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Treatment Response of PlatinumBased Chemoradiation on Locally Advanced Cervical Cancer Khonsa, Oni; Purbadi, Sigit; Supriana, Nana; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 4, October 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the efficacy (treatment response), toxicity, and overall survival of concomitant chemoradiation (CRT) with three-weekly cisplatin-ifosfamide compared to CRT with weekly cisplatin in advanced stage cervical cancers (stage IIB-IIIB). Method: This is a historical cohort between 32 patients receiving CRT with three-weekly cisplatin and ifosfamide and 29 patients receiving weekly cisplatin in Gynecologic Oncology division outpatient clinic and ward, Dr. Cipto Mangunkusumo Hospital. Results: There was no significant difference in treatment response, overall and disease-free survival. There was more gastrointestinal toxicity in the cisplatin-ifosfamide arm compared to the other arm (p=0.014), but other toxicity effects were not different. Conclusion: Platinum based-chemoradiation has the same efficacy in terms of treatment response for locally advanced cervical cancer. [Indones J Obstet Gynecol 2015; 3-4: 212-221] Keywords: cisplatin, concomitant chemoradiation, ifosfamide, locally advance stage cervical cancer

Radiotherapy Response of Cervical Cancer Patients at a Tertiary Referral Hospital in Indonesia Winarto, Hariyono; Supriana, nana
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 4, October 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the response of radiotherapy and related clinicopathologic characterictics on cervical cancer patients. Methods: This was a retrospective study. Subjects were patients diagnosed with cervical cancer stage IIA-IIIB who had undergone radiation therapy based on standard protocol in our hospital, during the period of January 2014 to December 2015. The clinical factors ofthose patients, such as age, Body Mass Index, blood pressure, hemoglobin level, blood leucocyte count, serum albumin, largest tumor diameter, the International Federation of Gynecology and Obstetrics (FIGO) staging, as well as pathologic characteristic, i.e histopathology and grading were recorded. During radiation protocol until 3months post radiation, we also noted any side effects of gastrointestinal tract, genitourinary tract, and hematologic. Evaluation of radiotherapy response was based on Response Evaluation Criteria in Solid Tumors (RECIST).  Results: A total of 123 subjects were enrolled in this study. 84 cases or 68.29% was complete response, 30 cases or 24.39% was partial response, 6 cases or 4.88% was stabile response, and 3 cases or 2.44% was progressive. Based on gastrointestinal side effect, there was no side effect or grade 0 on 99 cases (80.49%), grade 1 on 20 cases (16.26%), grade 2 on 4 cases (3.25%), grade 3 on 0 case (0%). Based on side effect of genitourinary, there was no side effect or grade 0 on 105 cases (85.37%), grade 1 on 17 cases (13.82%), grade 2 on 1 case (0.81%), grade 3 on 0 case (0%). Based on hematologic side effects, there was no side effecton 108 cases (87.80%), grade 1 on 15 cases (12.20%), grade 2 on 0 case (0%), grade 3 on 0 case (0%). Largest tumor diameter was statistically significant, with p=0.036 (RR 2.64 (1.07-6.56)). Conclusion: The majority of definitive-curative radiotherapy response on cervical cancer stage IIA-IIIB was complete (68.29%). Acute side effects involving the gastrointestinal, genitourinary, and hematologic system were commonly can be tolerable during and 3 months post radiation therapy. Clinicopathologic characteristics significantly associated with the complete response of radiotherapy was the largest tumor diameter. Keywords: largest tumor diameter, radiation response, radiationside effect

