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All Journal Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Cancer

Laila Nuranna

Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital

Author-ID : 334265

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 26 Documents Claim Missing Document

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Articles

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Giant Condyloma Acuminatum in a Woman with AIDS Laila Nuranna
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To describe a case of Giant Condyloma Acuminatum with aspect of HIV and some concerns about the CD4. Result: We describe 2 cases, the first case is a giant Condyloma in HIV patient and the second case is a giant Condyloma in pregnant woman. The patient in the first case was a 40-year-old woman with AIDS (CD4 is 290) who was undergoing anti-retroviral therapy. She was found to have a giant condyloma acuminatum of the vulva. Electrocautery excision was performed, and afterwards the quality of life has improved significantly. The second case patient is a 30-year-old G4P3A0 woman with a giant condyloma acuminatum. She was 30 weeks pregnant with a single fetus. On the external genitalia there was a giant condyloma mass on the vulva extending towards the peri-anal area, obstructing the introitus. The electrocautery excision was performed. She was discharged from the hospital on the second day in good condition. She had a spontaneous delivery after reaching full term. Conclusion: Although the giant Condyloma Acuminatum is combined with HIV, but itâ€™s not as difficult as imagined because the tumorâ€™s base is not wide, but shaped like inverted mushroom and it is not necessary to do local flap reconstruction. [Indones J Obstet Gynecol 2012; 36-4: 206-10] Keywords: electrocautery excision, giant condyloma acuminatum, surgery in AIDS

Human Papillomavirus Genotypes and its Prevalence in Normal Population: Genotip Human Papillomavirus dan Prevalensinya pada Populasi Normal Tofan W Utami; Andrijono Andrijono; Laila Nuranna; Darrell Fernando; Alexander AW Peters; Gert J Fleuren; Ekaterina S Jordanova; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Over 200 types of human papillomavirus (HPV) have been recognized on the basis of DNA sequence. Multiple infection is more prone to be persistent than single infection. The purpose of this study is to assess the variation of HPV types and their prevalence among negative VIA as normal population in Indonesian women. Method: We processed cervical swabs from 1,214 patients with negative VIA. HPV DNA and its genotypes were detected using PCR based INNO-Lipa HPV DNA test. We also classified whether each infection is single or multiple. Result: From 1,214 women with negative VIA, 39 (3.21%) samples were positive for HPV DNA. Among them, we detected 19 types of HPV, consisting of 13 types of high-risk HPV, 5 types of low-risk HPV, and 1 type of unknown HPV (type X). The most prevalent type was HPV type 52 (18.31%), followed by type 39 and X with the same proportion (9.86%), and HPV type 16, 18, and 74 (each 8.45%). Of the total 39 HPV-positive samples, 17 (43.6%) showed multiple-type infection and 22 (56.4%) showed single-type infection. The majority of single infection involves high-risk-HPV. The remaining were type 6, 44, 18, 51 and 66, with each single-type infection showing a prevalence of 4.54%. Conclusion: Our study shows that single HPV infection among the negative VIA population are dominated by high-risk type HPV (types 52, 39, 16, and 18). Single infection was more often encountered than multiple infection. Keywords: HPV DNA, HPV genotypes, multiple infection, negative VIA, single infection

Visual Inspection of Acetic Acid (VIA) as a Promising Standard for Cervical Cancer Screening: Inspeksi Visual dengan Asam Asetat (IVA) sebagai Standar Metode Skrining Kanker Serviks yang Menjanjikan Tofan W Utami; Laila Nuranna; Marendra Mahathir; Alexander AW Peters; Gert J Fleuren; Michelle Osse; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the "false negative" of VIA in our study population compared to HPV DNA test as the reference test or gold standard. Method: We processed the cervical swab from 1,279 patients with negative VIA and detected the HPV DNA by using INNO-Lipa HPV DNA test. Result: From 1,279 women with negative VIA, 65 samples were excluded because of incomplete data and duplicate examination. From the remaining 1,214 women with negative VIA, 39 samples were confirmed to be positive for HPV DNA by both PCR and hybridization, leading to a "false negative" result of 3.21%. Conclusion: This study shows VIA as a very effective method for cervical cancer screening. VIA gives an excellent result, particularly for ectocervix, with minimal cost. Therefore, it is very suitable to be used as cervical cancer screening in developing countries like Indonesia. Keywords: cervical cancer, HPV DNA, negative VIA, screening, VIA

