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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Sari Pediatri Majalah Kesehatan FKUB Jurnal Pengabdian Masyarakat dalam Kesehatan Jurnal Klinik dan Riset Kesehatan
Susanto Nugroho
Badan Karantina Pertanian, Balai Karantina Pertanian Kelas I Kupang. Program Studi Kesehatan Masyarakat Veteriner Sekolah Pascasarjana IPB
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Other

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Incidence of Candidemia in Neutropenia with Administration of Broad-Spectrum Antibiotics in Pediatric Patients with Acute Lymphoblastic Leukemia Ratridewi, Irene; Chrishariyati, Cahyani; Winaputri, Savitri Laksmi; Nugroho, Susanto
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 3 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i3.49650

Abstract

Candidemia is one of the main causes of morbidity and mortality in patients with hematological malignancies. However, the difficulty in establishing a definitive diagnosis causes these high rates. Therefore, a rapid diagnosis process is needed for the early stages of infection as the initial clinical management in pediatric patients with malignancy, especially accompanied by neutropenia. This study aims to determine the risk factors for candidemia in children using PCR (Polymerase Chain Reaction). A cross-sectional study design was used to determine the relationship between neutropenia and broad-spectrum antibiotics with the incidence of candidemia in pediatric patients with acute lymphoblastic leukemia (ALL). The results were analyzed statistically. 33 pediatric patients who met the inclusion criteria, 22 (66.67%) were positive for candida. The sample was dominated by male (66.67%) with a mean age of 4.5 years and had undergone the standard (14 patients) and high-risk (19 patients) chemotherapy protocols. The correlation test revealed no significant correlation between the administration of broad-spectrum antibiotics and the incidence of candidemia in pediatric patients with ALL (p= 0.052), neutropenia recorded a notable relationship to those patients (p=0.033). This study shows that neutropenia is a risk factor that affects the prevalence of candidemia in pediatric patients with ALL. Children with ALL who have severe neutropenia are at an increased risk of developing candidemia.
Analysis of ANC Levels after Filgrastim Therapy in Acute Leukemia Children with Neutropenia Widya, Reta Anggraeni; Nugroho, Susanto; Winarsih, Sri; Yulistiani, Yulistiani
Folia Medica Indonesiana Vol. 55 No. 1 (2019): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.058 KB) | DOI: 10.20473/fmi.v55i1.24287

Abstract

Cytotoxic chemotherapy suppresses the hematopoietic system, and the most serious hematologic toxicity is neutropenia. This can decrease a risk of infection that causes delays in treatment and reduction of dose intensity, which reduces therapeutic outcome. Filgrastim is used to increase neutrophils level whose therapeutic effect is unknown. The effectiveness of filgrastim is based on the ANC level pre- and post-therapy. This study aimed to analyze the use of filgrastim on ANC level changes in acute leukemia children with neutropenia, and to analyze the patient that achieve ANC level's targeted therapy = 1000 cell/mm3. A prospective observational study with a longitudinal design was conducted from June to October 2016. The inclusion criteria of the study were patients who diagnosed acute leukemia with neutropenia and received filgrastim 10 µg/kgBW for 3, 4, 5 days. Patients' ANC levels were measured before and after filgrastim therapy. This study has been approved its ethical clearance by Dr. Saiful Anwar Hospital, Malang. Data were obtained on the basis of neutropenic episodes, followed by 7 episodes of obtaining filgrastim for 3 days, 1 episode of obtaining filgrastim for 4 days, and 7 episodes of obtaining filgrastim for 5 days. Thus, it consists of 15 episodes. In 3 days, ANC levels increased by 9.5 fold from 381.3 ± 91.8 cell/mm3 to 3984.9 ± 426.8 cell/mm3, but in 5 days, ANC levels decreased by 0.9 fold from 200.9 cell/mm3 ± 98.2 to 189.7 ± 14.2 cell/mm3. Filgrastim was able to increased the ANC levels around nine fold for 3 days of theraphy. There were 53% neutropenia patients who achieved the goal of therapy. Filgrastim therapy with dose 10 µg/kgBW for 3 to 5 days has been able to reach the therapeutic target of 53% in acute leukemia children with neutropenia. The increased levels of ANC maximum was reached on the third day with increased levels of 9.5 fold.
EARLY DETECTION AND COUNSELLING OF ANXIETY DISORDERS IN CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATOSUS Wulandari, Desy; Barlianto, Wisnu; Nugroho, Susanto
Jurnal Pengabdian Masyarakat Dalam Kesehatan Vol. 7 No. 1 (2025): APRIL 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpmk.v7i1.62680