Treatment Response of PlatinumBased Chemoradiation on Locally Advanced Cervical Cancer Khonsa, Oni; Purbadi, Sigit; Supriana, Nana; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 4, October 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the efficacy (treatment response), toxicity, and overall survival of concomitant chemoradiation (CRT) with three-weekly cisplatin-ifosfamide compared to CRT with weekly cisplatin in advanced stage cervical cancers (stage IIB-IIIB). Method: This is a historical cohort between 32 patients receiving CRT with three-weekly cisplatin and ifosfamide and 29 patients receiving weekly cisplatin in Gynecologic Oncology division outpatient clinic and ward, Dr. Cipto Mangunkusumo Hospital. Results: There was no significant difference in treatment response, overall and disease-free survival. There was more gastrointestinal toxicity in the cisplatin-ifosfamide arm compared to the other arm (p=0.014), but other toxicity effects were not different. Conclusion: Platinum based-chemoradiation has the same efficacy in terms of treatment response for locally advanced cervical cancer. [Indones J Obstet Gynecol 2015; 3-4: 212-221] Keywords: cisplatin, concomitant chemoradiation, ifosfamide, locally advance stage cervical cancer

Radiotherapy Response of Cervical Cancer Patients at a Tertiary Referral Hospital in Indonesia Winarto, Hariyono; Rahakbauw, Erwin; Supriana, Nana
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 4, October 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the response of radiotherapy and related clinicopathologic characterictics on cervical cancer patients. Methods: This was a retrospective study. Subjects were patients diagnosed with cervical cancer stage IIA-IIIB who had undergone radiation therapy based on standard protocol in our hospital, during the period of January 2014 to December 2015. The clinical factors ofthose patients, such as age, Body Mass Index, blood pressure, hemoglobin level, blood leucocyte count, serum albumin, largest tumor diameter, the International Federation of Gynecology and Obstetrics (FIGO) staging, as well as pathologic characteristic, i.e histopathology and grading were recorded. During radiation protocol until 3months post radiation, we also noted any side effects of gastrointestinal tract, genitourinary tract, and hematologic. Evaluation of radiotherapy response was based on Response Evaluation Criteria in Solid Tumors (RECIST).  Results: A total of 123 subjects were enrolled in this study. 84 cases or 68.29% was complete response, 30 cases or 24.39% was partial response, 6 cases or 4.88% was stabile response, and 3 cases or 2.44% was progressive. Based on gastrointestinal side effect, there was no side effect or grade 0 on 99 cases (80.49%), grade 1 on 20 cases (16.26%), grade 2 on 4 cases (3.25%), grade 3 on 0 case (0%). Based on side effect of genitourinary, there was no side effect or grade 0 on 105 cases (85.37%), grade 1 on 17 cases (13.82%), grade 2 on 1 case (0.81%), grade 3 on 0 case (0%). Based on hematologic side effects, there was no side effecton 108 cases (87.80%), grade 1 on 15 cases (12.20%), grade 2 on 0 case (0%), grade 3 on 0 case (0%). Largest tumor diameter was statistically significant, with p=0.036 (RR 2.64 (1.07-6.56)). Conclusion: The majority of definitive-curative radiotherapy response on cervical cancer stage IIA-IIIB was complete (68.29%). Acute side effects involving the gastrointestinal, genitourinary, and hematologic system were commonly can be tolerable during and 3 months post radiation therapy. Clinicopathologic characteristics significantly associated with the complete response of radiotherapy was the largest tumor diameter. Keywords: largest tumor diameter, radiation response, radiationside effect