Papsmear Examination for Diagnosing PreCancer Lesion in Invisible SquamoColumnar Junction Laila Nuranna; Sulaeman Daud; Gatot Purwoto; Hariyono Winarto; Kartiwa H Nuryanto
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know the concealed pre-cancer lesion in women with invisible squamo-columnar junction (SCJ) by Papsmear examination. Method: This study was a descriptive cross-sectional design starting from August 2014 to March 2015 at several Public Health Cares in Jakarta. A total of 1,682 subjects were screened by Acetoacetate Visual Inspection (AVI) examination. After the data was collected, the process was continued by verification, editing, and coding. The descriptive analysis showed the percentage of SCJ in age distribution, the percentage of AVI examination based on SCJ, and the percentage of Papsmear examination in invisible SCJ according to negative AVI result. Result: There were 1,484 (88.2%) women with the visible SCJ and 198 (11.8%) women with invisible SCJ. The percentage of invisible SCJ in the menopausal women group was 122 (61,6%); meanwhile, in the non-menopausal women group, it was 76 (38.4%). Almost half of the percentage from visible SCJ was found in menopausal women group 45.8% (103/225 women). The positive AVI result was 4 (7.1%) in the menopausal women group and 52 (92.9%) in non-menopausal women group. The result of Papsmear examination with invisible SCJ were 197 (100%) normal. Conclusion: Almost half of visible SCJ was found in menopausal women group. Most of positive AVI result was found in the nonmenopausal women group. All women with the invisible SCJ have a normal Papsmear result. Keywords: acetoacetate visual inspection, papsmear, pre-cancer lesion, squamo-columnar junction

The SDGs Perspective of TeleDoVIA Reliability for Cervical Cancer Elimination in 2030: A Cross Sectional Study in Indonesia Widya Utami, Tofan; Nuranna, Laila; Purwoto, Gatot; Winarto, Hariyono; Fitriyadi Kusuma; Rizky Humairah , Inas; Faisha Rahma, Melly; Kekalih, Aria; Peters, Alexander AW
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 4 October 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i4.1956

Objective: To describe the prevalence of HPV infection in women with negative Visual Inspection with Acetic Acid (VIA) and introduce Teleconsultation of Documented VIA (TeleDoVIA) as an objective test and provide a rationalization for recommending TeleDoVIA as a “high-performance” test for cervical cancer screening in lower resource settings, from SDGs perspective, to accelerate the achievement of second pillar elimination and the third SDGs target in 2030. Methods: This is a 7-year cross-sectional study. Subjects were recruited consecutively from several public and private health providers in Jakarta. VIA test was documented and consulted to the experts panel (TeleDoVIA). Negative VIA women underwent HPV-DNA testing using SPF10-DEIA-LiPA25 for PCR and electrophoresis. Results: A total of 1,397 negative VIA subjects were collected, consist of 52 HPV-DNA positive. False-negative of VIA was 3.7% (95% CI 0.027–0.047). Conclusion: VIA is a reliable screening method with a low false-negative rate. TeleDoVIA could be recommended as a reliable cervical cancer screening method in low resource settings such as Indonesia, which is in line with the third SDG: good health and well-being. Keywords: Southeast Asia < Asia; public health.