Abstract

Introduction: Paediatric Systemic Lupus Erythematosus (pSLE) is a chronic autoimmune disease that affects the quality of life of patients. Anxiety is a mental health problem that is rarely addressed in Indonesia. There are still many instances of children and adolescents with anxiety due to the duration of therapy, the severity of the disease, psychological conditions, and support from the environment and family. Therefore, the detection of anxiety disorders in children and adolescents really needs to be improved. This community service activity aims to provide counselling on anxiety detection in children with SLE. Methods: This community service has been carried out in June 2024 at Polyclinic of Dr Saiful Anwar Hospital Malang. The counselling about SLE, mental health, and the relationship between the two was done directly to the paediatric and adolescent patients with SLE and the evaluation was done through questionnaires using the Screen for Child Anxiety and Related Emotional Disorders (SCARED). Results: After the delivery of content related to SLE and mental health as well as the completion of questionnaires, from this activity there were 12.5% of children and adolescents from 32 patients with systemic lupus erythematosus disease who experienced anxiety disorders so that further evaluation and intervention were needed. Conclusion: Although the number of patients who did not experience anxiety was more than patients who experienced anxiety in this community service activity, psychological support to maintain optimal mental health is needed besides primary treatment for paediatric and adolescent patients with chronic illnesses.
Sindroma Lisis Tumor pada Leukemia Limfoblastik Akut L2 Hari Oki, Hambiah; Dian Sukma Hanggara; Hani Susianti; Nugroho, Susanto
Jurnal Klinik dan Riset Kesehatan Vol 4 No 1 (2024): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.1.8

Abstract

Background: Tumor lysis syndrome is metabolic abnormalities due to accumulation of intracellular contents in systemic circulation. Cairo and Bishop criteria is used to diagnosing it. Patient with hematological malignancies such as acute leukemia is more prone to this syndrome, and also infection that comes with it. Evaluating tumor lysis syndrome, especially knowing which laboratory parameters used and probable complication are crucial. Case Report: Two years old boy undergone maintenance chemotherapy for his ALL L2 that has been diagnosed one year ago. Patient has no complaint at admission, but went to worsened condition as the chemotherapy was given. Electrolyte imbalances and clinical manifestations depicting tumor lysis syndrome was found. Patient also experiencing pneumonia, gastrointestinal tract infection and sepsis (PELOD score 15). Conclusion and Suggestion: Patient experiencing tumor lysis syndrome when he was going through maintenance chemotherapy. Even though he was admitted without any major complaints, but hyperuricemia and elevated creatinine at the time of admission should be considered before initiating chemotherapy. Sepsis in this patient might be cause by bacterial infection of the gastrointestinal tract due to his severe neutropenia condition.
Pendekatan Diagnosis dan Tatalaksana Awal Kelainan Hematologi pada Anak dengan Penyakit Jantung Bawaan Sianotik Amalia, Najwa; Koentartiwi, Dyahris; Nugroho, Susanto; Ramadhanti, Ardhanis
Sari Pediatri Vol 26, No 2 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.2.2024.125-30

