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All Journal Jurnal Sain Veteriner Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Indonesian Journal of Tropical and Infectious Disease Sari Pediatri Majalah Kesehatan FKUB Jurnal Pengabdian Masyarakat dalam Kesehatan Jurnal Klinik dan Riset Kesehatan Folia Medica Indonesiana
Susanto Nugroho
Badan Karantina Pertanian, Balai Karantina Pertanian Kelas I Kupang. Program Studi Kesehatan Masyarakat Veteriner Sekolah Pascasarjana IPB
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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p53/Surviving Ratio as a Parameter for Chemotherapy Induction Response in Children with Acute Myeloid Leukemia Lenggana, Rinaldi; Nugroho, Susanto; Winarsih, Sri
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.02

Abstract

Acute myeloid leukemia (AML) is a malignancy that is often found in children. Many studies into the failure of apoptosis function, or programmed cell death, is one of the most important regulatory mechanisms of cellular hemostasis which is closely linked to the development of cancer, are important. Also, regulation of the apoptotic (p53) and anti-apoptotic (surviving) proteins influence treatment outcome. One role of p53 is to monitor cellular stress necessary to induce apoptosis. Surviving (BIRC5) is a group of proteins in the apoptosis inhibitor which works by inhibiting caspase-3. The role of surviving is considered very important in oncogenesis proliferation and cell growth regulation. Chemotherapy in childhood AML can inhibit cell growth and induce slowing as well as stopping the cell cycle. Thus, the aim of this study was to compare p53 and surviving before and after receiving induction chemotherapy in children with AML and also to determine the p53/surviving ratio. Peripheral blood mononuclear cells were collected from AML children before treatment and three months after starting their induction therapy. p53 and surviving were measured by flowcytometry using monoclonal antibodies. Data were analyzed by t-test for comparison between groups and Spearman’s test to find out the correlation between variables with a significant value of p < 0.05. A total of 8 children were evaluated. The intensity of p53 expression was not significantly increased after induction phase chemotherapy (p = 0.224), but surviving expression and the ratio of p53/surviving were significantly increased in the treatment group compared with the levels prior to chemotherapy (p = 0.002, p = 0.034), and there was a strong negative correlation between p53 and surviving after chemotherapy (r = −0.63, p = 0.049).
Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease Putri, Rachmania; Suwarniaty, Renny; Fitri, Loeki Enggar; Nugroho, Susanto; Rahman, Mohammad Saifur
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.04

Abstract

Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant diff-erence (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure.
Co-Authors A.A. Ketut Agung Cahyawan W Amalia, Najwa Andrijanto Hauferson Angi, Andrijanto Hauferson Budiman Budiman Chrishariyati, Cahyani desy wulandari Dian Sukma Hanggara Eky Indyanty WL, Eky Indyanty Hani Susianti Hari Oki, Hambiah Harjoedi Adji Tjahjono, Harjoedi Adji Hidayat Suyuti Irene Ratridewi, Irene Koentartiwi, Dyahris Lenggana, Rinaldi Loeki Enggar Fitri Maimun Z Arthamin, Maimun Z Mikson M. D Nalle Muhammad Rivai Nurtjahjo Budi Santoso Putri, Rachmania Rahman, Mohammad Saifur Ramadhanti, Ardhanis Renny Suwarniaty, Renny Satrio Wibowo Siti Lintang Kawurjan Sri Winarsih Sumakto Sumakto Supraptiningsih, Eka Sari Wairo, Candy Maharani Widya Basmara, Tiara Arista Widya, Reta Anggraeni Widya, Reta Anggraeni Winaputri, Savitri Laksmi Wisnu Barlianto Yulistiani Yulistiani, Yulistiani