophrenia patients were p=0.001 (P≤0.05). There was a significant difference between the administration of a single atypical antipsychotic and a combination of atypical antipsychotics to LDL levels in patients with schizophrenia.

Co-Authors Adelia azis Azis Nasution Amelia Eka Damayanty Asri Ludin Tambunan Azzahra, Syifa Nadya BAITUL AMANAH BATUBARA, DIAN ERISYAWANTY CHANIAGO, LITA SEPTINA DAMAYANTI, AMELIA EKA DAPOT PARULIAN GULTOM Debby Mirani Lubis Debby Mirani Lubis Des Suryani Des Suryani ELMAN BOY ELMEIDA EFFENDY ELVIANI . ILHAM SYAHPUTRA Isra Thristy Isra Thristy LITA SEPTINA CHANIAGO Lubis, Debby Mirani Maharani, Vivia Melviana Lubis Muhammad Alwi Pohan Muhammad Iqbal Nathasya Putri Kinanti Nurhasanah Nurhasanah Nurhasanah Nurhasanah Octari Auliati Pohan, Muhammad Alwi Rizaldi, Aril RIZANA, RARA RIZKI WAHYU NAFIAH Robitah Asfur SAID MUNAZAR RAHMAT Siregar, Pinta Pudiyanti Siregar, Syahroni Siti Andira Sri Rizky Ayunita Tambunan, Asri Ludin Toniara, Safriwan TRIA ARDITA ZAHRAH SAFIRA Zulhilmi, Zulhilmi

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