Faktor-faktor Risiko Terjadinya Proktitis Radiasi Kronik pada Pasien Kanker Leher Rahim yang Mendapatkan Terapi Radiasi Mulia, Mulia; Makmun, Dadang; Abdullah, Murdani; Supriana, Nana
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pendahuluan. Proktitis radiasi merupakan komplikasi yang sering dijumpai akibat terapi radiasi pada pasien keganasan pelvis. Berbeda dengan proktitis radiasi akut yang umumnya self-limiting, proktitis radiasi kronik (PRK) dapat berdampak pada menurunnya kualitas hidup dan meningkatnya biaya kesehatan, morbiditas, dan bahkan mortalitas pasien. Penelitian ini bertujuan mengevaluasi insidens dan faktor-faktor risiko terjadinya PRK pada pasien kanker leher rahim (KLR) yang mendapatkan terapi radiasi. Metode. Dilakukan analisis retrospektif pada pasien-pasien KLR yang mendapatkan terapi radiasi di Departemen Radioterapi Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta selama kurun waktu 1 Januari 2010 sampai dengan 31 Desember 2010. Data mengenai pasien, faktor yang berhubungan dengan terapi radiasi, dan PRK akibat komplikasi lanjut dari terapi radiasi dikumpulkan dari catatan medik pasien. Hasil. Selama periode tersebut, terdapat 234 pasien yang memenuhi kriteria penelitian. Dengan median follow-up selama 30 bulan, didapatkan 12 pasien [5,1% (IK 95% 2,28-7,92%)] mengalami PRK (6 proktitis, 6 proktosigmoiditis). PRK terjadi pada 7-29 bulan setelah terapi radiasi selesai (median 14,5 bulan) dan 87% dari seluruh PRK terjadi dalam 24 bulan pertama setelah terapi radiasi. Dengan analisis multivariat Cox regresi, didapatkan hubungan bermakna antara dosis total radiasi yang diterima rektum >65 Gy (HR 7,96; IK 95% 2,30-27,50; p=0,001) dan usia ≥60 tahun (HR 5,42; IK 95% 1,65-17,86; p=0,005) dengan terjadinya PRK. Tidak didapatkan hubungan bermakna antara teknik radiasi 2 dimensional external radiation therapy (2D-XRT) (HR 1,36; IK 95% 0,41-4,51; p=0,616), riwayat histerektomi (HR 1,14; IK 95% 0,34-3,79; p=0,83), dan indeks massa tubuh (IMT) Simpulan. Insidens kumulatif PRK selama 3 tahun pada pasien KLR yang mendapatkan terapi radiasi adalah 5,1% (IK 95% 2,28-7,92%). Dosis total radiasi yang diterima rektum >65 Gy dan usia ≥60 tahun merupakan faktor risiko potensial terjadinya PRK pada pasien KLR yang mendapatkan terapi radiasi. Teknik radiasi 2D-XRT, riwayat histerektomi, dan IMT

PENGARUH GAYA KEPEMIMPINAN DAN MOTIVASI TERHADAP ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) RUMAH SAKIT PERTAMINA CIREBON Sumarsana, Asep; Trisnawati, Iis; Supriana, Nana; Supriyadi, Agung
Jurnal EBI Vol 6, No 2 (2024): Jurnal Ekonomi Bisnis dan Industri
Publisher : Fakultas Ekonomi dan Bisnis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52061/ebi.v6i2.312

This research aims to determine the influence of autocratic leadership style and work motivation on Organizational Citizenship Behavior (OCB) at Pertamina Hospital Cirebon Distribution.Respondents in this study were employees of Pertamina Hospital Cirebon Distribution using multiple linear regression methods and SPSS analysis tools.The results of this research show that autocratic leadership style influences Organizational Citizenship Behavior (OCB) and work motivation also influences Organizational Citizenship Behavior (OCB).

The Influence of Managerial Supervision on Service Quality at Tryas Hotel Cirebon Trisnawati, Iis; Supriana, Nana; Mufti, Imas
Strata International Journal of Social Issues Vol. 2 No. 2 (2025): August
Publisher : CV. Strata Persada Academia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59631/sijosi.v2i2.443