Comparison of USG and CT Scan Findings in Late Stage Ovarian Cancer in Dr. Cipto Mangunkusomo National Referral Hospital Sugianto, Sugianto; Purwoto, Gatot; Nuranna, Laila; Putra, Andi Darma; Nuryanto, Kartiwa Hadi; Shelly, Vannesa
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1369

Background: Ovarian cancer remains a leading cause of gynecological cancer mortality due to its typically late-stage diagnosis. Current diagnostic methods include ultrasonography (USG) and computed tomography (CT), with CT generally favored for its higher sensitivity and specificity. However, CT's limited availability in resource-poor settings raises the need to assess USG’s diagnostic viability in detecting advanced ovarian malignancies. This study aims to compare the diagnostic accuracy of USG and CT in detecting adnexal masses, ascites, lymph node involvement, omental cake, and distant metastasis in advanced-stage ovarian cancer.Method: A cross-sectional comparative study was conducted at Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, from January 2021 to December 2023. The study included 70 patients with histologically confirmed advanced ovarian cancer (FIGO stages III and IV) who underwent both USG and CT before surgical intervention. Diagnostic performance measures, including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), were calculated for each modality, using surgical findings as the gold standard. Statistical analysis was performed using SPSS software, with significance set at p 0.05.Results: Both imaging methods demonstrated high specificity (100%) and PPV for adnexal mass detection, indicating reliability in confirming positive cases. However, CT showed superior sensitivity and accuracy across most parameters, particularly for ascites (sensitivity: 93.94%), lymph node involvement (56%), and distant metastases (36.67%). In comparison, USG had lower sensitivity, especially for distant metastases (6.67%), but maintained high specificity. These findings suggest that while USG is effective for initial assessment, CT is preferred for detailed staging.Conclusion: This study confirms CT’s superiority over USG in comprehensive ovarian cancer staging, particularly for detecting metastatic indicators. However, USG’s accessibility and affordability support its role as an initial diagnostic tool, especially in resource-limited settings. A multimodal approach, integrating USG for preliminary screening with CT for confirmation, may optimize diagnostic outcomes. Further research should focus on enhancing USG’s sensitivity to bridge the diagnostic gap in underserved regions.

Co-Authors Abdul B. Saifuddin Abdullah, Iftikar Achmad Tjarta Aldri Frinaldi Alexander AW Peters Alexander AW Peters Alfu Nikmatul Laily Andi Darma Putra Andriansyah Andriansyah Andrijono Andrijono Andrijono Andrijono Andrijono Andrijono Ani Retno Prijanti Aria Kekalih Bambang Sutrisna Bambang Sutrisna Budiningsih Siregar Christin Wigin Hia Darrell Fernando Daud, Sulaeman Dewi Wulandari Dharmeizar Dharmeizar Ditha Adriana Loho Ekaterina S Jordanova Faisha Rahma, Melly Ferry Sandra Fitriyadi Kusuma Gatot Purwoto Gert J Fleuren Gita Pratama Gregorius Tanamas Gregorius Tanamas Harahap, Alida Roswita Hariyono Winarto Imam Rasjidi Jamhari Jamhari Jamtani, Mona Jasmine Iskandar Jasmine Iskandar Kartiwa H Nuryanto Kartiwa H Nuryanto Kartiwa Hadi Nuryanto Kayika, I. Putu G. Kusuma, Sang A F Adi Lestari, Linda Lestari, Linda M. F. Aziz Marendra Mahathir Michelle Osse Mona Jamtani Mpu Kanoko Nana Supriana Nessyah Fatahan Nuryanto, Kartiwa H Pelupessy, Nugraha Utama Rahma Prastasari Rizal Sanif Rizky Humairah , Inas Rochani Rochani Rukmini T. Mangunkusumo Santoso Cornain Shelly, Vannesa Sigit Purbadi Sigit Purbadi Sri Mutya Sekarutami Sugianto Sugianto Sulaeman Daud Sylvia D Elvira Tofan W Utami Tofan W Utami Tofan W Utami Tofan W Utami Widya Utami, Tofan

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