Abstract

Penyakit Jantung Bawaan sianotik adalah kelainan jantung bawaan akibat pirau darah dari kanan ke kiri yang mengakibatkan penurunan saturasi oksigen dalam sirkulasi sistemik. Pada PJB sianotik yang belum dikoreksi dalam jangka waktu yang lama akan terjadi hiperviskositas dan eritropoesis sekunder. Polisitemia, koagulopati, trombositopenia, dan anemia defisiensi besi relatif merupakan masalah yang sering ditemui. Tatalaksana awal kelainan hematologi ini sangat penting dalam menurunkan morbiditas dan mortalitas anak dengan PJB sianotik. Pemberian suplementasi zat besi untuk anemia defisiensi besi relatif, phlebotomi untuk kondisi polisitemia serta berbagai tatalaksana kelainan hematologi lainnya masih sangat terbatas dan kontroversial.
Hubungan antara Kadar Feritin Serum dan Kualitas Hidup Anak Talasemia Mayor dengan Hemosiderosis Widya Basmara, Tiara Arista; Wibowo, Satrio; Nugroho, Susanto; Tjahjono, Harjoedi Adji
Sari Pediatri Vol 26, No 5 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.5.2025.314-20

Abstract

Latar belakang. Talasemia mayor termasuk dalam penyakit kelainan darah yang diturunkan secara genetic autosomal resesif. Penyakit ini membutuhkan transfusi darah berulang sebagai terapi dari talasemia mayor dengan komplikasi berupa peningkatan kadar feritin serum berlebih yaitu hemosiderosis. Kualitas hidup anak dapat diukur dengan instrumen Pediatric Quality of Life Inventory (PedsQL) yang terdiri atas fungsi fisik, emosi, sosial, dan sekolah. Kadar feritin serum yang tinggi dapat mempengaruhi kualitas hidup. Tujuan. Tujuan untuk mengetahui hubungan kadar feritin serum dan kualitas hidup anak talasemia mayor dengan hemosiderosis Metode. Penelitian ini menggunakan desain penelitian korelatif dengan metode crosssectional. Kadar feritin serum didapatkan dari rekam medik dan kualitas hidup diukur dengan menggunakan PedsQL kategorik general. Digunakan uji statistik korelasi Pearson untuk uji normalitas normal dan Rank Spearman pada uji normalitas tidak normal. Hasil. dari analisis bivariate didapatkan hasil signifikan (p<0,05) antara kadar feritin serum dengan fungsi fisik dan fungsi sekolah. Pada hasil analisis bivariate antara kadar feritin serum dengan kualitas hidup anak talasemia mayor dengan hemosiderosis, fungsi emosi, dan fungsi sosial didapatkan hasil tidak signifikan (p>0,05)Kesimpulan. untuk penelitian lebih lanjut dibutuhkan metode penelitian yang berbeda untuk menganalisis lebih dalam terkait faktor-faktor yang turut serta mempengaruhi masing-masing variabel.
Co-Authors A.A. Ketut Agung Cahyawan W Amalia, Najwa Budiman Budiman Chrishariyati, Cahyani desy wulandari Dian Sukma Hanggara Eky Indyanty WL, Eky Indyanty Hani Susianti Hari Oki, Hambiah Harjoedi Adji Tjahjono, Harjoedi Adji Hidayat Suyuti Irene Ratridewi, Irene Koentartiwi, Dyahris Lenggana, Rinaldi Loeki Enggar Fitri Maimun Z Arthamin, Maimun Z Muhammad Rivai Nurtjahjo Budi Santoso Putri, Rachmania Rahman, Mohammad Saifur Ramadhanti, Ardhanis Renny Suwarniaty, Renny Satrio Wibowo Siti Lintang Kawurjan Sri Winarsih Sumakto Sumakto Supraptiningsih, Eka Sari Wairo, Candy Maharani Widya Basmara, Tiara Arista Widya, Reta Anggraeni Widya, Reta Anggraeni Winaputri, Savitri Laksmi Wisnu Barlianto Yulistiani Yulistiani, Yulistiani