The hospitality industry plays a pivotal role in Indonesia’s economic recovery by delivering services that directly influence guest satisfaction and organizational competitiveness. Within this sector, managerial supervision functions as a critical mechanism to ensure service consistency, employee discipline, and alignment with organizational objectives. This study investigates the influence of managerial supervision on service quality at Tryas Hotel Cirebon. A quantitative-descriptive analytic method was employed, involving 30 respondents selected through simple random sampling from a population of 42 hotel guests. Data were collected using structured observations, interviews, and questionnaires, and subsequently analyzed using Pearson’s product–moment correlation and t-tests at a 5% significance level. The results revealed that managerial supervision was categorized as “fairly good,” with an achievement level of 73.68%. Among the indicators, objective and precise supervision scored the highest, while goal-oriented supervision was rated the lowest. Statistical analysis demonstrated a strong and significant correlation (r = 0.761) between managerial supervision and service quality, with managerial supervision contributing 57.91% to service quality improvement. These findings highlight the necessity for hotel management to enhance supervisory practices by prioritizing goal alignment, objectivity, and continuous feedback. Strengthening these aspects is expected to foster employee performance improvements and elevate overall service quality in the hospitality sector.

REKONSTRUKSI PERTANGGUNGJAWABAN HUKUM TERHADAP PENYALAHGUNAAN KEUANGAN NEGARA DALAM PENGADAAN BARANG/JASA BERBASIS E-PROCUREMENT 2023–2025 Supriana, Nana; Iswanto, Candra
Causa: Jurnal Hukum dan Kewarganegaraan Vol. 12 No. 5 (2025): Causa: Jurnal Hukum dan Kewarganegaraan
Publisher : Cahaya Ilmu Bangsa

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Digitalisasi pengadaan barang/jasa melalui sistem e-procurement diharapkan mampu meningkatkan transparansi dan akuntabilitas pengelolaan keuangan negara. Namun, perkembangan praktik 2023–2025 menunjukkan bahwa penggunaan teknologi justru memunculkan pola penyimpangan baru yang memanfaatkan kerentanan sistem elektronik. Penelitian ini bertujuan mengkaji bentuk-bentuk penyalahgunaan keuangan negara dalam pengadaan berbasis elektronik, mengidentifikasi kekosongan norma dalam regulasi yang berlaku, serta merumuskan rekonstruksi model pertanggungjawaban hukum yang lebih adaptif terhadap risiko digital. Metode yang digunakan adalah penelitian hukum normatif dengan pendekatan peraturan perundang-undangan, konseptual, dan kasus. Hasil penelitian menunjukkan bahwa kerangka hukum yang ada, terutama Peraturan Presiden tentang PBJ dan Undang-Undang Perbendaharaan Negara, belum sepenuhnya mengatur tanggung jawab atas manipulasi data elektronik, gangguan sistem, ataupun penyalahgunaan akun digital. Oleh karena itu, diperlukan pembaruan norma yang mencakup pertanggungjawaban administratif, perdata, dan pidana, termasuk penguatan standar audit trail, autentikasi digital, dan kewenangan pengawasan berbasis elektronik. Penelitian ini menegaskan bahwa penguatan e-procurement tidak cukup bertumpu pada teknologi, tetapi harus disertai pembaruan hukum yang menjamin kepastian dan perlindungan terhadap keuangan negara. The digitalization of public procurement through e-procurement has been promoted as an instrument to enhance transparency and accountability in state financial management. However, practical developments during 2023–2025 reveal that technology has also created new forms of misuse that exploit vulnerabilities within electronic systems. This study examines patterns of state financial misuse in electronic procurement, identifies normative gaps within existing regulations, and proposes a reconstructed model of legal accountability that is more responsive to digital risks. The research employs a normative legal method with statutory, conceptual, and case approaches. The findings indicate that the current regulatory framework particularly the Presidential Regulation on Public Procurement and the State Treasury Law does not sufficiently govern accountability for electronic data manipulation, system interference, or the misuse of digital accounts. Consequently, legal reforms are required to strengthen administrative, civil, and criminal liability, including the establishment of clearer standards for digital authentication, audit trails, and oversight mechanisms. The study concludes that the effectiveness of e-procurement depends not only on technological sophistication but also on legal reforms capable of providing certainty and safeguarding state finances.

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